Advanced glycation end products and soluble receptor as markers of oxidative stress in children on hemodialysis.

Abstract:

BACKGROUND:Advanced glycation end products (AGEs) have biological properties that may contribute to the mortality of children on hemodialysis (HD). This study examines the relationship of LMW fluorescence AGEs, oxidized LDL (ox-LDL), soluble receptor AGE (sRAGE) as markers of oxidative stress in children with end stage renal disease (ESRD) undergoing HD. METHOD:Thirty children with ESRD undergoing HD, and 30 healthy, age- and sex-matched children were included. Serum levels of LMW fluorescence AGEs, sRAGE, oxidized LDL (ox-LDL), pre- and post-dialysis urea, high-sensitivity C-reactive protein (hs-CRP), hemoglobin (Hb) and serum albumin (ALB), were measured. RESULTS:Abnormal serum inflammatory changes: elevated levels of LMW AGEs, sRAGE, oxLDL, CRP and urea were exhibited in HD children compared with healthy controls; more so in anemic when compared to non-anemic patients. Significant positive correlation was found between serum levels of AGEs and sRAGE. CONCLUSION:The low molecular weight form of AGEs is associated with oxidative stress in children receiving chronic HD, and may be important in the mechanisms leading to atherosclerosis and inflammation in such patients. LMW AGEs levels showed a negative correlation with sRAGE and both exhibit a significant negative relation to seum urea.

journal_name

Ren Fail

journal_title

Renal failure

authors

El-Saeed GS,Fadel F,Elshamaa MF,Galal RE,Elghoroury EA,Nasr SA,Thabet EH,Abdelrahman SM

doi

10.3109/0886022X.2015.1077317

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

1452-6

issue

9

eissn

0886-022X

issn

1525-6049

journal_volume

37

pub_type

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