Tacrolimus restores podocyte injury and stabilizes the expression of Cabin1 in 5/6 nephrectomized rats.

Abstract:

:Podocyte injury is a vital factor, which induces massive proteinuria. Studies have shown that tacrolimus (TAC) protected podocyte via stabilizing cytoskeleton. Our latest study indicates that calcineurin binding protein 1 (Cabin1) undergoes nuclear translocation during podocytes injury. Whether TAC targets on Cabin1 during podocyte injury is still not clear. This study establishes non-immunological proteinuric model. To observe the effect of the treatment of TAC on Cabin1 expression in 5/6 nephrectomized rats. Sprague-Dawley rats were injected with TAC (0.2 mg/kg/day) for 4-8 weeks after 5/6 nephrectomy. Then, rats were sacrificed in the eighth week after operation, renal tissues were processed for morphological studies under light and electrical microscope. Cabin1 expression and distribution were detected by western blot and indirect immunofluorescence staining. In 5/6 nephrectomized rats, urinary protein excretion reached 90.2 ± 30.1 mg/24 h, glomerular sclerosis index and tubulointerstitial fibrosis score were significantly increased, and widespread of podocyte foot processes fusion was found. Moreover, Cabin1 protein expression was markedly increased, and its distribution became much more obviously in podocytes nuclei. In TAC treated rats, urinary protein excretion significantly decreased (44.9 ± 22.5 mg/24 h), glomerular sclerosis and tubulointerstitial fibrosis were alleviated, and podocyte foot processes fusion was inhibited. Furthermore, TAC alleviated the increased protein expression and abnormal distribution of Cabin1. In conclusion, TAC restores podocyte injury and stabilizes the expression of Cabin1. Cabin1 may become a new target to demonstrate the mechanism of TAC in podocyte injury.

journal_name

Ren Fail

journal_title

Renal failure

authors

Wen Y,Liu L,Zhou P,Li H,Wang Z,Zhang Y,Liang J

doi

10.3109/0886022X.2016.1148936

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

564-70

issue

4

eissn

0886-022X

issn

1525-6049

journal_volume

38

pub_type

杂志文章
  • Significant correlation between left ventricular systolic and diastolic dysfunction and decreased glomerular filtration rate.

    abstract::Cardiac dysfunction portends a poor prognosis in renal failure and vice versa. Functional abnormalities of heart in patients with renal insufficiency were frequently noted. The aim of this study is to assess the relationship between left ventricular systolic and diastolic function and renal function in patients with v...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2011.618792

    authors: Hsieh MC,Su HM,Wang SY,Tsai DH,Lin SD,Chen SC,Chen HC

    更新日期:2011-01-01 00:00:00

  • Early manifestation of nephropathy in rats with arterial calcinosis.

    abstract::In vascular smooth muscle, calcium overload is a highly pathogenic event, which increases with advancing age. An increase in the calcium content of arterial wall may be produced in rats by treatment with vitamin D3. The aim of this study was to evaluate the renal clearance of sulfanilamide (a model organic anion, pref...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1081/jdi-120021150

    authors: Quaglia NB,Brandoni A,Ferri A,Torres AM

    更新日期:2003-05-01 00:00:00

  • Nephro-oncology: a link in evolution.

    abstract::A multidisciplinary approach represents the best method to interact with patients. Neoplastic and renal diseases are closely related to each other because of an increased risk of cancer among individuals with end-stage renal disease and because of the high prevalence of renal failure in cancer patients. Physicians sho...

    journal_title:Renal failure

    pub_type: 杂志文章,评审

    doi:10.3109/0886022X.2015.1068514

    authors: Lacava V,Coppolino G,Puntorieri E,Cernaro V,Lupica R,Visconti L,Buemi A,Santoro D,Buemi M

    更新日期:2015-01-01 00:00:00

  • Bone mineral density in patients on maintenance hemodialysis and effect of chronic hepatitis C virus infection.

    abstract:OBJECTIVE:To determine the prevalence of osteopenia and osteoporosis in HD patients at our center; to investigate whether HCV infection affects BMD in hemodialysis patients; to test for correlations between bone mineral density (BMD) and clinical and laboratory parameters in this population. SUBJECTS AND METHODS:The s...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1081/jdi-120038501

    authors: Yücel AE,Kart-Köseoglu H,Isiklar I,Kuruinci E,Ozdemir FN,Arslan H

    更新日期:2004-03-01 00:00:00

  • A case of idiopathic granulomatous interstitial nephritis with an unusually large granuloma.

    abstract::Granulomatous interstitial nephritis (GIN) is a rare disease. Contributing factors such as drugs, sarcoidosis, infections, and paraproteinemia have been reported, and when no obvious contributing factors can be identified, the disease is classified as idiopathic GIN. We managed a patient with idiopathic GIN with an un...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860220903391218

    authors: Kim SJ,Hee Sung S

    更新日期:2010-01-01 00:00:00

  • Low-dose IL-2 expands CD4+ regulatory T cells with a suppressive function in vitro via the STAT5-dependent pathway in patients with chronic kidney diseases.

    abstract:BACKGROUND:Patients with chronic kidney disease (CKD) often have CD4+ regulatory T cells (Tregs) dysfunction and chronic inflammation. We aim to investigate the effect, function, and related mechanism of low-dose IL-2 on CD4+ regulatory T cells expansion in vitro from patients with CKD. METHODS:A total of 148 newly di...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2018.1456462

    authors: Li Y,Liu X,Wang W,Wang S,Zhang J,Jiang S,Wang Y,Li L,Li J,Zhang Y,Huang H

    更新日期:2018-11-01 00:00:00

  • Cardiovascular surgery after renal transplantation--indications, complications and outcome.

    abstract:UNLABELLED:Cardiovascular diseases are the major cause of morbidity and mortality in renal transplant recipients. We report our experience in the treatment of patients with renal allograft who required cardiovascular surgery. METHODS:Indications for cardiovascular surgery, postoperative complications, and outcome were...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2015.1052950

    authors: Basic-Jukic N,Ivanac-Jankovic R,Biocina B,Kes P

    更新日期:2015-07-01 00:00:00

  • Effects of dietary protein on renal ischemia induced tubular necrosis.

    abstract::Previously we have shown that the amount of protein in a dietary regimen prior to the induction of renal ischemia will significantly affect the degree of postischemic acute renal failure (Andrews PM, Bates SB: Kidney Int 30:299-303, 1986). The present investigation was undertaken to determine what effect dietary prote...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229309065566

    authors: Andrews PM

    更新日期:1993-01-01 00:00:00

  • Causes and prognosis of nontraumatic acute renal failure requiring dialysis in adult patients with and without diabetes.

    abstract::Despite advanced techniques of renal replacement therapy the overall mortality of patients with ARF is still high. The majority of patients with ARF requiring dialysis are those with nontraumatic ARF. In a retrospective study we compared the causes of nontraumatic ARF, the risk factors for the development of renal fai...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1081/jdi-120028542

    authors: Schmekal B,Pichler R,Biesenbach G

    更新日期:2004-01-01 00:00:00

  • A new update for radiocontrast-induced nephropathy aggravated with glycerol in rats: the protective potential of epigallocatechin-3-gallate.

    abstract::Contrast media (CM) is known to have nephrotoxic adverse effects. Epigallocatechin-3-gallate (EGCG) is the most abundant and active catechin in green tea, and has strong antioxidant and anti-inflammatory properties. This study investigated whether EGCG can reduce contrast-induced nephrotoxicity (CIN), alone or with gl...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2016.1277245

    authors: Palabiyik SS,Dincer B,Cadirci E,Cinar I,Gundogdu C,Polat B,Yayla M,Halici Z

    更新日期:2017-11-01 00:00:00

  • miR-15a-5p suppresses peritoneal fibrosis induced by peritoneal dialysis via targeting VEGF in rats.

    abstract:AIM:When peritoneal fibrosis (PF) causes ultrafiltration failure in peritoneal dialysis (PD) patients, PD has to be discontinued. Currently, there is no effective way to relieve PF. In this study, we aimed to determine whether miR-15a-5p is involved in PF and to determine the underlying mechanism. METHODS:Six normal r...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2020.1811123

    authors: He Q,Wen L,Wang L,Zhang Y,Yu W,Zhang F,Zhang W,Xiao J,Wen X,Zhao Z

    更新日期:2020-11-01 00:00:00

  • Successful treatment of severe iron intoxication with gastrointestinal decontamination, deferoxamine, and hemodialysis.

    abstract::Acute iron poisoning is a common and potentially serious problem in the pediatric population. Early recognition and treatment is crucial for a better outcome and to prevent morbidity and mortality. An 18-year-old female, who had accidental ingestion of 50 tablets of ferrous sulfate (100 mg of elemental iron per 335 mg...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2013.790299

    authors: Gumber MR,Kute VB,Shah PR,Vanikar AV,Patel HV,Balwani MR,Ghuge PP,Trivedi HL

    更新日期:2013-01-01 00:00:00

  • The combination of sirolimus and cyclosporine does not delay initial renal graft function recovery.

    abstract:BACKGROUND:Sirolimus has been considered to be a non-nephrotoxic agent. It may delay graft function due to a potential hindrance of the recovery from acute tubular necrosis. It remains controversial as to whether the concomitant administration of sirolimus (SRL) with calcineurin inhibitors delays graft function in Asia...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220701860989

    authors: Hsu HJ,Tian YC,Chen YC,Lai BC,Fang JT,Yang CW,Wu MS

    更新日期:2008-01-01 00:00:00

  • Protective effect of curcumin on busulfan-induced renal toxicity in male rats.

    abstract:AIM:The aim of this study was to evaluate the effects of curcumin in an experimental model of busulfan-induced renal toxicity with emphasis on importance of histological alterations. METHODS:In this study, we utilized 32 adult male Wistar rats (250 ± 10 g). All the animals were divided into four experimental groups ra...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2020.1818580

    authors: Abdollahifar MA,Ebrahimi V,Aliaghaei A,Raoofi A,Khosravi A,Hasani A,Mehdizadeh A,Asadi M

    更新日期:2020-11-01 00:00:00

  • High mobility group box 1 and tumor growth factor β: useful biomarkers in pediatric patients receiving peritoneal dialysis.

    abstract:BACKGROUND:Peritonitis, the most important limitation of peritoneal dialysis (PD), could be detected by biomarkers in dialysate effluent, representing a noninvasive method to indirectly assess the peritoneum status. The aim of our study was to test high mobility group box 1 (HMGB1) in PD patients, evaluating its role a...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2016.1216711

    authors: Chimenz R,Lacquaniti A,Colavita L,Chirico V,Fede C,Buemi M,Fede C

    更新日期:2016-10-01 00:00:00

  • SDS-electrophoresis of unconcentrated urine samples using a semi-automatic method.

    abstract::The study of urinary proteins is an important tool in the screening and diagnosis of patients with renal impairment. Quantification of total proteins, although useful, can provide only limited information. Gel electrophoresis of urine samples may provide more detailed information. ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229909085105

    authors: Behets GJ,De Broe ME

    更新日期:1999-05-01 00:00:00

  • Successful use of rituximab in fibrillary glomerulopathy.

    abstract::Fibrillary glomerulopathy (FG) can occur either alone or co-existing with other proteinuric glomerular disorders. FG has been associated with poor renal outcomes leading to End Stage Renal Disease (ESRD). Since FG is a relatively rare disorder, limited information is available concerning treatment protocols. We presen...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2014.918832

    authors: Chaudhary A,Gyamlani G,Cossey NL,Walker PD,Wall BM

    更新日期:2014-08-01 00:00:00

  • Cold preservation mediated renal injury: involvement of mitochondrial oxidative stress.

    abstract::Cold preservation has greatly facilitated the use of cadaveric kidneys for renal transplantation, but, clearly, damage occurs during both the preservation episode and the reperfusion phase (following transplantation). The aims of this study were twofold: to develop an in vivo model that was capable of evaluating renal...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220701813327

    authors: Saba H,Munusamy S,Macmillan-Crow LA

    更新日期:2008-01-01 00:00:00

  • The incidence of acute kidney injury in patients with traumatic brain injury.

    abstract::There is limited information on the incidence of acute kidney injury (AKI) in patients with traumatic brain injury (TBI) although AKI may contribute to morbidity and mortality. We investigated the incidence of AKI in patients with moderate and severe TBI and the association of AKI with risk factors and outcomes in the...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2010.510234

    authors: Moore EM,Bellomo R,Nichol A,Harley N,Macisaac C,Cooper DJ

    更新日期:2010-01-01 00:00:00

  • Long-term online hemodiafiltration does not reduce the frequency and severity of acquired cystic kidney disease in hemodialysis patients.

    abstract:BACKGROUND:Acquired cystic kidney disease (ACKD) is a frequent complication in chronic hemodialysis (HD) patients and a risk factor for renal cell carcinoma. Online hemodiafiltration (HDF) provides better clearance of middle molecular weight solutes, but its effect on ACKD has not been investigated. MATERIALS AND METH...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220903003412

    authors: Weng CJ,Chang MY,Chen YC,Tian YC,Fang JT,Yang CW

    更新日期:2009-01-01 00:00:00

  • Cola-colored dialysate as a gastrointestinal sequelae of cardiac surgery in a patient who underwent peritoneal dialysis.

    abstract::The discoloration of effluent peritoneal dialysate, which is transparent in origin, is seen in some particular conditions including chyloperitoneum, calcium channel blocker usage, hemoperitoneum, perforated cholecystitis, iron administration, and hemorrhagic pancreatitis. We report a case of a 60-year-old woman who un...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2012.711731

    authors: Ling EK,Lin BS,Chiang SS,Tsai MH

    更新日期:2012-01-01 00:00:00

  • Use of alpha-lipoic acid in prevention of contrast-induced nephropathy in diabetic patients.

    abstract::In this prospective study, we aimed to determine the protective antioxidant role of alpha-lipoic acid (ALA) on development of contrast-induced nephropathy (CIN) in diabetic patients undergoing coronary angiography. Seventy-eight diabetic patients undergoing coronary angiography were included. Thirty-nine patients were...

    journal_title:Renal failure

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/0886022X.2013.790298

    authors: Cicek M,Yıldırır A,Okyay K,Yazici AC,Aydinalp A,Kanyilmaz S,Muderrisoglu H

    更新日期:2013-01-01 00:00:00

  • Do neutrophil gelatinase-associated lipocalin and interleukin-18 predict renal dysfunction in patients with familial Mediterranean fever and amyloidosis?

    abstract:BACKGROUND:The aim of this study was to evaluate whether neutrophil gelatinase-associated lipocalin (NGAL) and interleukin-18 (IL-18) predict renal disfunction in patients with familial Mediterranean fever (FMF). METHODS:This prospective study consisted of 102 patients with FMF in attack-free period, and 40 matched he...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2013.865486

    authors: Deveci K,Korkmaz S,Senel S,Deveci H,Sancakdar E,Uslu AU,Deniz A,Alkan F,Seker MM,Sencan M

    更新日期:2014-04-01 00:00:00

  • Plasma fatty acid composition in continuous ambulatory peritoneal dialysis patients: an increased omega-6/omega-3 ratio and deficiency of essential fatty acids.

    abstract::Patients with end-stage renal disease, including those treated with peritoneal dialysis, have a high risk for death, particularly from cardiovascular causes. Plasma fatty acid (FA) composition is used as an indicator of disease risk, because its alteration has been related to metabolic disease and cardiovascular disea...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2011.601831

    authors: Yerlikaya FH,Mehmetoglu I,Kurban S,Tonbul Z

    更新日期:2011-01-01 00:00:00

  • Dysregulated microRNAs involved in contrast-induced acute kidney injury in rat and human.

    abstract:BACKGROUND:Contrast-induced nephropathy (CIN) is a complex syndrome of acute nephropathy that occurs following infusion of intravascular contrast agents, and is associated with an increased risk for adverse cardiovascular events. While there is no ideal biomarker for making an early diagnosis of CIN, we hypothesized th...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2015.1077322

    authors: Gutiérrez-Escolano A,Santacruz-Vázquez E,Gómez-Pérez F

    更新日期:2015-01-01 00:00:00

  • The role of aluminum in the pathogenesis of anemia in an outpatient hemodialysis population.

    abstract::Anemia is a well-defined complication of aluminum overload in chronic dialysis patients which may be present before other manifestations of aluminum toxicity are obvious. Causes of anemia in chronic renal failure are multiple, and at the present time there is no marker for aluminum-induced anemia. Deferoxamine (DFO) t...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860228909066949

    authors: Yuan B,Klein MH,Contiguglia RS,Mishell JL,Seligman PA,Miller NL,Molitoris BA,Alfrey AC,Shapiro JI

    更新日期:1989-01-01 00:00:00

  • Hyperkalemia-induced accelerated idioventricular rhythm in a patient with acute renal failure.

    abstract::Electrolyte disorders can alter cardiac ionic currents and depending on the changes can promote proarrhythmic effects. Potassium (K(+)) is the most common intracellular cation related to arrhythmic disorders. Hyperkalemia is mainly seen in the setting of impaired renal function. Severe hyperkalemia may lead to rhythm ...

    journal_title:Renal failure

    pub_type: 信件

    doi:10.3109/0886022X.2011.653752

    authors: Gul EE,Erdogan HI,Yıldırım O,Soylu A,Nikus KC

    更新日期:2012-01-01 00:00:00

  • Acute renal failure following bone marrow transplantation.

    abstract::Acute renal failure (ARF) is one of the most frequent and potentially life threatening complications following bone marrow transplantation (BMT). Several renal syndromes that occur are either unique or occur with a disproportionate frequency post-BMT. Clinically ARF can be classified according to the time of onset pos...

    journal_title:Renal failure

    pub_type: 杂志文章,评审

    doi:10.3109/08860229809045131

    authors: Pulla B,Barri YM,Anaissie E

    更新日期:1998-05-01 00:00:00

  • 3-aminobenzamide, a poly ADP ribose polymerase inhibitor, attenuates renal ischemia/reperfusion injury.

    abstract:INTRODUCTION:This study was designed to investigate whether 3-amino benzamide (3-AB), a poly (ADP-ribose) polymerase (PARP) inhibitor, has a protective effect on kidney injury induced by renal ischemia/reperfusion (I/R) by decreasing oxidative and nitrosative stress on renal dysfunction and injury. MATERIALS AND METHO...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220902882741

    authors: Oztas E,Guven A,Turk E,Uysal B,Akgul EO,Cayci T,Ersoz N,Korkmaz A

    更新日期:2009-01-01 00:00:00

  • Medical ozone therapy reduces shock wave therapy-induced renal injury.

    abstract:OBJECTIVES:Extracorporeal shock wave (ESW) lithotripsy is the preferred treatment modality for uncomplicated kidney stones. More recently free oxygen radical production following ESW application has been considered to be crucial in shock wave-induced renal damage. It has been shown that ozone therapy (OT) has ameliorat...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2016.1172941

    authors: Uğuz S,Demirer Z,Uysal B,Alp BF,Malkoc E,Guragac A,Turker T,Ateş F,Karademir K,Ozcan A,Yildirim I,Korkmaz A,Guven A

    更新日期:2016-07-01 00:00:00