Discrimination between postinfectious IgA-dominant glomerulonephritis and idiopathic IgA nephropathy.

Abstract:

BACKGROUND:A unique form of postinfectious glomerulonephritis (PIGN) with IgA-dominant deposition mimicking IgA nephropathy has been increasingly reported. METHODS:We compared the clinical and histological features of 12 patients with postinfectious IgA-dominant glomerulonephritis to 134 patients with idiopathic IgA nephropathy. RESULTS:In addition to hypocomplementemia and subepithelial hump-shaped deposits characteristic of PIGN, patients with postinfectious IgA-dominant glomerulonephritis had older age (62.3 +/- 16.9 vs. 37.9 +/- 16.3 years; p < 0.001) and more frequently presented with acute renal failure (83.3% vs. 10.4%; p < 0.001) than patients with idiopathic IgA nephropathy. Moreover, glomerular changes including endocapillary proliferation, neutrophil infiltration, and capillary loops deposits by immunofluorescence were more commonly present in postinfectious IgA-dominant glomerulonephritis group (p < 0.001). CONCLUSIONS:PIGN could be characterized by glomerular IgA-dominant deposition resembling idiopathic IgA nephropathy. It is essential to differentiate postinfectious IgA-dominant glomerulonephritis from idiopathic IgA nephropathy because of the different treatments and prognosis of the two diseases.

journal_name

Ren Fail

journal_title

Renal failure

authors

Wen YK,Chen ML

doi

10.3109/08860221003753331

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

572-7

issue

5

eissn

0886-022X

issn

1525-6049

journal_volume

32

pub_type

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