Abstract:
RATIONAL:The inhibition of renin-angiotensin-aldosterone system (RAAS) is a major strategy for slowing the progression of chronic kidney disease (CKD). The utility of anti-RAAS agents in patients with congenital or acquired solitary kidney is still controversial. OBJECTIVE:A systematic literature review was conducted. MAIN FINDINGS:The conclusions of the few available studies on the topic are homogeneously in agreement with a long-term reno-protective activity of anti-RAAS drugs in patients with solitary kidney, especially if patients are hypertensive or proteinuric. However, angiotensin 2 (ANG2) levels permit a functional adaptation to a reduced renal mass in adults and is crucial for sustaining complete kidney development and maturation in children. A hormonal interference on ANG2 levels has been supposed in women. Consequently, at least in children and women, the use of ARBs appears more appropriate. Principle conclusions: Available data on this topic are limited; however, by their overall assessment, it would appear that anti-RAAS drugs might also be reno-protective in patients with solitary kidney. The use of ARBs, especially in children and in women, seems to be more appropriate. However, more experimental data would be strictly necessary to confirm this hypothesis.
journal_name
Ren Failjournal_title
Renal failureauthors
Simeoni M,Armeni A,Summaria C,Cerantonio A,Fuiano Gdoi
10.1080/0886022X.2017.1361840subject
Has Abstractpub_date
2017-11-01 00:00:00pages
660-670issue
1eissn
0886-022Xissn
1525-6049journal_volume
39pub_type
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