Toward the optimal clinical use of the fraction excretion of solutes in oliguric azotemia.

Abstract:

:While the fractional excretion of solutes have long been considered excellent research tools to investigate tubular physiology, their clinical use has become common over the last 40 years in the diagnoses of many disorders; however, none have reached the clinical utility of the fractional excretion of sodium in the ability to distinguish pre-renal azotemia from acute tubular necrosis. Nevertheless, there are many drugs and medical conditions that interfere with that utility and recently other solutes, including urea, uric acid and lithium, have been recently investigated to improve the diagnostic ability in clinical situations where the fractional excretion of sodium is known to be unreliable. We review the tubular physiology of these solutes and show how the differences in tubular physiology might be exploited to develop a strategy for their optimal clinical use.

journal_name

Ren Fail

journal_title

Renal failure

authors

Diskin CJ,Stokes TJ,Dansby LM,Radcliff L,Carter TB

doi

10.3109/0886022X.2010.517353

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

1245-54

issue

10

eissn

0886-022X

issn

1525-6049

journal_volume

32

pub_type

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