Protective effect of N-benzoyl-beta-alanine against cisplatin nephrotoxicity in rats.

Abstract:

:Prophylactic effects of N-benzoyl-beta-alanine (betamipron, BP), one of a series of N-acyl amino acids, were examined against cisplatin-induced nephrotoxicity. Male Wistar rats were injected i.p. with 6 mg/kg of cisplatin combined with an i.p. BP dose given at various times and various doses. Rats were sacrificed 5 days after cisplatin injection to weigh the kidney and liver, and to determine blood urea nitrogen (BUN) and serum creatinine (serum Cr) levels. Preliminary results suggest that treatment with BP is an effective means of protection against cisplatin-induced nephrotoxicity. Combination with BP reduced the weight loss following treatment with cisplatin. The ratios of the kidney and liver weights to the body weight in the animals treated with cisplatin followed later with BP are significantly different (p < 0.05) from those in the animals that received only cisplatin. The BUN and serum Cr levels in the animals treated with cisplatin followed from -1 to 4 hr, and from -4 to 4 hr later with 250 mg/kg BP dose and followed 1 hr later with from 250 to 1000 mg/kg, and from 250 to 2000 mg/kg BP doses differed significantly (p < 0.05) from those in the animals that received only cisplatin. Histological analysis of the kidneys confirmed the protective effect of BP.

journal_name

Ren Fail

journal_title

Renal failure

authors

Tokunaga J,Kobayashi M,Nakamura C,Kitagawa A,Arimori K,Nakano M

doi

10.3109/08860229609052792

subject

Has Abstract

pub_date

1996-03-01 00:00:00

pages

225-40

issue

2

eissn

0886-022X

issn

1525-6049

journal_volume

18

pub_type

杂志文章
  • Sustained low-efficiency diafiltration is superior to hemodialysis in promoting renal function recovery in elderly wasp sting victims with stage III acute kidney injury: a retrospective study.

    abstract::Objective: To study the efficacy and safety of sustained low-efficiency diafiltration (SLEDf) versus hemodialysis (HD) for patients with wasp stings who developed stage III acute kidney injury (AKI). Methods: We retrospectively analyzed the clinical data of consecutive patients who developed AKI following wasp stings....

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2019.1655449

    authors: Deng YY,Shen JM,Mao YN,Gou R,Li WW,Ye TT

    更新日期:2019-11-01 00:00:00

  • Platelet parameters in children with upper urinary tract infection: is there a specific response?

    abstract::Although complete blood count is routinely ordered in most upper urinary tract infections (UTI), and information regarding the patient's platelet indices is made available without added cost, the relationship between platelet count and mean platelet volume (MPV) and specific platelet responses to different infectious ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220801947389

    authors: Catal F,Bavbek N,Bayrak O,Uz E,Isik B,Karabel M,Degirmencioglu H,Mete E,Akcay A

    更新日期:2008-01-01 00:00:00

  • Early detection of acute tubular injury with diffusion-weighted magnetic resonance imaging in a rat model of myohemoglobinuric acute renal failure.

    abstract::We evaluated the feasibility of magnetic resonance imaging (MRI) for early detection of tubular injury by monitoring changes in the apparent diffusion coefficient (ADC) of renal water in a rat model of myohemoglobinuric glycerol-induced acute renal failure (ARF). Diffusion-weighted MRI was performed concurrently with ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229609052773

    authors: Vexler VS,Roberts TP,Rosenau W

    更新日期:1996-01-01 00:00:00

  • The influence of l-carnitine supplementation on hematocrit and hemoglobin levels in patients with end stage renal failure on CAPD.

    abstract::The influence of L-carnitine supplementation on hematocrit (Hct) and hemoglobin (Hb) levels, in patients suffering from end stage renal disease (ESRD) on maintenance hemodialysis, are well known from several studies. The data concerning the serum levels of carnitine, in patients with ESRD on continuous ambulatory peri...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1081/jdi-120006777

    authors: Sotirakopoulos N,Athanasiou G,Tsitsios T,Mavromatidis K

    更新日期:2002-07-01 00:00:00

  • New options in the treatment of autosomal dominant polycystic kidney disease.

    abstract::Autosomal dominant polycystic disease (ADPKD) is one of the most common monogenic disorders, and globally is among the most common hereditary causes of end stage kidney disease. Until recently, the causes of this disease remained obscure. However, in the past decade there have been enormous advances in the understandi...

    journal_title:Renal failure

    pub_type: 杂志文章,评审

    doi:10.3109/0886022X.2015.1013404

    authors: Kazancioglu R,Gursu M

    更新日期:2015-05-01 00:00:00

  • Effects of pomegranate seed oil on oxidative stress markers, serum biochemical parameters and pathological findings in kidney and heart of streptozotocin-induced diabetic rats.

    abstract:PURPOSE:Oxidative stress due to hyperglycemia is a major cause of diabetes complications. The aim of this study was to evaluate the effects of pomegranate seed oil (PSO) on serum biochemical parameters, cardiomyopathy and nephropathy induced by diabetes mellitus. METHOD:W/A adult rats were divided into four groups (12...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2016.1207053

    authors: Mollazadeh H,Sadeghnia HR,Hoseini A,Farzadnia M,Boroushaki MT

    更新日期:2016-09-01 00:00:00

  • Erythropoietin production in patients with chronic renal failure.

    abstract::Studies were performed to reexamine the response of erythropoietin (Epo) production to acute hypoxic stimuli in patients with end-stage renal disease (ESRD). In the absence of acute bleeding or hypoxia, the serum Epo level in ESRD was similar to that of normal subjects despite severe anemia. In 11 dialysis patients wi...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229409044892

    authors: Kato A,Hishida A,Kumagai H,Furuya R,Nakajima T,Honda N

    更新日期:1994-01-01 00:00:00

  • Protective effect of curcumin on busulfan-induced renal toxicity in male rats.

    abstract:AIM:The aim of this study was to evaluate the effects of curcumin in an experimental model of busulfan-induced renal toxicity with emphasis on importance of histological alterations. METHODS:In this study, we utilized 32 adult male Wistar rats (250 ± 10 g). All the animals were divided into four experimental groups ra...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2020.1818580

    authors: Abdollahifar MA,Ebrahimi V,Aliaghaei A,Raoofi A,Khosravi A,Hasani A,Mehdizadeh A,Asadi M

    更新日期:2020-11-01 00:00:00

  • 3-aminobenzamide, a poly ADP ribose polymerase inhibitor, attenuates renal ischemia/reperfusion injury.

    abstract:INTRODUCTION:This study was designed to investigate whether 3-amino benzamide (3-AB), a poly (ADP-ribose) polymerase (PARP) inhibitor, has a protective effect on kidney injury induced by renal ischemia/reperfusion (I/R) by decreasing oxidative and nitrosative stress on renal dysfunction and injury. MATERIALS AND METHO...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220902882741

    authors: Oztas E,Guven A,Turk E,Uysal B,Akgul EO,Cayci T,Ersoz N,Korkmaz A

    更新日期:2009-01-01 00:00:00

  • Rhabdomyolysis and acute renal failure in intensive care unit.

    abstract::Rhabdomyolysis is common clinical and laboratory syndrome resulting from skeletal muscle injury and acute renal failure is the most important complication. Acute renal failure is common in critically ill medical patients. The aim of our study was to determine the prevalence of rhabdomyolysis induced acute renal failur...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229909094161

    authors: Hojs R,Ekart R,Sinkovic A,Hojs-Fabjan T

    更新日期:1999-11-01 00:00:00

  • The influence of low calcium dialysate on left ventricular diastolic function in peritoneal dialysis patients.

    abstract::Left ventricular (LV) diastolic function was found to be a significant predictor of cardiovascular events and general mortality in dialysis. Studies have indicated that dialysate calcium concentrations were significantly associated with cardiac function. However, the relationship between low calcium dialysate and LV d...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2016.1229986

    authors: Wang Z,Wen Y,Liang J,Liang X,Shi W

    更新日期:2016-11-01 00:00:00

  • Association of the angiotensinogen M235T and APO E gene polymorphisms in Turkish type 2 diabetic patients with and without nephropathy.

    abstract:BACKGROUND:Diabetic nephropathy (DN) is a leading cause of diabetes-related morbidity and mortality. The aim of this study was to evaluate the relationship of AGT M235T and apoprotein E (APO E) gene polymorphism with DN in Turkish patients of Type 2 diabetes, and to compare genotype and allele distributions among DN pa...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2011.568133

    authors: Reis KA,Ebinç FA,Koç E,Demirci H,Erten Y,Güz G,Derici UB,Bali M,Söylemezoğlu O,Arınsoy T,Sindel S

    更新日期:2011-01-01 00:00:00

  • Association of CYP3A variants with kidney transplant outcomes.

    abstract::Cyclosporine is used extensively in kidney transplantation and is a substrate for cytochrome P450 enzymes. The role of cytochrome p450 polymorphisms in kidney transplant outcome has not yet been fully elucidated. We investigate the clinical impact of single nucleotide polymorphisms in CYP3A4, CYP3A5, PPARα, and POR*28...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2015.1007013

    authors: Traynor C,Conlon P Jr,Phelan PJ,O'Kelly P,Elens L,McCormack M,Cavalleri G,Comber H,van Schaik RH,Conlon PJ

    更新日期:2015-05-01 00:00:00

  • Trends and variations in intravenous vitamin D use among hemodialysis patients in the United States.

    abstract::Injectable vitamin D agents are commonly used to manage secondary hyperparathyroidism in dialysis patients. Yet, there are few data documenting the trends and geographic variations in the use of these agents in large, representative samples. We sought to describe patterns and variations in the use of vitamin D formula...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2012.734260

    authors: Beaubrun AC,Brookhart MA,Sleath B,Wang L,Kshirsagar AV

    更新日期:2013-01-01 00:00:00

  • Influence of different stages of experimental chronic kidney disease on rats locomotor and postural skeletal muscles microcirculation.

    abstract:BACKGROUND:Chronic kidney disease (CKD) is associated with muscle excess fatigue and diminished maximal whole body oxygen consumption, which in part could be depended on poor muscle microcirculatory network. The aim of this study was to assume the influence of different stages of CKD on microcirculation vessels in func...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220801985694

    authors: Flisiński M,Brymora A,Elminowska-Wenda G,Bogucka J,Walasik K,Stefańska A,Odrowaz-Sypniewska G,Manitius J

    更新日期:2008-01-01 00:00:00

  • The role of the uncertainty of measurement of serum creatinine concentrations in the diagnosis of acute kidney injury.

    abstract::Uncertainty of measurement is the numeric expression of the errors associated with all measurements taken in clinical laboratories. Serum creatinine concentration is the most common diagnostic marker for acute kidney injury. The goal of this study was to determine the effect of the uncertainty of measurement of serum ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2015.1117925

    authors: Kin Tekce B,Tekce H,Aktas G,Uyeturk U

    更新日期:2016-01-01 00:00:00

  • Effects of uric acid-lowering therapy on the progression of chronic kidney disease: a systematic review and meta-analysis.

    abstract:OBJECTIVES:Whether uric acid levels were associated with the progression of chronic kidney disease (CKD) remained controversial. This meta-analysis was aimed to assess the effect of lowering serum uric acid therapy on the progression of CKD to clarify the role of uric acid in the progression of CKD indirectly. METHODS...

    journal_title:Renal failure

    pub_type: 杂志文章,meta分析,评审

    doi:10.1080/0886022X.2018.1456463

    authors: Liu X,Zhai T,Ma R,Luo C,Wang H,Liu L

    更新日期:2018-11-01 00:00:00

  • Leptospiral acute renal failure: effects of dopamine and furosemide.

    abstract::From unpublished experience of clinicians in the rural tropics, the combination of furosemide and dopamine is beneficial in the management of mild acute renal failure in tropical disease. We studied two groups of patients with leptospirosis and mild acute renal failure whose serum creatinine ranged from 2.4 to 5 mg/dL...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220601095850

    authors: Niwattayakul K,Sitprija V

    更新日期:2007-01-01 00:00:00

  • The impact of location and patency of the arteriovenous fistula on quality of life of kidney transplant recipients.

    abstract:BACKGROUND:Arteriovenous fistulae (AVFs) may remain patent after kidney transplantation (KTx), contributing to maladaptive cardiac remodeling. The flow in AVFs is associated with the diameter of its vessels and thus with the AVF location. The main objective of this study is to assess the influence of AVF location and i...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2020.1865171

    authors: Letachowicz K,Bardowska K,Królicki T,Kamińska D,Banasik M,Zajdel K,Mazanowska O,Madziarska K,Janczak D,Krajewska M

    更新日期:2021-12-01 00:00:00

  • Assessment of health-related fitness in the patients with end-stage renal disease on hemodialysis: using Eurofit Test Battery.

    abstract::The main objectives of this study were to evaluate the health-related physical fitness for the patients with end-stage renal disease on hemodialysis and determine the suitability of Eurofit Test Battery for adults to decide their health-related physical fitness level. Eighteen patients with end-stage renal disease (ES...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220701641330

    authors: Yurdalan SU,Kondu S,Malkoç M

    更新日期:2007-01-01 00:00:00

  • Chronic renal disease in Kuwaiti nationals: a prospective study during the past 4 years.

    abstract::Our study is a prospective one conducted at Al-Amiri Hospital and including all new cases of chronic renal disease (CRD) seen at the capital area of Kuwait between 1 January 1999 and 30 December 2003. Diagnosis of CRD was based on clinical, laboratory, and radiological features. Kidney biopsies were done when indicate...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:

    authors: El-Reshaid W,El-Reshaid K,Kapoor M,Hakim A

    更新日期:2005-01-01 00:00:00

  • Indwelling hemodialysis catheterization by transthoracic way.

    abstract::Chronic kidney failure can be described as a chronic and progressive disfunction in metabolic-endocrine function and in adjustment of fluid-electrolyte balance of kidney, as a result of reducing of glomerular filtration value. Besides being a medical issue, chronic kidney failure affects social, economic, and psycholo...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2015.1006115

    authors: Yildiz Z,Tort M,Çalik ES,Arslan Ü,Kaygin MA

    更新日期:2015-04-01 00:00:00

  • Predictive value of bedside effective renal plasma flow for renal recovery in severe acute renal failure.

    abstract::Single injection, single blood sample, effective renal plasma flow (ERPF) estimated by 131I-orthoiodohippurate can be performed accurately and conveniently without urine collection at the bedside. The purpose of this study was to determine if ERPF early in the course of severe acute renal failure (ARF) predicts recove...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860228709056321

    authors: Holland MD,Galla JH,Dubovsky EV,Luke RG

    更新日期:1987-01-01 00:00:00

  • Factors related to pulse wave velocity and augmentation index in chronic hemodialysis patients.

    abstract:BACKGROUND:Augmentation index (AIx) and pulse wave velocity (PWV) are early markers of atherosclerotic vascular changes and also have been shown to be predictive of cardiovascular disease and total mortality. The aim of our study was to evaluate the relationship between PWV and AIx-HR75, which is the corrected form of ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2011.615967

    authors: Celik G,Demirci MS,Tumuklu M,Ascı G,Sipahi S,Toz H,Bascı A,Ok E

    更新日期:2011-01-01 00:00:00

  • Urotensin-II immunoreactivity in children with chronic glomerulonephritis.

    abstract:BACKGROUND:Human urotensin-II (hU-II) is one of the most potent vasoconstrictors in mammals. To our knowledge, there is no study about the role of U-II in childhood glomerulonephritis. We first determined the expression of h U-II in kidneys of children with chronic glomerular diseases. METHODS:Normal human kidneys wer...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220701392108

    authors: Balat A,Karakök M,Yilmaz K,Kibar Y

    更新日期:2007-01-01 00:00:00

  • Valvular calcification and left ventricular modifying in peritoneal dialysis patients.

    abstract:BACKGROUND:Cardiac valve calcification (CVC) and left ventricular (LV) alterations are frequent complication in end-stage renal disease (ESRD). We determined the prevalence of CVC and LV hypertrophy (LVH) in ESRD patients before renal replacement therapy and 12 months after peritoneal dialysis (PD). METHODS:A prospect...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2015.1073495

    authors: Rebić D,Rašić S,Hamzić-Mehmedbašić A,Džemidžić J,Kurtalić E

    更新日期:2015-01-01 00:00:00

  • The effect of renal replacement therapies on serum gastrointestinal system hormones.

    abstract:BACKGROUND:The kidney is a major site for the inactivation, degradation, and clearance of a variety of peptide hormones. It has been shown that the uremia increases or decreases gastrointestinal system (GIS) hormones. Moreover, studies investigating the serum GIS hormones levels in chronic renal failure (CRF) were cond...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220701643799

    authors: Borazan A,Cavdar Z,Saglam F

    更新日期:2007-01-01 00:00:00

  • Effect of fenoldopam on ischemia/reperfusion-induced apoptosis.

    abstract::Recently we demonstrated the effect of fenoldopam on ischemia/reperfusion (I/R) induced NFkappaB mediated pro-inflammatory signal transduction. However, the effect of fenoldopam on I/R-induced apoptosis is not known. We utilized a rat model of acute ischemic nephropathy to test the hypothesis that fenoldopam attenuate...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220600583690

    authors: Aravindan N,Cata JP,Dougherty PM,Shaw AD

    更新日期:2006-01-01 00:00:00

  • The protective effect and mechanism of rapamycin in the rat model of IgA nephropathy.

    abstract:BACKGROUND:The pathogenesis of the development of IgA nephropathy has not been clear up to now. At present, some studies revealed that the mTOR pathway may participate in IgA nephropathy; however, the mechanism has not been systematically studied. In this study, we established an IgAN rat model to investigate the prote...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2019.1577257

    authors: Guo N,Liu S,Bow LM,Cui X,Zhang L,Xu S,Lu S,Tian J

    更新日期:2019-11-01 00:00:00

  • Melatonin with 1,25-dihydroxyvitamin D3 protects against apoptotic ischemia-reperfusion injury in the rat kidney.

    abstract::This study was designed to evaluate the preventive role of melatonin (Mel) and 1,25-dihydroxyvitamin D3 (VD3) in biochemical and apoptotic events leading to tissue injury and renal dysfunction after ischemia-reperfusion (I/R). Thirty male Wistar rats were divided into five groups: sham-operated, I/R, Mel + I/R, VD3 + ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2012.700887

    authors: Sinanoglu O,Sezgin G,Ozturk G,Tuncdemir M,Guney S,Aksungar FB,Yener N

    更新日期:2012-01-01 00:00:00