Analysis of potential risk factors for cancer incidence in patients with aristolochic acid nephropathy from Wenzhou, China.

Abstract:

BACKGROUND:The purpose of this study was to investigate the cancer incidence in patients with end-stage aristolochic acid nephropathy (AAN). METHODS:A total of 102 patients with end-stage AAN treated in our hospital between 2004 and 2013 were included in this study. The correlation of cancer incidence with age, gender, dosage of aristolochic acid (AA), the type of renal replacement therapies, and the polymorphisms of quinone oxidoreductase 1 (NQO1) C609T and cytochrome P450 1A1 (CYP1A1) A4889G was examined. RESULTS:The cancer incidence rate in our patients was 41.2% (42 in 102) including 39 cases of urinary cancer. The mortality rate in the patients with cancer was significantly higher than that in the patients without cancer (31%, 13/42 vs. 11.7%, 7/60, p<0.05). Thirteen patients developed cancer before entering end-stage renal disease (ESRD). Cancer incidence was significantly associated with the dosage of AA consumption (p=0.091). Hemodialysis, peritoneal dialysis and renal transplant did not affect the cancer incidence in our patients differently, but appeared to be associated with cancer at particular locations of urinary system. The patients undergoing hemodialysis seemed to more likely have bladder cancer (72.72%), while the patients receiving peritoneal dialysis appeared to develop cancer predominantly in the upper urinary tract (66.67%). CONCLUSIONS:The cancer initiation in our patients seems significantly correlate with the dosage of AA consumption. Different renal replacement therapies appear to be associated with cancer at particular locations of urinary system in our patients.

journal_name

Ren Fail

journal_title

Renal failure

authors

Sun M,Zhang J,Zheng C,Liu Y,Lin F,Xu F,Chen C

doi

10.3109/0886022X.2014.990347

subject

Has Abstract

pub_date

2015-03-01 00:00:00

pages

209-13

issue

2

eissn

0886-022X

issn

1525-6049

journal_volume

37

pub_type

杂志文章
  • The significance of serum levels of soluble interleukin-2 receptor in patients undergoing maintenance hemodialysis.

    abstract::Background: Elevated serum levels of sIL-2R are commonly observed in patients undergoing maintenance hemodialysis (MHD). However, the clinical implications in these subjects are unclear. This study is aimed to assess the significance of elevated sIL-2R levels in MHD patients.Methods: A total of 382 MHD patients were f...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2020.1761388

    authors: Chen X,Li Y,Ding X,Zou J,Shen B,Liu Z,Lv W,Cao X,Xiang F

    更新日期:2020-11-01 00:00:00

  • Association of CYP3A variants with kidney transplant outcomes.

    abstract::Cyclosporine is used extensively in kidney transplantation and is a substrate for cytochrome P450 enzymes. The role of cytochrome p450 polymorphisms in kidney transplant outcome has not yet been fully elucidated. We investigate the clinical impact of single nucleotide polymorphisms in CYP3A4, CYP3A5, PPARα, and POR*28...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2015.1007013

    authors: Traynor C,Conlon P Jr,Phelan PJ,O'Kelly P,Elens L,McCormack M,Cavalleri G,Comber H,van Schaik RH,Conlon PJ

    更新日期:2015-05-01 00:00:00

  • Angiotensin I converting enzyme activity in uranyl nitrate induced acute renal failure in rats.

    abstract::Angiotensin I converting enzyme (ACE) was measured in urine, serum, and tissues from rats with acute renal failure (ARF) induced by a single subcutaneous injection (15 mg/kg BW) of uranyl nitrate (UN). Urine was collected daily until day 5, when rats were sacrificed by decapitation for the obtention of blood serum and...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229509037603

    authors: Pedraza-Chaverrí J,Cruz C,del Socorro Blancas M,Hernández-Pando R,Ibarra-Rubio ME,Larriva-Sahd J,Tapia E

    更新日期:1995-07-01 00:00:00

  • Infection-related hospitalization after intensive immunosuppressive therapy among lupus nephritis and ANCA glomerulonephritis patients.

    abstract::Introduction: This study aimed to investigate the clinical characteristics, risk factors, and outcomes of infection-related hospitalization (IRH) in patients with lupus nephritis (LN) and ANCA glomerulonephritis after intensive immunosuppressive therapy.Methods: Patients diagnosed with LN or ANCA glomerulonephritis wh...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2020.1763400

    authors: Yin P,Li J,Wen Q,Qiu Y,Liang W,Wang J,Yu J,Zhong Z,Yang X,Yu X,Ye Q,Huang F

    更新日期:2020-11-01 00:00:00

  • Use of alpha-lipoic acid in prevention of contrast-induced nephropathy in diabetic patients.

    abstract::In this prospective study, we aimed to determine the protective antioxidant role of alpha-lipoic acid (ALA) on development of contrast-induced nephropathy (CIN) in diabetic patients undergoing coronary angiography. Seventy-eight diabetic patients undergoing coronary angiography were included. Thirty-nine patients were...

    journal_title:Renal failure

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/0886022X.2013.790298

    authors: Cicek M,Yıldırır A,Okyay K,Yazici AC,Aydinalp A,Kanyilmaz S,Muderrisoglu H

    更新日期:2013-01-01 00:00:00

  • Lupus nephritis at the University Hospital of the West Indies, Kingston, Jamaica: a 10-year experience.

    abstract::The case records of 75 patients who had systemic lupus erythematosus (SLE) and renal involvement on renal histology were reviewed. There were 70 females and 5 males, with a ratio of 14:1. The majority of the patients were in their second and third decades of life. SLE nephritis was distinctly uncommon in patients belo...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229009066962

    authors: Williams W,Shah D

    更新日期:1990-01-01 00:00:00

  • The effect of cholesterol overload on mouse kidney and kidney-derived cells.

    abstract:INTRODUCTION:Dyslipidemia is one of the onset and risk factors of chronic kidney disease and renal function drop is seen in lipoprotein abnormal animal models. However, the detailed molecular mechanism of renal lipotoxicity has not been clarified. Therefore, the present study aimed to investigate the influence of chole...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2017.1419974

    authors: Honzumi S,Takeuchi M,Kurihara M,Fujiyoshi M,Uchida M,Watanabe K,Suzuki T,Ishii I

    更新日期:2018-11-01 00:00:00

  • Endothelial function and oxidative stress in chronic kidney disease of varying severity and the effect of acute hemodialysis.

    abstract:AIM:Oxidative stress (OS) and endothelial dysfunction are implicated in accelerated atherosclerosis in chronic kidney disease (CKD). We assessed endothelial function, OS, and carotid intimal medial thickness (CIMT) and their correlates in 44 CKD stage 5 patients (group III) before and after hemodialysis (HD), 40 patien...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2011.568138

    authors: Khaira A,Mahajan S,Kumar A,Saraya A,Tiwari SC,Prakash S,Gupta A,Bhowmik D,Agarwal SK

    更新日期:2011-01-01 00:00:00

  • Effects of oral carbonic adsorbent (AST-120) on kidney of early-stage chronic kidney disease rats.

    abstract:AIM:To investigate the therapeutic effects of oral carbonic adsorbent on rats with early-stage renal failure. METHODS:The early-stage renal failure model was established with three-fourth subtotal nephrectomy Wistar rats. Four weeks after the subtotal nephrectomy, the rats were randomly divided into four groups: (1) a...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2014.986006

    authors: Tan X,He J,Cao X,Zou J,Liu H,Ding X

    更新日期:2015-03-01 00:00:00

  • The aqueous extract of aged black garlic ameliorates colistin-induced acute kidney injury in rats.

    abstract::The use of colistin in the treatment of multidrug-resistant Gram-negative bacterial infections is restricted due to nephrotoxicity. We investigated the effects of aged black garlic extract (ABGE) on colistin-induced kidney injury in rats. Rats were assigned to four groups. Normal saline was intraperitoneally and intra...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2018.1561375

    authors: Lee TW,Bae E,Kim JH,Jang HN,Cho HS,Chang SH,Park DJ

    更新日期:2019-11-01 00:00:00

  • Radial augmentation index may be an effective predictor of vascular calcification in patients on peritoneal dialysis.

    abstract::Vascular calcification (VC) is an important promoter of cardiovascular disease (CVD) in patients undergoing peritoneal dialysis (PD). Several indices can be used to evaluate VC, including the abdominal aortic calcification index (AACI) and carotid artery intima-media thickness (IMT); however, simpler and lesser expens...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2020.1762646

    authors: Yang N,Yang W,Cui W,Zhou D,Du X,Li L

    更新日期:2020-11-01 00:00:00

  • Development of hypertension in a pyelonephritis-induced model: the effect of salt intake and inability of renal sodium handling.

    abstract::The role of the kidney in the control of blood pressure has been convincingly demonstrated by several studies. Recent evidence has suggested that subtle acquired tubulointerstitial injury may cause a defect in sodium excretion function, thus leading to salt-sensitive hypertension. There are no reports, however, examin...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220600779058

    authors: de Magalhães Sartim R,Fantinato Menegon L,de Almeida AR,Rocha Gontijo JA,Aline Boer P

    更新日期:2006-01-01 00:00:00

  • Unilateral renal venous thrombosis secondary to the use of vibration belt in a young woman.

    abstract::We report on the isolated unilateral renal venous thrombosis (RVT) detected in a young patient who used vibration belt to stay thin. Apart from her sickle cell trait, the patient presented no other clinical situations associated with RVT. ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2012.712848

    authors: Balal M,Paydas S,Inal M

    更新日期:2012-01-01 00:00:00

  • Assessment of protein nitrogen appearance in Chinese peritoneal dialysis patients-which method to use?

    abstract:OBJECTIVE:We compared the Bergstrom's and Randerson's formula for PNA determination, and compared the normalization of PNA by ideal body weight (IBW) and standard body weight (SBW) as estimated by the Watson's formula. METHODS. We studied 208 Chinese PD patients. Two 24-h dialysate and urine collections were performed ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1081/jdi-120018724

    authors: Szeto CC,Chow KM,Leung CB,Wong TY,Li PK

    更新日期:2003-03-01 00:00:00

  • Mrna expression of transforming growth factor-alpha and the EGF receptor following nephrotoxic renal injury.

    abstract::We studied gene expression for transforming growth factor (TGF)-alpha, epidermal growth factor (EGF), heparin binding (HB) EGF, and the EGF receptor following acute renal failure induced by mercuric chloride administration to gain insight into potential mechanisms of renal repair. Twenty four hours after HgCl2, 2 mg/k...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1081/jdi-100100884

    authors: Hise MK,Liu L,Salmanullah M,Drachenberg CI,Papadimitriou JC,Rohan RM

    更新日期:2000-01-01 00:00:00

  • Kidney function and histological damage in autopsy subjects with myocardial infarction.

    abstract:OBJECTIVES:Chronic kidney disease (CKD) is a major risk factor for cardiovascular disease (CVD). We previously reported renal parenchymal damage in autopsy subjects with stroke or abdominal aortic aneurysm. The aim of this study is to evaluate the relationship between renal histology and clinical characteristics of pat...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2011.605531

    authors: Niizuma S,Nakamura S,Ishibashi-Ueda H,Yoshihara F,Kawano Y

    更新日期:2011-01-01 00:00:00

  • Nutritional status in stage V dialyzed patient versus CKD patient on conservative therapy across different economic status.

    abstract:BACKGROUND:This aim of this multi-centric cross-sectional study was to assess the nutritional status in Indian chronic kidney disease (CKD) patients and to compare the nutritional indicators between stage 5 dialyzed (CKD-D) patients below the poverty line (BPL), and stage 3-4 non-dialyzed (CKD-ND) patients above (APL) ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2013.872570

    authors: Vijayan M,Abraham G,Alex ME,Vijayshree N,Reddy Y,Fernando E,Mathew M,Nair S,Yuvaraj A

    更新日期:2014-04-01 00:00:00

  • Which echocardiographic parameter is a better marker of volume status in hemodialysis patients?

    abstract:AIM:Bio-impedance analysis (BIA) is a preferred method for estimating the volume status. However, it cannot be utilized in daily practice. Since the assessment of the volume status is important and challenging for hemodialysis (HD) patients, the aim of study was to determine the volume status in chronic HD patients usi...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2016.1229968

    authors: Sabaghian T,Hajibaratali B,Samavat S

    更新日期:2016-11-01 00:00:00

  • Renal cortical mitochondria are the source of oxygen free radicals enhanced by gentamicin.

    abstract::Rat renal cortical mitochondria were isolated from Wistar male rats weighing 80 to 120 g to investigate whether the source of oxygen free radicals was renal cortical mitochondria enhanced by gentamicin. In renal cortical mitochondria with or without the addition of gentamicin, DMSO, DFO, CAT, SOD, and MT1 were added s...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229509036371

    authors: Yang CL,Du XH,Han YX

    更新日期:1995-01-01 00:00:00

  • Dysregulated microRNAs involved in contrast-induced acute kidney injury in rat and human.

    abstract:BACKGROUND:Contrast-induced nephropathy (CIN) is a complex syndrome of acute nephropathy that occurs following infusion of intravascular contrast agents, and is associated with an increased risk for adverse cardiovascular events. While there is no ideal biomarker for making an early diagnosis of CIN, we hypothesized th...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2015.1077322

    authors: Gutiérrez-Escolano A,Santacruz-Vázquez E,Gómez-Pérez F

    更新日期:2015-01-01 00:00:00

  • Erythropoietin production in patients with chronic renal failure.

    abstract::Studies were performed to reexamine the response of erythropoietin (Epo) production to acute hypoxic stimuli in patients with end-stage renal disease (ESRD). In the absence of acute bleeding or hypoxia, the serum Epo level in ESRD was similar to that of normal subjects despite severe anemia. In 11 dialysis patients wi...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229409044892

    authors: Kato A,Hishida A,Kumagai H,Furuya R,Nakajima T,Honda N

    更新日期:1994-01-01 00:00:00

  • The differences of asymmetric dimethylarginine removal by different dialysis treatments.

    abstract:BACKGROUND:Asymmetric dimethylarginine (ADMA) as a uremia toxin is accumulated in end-stage renal disease (ESRD) patients. Elevated ADMA level has been shown to be predictive of cardiovascular diseases (CVDs) and all-cause mortality in ESRD. Therefore, we investigated the removal of ADMA by different dialysis treatment...

    journal_title:Renal failure

    pub_type: 杂志文章,随机对照试验

    doi:10.3109/0886022X.2010.502281

    authors: Zhang DL,Liu J,Liu S,Zhang Y,Liu WH

    更新日期:2010-01-01 00:00:00

  • Rhabdomyolysis and acute renal failure in intensive care unit.

    abstract::Rhabdomyolysis is common clinical and laboratory syndrome resulting from skeletal muscle injury and acute renal failure is the most important complication. Acute renal failure is common in critically ill medical patients. The aim of our study was to determine the prevalence of rhabdomyolysis induced acute renal failur...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229909094161

    authors: Hojs R,Ekart R,Sinkovic A,Hojs-Fabjan T

    更新日期:1999-11-01 00:00:00

  • Low-dose IL-2 expands CD4+ regulatory T cells with a suppressive function in vitro via the STAT5-dependent pathway in patients with chronic kidney diseases.

    abstract:BACKGROUND:Patients with chronic kidney disease (CKD) often have CD4+ regulatory T cells (Tregs) dysfunction and chronic inflammation. We aim to investigate the effect, function, and related mechanism of low-dose IL-2 on CD4+ regulatory T cells expansion in vitro from patients with CKD. METHODS:A total of 148 newly di...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2018.1456462

    authors: Li Y,Liu X,Wang W,Wang S,Zhang J,Jiang S,Wang Y,Li L,Li J,Zhang Y,Huang H

    更新日期:2018-11-01 00:00:00

  • A rare complication of idiopathic membranous nephropathy: crescentic transformation.

    abstract:INTRODUCTION:In this study, the cause of rapidly deteriorating renal functions in a follow-up period of a 65-year-old female patient, who applied with nephrotic syndrome findings and diagnosed as membranous nephropathy, is presented. CASE REPORT:A 65-year-old patient with findings of nephrotic syndrome had normal kidn...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220802064804

    authors: Unver S,Haholu A,Atasoyu EM,Karatas M,Akcan R,Evrenkaya TR

    更新日期:2008-01-01 00:00:00

  • Factors associated with hyperhomocysteinemia after renal transplantation.

    abstract::Recent studies show that clinically stable renal transplant recipients have an increased prevalence of hyperhomocysteinemia (hyperHcy), but the mechanism of this disorder has not yet been elucidated. The aim of the present study was to evaluate the factors associated with hyperHcy after a successful renal transplantat...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220500461260

    authors: Simić-Ogrizović S,Radivojević D,Radovic M,Lezaic V,Mirković D,Babić D,Dukanović L

    更新日期:2006-01-01 00:00:00

  • Tacrolimus restores podocyte injury and stabilizes the expression of Cabin1 in 5/6 nephrectomized rats.

    abstract::Podocyte injury is a vital factor, which induces massive proteinuria. Studies have shown that tacrolimus (TAC) protected podocyte via stabilizing cytoskeleton. Our latest study indicates that calcineurin binding protein 1 (Cabin1) undergoes nuclear translocation during podocytes injury. Whether TAC targets on Cabin1 d...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2016.1148936

    authors: Wen Y,Liu L,Zhou P,Li H,Wang Z,Zhang Y,Liang J

    更新日期:2016-01-01 00:00:00

  • The role of erythrocytes phosphatidylserine exposure in anemia in peritoneal dialysis patients.

    abstract:BACKGROUND:An increased red blood cell (RBC) phosphatidylserine (PS) exposure in uremic patients was found that could promote macrophage recognition and decrease RBC survival time. Furthermore, a reduced red cell life span was found to contribute anemia in patients with renal failure. It is therefore possible to hypoth...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220600839647

    authors: Bi SH,Cheng LT,Wang T

    更新日期:2006-01-01 00:00:00

  • Fasudil ameliorates rhabdomyolysis-induced acute kidney injury via inhibition of apoptosis.

    abstract::During times of war or natural disasters, rhabdomyolysis leading to acute kidney injury (AKI) can assume epidemic proportions. Fasudil attenuates ischemia/reperfusion-induced AKI. We investigated the therapeutic effect of an early application of fasudil on AKI induced by rhabdomyolysis and explored the potential mecha...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2011.601830

    authors: Wang YD,Zhang L,Cai GY,Zhang XG,Lv Y,Hong Q,Shi SZ,Yin Z,Liu XF,Chen XM

    更新日期:2011-01-01 00:00:00

  • Evaluation and outcome of antenatal hydronephrosis: a prospective study.

    abstract::Antenatal hydronephrosis (AHN), defined as dilatation of renal pelvis and/or calyces, is the most frequently detected antenatal abnormality. However, postnatal management of AHN is controversial. The purpose of this study was to describe the clinical outcomes of infants with AHN and to contribute to the definition of ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2012.676492

    authors: Gökaslan F,Yalçınkaya F,Fitöz S,Özçakar ZB

    更新日期:2012-01-01 00:00:00