Abstract:
INTRODUCTION:Preimplantation biopsy provides a window on the state of the renal allograft. In this study, the prognostic value of frozen section preimplantation graft biopsy was estimated and compared to regularly processed formalin-fixed biopsy. MATERIALS AND METHODS:Seventy-four renal allograft recipients were studied. The degree of glomerulosclerosis, acute tubular necrosis, interstitial fibrosis, arteriosclerosis, and arteriolosclerosis was rapidly estimated in frozen sections and correlated to the renal function in the immediate posttransplantation period and 3 months thereafter. The histological changes were also examined in paraffin-embedded sections. RESULTS:The histological changes observed in rapidly processed frozen sections were comparable to those observed on regularly processed sections and their differences did not reach statistical significance. Glomerulosclerosis and arteriolosclerosis were underestimated, whereas acute tubular necrosis and interstitial fibrosis were overestimated, in the frozen sections compared to permanent ones, but those differences were not statistically significant. Immediate graft function was observed in 45 patients (61%). Delayed graft function was more frequently observed among recipients with donor age above 60 years (57% vs. 32%). Serum creatinine 3 months after transplantation was above 2 mg/dL in 33 recipients (44.5%) and was positively correlated to the degree of tubular necrosis (p = 0.04) and donor age (p = 0.03). Donor age was correlated to the degree of arteriolosclerosis (p < 0.01). CONCLUSIONS:Frozen section preimplantation biopsy gives reliable information for the situation of the graft that is related to the outcome of renal transplantation.
journal_name
Ren Failjournal_title
Renal failureauthors
Goumenos DS,Kalliakmani P,Tsamandas AC,Maroulis I,Savidaki E,Fokaefs E,Papachristou E,Karavias D,Vlachojannis JGdoi
10.3109/08860221003658241subject
Has Abstractpub_date
2010-05-01 00:00:00pages
434-9issue
4eissn
0886-022Xissn
1525-6049journal_volume
32pub_type
杂志文章相关文献
RENAL FAILURE文献大全abstract::Although sudden sensorineural hearing loss (SSNHL) affects chronic kidney disease (CKD) patients more frequently than non-CKD patients, few reports have described SSNHL in dialysis patients. We aimed to review the characteristics of SSNHL in chronic dialysis patients and evaluate treatment responses to steroid therapy...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2018.1450760
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND AND AIMS:Patients on maintenance hemodialysis (HD) face an increased risk of atherosclerosis, a crucial problem and the leading cause of cardiovascular morbidity and mortality. This study was designed to evaluate the effects of zinc supplementation on paraoxonase (PON) enzyme activity in patients on HD. MET...
journal_title:Renal failure
pub_type: 杂志文章,随机对照试验
doi:10.3109/0886022X.2012.717479
更新日期:2012-01-01 00:00:00
abstract::Cognitive dysfunction is a well-known complication of chronic renal failure that is evident in 30% of hemodialysis (HD) patients. However, the pathogenesis of this dysfunction is unknown. Left ventricular hypertrophy could develop in hypertensive HD patients without establishing normovolemia. Our aim was to evaluate t...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860220903134548
更新日期:2009-01-01 00:00:00
abstract::Continuous efforts have been made to find out precise and simple method for determination of glomerular filtration rate (GFR). Cystatin C (cysteine proteinase inhibitor = CyC) is a low molecular weight (LMW) protein which is produced constantly by all nucleated cells independently of different pathological conditions ...
journal_title:Renal failure
pub_type: 临床试验,杂志文章
doi:10.1081/jdi-120017475
更新日期:2003-01-01 00:00:00
abstract::Transforming growth factor-β1 (TGF-β1) is a crucial factor implicated in the development of renal inflammation and tubulointerstitial fibrosis (TIF). The cytokine interleukin 22 (IL-22) was previously reported to involve in the pathogenesis of chronic inflammatory diseases, however recent studies showed that IL-22 cou...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2020.1753538
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:Renal cystic disorders (RCD) constitute an important and leading cause of end-stage renal disease (ESRD) in children. It can be acquired or inherited; isolated or associated with extrarenal manifestations. The precise diagnosis represents a difficult clinical challenge. METHODS:The aim of this study was to ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2014.883996
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:An increased red blood cell (RBC) phosphatidylserine (PS) exposure in uremic patients was found that could promote macrophage recognition and decrease RBC survival time. Furthermore, a reduced red cell life span was found to contribute anemia in patients with renal failure. It is therefore possible to hypoth...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220600839647
更新日期:2006-01-01 00:00:00
abstract::During times of war or natural disasters, rhabdomyolysis leading to acute kidney injury (AKI) can assume epidemic proportions. Fasudil attenuates ischemia/reperfusion-induced AKI. We investigated the therapeutic effect of an early application of fasudil on AKI induced by rhabdomyolysis and explored the potential mecha...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2011.601830
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:In order to evaluate the clinical and pathological characteristics of diuretics associated acute kidney injury (AKI) and its management. METHODS:We performed a retrospective study including 131 cases that diagnosed as diuretics associated AKI from 1 January 1999 to 1 January 2010 in Ruijin Hospital affiliate...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2014.917560
更新日期:2014-08-01 00:00:00
abstract:OBJECTIVE:We investigate the mechanism of neutrophil/lymphocyte ratio (NLR) elevation, a useful prognostic marker in patients with cardiovascular diseases (CVDs). METHODS:In this clinical study, we retrospectively searched for factors associated with NLR elevation in cardiovascular outpatients. In animal experiments u...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2019.1597736
更新日期:2019-11-01 00:00:00
abstract::The single dose administration of the aminonucleoside of puromycin (PAN) induces a nephrotic syndrome in rats characterized by massive proteinuria and progressive histologic changes. This model of acute parenchymal nephritis is thought to be mediated by the renal recruitment of monocytes and macrophages. To investigat...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229809045089
更新日期:1998-01-01 00:00:00
abstract::Spontaneous nontraumatic rupture of the kidney (Wunderlich syndrome) is an extremely uncommon condition on hemodialysis. We report a case of 44-year-old hemodialysis patient presented with hemorrhagic shock and a right quadrant abdominal pain to the emergency department. There was no history of trauma. A kidney ruptur...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2012.706887
更新日期:2012-01-01 00:00:00
abstract::Objective The objective of this study is to explore the efficacy and safety of mizoribine (MZR) in treating nephrotic syndrome patients afflicted with hepatitis B virus (HBV). Methods The present study included 36 nephrotic syndrome patients accompanied with HBV infection. A draft of MZR (150-200 mg/d), methylpredniso...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2016.1158035
更新日期:2016-06-01 00:00:00
abstract:AIM:Estimation of eGFR in children with normal kidney function using the Schwartz equations results in underestimating real GFR. MATERIALS AND METHODS:We propose modification of three Schwartz equations - two based on creatinine concentration (eGFRScrBS bedside) and (eGFRScr) and one 3-marker based on creatinine, urea...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2016.1163152
更新日期:2016-06-01 00:00:00
abstract:INTRODUCTION:In this study, the cause of rapidly deteriorating renal functions in a follow-up period of a 65-year-old female patient, who applied with nephrotic syndrome findings and diagnosed as membranous nephropathy, is presented. CASE REPORT:A 65-year-old patient with findings of nephrotic syndrome had normal kidn...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220802064804
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Glutathione S-transferases (GSTs) belong to a family of ubiquitous and multifunctional enzymes that work as one of the endogenous antioxidants in our body. This study was designed to look into the association of GST polymorphism with oxidative stress in both diabetic and nondiabetic chronic kid...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2010.517348
更新日期:2010-01-01 00:00:00
abstract::Cyclosporine is used extensively in kidney transplantation and is a substrate for cytochrome P450 enzymes. The role of cytochrome p450 polymorphisms in kidney transplant outcome has not yet been fully elucidated. We investigate the clinical impact of single nucleotide polymorphisms in CYP3A4, CYP3A5, PPARα, and POR*28...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2015.1007013
更新日期:2015-05-01 00:00:00
abstract::Acute renal failure is the most common complication of rhabdomyolysis, with an 8-20% reported incidence. In particular, rhabdomyolysis associated with acute renal failure is frequently observed in critically ill patients, with a 6-16% reported incidence in Intensive Care Units. Dialytic treatment is necessary to corre...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-100103490
更新日期:2001-03-01 00:00:00
abstract::Objective: To study the efficacy and safety of sustained low-efficiency diafiltration (SLEDf) versus hemodialysis (HD) for patients with wasp stings who developed stage III acute kidney injury (AKI). Methods: We retrospectively analyzed the clinical data of consecutive patients who developed AKI following wasp stings....
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2019.1655449
更新日期:2019-11-01 00:00:00
abstract::Studies were performed to reexamine the response of erythropoietin (Epo) production to acute hypoxic stimuli in patients with end-stage renal disease (ESRD). In the absence of acute bleeding or hypoxia, the serum Epo level in ESRD was similar to that of normal subjects despite severe anemia. In 11 dialysis patients wi...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229409044892
更新日期:1994-01-01 00:00:00
abstract::Ten-Eleven Translocation (TET) proteins oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytonsie (5hmC). Our recent work found a decline in global 5hmC level in mouse kidney insulted by ischemia reperfusion (IR). However, the genomic distribution of 5hmC in mouse kidney and its relationship with gene expression remai...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2016.1172973
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Asymmetric dimethylarginine (ADMA) as a uremia toxin is accumulated in end-stage renal disease (ESRD) patients. Elevated ADMA level has been shown to be predictive of cardiovascular diseases (CVDs) and all-cause mortality in ESRD. Therefore, we investigated the removal of ADMA by different dialysis treatment...
journal_title:Renal failure
pub_type: 杂志文章,随机对照试验
doi:10.3109/0886022X.2010.502281
更新日期:2010-01-01 00:00:00
abstract::There are conflicting results in studies concerning the best marker for liver histopathological features of HCV infection in HD patients. We planned a prospective study to follow HCV viremia and laboratory parameters of HD patients and correlate these with clinic features and histopathological findings. We included 68...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-100108192
更新日期:2001-11-01 00:00:00
abstract:BACKGROUND:Cardiac valve calcification (CVC) and left ventricular (LV) alterations are frequent complication in end-stage renal disease (ESRD). We determined the prevalence of CVC and LV hypertrophy (LVH) in ESRD patients before renal replacement therapy and 12 months after peritoneal dialysis (PD). METHODS:A prospect...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2015.1073495
更新日期:2015-01-01 00:00:00
abstract::Secondary hyperparathyroidism is one of the most common complications of chronic renal failure (CRF). Its pathogenesis is multifactorial and still not completely understood. Pathological mechanism of hypocalcemia, hyperphosphatemia and calcitriol deficiency are basic characteristics of CRF and main reason for morpholo...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-100103500
更新日期:2001-03-01 00:00:00
abstract::The prognosis of uremia patients on continuous ambulatory peritoneal dialysis (CAPD) is related to frequent peritonitis rate. Frequent peritonitis will lead to peritoneum failure, making CAPD unfeasible. We have performed proteomic profiling of peritoneal dialysis effluent samples from a cross-section of CAPD patients...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220802248969
更新日期:2008-01-01 00:00:00
abstract::The present work examines the role of uremia and the effect of dialysis treatment on red blood cells (RBCs) membrane properties of hemodialysis patients. The results showed that, the uremic patients had a lower values of erythrocyte deformability than that of healthy control subject. The median osmotic fragility (MOF)...
journal_title:Renal failure
pub_type: 临床试验,杂志文章
doi:10.1081/jdi-120015680
更新日期:2002-11-01 00:00:00
abstract::We report on the isolated unilateral renal venous thrombosis (RVT) detected in a young patient who used vibration belt to stay thin. Apart from her sickle cell trait, the patient presented no other clinical situations associated with RVT. ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2012.712848
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Intima-Media-Thickness of the carotid artery wall (cIMT) is a strong predictor of cardiovascular (CV) disease. The aim of this study was to investigate the significance of cIMT as an independent prognostic factor for CV morbidity and mortality in patients with chronic kidney disease (CKD) and diabetes mellit...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2019.1585372
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:The hemodialysis adequacy is one of the most important issues influencing the survival of patients on maintenance hemodialysis (HD). Assessment of measuring the delivered dialysis dose using clearance x time/volume (Kt/V) index requires multiple blood sampling. New methods for assessment of dialysis dose bas...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220500200262
更新日期:2005-01-01 00:00:00