Abstract:
:Aquaporin-2 protein levels can be detected in the urine of normal of subjects if measured after fluid deprivation. By contrast, in patients with nephrogenic diabetes insipidus caused by mutations in the aquaporin-2 gene, urine aquaporin-2 protein excretion cannot be detected. We propose that properly standardized measurements of urinary aquaporin-2 protein may provide a useful biomarker of distal tubular function in a variety of acquired conditions that impair concentrating ability including some nephrotoxic agents.
journal_name
Ren Failjournal_title
Renal failureauthors
Sisson D,Batlle Ddoi
10.3109/08860229909085095subject
Has Abstractpub_date
1999-05-01 00:00:00pages
331-6issue
3-4eissn
0886-022Xissn
1525-6049journal_volume
21pub_type
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