Abstract:
BACKGROUND:The renin-angiotensin system (RAS) has significant influences on heart and renal disease progression. Angiotensin converting enzyme (ACE) and angiotensin converting enzyme II (ACE2) are major peptidases of RAS components and play counteracting functions through angiotensin II (Ang II)/ATIR and angiotensin-(1-7) (Ang-(1-7))/Mas axis, respectively. METHODS:There were 360 uremic patients on regular hemodialysis (HD) treatment (inclusive of 119 HD patients with cardiovascular diseases (CVD) and 241 HD patients without CVD and 50 healthy subjects were enrolled in this study. Plasma ACE, ACE2, Ang II and Ang-(1-7) levels of the HD patients were determined. RESULTS:We compared pre-HD levels of plasma ACE, ACE2, Ang II and Ang-(1-7) in the HD patients with and without CVD to those of the controls. The HD patients, particularly those with CVD, showed a significant increase in the levels of ACE and Ang II, whereas ACE2 and Ang-(1-7) levels were lower than those in the healthy controls. Therefore, imbalanced ACE/ACE2 was observed in the HD patients with CVD. In the course of a single HD session, the plasma ACE, ACE/ACE2 and Ang II levels in the HD patients with CVD were increased from pre-HD to post-HD. On the contrary, ACE2 levels were decreased after the HD session. These changes were not detected in the HD patients without CVD. CONCLUSIONS:Pathogenically imbalanced circulating ACE/ACE2 was detected in the HD patients, particularly those with CVD. HD session could increase ACE/Ang II/AT1R axis and decrease ACE2/Ang-(1-7)/Mas axis activity in the circulation of HD patients with CVD.
journal_name
Ren Failjournal_title
Renal failureauthors
Yang CW,Lu LC,Chang CC,Cho CC,Hsieh WY,Tsai CH,Lin YC,Lin CSdoi
10.1080/0886022X.2017.1398665subject
Has Abstractpub_date
2017-11-01 00:00:00pages
719-728issue
1eissn
0886-022Xissn
1525-6049journal_volume
39pub_type
杂志文章相关文献
RENAL FAILURE文献大全abstract::Renal biopsy data indicate that tubular epithelial cells serve as a reservoir for HIV-1 infection. We studied the effect of HIV-1 gp120 envelope gene expression on tubular cell apoptosis. HIV-1 gp120 was expressed in a lentiviral vector pHR-CMV-IRES2-EGFP-DeltaB. This plasmid construct was used to produce pseudotyped ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220902780101
更新日期:2009-01-01 00:00:00
abstract::Paraproteins or monoclonal proteins are the result of clonal B-cell or plasma cell proliferation of a malignant, premalignant or non-malignant nature. Monoclonal proteins may consist of intact immunoglobulin molecules or of heavy or light chains only. Depending on their rate of production and/or secretion they may acc...
journal_title:Renal failure
pub_type: 杂志文章,评审
doi:10.3109/08860229809045179
更新日期:1998-11-01 00:00:00
abstract::We present a patient with AL amyloidosis who had an autologous stem cell transplant (ASCT) over 9 years ago. She has since then developed slowly progressive renal insufficiency and the nephrotic syndrome. Hematologic evaluation has failed to identify recurrent disease and a renal biopsy demonstrated extensive amyloid ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2012.669320
更新日期:2012-01-01 00:00:00
abstract::In various renal injuries, tissue damage occurs and platelet activation is observed. Recent studies suggest that some factors, such as serotonin, are released into microenvironment upon platelet activation following renal injury. In the present study, we aimed to investigate whether platelets and platelet-released ser...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2016.1194165
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVE:We investigate the mechanism of neutrophil/lymphocyte ratio (NLR) elevation, a useful prognostic marker in patients with cardiovascular diseases (CVDs). METHODS:In this clinical study, we retrospectively searched for factors associated with NLR elevation in cardiovascular outpatients. In animal experiments u...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2019.1597736
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:A nephrologist in the millennium offers comprehensive care to renal failure patients. Interventional nephrology plays a major role in this new approach. Overton Brooks Veterans Affairs Medical Center (OBVAMC) is the first federal health care provider in the nation offering such services. Lack of intervention...
journal_title:Renal failure
pub_type: 杂志文章,评审
doi:
更新日期:2005-01-01 00:00:00
abstract::Electrolyte disorders can alter cardiac ionic currents and depending on the changes can promote proarrhythmic effects. Potassium (K(+)) is the most common intracellular cation related to arrhythmic disorders. Hyperkalemia is mainly seen in the setting of impaired renal function. Severe hyperkalemia may lead to rhythm ...
journal_title:Renal failure
pub_type: 信件
doi:10.3109/0886022X.2011.653752
更新日期:2012-01-01 00:00:00
abstract::Cognitive dysfunction is a well-known complication of chronic renal failure that is evident in 30% of hemodialysis (HD) patients. However, the pathogenesis of this dysfunction is unknown. Left ventricular hypertrophy could develop in hypertensive HD patients without establishing normovolemia. Our aim was to evaluate t...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860220903134548
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:To observe effectiveness and renal safety of long-term low-dose cyclosporine in idiopathic membranous nephropathy (IMN). METHODS:Sixty-eight patients were enrolled in this prospective cohort study. Renal endpoint was defined as a decrease in eGFR ≥50% from baseline and a development of eGFR ≤60 ml/min/1.73m...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2017.1373130
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to investigate the cancer incidence in patients with end-stage aristolochic acid nephropathy (AAN). METHODS:A total of 102 patients with end-stage AAN treated in our hospital between 2004 and 2013 were included in this study. The correlation of cancer incidence with age, gender...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2014.990347
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Although adequate peritoneal dialysis is not well defined, Kt/Vurea has been used as an index, and various values have been proposed. However, conflicting evidence existed regarding the appropriateness of using Kt/Vurea to define dialysis adequacy and its optimal value. Therefore, the present study performed...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220601166586
更新日期:2007-01-01 00:00:00
abstract::Our study is a prospective one conducted at Al-Amiri Hospital and including all new cases of chronic renal disease (CRD) seen at the capital area of Kuwait between 1 January 1999 and 30 December 2003. Diagnosis of CRD was based on clinical, laboratory, and radiological features. Kidney biopsies were done when indicate...
journal_title:Renal failure
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND/OBJECTIVE:Previous studies have shown that MPO -463G > A (rs2333227) might be associated with chronic kidney disease (CKD) susceptibility, but sample sizes of those studies are relatively small. Hence, we decided to perform a meta-analysis to evaluate the association. Methods/main results: Two investigators ...
journal_title:Renal failure
pub_type: 杂志文章,meta分析
doi:10.1080/0886022X.2018.1499529
更新日期:2018-11-01 00:00:00
abstract:AIM:Endoplasmic reticulum (ER) stress and unfolded protein response (UPR) are implicated in many fibrotic diseases, including renal fibrosis. Whether Ginsenoside-Rg1 (G-Rg1) could attenuate renal fibrosis via suppression of ER stress and UPR has not been reported. The aim of this study was to explore the effect of G-Rg...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2015.1015427
更新日期:2015-06-01 00:00:00
abstract::Objective: The present study assesses whether phosphodiesterase type 5 (PDE-5) inhibitor or carnitine exert nephroprotective effects against clinical contrast-induced nephropathy (CIN).Materials and Methods: The present study consisted of three groups of CKD patients. The first group was control group, who were treate...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2019.1669459
更新日期:2019-11-01 00:00:00
abstract::In kidney disease, inflammation and lipid dysmetabolism are often associated together, however, the effect and mechanism of inflammatory mediators and lipid dysmetabolism on kidney damage is still unclear. In this study, Wistar rats were randomized into four groups: normal diet + saline (Group N), high-fat diet (HF)+ ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2018.1450763
更新日期:2018-11-01 00:00:00
abstract::Postpartum acute kidney injury (PPAKI) constitutes an important cause of obstetric AKI. It is associated with high maternal and fetal mortality in developing nations. The aim of this study is to survey the etiology and outcomes of PPAKI in a tertiary care Indian hospital. Ninety-nine patients, without prior comorbidit...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2016.1164015
更新日期:2016-07-01 00:00:00
abstract:INTRODUCTION:In this study, the cause of rapidly deteriorating renal functions in a follow-up period of a 65-year-old female patient, who applied with nephrotic syndrome findings and diagnosed as membranous nephropathy, is presented. CASE REPORT:A 65-year-old patient with findings of nephrotic syndrome had normal kidn...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220802064804
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Patients on maintenance hemodialysis (HD) face an increased risk of atherosclerosis, a crucial problem and the leading cause of cardiovascular morbidity and mortality. This study was designed to evaluate the effects of zinc supplementation on paraoxonase (PON) enzyme activity in patients on HD. MET...
journal_title:Renal failure
pub_type: 杂志文章,随机对照试验
doi:10.3109/0886022X.2012.717479
更新日期:2012-01-01 00:00:00
abstract::Uremic patients are characterized by a "pro-arrhythmic substrate." Arrhythmia appearance during hemodialysis (HD) is an unexpected event with a high incidence of mortality and morbidity and difficult to record in patients repeatedly checked using electrocardiogram (ECG). Furthermore the carrying out of this important ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2012.673530
更新日期:2012-01-01 00:00:00
abstract::To evaluate the role of the inducible nitric oxide synthase (iNOS), selective nuclear factor-kB (NF-kB), and p38-mitogene-activated protein kinase (p38-MAPK) on hyperoxaluria-induced oxidative stress and stone formation in rat kidneys. The rats were divided into five groups: group 1, control group; group 2: ethylene g...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220902963871
更新日期:2009-01-01 00:00:00
abstract::Aquaporin-2 protein levels can be detected in the urine of normal of subjects if measured after fluid deprivation. By contrast, in patients with nephrogenic diabetes insipidus caused by mutations in the aquaporin-2 gene, urine aquaporin-2 protein excretion cannot be detected. We propose that properly standardized meas...
journal_title:Renal failure
pub_type: 杂志文章,评审
doi:10.3109/08860229909085095
更新日期:1999-05-01 00:00:00
abstract:AIM:Returning to society plays an important role in improving the quality of life in maintenance hemodialysis (MHD) patients, and retention of employment is one of the core enablers. The study is to assess the employment status and to determine the variables for unemployment in Chinese MHD patients. METHODS:Prevalent ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2017.1361834
更新日期:2017-11-01 00:00:00
abstract::The aim of this study was to assess the effect of nifedipine and piracetam alone or in combination in the protection of renal function and morphology after cyclosporin A (CyA) administration. Thirty healthy mongrel dogs with a mean body weight of 15 kg were sacrificed. Six animals (group C) were given CyA 20 mg/kg bod...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229209047658
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:The thrombotic thrombocytopenic purpura (TTP) is a rare disorder with a high mortality rate if untreated or delayed therapy. Whether immediate diagnosis and promptly treated with plasma exchange can change the grave prognosis? METHOD:Retrospective analysis was performed on clinical characteristics and treat...
journal_title:Renal failure
pub_type: 临床试验,杂志文章
doi:10.1081/jdi-120017440
更新日期:2003-01-01 00:00:00
abstract::Heat stroke occurs in the desert area of Saudi Arabia quite frequently and manifest in different patterns including coagulopathy. Frequently encountered complications include renal or hepatic failure, rhabdomyolysis, acute respiratory distress syndrome (ARDS), disseminated intravascular coagulation (DIC), and seizure....
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-100107370
更新日期:2001-09-01 00:00:00
abstract::Medication errors are ongoing problems among hospitalized patients especially those with multiple co-morbidities and polypharmacy such as patients with renal diseases. This study evaluated the frequency, types and direct related cost of medication errors in nephrology ward and the role played by clinical pharmacists. ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2014.934650
更新日期:2014-09-01 00:00:00
abstract::Background: Elevated serum levels of sIL-2R are commonly observed in patients undergoing maintenance hemodialysis (MHD). However, the clinical implications in these subjects are unclear. This study is aimed to assess the significance of elevated sIL-2R levels in MHD patients.Methods: A total of 382 MHD patients were f...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2020.1761388
更新日期:2020-11-01 00:00:00
abstract::In chronic renal failure (CRF), phosphate (Pi) retention may lead to secondary hyperparathyroidism and progression to end-stage renal disease (ESRD). Dietary phosphorus restriction or phosphate binders can slow progression in experimental CRF. Conversely, diets high in phosphorus can accelerate the progression toward ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229609047712
更新日期:1996-11-01 00:00:00
abstract:OBJECTIVE:The association between poor intraoperative glycemic control and postoperative acute kidney injury (AKI) in adult cardiac surgery has been observed, but data in the pediatrics remain unknown. We performed a hypothesis that intraoperative hyperglycemia and/or wider glycemic fluctuation were associated with the...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2018.1532908
更新日期:2018-11-01 00:00:00