Current evidence on the use of anti-RAAS agents in congenital or acquired solitary kidney.

Abstract:

RATIONAL:The inhibition of renin-angiotensin-aldosterone system (RAAS) is a major strategy for slowing the progression of chronic kidney disease (CKD). The utility of anti-RAAS agents in patients with congenital or acquired solitary kidney is still controversial. OBJECTIVE:A systematic literature review was conducted. MAIN FINDINGS:The conclusions of the few available studies on the topic are homogeneously in agreement with a long-term reno-protective activity of anti-RAAS drugs in patients with solitary kidney, especially if patients are hypertensive or proteinuric. However, angiotensin 2 (ANG2) levels permit a functional adaptation to a reduced renal mass in adults and is crucial for sustaining complete kidney development and maturation in children. A hormonal interference on ANG2 levels has been supposed in women. Consequently, at least in children and women, the use of ARBs appears more appropriate. Principle conclusions: Available data on this topic are limited; however, by their overall assessment, it would appear that anti-RAAS drugs might also be reno-protective in patients with solitary kidney. The use of ARBs, especially in children and in women, seems to be more appropriate. However, more experimental data would be strictly necessary to confirm this hypothesis.

journal_name

Ren Fail

journal_title

Renal failure

authors

Simeoni M,Armeni A,Summaria C,Cerantonio A,Fuiano G

doi

10.1080/0886022X.2017.1361840

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

660-670

issue

1

eissn

0886-022X

issn

1525-6049

journal_volume

39

pub_type

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