Early manifestation of nephropathy in rats with arterial calcinosis.


:In vascular smooth muscle, calcium overload is a highly pathogenic event, which increases with advancing age. An increase in the calcium content of arterial wall may be produced in rats by treatment with vitamin D3. The aim of this study was to evaluate the renal clearance of sulfanilamide (a model organic anion, preferentially eliminated by the kidneys) and other parameters of global renal function in rats with arterial calcinosis. Arterial calcinosis was produced in adult rats by means of a single dose of vitamin D3 (300,000 UI/kg bw, i.m.) 5 days before the experiment. Treated rats showed a large increase in calcium content of aortic tissue and an increase in systolic arterial pressure. No modifications were observed in plasma calcium levels and in plasma lipid profiles. Statistically significant decrements were observed in renal clearance of sulfanilamide, in renal blood flow, in fractional excretion of sodium and potassium. A slight decrease, not statistically different, was observed in the glomerular filtration rate. Rats with arterial calcinosis also showed an increment of total calcium levels in renal tissue, in fractional excretion of calcium and in the expression of organic anion transporter 1 (OAT1). Histological studies revealed tubular alterations. In summary, modifications in hemodynamics and tubular parameters are early manifestations of nephropathy in rats with arterial calcinosis, some of which may account for the changes observed in organic anions renal depuration. It is important to mention that the decrease in clearance of organic anions were seen in spite of the increase in expression of OAT1.


Ren Fail


Renal failure


Quaglia NB,Brandoni A,Ferri A,Torres AM




Has Abstract


2003-05-01 00:00:00












  • Associations between endothelial nitric oxide synthase polymorphisms and risk of diabetic nephropathy: an updated meta-analysis.

    abstract:BACKGROUND:Genetic polymorphism of endothelial nitric oxide synthase (eNOS) has been implicated in the risk of diabetic nephropathy (DN), but the published findings were inconsistent. We performed a comprehensive meta-analysis to derive a more precise estimation of the association between genetic polymorphisms of eNOS ...

    journal_title:Renal failure

    pub_type: 杂志文章,meta分析


    authors: Zhang Y,Xiao HQ,Zeng XT,Zuo HX,Xu YC

    更新日期:2015-11-01 00:00:00

  • Hemodynamic maladjustment and disease progression in nephrosis with FSGS.

    abstract::Idiopathic nephrotic syndrome (NS) associated with focal segmental glomerulosclerosis (FSGS) and severe renal function impairment is usually refractory to the conventional treatment and progresses to end-stage renal disease. Herein, we reported 10 patients with NS-FSGS who had initially had CCr 34 +/- 12 mL/min/1.73 m...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Futrakul N,Siriviriyakul P,Deekajorndej T,Futrakul P

    更新日期:2004-05-01 00:00:00

  • Acute kidney injury in patients with pyogenic liver abscess.

    abstract::Incidence of acute kidney injury (AKI) in patients with pyogenic liver abscess is rare. In our study we found AKI in 32.6% of patients with liver abscess. Majority of the patients were in their fifties and sixties. As per acute kidney injury network trial criteria, renal failure was in stage 1 in 26.6%, stage 2 in 40%...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Sriramnaveen P,Sridhar A,Sandeep Y,Krishnakishore C,Sainaresh V,Manjusha Y,Sivakumar V

    更新日期:2011-01-01 00:00:00

  • Association between VEGF receptors and baseline peritoneal transport status in new peritoneal dialysis patients.

    abstract:BACKGROUND:Peritoneal transport status is important not only for prescription, but also as a prognostic index. Flt-1 and Flk-1, the major vascular endothelial growth factor receptors involved in angiogenesis and hyperpermeability, may play a potent role in determining peritoneal transport characteristics. However, the ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Zhang AH,Wang G,Zhang DL,Zhang QD,Liu S,Liao Y,Yin Y,Liu WH

    更新日期:2012-01-01 00:00:00

  • Posttreatment with aminoguanidine attenuates renal ischemia/reperfusion injury in rats.

    abstract::Acute renal failure secondary to ischemia/reperfusion (I/R) injury is associated with significant mortality and morbidity. Aminoguanidine (AG), an inducible nitric oxide synthase inhibitor with antioxidant properties, has been reported beneficial in renal I/R injury. The aim of the present study was to investigate the...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Onem Y,Ipcioglu OM,Haholu A,Sen H,Aydinoz S,Suleymanoglu S,Bilgi O,Akyol I

    更新日期:2009-01-01 00:00:00

  • Alkaline phosphatase is independently associated with renal function in normoalbuminuric type 1 diabetic patients.

    abstract::Nonalcoholic fatty liver disease (NAFLD) is associated with an increased prevalence of chronic kidney disease in patients with type 1 diabetes. The aim of this study was to explore the relationship between markers of NAFLD, namely concentrations of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alka...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Bulum T,Kolarić B,Duvnjak M,Duvnjak L

    更新日期:2014-04-01 00:00:00

  • Analgesic use, parents' clan, and coffee intake are three independent risk factors of chronic kidney disease in middle and elderly-aged population: a community-based study.

    abstract::Chronic kidney disease (CKD) is a world-wide public health problem. The purpose of this study was to identify the role of some controversial potential risk factors in development of CKD. "Community Complex Health Screening" is a large-scale, free, health program for individuals ≥40 years of age that has been available...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Hsu YC,Lee PH,Lei CC,Shih YH,Lin CL

    更新日期:2014-04-01 00:00:00

  • Effect of cholecalciferol replacement on vascular calcification and left ventricular mass index in dialysis patients.

    abstract:OBJECTIVE:The aim of this study was to determine the effect of oral cholecalciferol treatment on vascular calcification, left ventricular mass index (LVMI) and other cardiac functions in dialysis patients. DESIGN AND METHODS:A six-month course of oral cholecalciferol treatment was recommended to dialysis patients with...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Kidir V,Ersoy I,Altuntas A,Gultekin F,Inal S,Dagdeviren BH,Dogan A,Sezer MT

    更新日期:2015-05-01 00:00:00

  • Mortality risk factors in chronic renal failure patients after coronary artery bypass grafting.

    abstract::Perioperative risk during coronary artery bypass grafting (CABG) is high in patients with chronic renal disease. We aimed to determine postoperative two-year mortality and identify the preoperative risk factors of mortality during CABG surgery in hemodialysis (HD)-dependent and HD-non-dependent CRF patients. We includ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Akman B,Bilgic A,Sasak G,Sezer S,Sezgin A,Arat Z,Ozdemir FN,Haberal M

    更新日期:2007-01-01 00:00:00

  • Late onset renal failure and nephrotic syndrome after autologous stem cell transplant for Al amyloidosis.

    abstract::We present a patient with AL amyloidosis who had an autologous stem cell transplant (ASCT) over 9 years ago. She has since then developed slowly progressive renal insufficiency and the nephrotic syndrome. Hematologic evaluation has failed to identify recurrent disease and a renal biopsy demonstrated extensive amyloid ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Rifkin SI,Weinstein SS

    更新日期:2012-01-01 00:00:00

  • Safety and efficacy of fluvastatin in hyperlipidemic patients with chronic renal disease.

    abstract:BACKGROUND:There are few reports on the safety and efficacy of long-term treatment with statins in patients with chronic renal disease and hyperlipidemia. We evaluated these subjects treated with fluvastatin. METHODS:After a 4-week run-in period, a total of 80 patients with diabetic nephropathy or chronic glomerulonep...

    journal_title:Renal failure

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Yasuda G,Kuji T,Hasegawa K,Ogawa N,Shimura G,Ando D,Umemura S

    更新日期:2004-07-01 00:00:00

  • Role of ticlopidine on adriamycin-induced nephropathy.

    abstract::The effect of ticlopidine on rats with adriamycin nephropathy was observed during 26 weeks. In the ticlopidine-treated nephrotic animals (TNG), proteinuria was less than in the untreated nephrotic animals (NG), but this difference was significant only at week 6 (TNG = 47.27 +/- 16.52 versus NG = 100.08 +/- 13.83 mg/24...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Riyuzo MC,Soares VA

    更新日期:1999-09-01 00:00:00

  • Therapeutic use of the natriuretic peptide ularitide in acute renal failure.

    abstract:BACKGROUND:Ularitide is a member of the natriuretic peptide family. This hormone exhibits an N-terminal extension by four amino acids compared with atrial natriuretic peptide. Ularitide was shown to exert strong diuretic and natriuretic effects when infused intravenously. Its main action sites are the glomerulum, induc...

    journal_title:Renal failure

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Meyer M,Pfarr E,Schirmer G,Uberbacher HJ,Schöpe K,Böhm E,Flüge T,Mentz P,Scigalla P,Forssmann WG

    更新日期:1999-01-01 00:00:00

  • Evaluation of the protective effect of agmatine against cisplatin nephrotoxicity with 99mTc-DMSA renal scintigraphy and cystatin-C.

    abstract:BACKGROUND:The aim of the current study was to investigate whether agmatine (AGM) has a protective effect against cisplatin-induced nephrotoxicity. MATERIALS AND METHODS:Thirty-two rats were randomly divided into four groups: (1) Saline (control); (2) Cisplatin (CDDP; 7.5 mg/kg intraperitoneally); (3) Agmatine (AGM; 1...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Salihoglu YS,Elri T,Gulle K,Can M,Aras M,Ozacmak HS,Cabuk M

    更新日期:2016-10-01 00:00:00

  • The association of overhydration with megafistulas in hemodialysis patients.

    abstract::Objectives: Diffuse enlargements of arteriovenous dialysis fistulas customarily attributed to either excessive arterial inflow or central outflow stenosis. The relationship between volume status and clinically enlarged (arteriovenous) fistula (CEF) formation in end-stage renal disease (ESRD) patients is not well under...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Tapolyai M,Faludi M,Berta K,Forró M,Zsom L,Pethő ÁG,Rosivall L,Fülöp T

    更新日期:2019-11-01 00:00:00

  • FK506 inhibits the mice glomerular mesangial cells proliferation by affecting the transforming growth factor-β and Smads signal pathways.

    abstract::Abstract TGF-β1 plays an important role in the pathogenesis of chronic renal diseases. Although the specific mechanism is unknown, a major factor is the potent fibrogenic activity of TGF-β1 in the chronic progression of renal diseases. TGF-β1 closely correlates with renal fibrosis in cooperation with several fibrosis-...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Qi R,Li W,Yu S

    更新日期:2014-05-01 00:00:00

  • Calcium antagonists and renal protection.

    abstract::A growing body of evidence supports the notion that calcium antagonists exert a renal protective effect. Calcium antagonists may play an important future role in renal hemodynamics related to their reversal of renal vasoconstrictors. Calcium antagonists are also capable of blocking intracellular calcium overload induc...

    journal_title:Renal failure

    pub_type: 杂志文章,评审


    authors: Neumayer HH,Gellert J,Luft FC

    更新日期:1993-01-01 00:00:00

  • Urinary excretion of creatol, an in vivo biomarker of hydroxyl radical, in patients with chronic renal failure.

    abstract::Creatol (CTL) is a hydroxyl radical adduct of creatinine (Cr). The serum methylguanidine (MG) level and the MG/Cr molar ratio are reported to be biomarkers for oxidative stress. The aim of this study was to examine whether urinary excretion of CTL, another oxidative stress-related marker, is increased in patients with...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Ienaga K,Nakamura K,Fujisawa T,Fukunaga Y,Nihei H,Narita M,Tomino Y,Sanaka T,Aoyagi K,Nakano K,Koide H

    更新日期:2007-01-01 00:00:00

  • Acute renal failure due to hemorrhagic fever with renal syndrome.

    abstract::The aim of our study was to analyze the clinical course and outcome of acute renal failure (ARF) in patients with hemorrhagic fever with renal syndrome (HFRS). From 1983 to 1995, we treated 33 patients (27 males, 6 females) aged from 16 to 71 years. Half of patients were connected with work at a farm or in a forest. T...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Bren AF,Pavlovcic SK,Koselj M,Kovac J,Kandus A,Kveder R

    更新日期:1996-07-01 00:00:00

  • Evaluation of relationship between sexual functions, depression and quality of life in patients with chronic kidney disease at predialysis stage.

    abstract:AIM:The relation of chronic kidney disease (CKD) with metabolic, psychiatric and endocrinologic disorder is well-known. Depressive mood and sexual dysfunction are frequently observed as renal functions deteriorate. We aimed to analyze the relationship of sexual dysfunction, depressive mood and life quality in patients ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Esen B,Kahvecioglu S,Atay AE,Ozgen G,Okumus MM,Seyahi N,Sit D,Kadioglu P

    更新日期:2015-03-01 00:00:00

  • Nutritional status in stage V dialyzed patient versus CKD patient on conservative therapy across different economic status.

    abstract:BACKGROUND:This aim of this multi-centric cross-sectional study was to assess the nutritional status in Indian chronic kidney disease (CKD) patients and to compare the nutritional indicators between stage 5 dialyzed (CKD-D) patients below the poverty line (BPL), and stage 3-4 non-dialyzed (CKD-ND) patients above (APL) ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Vijayan M,Abraham G,Alex ME,Vijayshree N,Reddy Y,Fernando E,Mathew M,Nair S,Yuvaraj A

    更新日期:2014-04-01 00:00:00

  • Bcıı--RFLP profiles for serum amiloid A1 and mutated MEFV gene prevalence in chronic renal failure patients requiring long-term hemodialysis.

    abstract:BACKGROUND AND AIM:There is an increased mortality risk in long-term hemodialysis patients of renal failure due to the chronic inflammation. The relationship between the chronic renal failure (CRF) and the role of familial genetic markers remains incompletely understood. In the current study, it was aimed to find out t...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Ozdemir O,Kayatas M,Cetinkaya S,Yildirim ME,Silan F,Kurtulgan HK,Koksal B,Urfali M,Candan F

    更新日期:2015-03-01 00:00:00

  • The differences of asymmetric dimethylarginine removal by different dialysis treatments.

    abstract:BACKGROUND:Asymmetric dimethylarginine (ADMA) as a uremia toxin is accumulated in end-stage renal disease (ESRD) patients. Elevated ADMA level has been shown to be predictive of cardiovascular diseases (CVDs) and all-cause mortality in ESRD. Therefore, we investigated the removal of ADMA by different dialysis treatment...

    journal_title:Renal failure

    pub_type: 杂志文章,随机对照试验


    authors: Zhang DL,Liu J,Liu S,Zhang Y,Liu WH

    更新日期:2010-01-01 00:00:00

  • Parathyroid hormone levels, calcium-channel blockers, and the dyslipidemia of nondiabetic hemodialysis patients.

    abstract:BACKGROUND:Experimental studies have shown that increased levels of parathyroid hormone (PTH) in uremia may cause elevation of intracellular calcium, predisposing to insulin resistance and lipid metabolism abnormalities. Administration of calcium-channel blockers (CCBs) in these models protects against the development ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Zanos S,Mitsopoulos E,Sakellariou G

    更新日期:2005-01-01 00:00:00

  • Toward the optimal clinical use of the fraction excretion of solutes in oliguric azotemia.

    abstract::While the fractional excretion of solutes have long been considered excellent research tools to investigate tubular physiology, their clinical use has become common over the last 40 years in the diagnoses of many disorders; however, none have reached the clinical utility of the fractional excretion of sodium in the ab...

    journal_title:Renal failure

    pub_type: 杂志文章,评审


    authors: Diskin CJ,Stokes TJ,Dansby LM,Radcliff L,Carter TB

    更新日期:2010-01-01 00:00:00

  • Lipoprotein-A and carotid intima media thickness as cardiovascular risk factors in patients of chronic kidney disease.

    abstract::Patients in all stages of chronic kidney disease (CKD) are considered in the "high-risk group" for development of cardiovascular disease (CVD). The study was undertaken in 60 adult patients of chronic renal failure. The patients were divided into three groups: Group I had subjects with CKD (stages 1 and 2); Group II h...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Aggarwal HK,Jain D,Lathar M,Yadav RK,Sawhney A

    更新日期:2010-07-01 00:00:00

  • Kidney function and histological damage in autopsy subjects with myocardial infarction.

    abstract:OBJECTIVES:Chronic kidney disease (CKD) is a major risk factor for cardiovascular disease (CVD). We previously reported renal parenchymal damage in autopsy subjects with stroke or abdominal aortic aneurysm. The aim of this study is to evaluate the relationship between renal histology and clinical characteristics of pat...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Niizuma S,Nakamura S,Ishibashi-Ueda H,Yoshihara F,Kawano Y

    更新日期:2011-01-01 00:00:00

  • Renal failure and nephrotoxic drug-induced disturbances in rat kidney tissue.

    abstract::The injection to rats of glycerol, cisplatin, uranyl acetate, sodium dichromate, and mercuric chloride is followed on the third day by acute renal failure. A new approach for quantitative estimation of disturbance of excretory renal function is presented. The decrease in renal function due to uranyl acetate was 77%; s...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Natochin YV,Bakhteeva VT,Karpenko LA

    更新日期:1994-11-01 00:00:00

  • Effect of fenoldopam on ischemia/reperfusion-induced apoptosis.

    abstract::Recently we demonstrated the effect of fenoldopam on ischemia/reperfusion (I/R) induced NFkappaB mediated pro-inflammatory signal transduction. However, the effect of fenoldopam on I/R-induced apoptosis is not known. We utilized a rat model of acute ischemic nephropathy to test the hypothesis that fenoldopam attenuate...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Aravindan N,Cata JP,Dougherty PM,Shaw AD

    更新日期:2006-01-01 00:00:00

  • Angiotensin I converting enzyme activity in uranyl nitrate induced acute renal failure in rats.

    abstract::Angiotensin I converting enzyme (ACE) was measured in urine, serum, and tissues from rats with acute renal failure (ARF) induced by a single subcutaneous injection (15 mg/kg BW) of uranyl nitrate (UN). Urine was collected daily until day 5, when rats were sacrificed by decapitation for the obtention of blood serum and...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Pedraza-Chaverrí J,Cruz C,del Socorro Blancas M,Hernández-Pando R,Ibarra-Rubio ME,Larriva-Sahd J,Tapia E

    更新日期:1995-07-01 00:00:00