Assessment of matrix Gla protein, Klotho gene polymorphisms, and oxidative stress in chronic kidney disease.

abstract：:Prophylactic effects of N-benzoyl-beta-alanine (betamipron, BP), one of a series of N-acyl amino acids, were examined against cisplatin-induced nephrotoxicity. Male Wistar rats were injected i.p. with 6 mg/kg of cisplatin combined with an i.p. BP dose given at various times and various doses. Rats were sacrificed 5 da...

journal_title：Renal failure

authors： Tokunaga J,Kobayashi M,Nakamura C,Kitagawa A,Arimori K,Nakano M

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:Chronic kidney disease (CKD) is a world-wide public health problem. Hypertension is both a cause and a complication of CKD, and a risk factor for progression of kidney disease. The effect of salt intake on blood pressure (BP) and the salt sensitivity in non-dialysis patients with CKD were studied. METHODS:O...

journal_title：Renal failure

authors： Meng L,Fu B,Zhang T,Han Z,Yang M

更新日期：2014-04-01 00:00:00

abstract：:Aims: The aim was to determine whether anti-neutrophil cytoplasmic antibody (ANCA)-positive serology in patients with lupus nephritis (LN) is associated with different clinicopathologic features and outcomes.Methods: In our retrospective analysis, 283 patients were enrolled between 2013 and 2018. Thirty-six patients w...

journal_title：Renal failure

authors： Wang S,Shang J,Xiao J,Zhao Z

更新日期：2020-11-01 00:00:00

abstract：:Objective The objective of this study is to explore the efficacy and safety of mizoribine (MZR) in treating nephrotic syndrome patients afflicted with hepatitis B virus (HBV). Methods The present study included 36 nephrotic syndrome patients accompanied with HBV infection. A draft of MZR (150-200 mg/d), methylpredniso...

journal_title：Renal failure

authors： Liu J,Zhang K,Ji Y,Zhang W,Li W,Yong Q,Wang J,Sun J,Zhang H

更新日期：2016-06-01 00:00:00

abstract：:Urinary N-acetyl-β-d-glucosaminidase (NAG) has been suggested as a marker for early diabetic nephropathy. This study aimed to prospectively investigate the relationship between asymptomatic leukocyturia (ASL) and NAG in women. One hundred and five female outpatients aged 31-86 years were selected for a 10-year follow-...

journal_title：Renal failure

authors： Sekimizu K,Suzuki T,Igari Y,Okazaki M,Hashimoto M,Suzuki K,Ouchi M,Watanabe K,Nakano H,Oba K

更新日期：2012-01-01 00:00:00

abstract：:Medication errors are ongoing problems among hospitalized patients especially those with multiple co-morbidities and polypharmacy such as patients with renal diseases. This study evaluated the frequency, types and direct related cost of medication errors in nephrology ward and the role played by clinical pharmacists. ...

journal_title：Renal failure

authors： Gharekhani A,Kanani N,Khalili H,Dashti-Khavidaki S

更新日期：2014-09-01 00:00:00

abstract：:Background: Elevated serum levels of sIL-2R are commonly observed in patients undergoing maintenance hemodialysis (MHD). However, the clinical implications in these subjects are unclear. This study is aimed to assess the significance of elevated sIL-2R levels in MHD patients.Methods: A total of 382 MHD patients were f...

journal_title：Renal failure

authors： Chen X,Li Y,Ding X,Zou J,Shen B,Liu Z,Lv W,Cao X,Xiang F

更新日期：2020-11-01 00:00:00

abstract：:Secondary hyperparathyroidism and anemia are the hallmarks in uremic patients. It is suggested that parathyroid hormone increases erythrocyte osmotic fragility and induces hemolysis. The present study was undertaken to examine the possible relationship between erythrocyte osmotic fragility and secondary hyperparathyro...

journal_title：Renal failure

authors： Koşan C,Sever L,Arisoy N

更新日期：2004-11-01 00:00:00

abstract：:Uremic patients are characterized by a "pro-arrhythmic substrate." Arrhythmia appearance during hemodialysis (HD) is an unexpected event with a high incidence of mortality and morbidity and difficult to record in patients repeatedly checked using electrocardiogram (ECG). Furthermore the carrying out of this important ...

journal_title：Renal failure

authors： Lacquaniti A,Donato V,Lucisano S,Buemi A,Buemi M

更新日期：2012-01-01 00:00:00

abstract：:Acute renal failure secondary to tumor infiltration of the kidneys is uncommon and largely described in patients with lymphoma or leukemia. We report a 64-year-old man previously diagnosed with limited stage small cell lung cancer who presented with acute renal failure (ARF). Renal imaging showed bilateral enlargement...

journal_title：Renal failure

authors： Wen YK,Chen ML

更新日期：2006-01-01 00:00:00

abstract：:Acetaminophen (APAP), also known as paracetamol, is the commonest cause of toxic ingestion in the world. Because overdose of APAP has life-threatening effects on kidney, treatment of APAP-induced nephrotoxicity has life-saving importance. Aim of the study was to evaluate the efficacy of medical ozone therapy in experi...

journal_title：Renal failure

authors： Demirbag S,Uysal B,Guven A,Cayci T,Ozler M,Ozcan A,Kaldirim U,Surer I,Korkmaz A

更新日期：2010-05-01 00:00:00

abstract：:The single dose administration of the aminonucleoside of puromycin (PAN) induces a nephrotic syndrome in rats characterized by massive proteinuria and progressive histologic changes. This model of acute parenchymal nephritis is thought to be mediated by the renal recruitment of monocytes and macrophages. To investigat...

journal_title：Renal failure

authors： Berens KL,Verani RR,Luke DR

更新日期：1998-01-01 00:00:00

abstract：:The proximal convoluted tubule (PCT) is the major target for injury in gentamicin nephrotoxicity but the necrosis is often patchy and focal. The PCT is structurally, functionally, and metabolically heterogeneous, and the possibility of differential vulnerability to gentamicin-induced necrosis based on this heterogenei...

journal_title：Renal failure

authors： Shanley PF,Burke TJ

更新日期：1990-01-01 00:00:00

abstract：:While the fractional excretion of solutes have long been considered excellent research tools to investigate tubular physiology, their clinical use has become common over the last 40 years in the diagnoses of many disorders; however, none have reached the clinical utility of the fractional excretion of sodium in the ab...

journal_title：Renal failure

authors： Diskin CJ,Stokes TJ,Dansby LM,Radcliff L,Carter TB

更新日期：2010-01-01 00:00:00

abstract：AIM:The aim of this study was to evaluate the effects of curcumin in an experimental model of busulfan-induced renal toxicity with emphasis on importance of histological alterations. METHODS:In this study, we utilized 32 adult male Wistar rats (250 ± 10 g). All the animals were divided into four experimental groups ra...

journal_title：Renal failure

authors： Abdollahifar MA,Ebrahimi V,Aliaghaei A,Raoofi A,Khosravi A,Hasani A,Mehdizadeh A,Asadi M

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:In this study, it was aimed to determine the effects of alfuzosin on experimentally generated unilateral partial ureteropelvic junction obstruction (UPO) in rats. MATERIALS AND METHODS:Thirty Long-Evans rats were randomly allocated into five groups. In control group (C), nothing was performed; in group Sham...

journal_title：Renal failure

authors： Kose F,Turkyilmaz Z,Sonmez K,Karabulut R,Poyraz A,Gulbahar O,Aral A,Damar C,Kaya C,Can Basaklar A

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:The aim of the current study was to investigate whether agmatine (AGM) has a protective effect against cisplatin-induced nephrotoxicity. MATERIALS AND METHODS:Thirty-two rats were randomly divided into four groups: (1) Saline (control); (2) Cisplatin (CDDP; 7.5 mg/kg intraperitoneally); (3) Agmatine (AGM; 1...

journal_title：Renal failure

authors： Salihoglu YS,Elri T,Gulle K,Can M,Aras M,Ozacmak HS,Cabuk M

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVE:To investigate the prevalence and risk factors for chronic kidney disease (CKD) among community elderly population in Shanghai, China, in order to provide early diagnosis and treatment of CKD, and improve the quality of life for elderly people. METHODS:In all, 24,886 residents (≥65 years old) were selected f...

journal_title：Renal failure

authors： Huang YP,Zheng T,Zhang DH,Chen LY,Mao PJ

更新日期：2016-11-01 00:00:00

abstract：:In chronic renal failure (CRF), phosphate (Pi) retention may lead to secondary hyperparathyroidism and progression to end-stage renal disease (ESRD). Dietary phosphorus restriction or phosphate binders can slow progression in experimental CRF. Conversely, diets high in phosphorus can accelerate the progression toward ...

journal_title：Renal failure

authors： Loghman-Adham M,Motock GT

更新日期：1996-11-01 00:00:00

abstract：OBJECTIVE:We investigate the mechanism of neutrophil/lymphocyte ratio (NLR) elevation, a useful prognostic marker in patients with cardiovascular diseases (CVDs). METHODS:In this clinical study, we retrospectively searched for factors associated with NLR elevation in cardiovascular outpatients. In animal experiments u...

journal_title：Renal failure

authors： Ito S,Ohno Y,Tanaka T,Kobuchi S,Ayajiki K,Manabe E,Masuyama T,Jun-Ichi S,Tsujino T

更新日期：2019-11-01 00:00:00

abstract：AIM:Estimation of eGFR in children with normal kidney function using the Schwartz equations results in underestimating real GFR. MATERIALS AND METHODS:We propose modification of three Schwartz equations - two based on creatinine concentration (eGFRScrBS bedside) and (eGFRScr) and one 3-marker based on creatinine, urea...

journal_title：Renal failure

authors： Zachwieja K,Korohoda P,Kwinta-Rybicka J,Miklaszewska M,Moczulska A,Bugajska J,Berska J,Drożdż D,Pietrzyk JA

更新日期：2016-06-01 00:00:00

abstract：:Autosomal dominant polycystic disease (ADPKD) is one of the most common monogenic disorders, and globally is among the most common hereditary causes of end stage kidney disease. Until recently, the causes of this disease remained obscure. However, in the past decade there have been enormous advances in the understandi...

journal_title：Renal failure

authors： Kazancioglu R,Gursu M

更新日期：2015-05-01 00:00:00

abstract：:Retroperitoneal fibrosis (RF) is a clinical entity characterized by the progressive proliferation of connective tissue that rarely forms a mass involving the periaortic area of the abdomen, which may be idiopathic as well as a result of an inflammatory process after aneurysmal dilatation of the aorta. This fibrotic ti...

journal_title：Renal failure

authors： Dişel U,Alpay NR,Paydas S

更新日期：2007-01-01 00:00:00

abstract：:We evaluated amount and composition of amino acids in supplementation of hyperalimentation from the standpoint of whether it may improve nutrition and/or reduce the indexes of uremia such as BUN. Rats with established uremia, by 5/6 nephrectomy, were treated with various isocaloric solutions containing different amoun...

journal_title：Renal failure

authors： Kikuchi T,Tanaka H,Kokuba Y,Sato M

更新日期：1994-01-01 00:00:00

abstract：:Investigations were done in 10- and 55-day-old Wistar rats. Glutathione (GSH) level in kidney was decreased by 8 mmol buthionine sulfoximine (BSO)/100 g BW. There was no effect on the renal function and nephrotoxicity of cisplatin (0.6 mg CP/100 g BW) in adult rats. In young rats BSO treatment was followed by nephroto...

journal_title：Renal failure

authors： Appenroth D,Winnefeld K

更新日期：1993-01-01 00:00:00

abstract：:More than 70% of acute renal failure in man is of circulatory nature and results from hypoxic injury to the kidney. Since intrarenal hemodynamic and metabolic events cannot be accurately assessed in human acute renal failure, various experimental models of renal hypoperfusion or complete interruption of renal blood su...

journal_title：Renal failure

authors： Mohaupt M,Kramer HJ

更新日期：1989-01-01 00:00:00

abstract：:Cyclosporine is used extensively in kidney transplantation and is a substrate for cytochrome P450 enzymes. The role of cytochrome p450 polymorphisms in kidney transplant outcome has not yet been fully elucidated. We investigate the clinical impact of single nucleotide polymorphisms in CYP3A4, CYP3A5, PPARα, and POR*28...

journal_title：Renal failure

authors： Traynor C,Conlon P Jr,Phelan PJ,O'Kelly P,Elens L,McCormack M,Cavalleri G,Comber H,van Schaik RH,Conlon PJ

更新日期：2015-05-01 00:00:00

abstract：:Glycine has been shown to protect against cisplatin (CP) nephrotoxicity in rats and to enhance the in vitro expression of heat-shock protein (hsp) 70 in renal epithelial cells following sublethal heat shock. We hypothesized that the protective effect of glycine against CP nephrotoxicity may be due to an up-regulation ...

journal_title：Renal failure

authors： Musio F,Carome MA,Bohen EM,Sabnis S,Yuan CM

更新日期：1997-01-01 00:00:00

abstract：:Nontraumatic rhabdomyolysis may be associated with severe metabolic disturbances. In particular, previous literature has described a 8-20% incidence of acute renal failure in rhabdomyolysis. The aim of this study was to evaluate our experience on 11 patients with acute renal failure treated by high-efficiency daily he...

journal_title：Renal failure

authors： Tozzo C,Mazzarella V,Splendiani G,Casciani CU

更新日期：1997-05-01 00:00:00

abstract：:Daily intraperitoneal (i.p.) injection of genatmicin at a dose of 70 mg/kg for 11 days produced nephrotoxicity in female Sprague-Dawley rats as evidenced by increased excretion of urinary protein and trypsin inhibitory activity as well as rise in renal individual class and total phospholipid. The observed proteinuria ...

journal_title：Renal failure

authors： Smetana S,Khalef S,Kopolovic G,Bar-Khayim Y,Birk Y,Kacew S

更新日期：1992-01-01 00:00:00