Abstract:
:In chronic renal failure (CRF), phosphate (Pi) retention may lead to secondary hyperparathyroidism and progression to end-stage renal disease (ESRD). Dietary phosphorus restriction or phosphate binders can slow progression in experimental CRF. Conversely, diets high in phosphorus can accelerate the progression toward ESRD. Phosphate binders reduce intestinal Pi absorption but have no effect on its renal excretion. Phosphonoformic acid (PFA, foscarnet) is a specific inhibitor of both intestinal and renal brush border Na(+)-Pi cotransport. It causes phosphaturia when administered parenterally or orally to rats. To determine the effect of oral PFA on renal function and on phosphate excretion in renal insufficiency, PFA was administered in drinking water to rats with CRF produced by 5/6th nephrectomy. Blood and 24-h urine collections were performed every 2 weeks for determination of plasma Pi and creatinine concentrations, urinary protein excretion, and urinary creatinine and Pi clearances. PFA, administered for 8 weeks, did not exert any adverse effects on any of the measured parameters. The slopes of the reciprocal of plasma creatinine versus time were not different between control and PFA-treated rats. Although PFA increased Pi excretion over the baseline, it had no persistent effect on plasma Pi concentrations under these experimental conditions.
journal_name
Ren Failjournal_title
Renal failureauthors
Loghman-Adham M,Motock GTdoi
10.3109/08860229609047712subject
Has Abstractpub_date
1996-11-01 00:00:00pages
855-66issue
6eissn
0886-022Xissn
1525-6049journal_volume
18pub_type
杂志文章相关文献
RENAL FAILURE文献大全abstract:OBJECTIVE:The aim of this study was to determine the effect of oral cholecalciferol treatment on vascular calcification, left ventricular mass index (LVMI) and other cardiac functions in dialysis patients. DESIGN AND METHODS:A six-month course of oral cholecalciferol treatment was recommended to dialysis patients with...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2015.1010416
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVES:Chronic kidney disease (CKD) is a major risk factor for cardiovascular disease (CVD). We previously reported renal parenchymal damage in autopsy subjects with stroke or abdominal aortic aneurysm. The aim of this study is to evaluate the relationship between renal histology and clinical characteristics of pat...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2011.605531
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Despite the effectiveness of intravenous calcitriol in suppressing parathyroid hormone secretion in patients with uremic hyperparathyroidism, 50% of the patients remain refractory to this treatment. There are conflicting reports regarding the factors that can predict the response to treatment. Technetium-99m...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-120004093
更新日期:2002-03-01 00:00:00
abstract:BACKGROUND:Genetic polymorphism of endothelial nitric oxide synthase (eNOS) has been implicated in the risk of diabetic nephropathy (DN), but the published findings were inconsistent. We performed a comprehensive meta-analysis to derive a more precise estimation of the association between genetic polymorphisms of eNOS ...
journal_title:Renal failure
pub_type: 杂志文章,meta分析
doi:10.3109/0886022X.2015.1062339
更新日期:2015-11-01 00:00:00
abstract::The derangements in bone metabolism in patients with chronic renal failure (CRF) are summarized as uremic bone disease (UBD). In this study, we planned to determine the serum prolidase to compare it with the other biochemical markers. This study was performed on 44 patients (19 females, 25 males, mean age = 56.8 +/- 1...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220600577726
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Although adequate peritoneal dialysis is not well defined, Kt/Vurea has been used as an index, and various values have been proposed. However, conflicting evidence existed regarding the appropriateness of using Kt/Vurea to define dialysis adequacy and its optimal value. Therefore, the present study performed...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220601166586
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:Organic solvents are liquid substances commonly used in everyday life at home and in industrial workplaces. These solvents are found primarily in paint as thinner. Because other narcotics are hard to find, thinner is used as a narcotic especially among youngsters of low socioeconomic level. The aim of this...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2010.536290
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Advanced glycation end products (AGEs) have biological properties that may contribute to the mortality of children on hemodialysis (HD). This study examines the relationship of LMW fluorescence AGEs, oxidized LDL (ox-LDL), soluble receptor AGE (sRAGE) as markers of oxidative stress in children with end stage...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2015.1077317
更新日期:2015-01-01 00:00:00
abstract::Diabetic nephropathy (DN) is the most common cause of end-stage renal disease worldwide. The pathophysiologic mechanisms of diabetic nephropathy are incompletely understood but include overproduction of various growth factors and cytokines. Upregulation of vascular endothelial growth factor (VEGF) is a pathogenic even...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2014.900404
更新日期:2014-07-01 00:00:00
abstract::Although sudden sensorineural hearing loss (SSNHL) affects chronic kidney disease (CKD) patients more frequently than non-CKD patients, few reports have described SSNHL in dialysis patients. We aimed to review the characteristics of SSNHL in chronic dialysis patients and evaluate treatment responses to steroid therapy...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2018.1450760
更新日期:2018-11-01 00:00:00
abstract::Amidinotransferase (transamidinase, L-arginine: glycine amidinotransferase, EC 2.1.4.1) is an enzyme that catalyses the first step in creatine synthesis primarily in the kidney and pancreas. The kidney is also the primary target organ for the toxic effect of mercury. Therefore, we studied the effect of acute uremic sy...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-200037149
更新日期:2004-11-01 00:00:00
abstract::A 68-year-old male presented with acute myeloid leukemia, renal failure, hypokalemia, and enlarged kidneys on renal ultrasound. Renal biopsy revealed massive leukemic infiltration of the kidney. After systemic chemotherapy, the patient developed tumor lysis syndrome followed by a phase of proximal tubule dysfunction p...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220902972187
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:To explore the association of urinary podocyte excretion and renal expression of podocyte-specific marker podocalyxin (PCX) with clinicopathological changes in immunoglobulin A nephropathy (IgAN). METHODS:Morning urine samples from IgAN patients and healthy controls were collected. The expression of glomerul...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2011.643352
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Despite the widespread availability of dialytic and intensive care unit technology, the probability of early mortality in critically ill patients with acute renal failure (ARF) is still high, and the evaluation of the patients' prognosis has been difficult. The Acute Physiology and Chronic Health Evaluation ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-100001284
更新日期:2001-01-01 00:00:00
abstract::Chronic kidney disease (CKD) is a world-wide public health problem. The purpose of this study was to identify the role of some controversial potential risk factors in development of CKD. "Community Complex Health Screening" is a large-scale, free, health program for individuals ≥40 years of age that has been available...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2013.866017
更新日期:2014-04-01 00:00:00
abstract::N-acetylglucosaminidase (NAG) is a lysosomal enzyme produced by renal proximal tubular cells and has been widely used as a marker, which indicates a degree of renal tubular damage. An increase in urinary NAG excretion is though to result from the renal tubular damage. The aim of this study was to evaluate whether even...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-120002662
更新日期:2002-01-01 00:00:00
abstract::Oxidative stress is one of the important mechanisms of cisplatin-induced nephrotoxicity. Therefore, this study was designed to explore the potential protective effects of morin and/or hesperidin on oxidative stress in cisplatin-induced nephrotoxicity. This study was performed on 42 Wistar rats. Rats were divided into ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2016.1209383
更新日期:2016-09-01 00:00:00
abstract::The nephrotoxicity of amikacin (AK) was prevented with pentoxifylline (PTX) in a rat model. Rats were received a single injection of AK (1.2 g/kg, i.p.) with or without PTX pretreatment (25 mg/kg, orally). Renal morphology was investigated by light microscopy. Tissue samples and trunk blood were also obtained to deter...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220802595492
更新日期:2009-01-01 00:00:00
abstract::The influence of L-carnitine supplementation on hematocrit (Hct) and hemoglobin (Hb) levels, in patients suffering from end stage renal disease (ESRD) on maintenance hemodialysis, are well known from several studies. The data concerning the serum levels of carnitine, in patients with ESRD on continuous ambulatory peri...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-120006777
更新日期:2002-07-01 00:00:00
abstract::While the fractional excretion of solutes have long been considered excellent research tools to investigate tubular physiology, their clinical use has become common over the last 40 years in the diagnoses of many disorders; however, none have reached the clinical utility of the fractional excretion of sodium in the ab...
journal_title:Renal failure
pub_type: 杂志文章,评审
doi:10.3109/0886022X.2010.517353
更新日期:2010-01-01 00:00:00
abstract::Depression is common in patients with end-stage renal disease (ESRD) and is associated with increased mortality and morbidity. Several investigators have estimated that depression occurs in about 20% to 30% of dialysis patients. The aim of this study was to investigate the relationship between depression, some laborat...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220500242728
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVES:To explore the capacity of mutant lactobacilli to remove creatinine (Cr) and urea nitrogen (UN) via the gastrointestinal tract and its effects on renal pathology in the 5/6 nephrectomized rat model of chronic renal failure. METHODS:Sixty Sprague-Dawley rats were randomly divided into a Sham group, a Model g...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2016.1227617
更新日期:2016-10-01 00:00:00
abstract::Randomized control trials (RCTs) are considered as most rigors way of determining the cause-effect relationship of a treatment and outcome. Activation of rennin angiotensin aldosterone system (RAAS) is an important contributor to hypertension in hemodialysis patients. The prevalence of hypertension in hemodialysis pat...
journal_title:Renal failure
pub_type: 杂志文章,评审
doi:10.3109/0886022X.2016.1138833
更新日期:2016-01-01 00:00:00
abstract::Single injection, single blood sample, effective renal plasma flow (ERPF) estimated by 131I-orthoiodohippurate can be performed accurately and conveniently without urine collection at the bedside. The purpose of this study was to determine if ERPF early in the course of severe acute renal failure (ARF) predicts recove...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860228709056321
更新日期:1987-01-01 00:00:00
abstract::There are conflicting results in studies concerning the best marker for liver histopathological features of HCV infection in HD patients. We planned a prospective study to follow HCV viremia and laboratory parameters of HD patients and correlate these with clinic features and histopathological findings. We included 68...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-100108192
更新日期:2001-11-01 00:00:00
abstract:BACKGROUND:Spontaneous crescentic glomerulonephritis (SCG)/Kj mice are a candidate for suitable animal model of human pauci-immune crescentic glomerulonephritis (GN). In the present study, we used renal biopsy technique and analyzed time sequence correlations among crescent formation and glomerular neutrophil infiltrat...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-120013958
更新日期:2002-09-01 00:00:00
abstract::Polyarteritis nodosa (PAN) is a necrotizing inflammatory vasculitis of small- and medium-sized muscular arteries. Multiple organs, especially the kidney, skin, peripheric nerves, striated muscles, and intestine, are affected. In this case report, a patient with renal and hepatic involvement and axillary and brachial a...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2011.618427
更新日期:2011-01-01 00:00:00
abstract::We studied gene expression for transforming growth factor (TGF)-alpha, epidermal growth factor (EGF), heparin binding (HB) EGF, and the EGF receptor following acute renal failure induced by mercuric chloride administration to gain insight into potential mechanisms of renal repair. Twenty four hours after HgCl2, 2 mg/k...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-100100884
更新日期:2000-01-01 00:00:00
abstract::Recently we demonstrated the effect of fenoldopam on ischemia/reperfusion (I/R) induced NFkappaB mediated pro-inflammatory signal transduction. However, the effect of fenoldopam on I/R-induced apoptosis is not known. We utilized a rat model of acute ischemic nephropathy to test the hypothesis that fenoldopam attenuate...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220600583690
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND AND AIM:There is an increased mortality risk in long-term hemodialysis patients of renal failure due to the chronic inflammation. The relationship between the chronic renal failure (CRF) and the role of familial genetic markers remains incompletely understood. In the current study, it was aimed to find out t...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2014.982954
更新日期:2015-03-01 00:00:00