Abstract:
BACKGROUND AND OBJECTIVE:Prolonged corticosteroid (CS) use induces osteoporosis; the pathogenesis of this condition is multifactorial and includes CS-induced hypercalciuria. We investigated the course of hypercalciuria and related markers of bone metabolism parameters during and after the CS treatment. MATERIALS AND METHODS:We recruited 42 patients who were taking at least 10 mg/day of methylprednisolone or an equivalent dose of CSs for at least 30 days. The 24-h urinary calcium and sodium, a spot urinary calcium/creatinine ratio, and urinary deoxypyridinoline were measured prior to the treatment, at day 7, at days 30-60, and after the cessation of the treatment. Additionally, the serum levels of phosphorus, calcium, alkaline phosphatase (ALP), albumin, creatinine, osteocalcin, and parathyroid hormone (PTH) were analyzed. RESULTS:The 24-h urinary calcium excretion was significantly increased at day 7 (182.2 ± 158.6 mg/day; p < 0.001) and at days 30-60 (196.9 ± 167.8 mg/day; p < 0.001) compared with baseline (98.7 ± 88.1 mg/day) and returned to basal level after the cessation of the CSs (118.9 ± 90.2 mg/day; p = 0.725). The urinary deoxypyridinoline level was significantly higher at days 30-60 compared with basal level. The serum osteocalcin level was decreased at days 30-60 when compared with day 7. No significant changes were detected in the PTH, phosphorus, creatinine, and ALP levels. CONCLUSIONS:CS treatment induces hypercalciuria just after starting the treatment until the end of it. CS-induced hypercalciuria promptly improved after cessation of the treatment. By days 30-60, the excretion of urinary deoxypyridinoline was accompanied by hypercalciuria. The serum osteocalcin level was decreased at days 30-60 when compared with day 7.
journal_name
Ren Failjournal_title
Renal failureauthors
Duzen O,Erkoc R,Begenik H,Soyoral YU,Aldemir MNdoi
10.3109/0886022X.2011.648596subject
Has Abstractpub_date
2012-01-01 00:00:00pages
338-42issue
3eissn
0886-022Xissn
1525-6049journal_volume
34pub_type
杂志文章相关文献
RENAL FAILURE文献大全abstract:BACKGROUND:Despite the widespread availability of dialytic and intensive care unit technology, the probability of early mortality in critically ill patients with acute renal failure (ARF) is still high, and the evaluation of the patients' prognosis has been difficult. The Acute Physiology and Chronic Health Evaluation ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-100001284
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:This aim of this multi-centric cross-sectional study was to assess the nutritional status in Indian chronic kidney disease (CKD) patients and to compare the nutritional indicators between stage 5 dialyzed (CKD-D) patients below the poverty line (BPL), and stage 3-4 non-dialyzed (CKD-ND) patients above (APL) ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2013.872570
更新日期:2014-04-01 00:00:00
abstract::Cognitive dysfunction is a well-known complication of chronic renal failure that is evident in 30% of hemodialysis (HD) patients. However, the pathogenesis of this dysfunction is unknown. Left ventricular hypertrophy could develop in hypertensive HD patients without establishing normovolemia. Our aim was to evaluate t...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860220903134548
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Acquired cystic kidney disease (ACKD) is a frequent complication in chronic hemodialysis (HD) patients and a risk factor for renal cell carcinoma. Online hemodiafiltration (HDF) provides better clearance of middle molecular weight solutes, but its effect on ACKD has not been investigated. MATERIALS AND METH...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220903003412
更新日期:2009-01-01 00:00:00
abstract:PURPOSE:Oxidative stress due to hyperglycemia is a major cause of diabetes complications. The aim of this study was to evaluate the effects of pomegranate seed oil (PSO) on serum biochemical parameters, cardiomyopathy and nephropathy induced by diabetes mellitus. METHOD:W/A adult rats were divided into four groups (12...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2016.1207053
更新日期:2016-09-01 00:00:00
abstract::Acute iron poisoning is a common and potentially serious problem in the pediatric population. Early recognition and treatment is crucial for a better outcome and to prevent morbidity and mortality. An 18-year-old female, who had accidental ingestion of 50 tablets of ferrous sulfate (100 mg of elemental iron per 335 mg...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2013.790299
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Fabry disease (FD) is an X-linked lysosomal storage disorder caused by the mutation of the GLA gene, encoding the α-galactosidase, which is responsible for the catabolism of neutral glycosphingolipids. Microalbuminuria or low-grade proteinuria, and continuously progressive renal failure are common manifestat...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2020.1818578
更新日期:2020-11-01 00:00:00
abstract::Oxygen metabolites play an important role in the pathogenesis of myoglobinuric acute renal failure (ARF). Previously, we have reported a down regulation of peroxisome proliferator activated receptor gamma (PPARgamma) in glycerol-induced ARF, and the induction of PPARgamma has been shown to provide renal protection. In...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220701573483
更新日期:2007-01-01 00:00:00
abstract::Renal ischemia reperfusion injury (IRI) is a major problem, currently without treatments in clinical use. This reflects the failure of animal models to mimic the severity of IRI observed in clinical practice. Most described models lack both the ability to inflict a permanent reduction in renal function and the sensiti...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2016.1144024
更新日期:2016-11-01 00:00:00
abstract::Objectives: To improve the mouse model of relief for unilateral ureteral obstruction (RUUO) and explore the pathological process of renal fibrosis after the obstruction was relieved. Methods: C57BL/6 mice in model group were randomly divided into RUUO group, improved RUUO group, and UUO group. After leaving Unilateral...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2019.1624263
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:Sirolimus has been considered to be a non-nephrotoxic agent. It may delay graft function due to a potential hindrance of the recovery from acute tubular necrosis. It remains controversial as to whether the concomitant administration of sirolimus (SRL) with calcineurin inhibitors delays graft function in Asia...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220701860989
更新日期:2008-01-01 00:00:00
abstract::During exercise, the plasma urate levels and urinary excretion increase due to the enhanced purine degradation in skeletal muscle. Although urate transporter-1 (URAT1) is the main transporter responsible for the reabsorption of filtered urate, potential changes in its activity and expression during exercise have not b...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2010.494805
更新日期:2010-01-01 00:00:00
abstract::Antenatal hydronephrosis (AHN), defined as dilatation of renal pelvis and/or calyces, is the most frequently detected antenatal abnormality. However, postnatal management of AHN is controversial. The purpose of this study was to describe the clinical outcomes of infants with AHN and to contribute to the definition of ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2012.676492
更新日期:2012-01-01 00:00:00
abstract:RATIONAL:The inhibition of renin-angiotensin-aldosterone system (RAAS) is a major strategy for slowing the progression of chronic kidney disease (CKD). The utility of anti-RAAS agents in patients with congenital or acquired solitary kidney is still controversial. OBJECTIVE:A systematic literature review was conducted....
journal_title:Renal failure
pub_type: 杂志文章,评审
doi:10.1080/0886022X.2017.1361840
更新日期:2017-11-01 00:00:00
abstract::Recently we demonstrated the effect of fenoldopam on ischemia/reperfusion (I/R) induced NFkappaB mediated pro-inflammatory signal transduction. However, the effect of fenoldopam on I/R-induced apoptosis is not known. We utilized a rat model of acute ischemic nephropathy to test the hypothesis that fenoldopam attenuate...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220600583690
更新日期:2006-01-01 00:00:00
abstract::Objective The objective of this study is to explore the efficacy and safety of mizoribine (MZR) in treating nephrotic syndrome patients afflicted with hepatitis B virus (HBV). Methods The present study included 36 nephrotic syndrome patients accompanied with HBV infection. A draft of MZR (150-200 mg/d), methylpredniso...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2016.1158035
更新日期:2016-06-01 00:00:00
abstract::Creation of arteriovenous fistula (AVF) may lead to left ventricle hypertrophy and predispose for development or worsening of heart failure. It was postulated to reduce access blood flow if exceeded 2 L/min or cardiac index was higher than 3.0 L/min/m(2). Numbers of techniques decreasing flow were described. The major...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2016.1184936
更新日期:2016-08-01 00:00:00
abstract::Anemia is a well-defined complication of aluminum overload in chronic dialysis patients which may be present before other manifestations of aluminum toxicity are obvious. Causes of anemia in chronic renal failure are multiple, and at the present time there is no marker for aluminum-induced anemia. Deferoxamine (DFO) t...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860228909066949
更新日期:1989-01-01 00:00:00
abstract::This study was designed to investigate whether the treatment with the N-acetyl-L-cysteine prior to the administration of chemotherapy drug would prevent from nephrotoxicity and the loss of reproductive performance induced from chemotherapy treatment. Female rats were divided into five equal groups of six each: 1/contr...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2015.1127742
更新日期:2016-01-01 00:00:00
abstract::Objective: The present study assesses whether phosphodiesterase type 5 (PDE-5) inhibitor or carnitine exert nephroprotective effects against clinical contrast-induced nephropathy (CIN).Materials and Methods: The present study consisted of three groups of CKD patients. The first group was control group, who were treate...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2019.1669459
更新日期:2019-11-01 00:00:00
abstract::Herein we present one of the largest single-center reports of the response of hemodialysis patients to a two-vaccine hepatitis B virus vaccination protocol in a European dialysis population. A hepatitis B recombinant DNA vaccine, HBvaxPRO, was given at a dose of 40 µg intramuscularly using a four-dose schedule at 0, 1...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2011.559300
更新日期:2011-01-01 00:00:00
abstract::Increased vascular calcification and oxidative stress are considered as extra renal risk factors at the pathogenesis cardiovascular events in chronic kidney disease (CKD). We investigated matrix Gla protein (MGP) (T-138C, Glu60X, Thr83Ala) and Klotho (Cys370Ser) gene polymorphisms, serum MGP levels, and oxidative stre...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2011.605534
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:The aim of the current study was to investigate whether agmatine (AGM) has a protective effect against cisplatin-induced nephrotoxicity. MATERIALS AND METHODS:Thirty-two rats were randomly divided into four groups: (1) Saline (control); (2) Cisplatin (CDDP; 7.5 mg/kg intraperitoneally); (3) Agmatine (AGM; 1...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2016.1227919
更新日期:2016-10-01 00:00:00
abstract::Angiotensin I converting enzyme (ACE) was measured in urine, serum, and tissues from rats with acute renal failure (ARF) induced by a single subcutaneous injection (15 mg/kg BW) of uranyl nitrate (UN). Urine was collected daily until day 5, when rats were sacrificed by decapitation for the obtention of blood serum and...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229509037603
更新日期:1995-07-01 00:00:00
abstract::Background: Renal interstitial fibrosis is a common pathway of chronic kidney disease to end-stage renal disease, which is characterized by an imbalance between the synthesis and degradation of the collagen-rich extracellular matrix (ECM). While, discoidin domain receptor 2 (DDR2) can be activated when it binds to som...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2019.1621759
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:Genetic polymorphism of endothelial nitric oxide synthase (eNOS) has been implicated in the risk of diabetic nephropathy (DN), but the published findings were inconsistent. We performed a comprehensive meta-analysis to derive a more precise estimation of the association between genetic polymorphisms of eNOS ...
journal_title:Renal failure
pub_type: 杂志文章,meta分析
doi:10.3109/0886022X.2015.1062339
更新日期:2015-11-01 00:00:00
abstract::Ciprofloxacin has been associated with several side effects including interstitial nephritis and hemolytic anemia. The combination of both side effects is extremely rare. In this report, we describe a case of ciprofloxacin-induced interstitial nephritis and autoimmune hemolytic anemia. Hemolytic anemia improved after ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-120022557
更新日期:2003-07-01 00:00:00
abstract::Acute renal failure secondary to tumor infiltration of the kidneys is uncommon and largely described in patients with lymphoma or leukemia. We report a 64-year-old man previously diagnosed with limited stage small cell lung cancer who presented with acute renal failure (ARF). Renal imaging showed bilateral enlargement...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220600580423
更新日期:2006-01-01 00:00:00
abstract::Creatol (CTL) is a hydroxyl radical adduct of creatinine (Cr). The serum methylguanidine (MG) level and the MG/Cr molar ratio are reported to be biomarkers for oxidative stress. The aim of this study was to examine whether urinary excretion of CTL, another oxidative stress-related marker, is increased in patients with...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220701219863
更新日期:2007-01-01 00:00:00
abstract:AIM:Bio-impedance analysis (BIA) is a preferred method for estimating the volume status. However, it cannot be utilized in daily practice. Since the assessment of the volume status is important and challenging for hemodialysis (HD) patients, the aim of study was to determine the volume status in chronic HD patients usi...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2016.1229968
更新日期:2016-11-01 00:00:00