Abstract:
BACKGROUND:An increased red blood cell (RBC) phosphatidylserine (PS) exposure in uremic patients was found that could promote macrophage recognition and decrease RBC survival time. Furthermore, a reduced red cell life span was found to contribute anemia in patients with renal failure. It is therefore possible to hypothesize that increased PS externalization of RBC may influence renal anemia. The present study preliminarily explored the role of erythrocytes' PS exposure in anemia in uremic patients. METHOD:Erythrocyte PS exposure was measured in 67 stable patients on continuous ambulatory peritoneal dialysis (CAPD). An investigation was conducted in the relationship between the level of erythrocyte PS exposure and hemoglobin concentration. A flow-cytometric assay based on FITC-Annexin V was used to measure the PS exposure of erythrocytes. RESULTS:An inverse correlation was found between the percentage of PS-positive RBCs and hemoglobin concentration (r = -0.2601, p < 0.05). Logistic regression analysis revealed that the percentage of PS-positive RBCs was identified as a risk factor for anemia (Hazards ratio = -0.421, p < 0.05). CONCLUSION:This study found that elevated PS exposure in erythrocytes might be a risk factor for anemia and contribute to the development of anemia in peritoneal dialysis patients.
journal_name
Ren Failjournal_title
Renal failureauthors
Bi SH,Cheng LT,Wang Tdoi
10.1080/08860220600839647subject
Has Abstractpub_date
2006-01-01 00:00:00pages
573-6issue
7eissn
0886-022Xissn
1525-6049pii
N42794763L760L99journal_volume
28pub_type
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