Relationship between renal function and blood level of chromogranin A.

Abstract:

:Chromogranin A (CGA) is a low MW (49,000) acidic hydrophilic protein. It is synthesized in the chromaffm granules of the neuroendocrine cells, and has been found circulating in the blood of healthy subjects. The aim of this study was to assess the relationship between serum levels of CGA and renal function. One hundred two renal patients (45 M and 57 F; age 14-76 years, mean 52) participated in the study. Glomerular filtration rate (GFR) was measured by the bladder cumulative method, using 99mTc-DTPA as a tracer. Blood CGA was determined by RIA. Plasma creatinine, beta2microglobulin (beta2m) and tumor associated trypsin inhibitor (TATI) were also determined. The reduction in renal function was associated with an increase in all of the above studied parameters. In patients with advanced renal failure (GFR <20 mL/min) CGA levels increased by 22-fold as compared to the patients with normal renal function (GFR> 100 mL/min). The other studied parameters were also increased but to a lesser degree, e.g., TATI 14-, beta2m 8- and creatinine 5-fold. The results of this study demonstrate that renal handling of the CGA is similar to other low MW proteins, and it accumulates in the blood in renal failure.

journal_name

Ren Fail

journal_title

Renal failure

authors

Tramonti G,Ferdeghini M,Annichiarico C,Norpoth M,Donadio C,Bianchi R,Bianchi C

doi

10.1081/jdi-100104728

subject

Has Abstract

pub_date

2001-05-01 00:00:00

pages

449-57

issue

3-4

eissn

0886-022X

issn

1525-6049

journal_volume

23

pub_type

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