Renal failure and nephrotoxic drug-induced disturbances in rat kidney tissue.

abstract：BACKGROUND:Elevated plasminogen activator inhibitor-1 (PAI-1) levels are associated with increased cardiovascular (CV) risk in the general population. It has been shown that peritoneal dialysis (PD) patients have increased plasma levels of PAI-1. The aim of this study was to investigate whether PAI-1 independently pred...

journal_title：Renal failure

authors： Arikan H,Koc M,Tuglular S,Ozener C,Akoglu E

更新日期：2009-01-01 00:00:00

abstract：AIM:The aim of this study was to evaluate the effects of curcumin in an experimental model of busulfan-induced renal toxicity with emphasis on importance of histological alterations. METHODS:In this study, we utilized 32 adult male Wistar rats (250 ± 10 g). All the animals were divided into four experimental groups ra...

journal_title：Renal failure

authors： Abdollahifar MA,Ebrahimi V,Aliaghaei A,Raoofi A,Khosravi A,Hasani A,Mehdizadeh A,Asadi M

更新日期：2020-11-01 00:00:00

abstract：:Recently, we demonstrated that furosemide improves renal hemodynamics and attenuates ischemia/reperfusion (I/R)-associated changes in angiogenesis-related gene expression. However, the effect of furosemide on I/R-induced apoptosis is not known. We utilized a rat model of acute ischemic nephropathy to test the hypothes...

journal_title：Renal failure

authors： Aravindan N,Aravindan S,Riedel BJ,Weng HR,Shaw AD

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:There are little data on the incidence of acute renal failure (ARF) from India due to the absence of central registry. The etiology, course, and outcome of ARF differ in various parts of India. Significant trend changes were reported even within a same center over a period of time. AIM:To find out the epide...

journal_title：Renal failure

authors： Jayakumar M,Prabahar MR,Fernando EM,Manorajan R,Venkatraman R,Balaraman V

更新日期：2006-01-01 00:00:00

abstract：:Glomerular function shows a progression directly correlated to gestational age (GA) and postnatal age in preterm infants. In preterms, glomerular filtration rate (GFR) is significantly lower than in term infants, and it matures more slowly in the postnatal period. In infants with very low GA, due to decreased GFR, nor...

journal_title：Renal failure

authors： Aydemir O,Erdeve O,Oguz SS,Uras N,Dilmen U

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:The goal of this study was to define the clinical and histological differences in new-onset IgA nephropathy between young adults and the elderly. METHODS:We retrospectively examined renal biopsy findings, clinical features at presentation and outcomes in 82 young adults (mean age 30.3+/-10.2 years) and 17 e...

journal_title：Renal failure

authors： Wen YK,Chen ML

更新日期：2010-01-01 00:00:00

abstract：:Angiotensin I converting enzyme (ACE) was measured in urine, serum, and tissues from rats with acute renal failure (ARF) induced by a single subcutaneous injection (15 mg/kg BW) of uranyl nitrate (UN). Urine was collected daily until day 5, when rats were sacrificed by decapitation for the obtention of blood serum and...

journal_title：Renal failure

authors： Pedraza-Chaverrí J,Cruz C,del Socorro Blancas M,Hernández-Pando R,Ibarra-Rubio ME,Larriva-Sahd J,Tapia E

更新日期：1995-07-01 00:00:00

abstract：BACKGROUND:The pathogenesis of the development of IgA nephropathy has not been clear up to now. At present, some studies revealed that the mTOR pathway may participate in IgA nephropathy; however, the mechanism has not been systematically studied. In this study, we established an IgAN rat model to investigate the prote...

journal_title：Renal failure

authors： Guo N,Liu S,Bow LM,Cui X,Zhang L,Xu S,Lu S,Tian J

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Peritonitis, the most important limitation of peritoneal dialysis (PD), could be detected by biomarkers in dialysate effluent, representing a noninvasive method to indirectly assess the peritoneum status. The aim of our study was to test high mobility group box 1 (HMGB1) in PD patients, evaluating its role a...

journal_title：Renal failure

authors： Chimenz R,Lacquaniti A,Colavita L,Chirico V,Fede C,Buemi M,Fede C

更新日期：2016-10-01 00:00:00

abstract：:The aim of this study was to assess the effect of nifedipine and piracetam alone or in combination in the protection of renal function and morphology after cyclosporin A (CyA) administration. Thirty healthy mongrel dogs with a mean body weight of 15 kg were sacrificed. Six animals (group C) were given CyA 20 mg/kg bod...

journal_title：Renal failure

authors： Grekas D,Alivanis P,Kalekou H,Papayianni K,Karamouzis M,Tourkantonis A

更新日期：1992-01-01 00:00:00

abstract：:Abnormal glucose metabolism in uremia may result from a complex interplay between decreased insulin secretion and insulin resistance. Recent studies report beneficial effect of biotin administration in glucose metabolism in diabetic animals and in a small number of patients with diabetes mellitus. The aim of the prese...

journal_title：Renal failure

authors： Koutsikos D,Fourtounas C,Kapetanaki A,Agroyannis B,Tzanatos H,Rammos G,Kopelias I,Bosiolis B,Bovoleti O,Darema M,Sallum G

更新日期：1996-01-01 00:00:00

abstract：:Left ventricular hypertrophy (LVH) is a common abnormality in hemodialysis (HD) patients. Mitochondrial dysfunction contributes to the progression of LVH. As an inner mitochondrial membrane structural protein, mitofilin plays a key role in maintaining mitochondrial structure and function. The aim of this study was to ...

journal_title：Renal failure

authors： Wu QS,He Q,He JQ,Chao J,Wang WY,Zhou Y,Lou JZ,Kong W,Chen JF

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:The syndrome of rapid onset end-stage renal disease (SORO-ESRD) was first described in the journal Renal Failure in 2010. This is an acute precipitate unpredictable yet irreversible ESRD following acute kidney injury (AKI), as distinct from "classic" ESRD where chronic kidney disease (CKD)-ESRD progression w...

journal_title：Renal failure

authors： Onuigbo M,Agbasi N

更新日期：2015-01-01 00:00:00

abstract：:To evaluate the role of the inducible nitric oxide synthase (iNOS), selective nuclear factor-kB (NF-kB), and p38-mitogene-activated protein kinase (p38-MAPK) on hyperoxaluria-induced oxidative stress and stone formation in rat kidneys. The rats were divided into five groups: group 1, control group; group 2: ethylene g...

journal_title：Renal failure

authors： Ilbey YO,Ozbek E,Simsek A,Cekmen M,Somay A,Tasci AI

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:To assess the safety and clinical efficacy of leflunomide (LEF) and prednisone on refractory nephrotic syndrome (RNS). METHODS:A total of 52 patients with RNS were treated for 24 weeks between 2010 and 2014 in our hospital. In the treated group, 26 patients were treated with LEF and prednisone, and, in the c...

journal_title：Renal failure

authors： Liu Y,Qu X,Chen W,Zhang Y,Liu L

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Emerging evidence demonstrates that gut dysbiosis is implicated in the pathogenesis of chronic kidney disease (CKD) with underlying mechanisms involving mucosal and/or systematic immunity or metabolic disorders. However, the profile of gut microbiota in patients with CKD has not been completely explored. ME...

journal_title：Renal failure

authors： Zhao J,Ning X,Liu B,Dong R,Bai M,Sun S

更新日期：2021-12-01 00:00:00

abstract：UNLABELLED:Cardiovascular diseases are the major cause of morbidity and mortality in renal transplant recipients. We report our experience in the treatment of patients with renal allograft who required cardiovascular surgery. METHODS:Indications for cardiovascular surgery, postoperative complications, and outcome were...

journal_title：Renal failure

authors： Basic-Jukic N,Ivanac-Jankovic R,Biocina B,Kes P

更新日期：2015-07-01 00:00:00

abstract：:The discoloration of effluent peritoneal dialysate, which is transparent in origin, is seen in some particular conditions including chyloperitoneum, calcium channel blocker usage, hemoperitoneum, perforated cholecystitis, iron administration, and hemorrhagic pancreatitis. We report a case of a 60-year-old woman who un...

journal_title：Renal failure

authors： Ling EK,Lin BS,Chiang SS,Tsai MH

更新日期：2012-01-01 00:00:00

abstract：INTRODUCTION:Dyslipidemia is one of the onset and risk factors of chronic kidney disease and renal function drop is seen in lipoprotein abnormal animal models. However, the detailed molecular mechanism of renal lipotoxicity has not been clarified. Therefore, the present study aimed to investigate the influence of chole...

journal_title：Renal failure

authors： Honzumi S,Takeuchi M,Kurihara M,Fujiyoshi M,Uchida M,Watanabe K,Suzuki T,Ishii I

更新日期：2018-11-01 00:00:00

abstract：:The single dose administration of the aminonucleoside of puromycin (PAN) induces a nephrotic syndrome in rats characterized by massive proteinuria and progressive histologic changes. This model of acute parenchymal nephritis is thought to be mediated by the renal recruitment of monocytes and macrophages. To investigat...

journal_title：Renal failure

authors： Berens KL,Verani RR,Luke DR

更新日期：1998-01-01 00:00:00

abstract：:Atrial Natriuretic Peptide (ANP), has protective effect on the outcome of acute renal failure in animals when infused over short periods of time. Escherichia Coli heat-stable enterotoxin (STa) acts on a particulate guanylate cyclase receptors leading to an increase in cytosolic cGMP similar to ANP. STa has longer dura...

journal_title：Renal failure

authors： Abdulla HM

更新日期：2000-01-01 00:00:00

abstract：AIM:To investigate the effects of lentivirus-mediated shRNA targeting collagen type I on the mesangial cells of rats and the feasibility of lentivirus-mediated shRNA delivery through renal parenchyma injection. METHODS:Anti-collagen type I shRNA lentiviral vector was constructed, and rat mesangial cells were transfect...

journal_title：Renal failure

authors： Zhou C,Shan Y,Zhao H,He P

更新日期：2011-01-01 00:00:00

abstract：:Kidney transplant recipients have increased risk of cancers when compared with the general population. Hepatocellular carcinoma (HCC) is extremely important in Asia where hepatitis B virus (HBV) infection is endemic. The aim is to study the epidemiological and clinical aspects of all de novo HCC in our kidney transpla...

journal_title：Renal failure

authors： Cheung CY,Lam MF,Chow KM,Lee W,Cheng YL,Yuen SK,Wong PN,Mo KL,Leung KT,Wong SH,Ho YW,Chau KF

更新日期：2014-07-01 00:00:00

abstract：:GRACILE syndrome is a rare autosomal recessive disease characterized by fetal growth retardation, Fanconi type aminoaciduria, cholestasis, iron overload, profound lactic acidosis, and early death. It is caused by homozygosity for a missense mutation in the BCS1L gene. The BCS1L gene encodes a chaperone responsible for...

journal_title：Renal failure

authors： Kasapkara ÇS,Tümer L,Ezgü FS,Küçükçongar A,Hasanoğlu A

更新日期：2014-07-01 00:00:00

abstract：:Approximately one-third of all dialysis patients have mild to moderate malnutrition, while 6-8% have severe malnutrition, which is associated with increased morbidity and mortality rates and numerous pre-existing factors directly correlated with, or existing prior to, replacement hemodialysis. However, moderate to sev...

journal_title：Renal failure

authors： Lacquaniti A,Bolignano D,Campo S,Perrone C,Donato V,Fazio MR,Buemi A,Sturiale A,Buemi M

更新日期：2009-01-01 00:00:00

abstract：:Acute renal failure secondary to ischemia/reperfusion (I/R) injury is associated with significant mortality and morbidity. Aminoguanidine (AG), an inducible nitric oxide synthase inhibitor with antioxidant properties, has been reported beneficial in renal I/R injury. The aim of the present study was to investigate the...

journal_title：Renal failure

authors： Onem Y,Ipcioglu OM,Haholu A,Sen H,Aydinoz S,Suleymanoglu S,Bilgi O,Akyol I

更新日期：2009-01-01 00:00:00

abstract：:A 68-year-old male presented with acute myeloid leukemia, renal failure, hypokalemia, and enlarged kidneys on renal ultrasound. Renal biopsy revealed massive leukemic infiltration of the kidney. After systemic chemotherapy, the patient developed tumor lysis syndrome followed by a phase of proximal tubule dysfunction p...

journal_title：Renal failure

authors： Rüger W,Kruip MJ,Betjes MG

更新日期：2009-01-01 00:00:00

abstract：:Acute renal failure (ARF) is a frequent complication in hospitalized patients and is strongly related to increase in mortality. In order to analyze the clinical outcome and the prognostic factors in hospital-acquired ARF, a prospective study was performed. Data from 200 patients with established ARF during the period ...

journal_title：Renal failure

authors： Barretti P,Soares VA

更新日期：1997-03-01 00:00:00

abstract：:We studied gene expression for transforming growth factor (TGF)-alpha, epidermal growth factor (EGF), heparin binding (HB) EGF, and the EGF receptor following acute renal failure induced by mercuric chloride administration to gain insight into potential mechanisms of renal repair. Twenty four hours after HgCl2, 2 mg/k...

journal_title：Renal failure

authors： Hise MK,Liu L,Salmanullah M,Drachenberg CI,Papadimitriou JC,Rohan RM

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Serious hyperkalemia was reported in 10% of chronic hemodialysis (HD) patients that could lead to arrhythmia and death. Angiotensin-converting enzyme inhibitors (ACE-I) and angiotensin II receptor blockers (ARB) are well accepted for cardio-protective benefits. The relationship between renin-angiotensin syst...

journal_title：Renal failure

authors： Lin HH,Yang YF,Chang JK,Ting IW,Kuo HL,Wang IK,Huang CC

更新日期：2009-01-01 00:00:00