Acute renal failure and pregnancy: a seventeen-year experience of a Tunisian intensive care unit.

Abstract:

PURPOSE:To describe the epidemiologic features of acute renal failure related to pregnancy (PRARF) and to evaluate its prognostic impact. METHODS:Retrospective study conducted in a Tunisian intensive care unit over a period of 17 years (1995-2011). Women were included if they were more than 20 weeks pregnant and were admitted to the ICU during pregnancy or immediately (<7 d) post partum. PRARF was defined by a serum creatinine level >0.8 mg/dL and was classified as mild (0.9 to 1.4 mg/dL), moderate (1.5 to 2.9 mg/dL) or severe (>3 mg/dL). RESULTS:Five hundred and fifty patients were included. Mean age was 31 ± 6 years. Mean SOFA score was 4 ± 3. PRARF was diagnosed in 313 patients (56.9%). ARF was mild in 215 cases (39.1%), moderate in 65 cases (11.8%) and severe in 33 cases (6%). Main causes leading to this complication were preeclampsia (66.5%) and acute hemorrhage (27.8%). Only two patients (0.4%) developed chronic renal failure and needed long-term dialysis. Patients who developed this complication had higher SOFA score (4.7 ± 3.5 vs. 3.2 ± 2.1; p < 0.001). Thirty-three patients (6%) died in the ICU. The rate of ICU mortality was significantly higher in patients with PRARF (9.3 vs. 1.7%; p < 0.001). CONCLUSIONS:PRARF is associated with higher mortality. Thus, appropriate monitoring of pregnancies is needed in order to prevent its onset by an early and prompt management of the underlying risk factors.

journal_name

Ren Fail

journal_title

Renal failure

authors

Bouaziz M,Chaari A,Turki O,Dammak H,Chelly H,Ammar R,Nasri A,Ben Algia N,Bahloul M,Ben Hamida C

doi

10.3109/0886022X.2013.819767

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

1210-5

issue

9

eissn

0886-022X

issn

1525-6049

journal_volume

35

pub_type

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