Role of serotonin in the regulation of renal proximal tubular epithelial cells.

Abstract:

:In various renal injuries, tissue damage occurs and platelet activation is observed. Recent studies suggest that some factors, such as serotonin, are released into microenvironment upon platelet activation following renal injury. In the present study, we aimed to investigate whether platelets and platelet-released serotonin are involved in the functional regulation of renal proximal tubular epithelial cells (PTECs). PTECs were obtained by primary cell culture and treated with platelet lysate (PL) (2 × 10(6)/mL, 4 × 10(6)/mL, 8 × 10(6)/mL) or serotonin (1 μM or 5 μM) for 12 or 24 h. Phenotypic transdifferentiation of epithelial cells into myofibroblasts were demonstrated under light microscope and confirmed by the determination of α-smooth muscle actin gene expression. Serotonin and PL were shown to induce epithelial-mesenchymal transdifferentiation of PTECs. After stimulation of PTECs with serotonin or PL, matrix metalloproteinase-2, tissue inhibitor of metalloproteinase-1, and collagen-α1 gene expressions, which were reported to be elevated in renal injury, were determined by real-time PCR and found to be upregulated. Expressions of some inflammatory cytokines such as tumor necrosis factor-α, interleukin-6, and transforming growth factor-β1 were found to be increased in both protein and gene levels. Recently there is no published report on the effect of serotonin on renal PTECs. Results obtained in this study have lightened the role of serotonin and platelet-mediated effects of serotonin on fibrotic and inflammatory processes in PTECs.

journal_name

Ren Fail

journal_title

Renal failure

authors

Erikci A,Ucar G,Yabanoglu-Ciftci S

doi

10.1080/0886022X.2016.1194165

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

1141-50

issue

7

eissn

0886-022X

issn

1525-6049

journal_volume

38

pub_type

杂志文章
  • Melatonin with 1,25-dihydroxyvitamin D3 protects against apoptotic ischemia-reperfusion injury in the rat kidney.

    abstract::This study was designed to evaluate the preventive role of melatonin (Mel) and 1,25-dihydroxyvitamin D3 (VD3) in biochemical and apoptotic events leading to tissue injury and renal dysfunction after ischemia-reperfusion (I/R). Thirty male Wistar rats were divided into five groups: sham-operated, I/R, Mel + I/R, VD3 + ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2012.700887

    authors: Sinanoglu O,Sezgin G,Ozturk G,Tuncdemir M,Guney S,Aksungar FB,Yener N

    更新日期:2012-01-01 00:00:00

  • BCS1L gene mutation causing GRACILE syndrome: case report.

    abstract::GRACILE syndrome is a rare autosomal recessive disease characterized by fetal growth retardation, Fanconi type aminoaciduria, cholestasis, iron overload, profound lactic acidosis, and early death. It is caused by homozygosity for a missense mutation in the BCS1L gene. The BCS1L gene encodes a chaperone responsible for...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2014.900422

    authors: Kasapkara ÇS,Tümer L,Ezgü FS,Küçükçongar A,Hasanoğlu A

    更新日期:2014-07-01 00:00:00

  • Evaluation of volume overload by bioelectrical impedance analysis, NT-proBNP and inferior vena cava diameter in patients with stage 3&4 and 5 chronic kidney disease.

    abstract:BACKGROUND:Determination of fluid overload is important in chronic kidney disease. Early diagnosis and treatment of volume overload may decrease morbidity and mortality. We aimed to determine body composition by using bioelectrical impedance analysis, and studying other clinical characteristics, inferior vena cava diam...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2013.875815

    authors: Yilmaz Z,Yildirim Y,Oto F,Aydin FY,Aydin E,Kadiroglu AK,Yilmaz ME

    更新日期:2014-05-01 00:00:00

  • A prospective study of hepatitis B vaccination - a comparison of responders versus nonresponders.

    abstract::Herein we present one of the largest single-center reports of the response of hemodialysis patients to a two-vaccine hepatitis B virus vaccination protocol in a European dialysis population. A hepatitis B recombinant DNA vaccine, HBvaxPRO, was given at a dose of 40 µg intramuscularly using a four-dose schedule at 0, 1...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2011.559300

    authors: Brown CM,Donlon S,O'Kelly P,Casey AM,Collier C,Conlon PJ,Walshe JJ

    更新日期:2011-01-01 00:00:00

  • Analysis on weight-turnaround time properties for point-of-care testing tool for microalbumin determination: implication for using in distanced site.

    abstract::Microalbumin is a basic biochemical test that is widely used at present. Owing to the concept of point-of-care testing (POCT), there are tools available for analysis of microalbumin. Here, the author performs a brief assessment on weight-turnaround time properties for available POCT for determination of microalbumin i...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860221003664249

    authors: Wiwanitkit V

    更新日期:2010-05-01 00:00:00

  • The influence of l-carnitine supplementation on hematocrit and hemoglobin levels in patients with end stage renal failure on CAPD.

    abstract::The influence of L-carnitine supplementation on hematocrit (Hct) and hemoglobin (Hb) levels, in patients suffering from end stage renal disease (ESRD) on maintenance hemodialysis, are well known from several studies. The data concerning the serum levels of carnitine, in patients with ESRD on continuous ambulatory peri...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1081/jdi-120006777

    authors: Sotirakopoulos N,Athanasiou G,Tsitsios T,Mavromatidis K

    更新日期:2002-07-01 00:00:00

  • Effects of dietary protein on renal ischemia induced tubular necrosis.

    abstract::Previously we have shown that the amount of protein in a dietary regimen prior to the induction of renal ischemia will significantly affect the degree of postischemic acute renal failure (Andrews PM, Bates SB: Kidney Int 30:299-303, 1986). The present investigation was undertaken to determine what effect dietary prote...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229309065566

    authors: Andrews PM

    更新日期:1993-01-01 00:00:00

  • Differential susceptibility to gentamicin toxicity within the proximal convoluted tubule.

    abstract::The proximal convoluted tubule (PCT) is the major target for injury in gentamicin nephrotoxicity but the necrosis is often patchy and focal. The PCT is structurally, functionally, and metabolically heterogeneous, and the possibility of differential vulnerability to gentamicin-induced necrosis based on this heterogenei...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229009087122

    authors: Shanley PF,Burke TJ

    更新日期:1990-01-01 00:00:00

  • Bacterial colonization in hemodialysis temporary dual lumen catheters: a prospective study.

    abstract:AIMS:The use of hemodialysis temporary dual-lumen catheters is often complicated by infections, which may be a significant cause of death among patients with end stage renal disease (ESRD). The aim of this study was to assess the incidence of bacteremia and bacterial colonization related to non-tunneled, non-cuffed, du...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220701741940

    authors: de Freitas LW,Neto MM,Nascimento MM,Figueiredo JF

    更新日期:2008-01-01 00:00:00

  • FK 506 reduces the injury experienced following renal ischemia and reperfusion.

    abstract::The effect of FK 506 pretreatment on renal ischemia and reperfusion (I/R) injury was investigated. Adult male rats were assigned to one of two groups (20 animals each). Group 1 (controls) received 0.5 mL saline while group 2 received FK 506 (0.3 mg/kg) intravenously 24 h prior to the induction of renal ischemia. After...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229209106630

    authors: Van Thiel DH,Sakr M,Zetti G,McClain C

    更新日期:1992-01-01 00:00:00

  • Higher urine heat shock protein 70/creatinine ratio in type 1 diabetes mellitus.

    abstract::Insidious progressive renal damage caused by type 1 diabetes mellitus (T1DM) begins in childhood before it becomes manifest in adult ages. Heat shock proteins (HSPs) regulate the cell response to any hazardous factors to prevent cell structure. The aim of the study is to determine whether urine levels of HSPs increase...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2015.1136893

    authors: Yilmaz A,Gedikbasi A,Yuruk Yildirim Z,Pehlivanoglu C,Seker B,Sucu A,Bundak R,Emre S

    更新日期:2016-01-01 00:00:00

  • Rhabdomyolysis, acute renal failure, and multiple focal neuropathies after drinking alcohol soaked with centipede.

    abstract::Many Chinese like to drink alcohol soaked with creatures for promoting health. This study reports a 49-year-old male who presented with multiple focal neuropathies of the upper limbs, coagulopathy, erythematous swelling of the bilateral upper extremities and trunk with bullous skin lesions, and rhabdomyolysis associat...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1081/jdi-120028562

    authors: Wang IK,Hsu SP,Chi CC,Lee KF,Lin PY,Chang HW,Chuang FR

    更新日期:2004-01-01 00:00:00

  • Renal failure and nephrotoxic drug-induced disturbances in rat kidney tissue.

    abstract::The injection to rats of glycerol, cisplatin, uranyl acetate, sodium dichromate, and mercuric chloride is followed on the third day by acute renal failure. A new approach for quantitative estimation of disturbance of excretory renal function is presented. The decrease in renal function due to uranyl acetate was 77%; s...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229409044898

    authors: Natochin YV,Bakhteeva VT,Karpenko LA

    更新日期:1994-11-01 00:00:00

  • Neutrophil/lymphocyte ratio elevation in renal dysfunction is caused by distortion of leukocyte hematopoiesis in bone marrow.

    abstract:OBJECTIVE:We investigate the mechanism of neutrophil/lymphocyte ratio (NLR) elevation, a useful prognostic marker in patients with cardiovascular diseases (CVDs). METHODS:In this clinical study, we retrospectively searched for factors associated with NLR elevation in cardiovascular outpatients. In animal experiments u...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2019.1597736

    authors: Ito S,Ohno Y,Tanaka T,Kobuchi S,Ayajiki K,Manabe E,Masuyama T,Jun-Ichi S,Tsujino T

    更新日期:2019-11-01 00:00:00

  • Renal cortical necrosis is a disappearing entity in obstetric acute kidney injury in developing countries: our three decade of experience from India.

    abstract:RATIONAL:Obstetrical complications are the commonest causes of Renal Cortical Necrosis (RCN). However, the overall incidence of RCN in obstetric acute kidney injury in developing countries has been decreasing in recent years. OBJECTIVE:The aim of this study was to evaluate the changing profile of RCN in obstetric AKI ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2015.1062340

    authors: Prakash J,Pant P,Singh AK,Sriniwas S,Singh VP,Singh U

    更新日期:2015-08-01 00:00:00

  • Which echocardiographic parameter is a better marker of volume status in hemodialysis patients?

    abstract:AIM:Bio-impedance analysis (BIA) is a preferred method for estimating the volume status. However, it cannot be utilized in daily practice. Since the assessment of the volume status is important and challenging for hemodialysis (HD) patients, the aim of study was to determine the volume status in chronic HD patients usi...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2016.1229968

    authors: Sabaghian T,Hajibaratali B,Samavat S

    更新日期:2016-11-01 00:00:00

  • The effect of alfuzosin on renal resistive index, urinary electrolytes and β2 microglobulin levels and TGF β-1 levels of kidney tissue in rats with unilateral ureteropelvic junction obstruction.

    abstract:BACKGROUND:In this study, it was aimed to determine the effects of alfuzosin on experimentally generated unilateral partial ureteropelvic junction obstruction (UPO) in rats. MATERIALS AND METHODS:Thirty Long-Evans rats were randomly allocated into five groups. In control group (C), nothing was performed; in group Sham...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2016.1207049

    authors: Kose F,Turkyilmaz Z,Sonmez K,Karabulut R,Poyraz A,Gulbahar O,Aral A,Damar C,Kaya C,Can Basaklar A

    更新日期:2016-09-01 00:00:00

  • Effects of nitric oxide synthesis inhibition on FK506-induced nephrotoxicity in rats.

    abstract::This study was designed to evaluate the role of nitric oxide (NO) in FK506-induced nephrotoxicity by administering an inhibitor of NO synthesis, N omega-nitro-L-arginine methyl ester (L-NAME) to rats treated with FK506. After one week of treatment with FK506 (3.2 mg/kg/day, intramuscularly) and/or L-NAME (5 mg/100 mL ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1081/jdi-100001279

    authors: Wang L,Kubodera S,Ueno A,Takeda M

    更新日期:2001-01-01 00:00:00

  • Acute toxic kidney injury.

    abstract::Substances toxic to the kidney are legion in the modern world. The sheer number and variety, their mutual interactions and, metabolism within the body are a challenge to research. Moreover, the kidney is especially prone to injury owing to its physiology. Acute kidney injury (AKI) induced by poisonous or primarily nep...

    journal_title:Renal failure

    pub_type: 杂志文章,评审

    doi:10.1080/0886022X.2019.1628780

    authors: Petejova N,Martinek A,Zadrazil J,Teplan V

    更新日期:2019-11-01 00:00:00

  • Readability and comprehensibility of over-the-counter medication labels.

    abstract::Nonprescription medications are relatively safe, but not risk-free and can lead to serious adverse events, particularly if used contrary to directions or without attention to depicted warnings. The question arises whether the information presented on the product label is readable and comprehensible to the average lay ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2013.872571

    authors: Trivedi H,Trivedi A,Hannan MF

    更新日期:2014-04-01 00:00:00

  • SDS-electrophoresis of unconcentrated urine samples using a semi-automatic method.

    abstract::The study of urinary proteins is an important tool in the screening and diagnosis of patients with renal impairment. Quantification of total proteins, although useful, can provide only limited information. Gel electrophoresis of urine samples may provide more detailed information. ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229909085105

    authors: Behets GJ,De Broe ME

    更新日期:1999-05-01 00:00:00

  • Acute renal failure caused by nontraumatic rhabdomyolysis.

    abstract::Nontraumatic rhabdomyolysis may be associated with severe metabolic disturbances. In particular, previous literature has described a 8-20% incidence of acute renal failure in rhabdomyolysis. The aim of this study was to evaluate our experience on 11 patients with acute renal failure treated by high-efficiency daily he...

    journal_title:Renal failure

    pub_type: 临床试验,杂志文章

    doi:10.3109/08860229709047729

    authors: Tozzo C,Mazzarella V,Splendiani G,Casciani CU

    更新日期:1997-05-01 00:00:00

  • Protective effect of N-benzoyl-beta-alanine against cisplatin nephrotoxicity in rats.

    abstract::Prophylactic effects of N-benzoyl-beta-alanine (betamipron, BP), one of a series of N-acyl amino acids, were examined against cisplatin-induced nephrotoxicity. Male Wistar rats were injected i.p. with 6 mg/kg of cisplatin combined with an i.p. BP dose given at various times and various doses. Rats were sacrificed 5 da...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229609052792

    authors: Tokunaga J,Kobayashi M,Nakamura C,Kitagawa A,Arimori K,Nakano M

    更新日期:1996-03-01 00:00:00

  • Effect of fenoldopam on ischemia/reperfusion-induced apoptosis.

    abstract::Recently we demonstrated the effect of fenoldopam on ischemia/reperfusion (I/R) induced NFkappaB mediated pro-inflammatory signal transduction. However, the effect of fenoldopam on I/R-induced apoptosis is not known. We utilized a rat model of acute ischemic nephropathy to test the hypothesis that fenoldopam attenuate...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220600583690

    authors: Aravindan N,Cata JP,Dougherty PM,Shaw AD

    更新日期:2006-01-01 00:00:00

  • Acute renal failure due to acute rhabdomyolysis precipitated by MAST trousers and diflunisal.

    abstract::This report describes a patient who developed acute rhabdomyolysis and acute renal failure following the application of MAST trousers associated with an overdose of diflunisal. This association has not previously been reported. ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229309069415

    authors: Pilmore H,Walker RJ

    更新日期:1993-01-01 00:00:00

  • Clinicopathologic characteristics and outcomes of lupus nephritis with positive antineutrophil cytoplasmic antibody.

    abstract::Aims: The aim was to determine whether anti-neutrophil cytoplasmic antibody (ANCA)-positive serology in patients with lupus nephritis (LN) is associated with different clinicopathologic features and outcomes.Methods: In our retrospective analysis, 283 patients were enrolled between 2013 and 2018. Thirty-six patients w...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2020.1735416

    authors: Wang S,Shang J,Xiao J,Zhao Z

    更新日期:2020-11-01 00:00:00

  • The role of erythrocytes phosphatidylserine exposure in anemia in peritoneal dialysis patients.

    abstract:BACKGROUND:An increased red blood cell (RBC) phosphatidylserine (PS) exposure in uremic patients was found that could promote macrophage recognition and decrease RBC survival time. Furthermore, a reduced red cell life span was found to contribute anemia in patients with renal failure. It is therefore possible to hypoth...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220600839647

    authors: Bi SH,Cheng LT,Wang T

    更新日期:2006-01-01 00:00:00

  • A potential role for immune activation in hemodialysis hypotension.

    abstract::The necessary exposure of blood to biomembranes during hemodialysis has been viewed by many as an immunogenic challenge leading to an acute phase response. In this study we examined the relationship between hemodialysis-induced immune activation and intradialytic hypotension, using the acute phase reactant serum C-rea...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1081/jdi-100107360

    authors: Tomita M,Malhotra D,Dheenan S,Shapiro JI,Henrich WL,Santoro TJ

    更新日期:2001-09-01 00:00:00

  • Long-term efficacy and safety of quadruple therapy in childhood diffuse proliferative lupus nephritis.

    abstract::In this study, we evaluated the frequency, clinical presentation, treatment protocols, prognostic factors, and outcome in children with diffuse proliferative lupus nephritis (DPLN). Between June 1990 and December 2004, 46 patients were diagnosed to have systemic lupus erythematosus (SLE), and 26 of them (56.5%) were f...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220802132171

    authors: Demircin G,Oner A,Erdoğan O,Delibaş A,Baysun S,Bülbül M,Bek K,Oksal A

    更新日期:2008-01-01 00:00:00

  • Furosemide prevents apoptosis and associated gene expression in a rat model of surgical ischemic acute renal failure.

    abstract::Recently, we demonstrated that furosemide improves renal hemodynamics and attenuates ischemia/reperfusion (I/R)-associated changes in angiogenesis-related gene expression. However, the effect of furosemide on I/R-induced apoptosis is not known. We utilized a rat model of acute ischemic nephropathy to test the hypothes...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220701263671

    authors: Aravindan N,Aravindan S,Riedel BJ,Weng HR,Shaw AD

    更新日期:2007-01-01 00:00:00