Abstract:
:While the fractional excretion of solutes have long been considered excellent research tools to investigate tubular physiology, their clinical use has become common over the last 40 years in the diagnoses of many disorders; however, none have reached the clinical utility of the fractional excretion of sodium in the ability to distinguish pre-renal azotemia from acute tubular necrosis. Nevertheless, there are many drugs and medical conditions that interfere with that utility and recently other solutes, including urea, uric acid and lithium, have been recently investigated to improve the diagnostic ability in clinical situations where the fractional excretion of sodium is known to be unreliable. We review the tubular physiology of these solutes and show how the differences in tubular physiology might be exploited to develop a strategy for their optimal clinical use.
journal_name
Ren Failjournal_title
Renal failureauthors
Diskin CJ,Stokes TJ,Dansby LM,Radcliff L,Carter TBdoi
10.3109/0886022X.2010.517353subject
Has Abstractpub_date
2010-01-01 00:00:00pages
1245-54issue
10eissn
0886-022Xissn
1525-6049journal_volume
32pub_type
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