Clinicopathologic characteristics and outcomes of lupus nephritis with positive antineutrophil cytoplasmic antibody.

Abstract:

:Aims: The aim was to determine whether anti-neutrophil cytoplasmic antibody (ANCA)-positive serology in patients with lupus nephritis (LN) is associated with different clinicopathologic features and outcomes.Methods: In our retrospective analysis, 283 patients were enrolled between 2013 and 2018. Thirty-six patients were ANCA-positive, and this group was compared with the remaining 247 patients who were confirmed as ANCA-negative at the time of biopsy.Results: ANCA-positive LN patients exhibited higher anti-dsDNA antibody titers and serum creatinine levels and lower serum hemoglobin concentrations than ANCA-negative LN patients. On pathological evaluation, segmental endocapillary hypercellularity observed by light microscopy was significantly more common in the ANCA-positive group. This feature was not significantly different in the treatment group, but the response to treatment was significantly different, as was remission (76.1% vs 69.4%, p < 0.001), between the ANCA-negative and ANCA-positive groups. During follow-up, the times to renal replacement therapy (RRT) and death were significantly different between the two unmatched groups (chi-square test, p = 0.041). Multivariate Cox analysis revealed that neurological disorders, ANCA positivity, and the chronicity index (CI) remained independent risk factors for patient survival. Pulmonary infection was the main cause of death and was most often due to fungal infection.Conclusion: ANCA-positive LN patients typically exhibited higher anti-dsDNA antibody titers, lower serum hemoglobin concentrations and worse renal function than ANCA-negative LN patients. Fungal infection was the main cause of death. We observed that ANCA positivity was an independent risk factor for patient survival.

journal_name

Ren Fail

journal_title

Renal failure

authors

Wang S,Shang J,Xiao J,Zhao Z

doi

10.1080/0886022X.2020.1735416

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

244-254

issue

1

eissn

0886-022X

issn

1525-6049

journal_volume

42

pub_type

杂志文章
  • Neutrophil-lymphocyte ratio predicts cardiovascular and all-cause mortality in hemodialysis patients.

    abstract::Neutrophil-lymphocyte ratio (NLR) is a marker of systemic inflammation that has been shown to predict mortality in patients with malignancies, ischemic heart disease and peripheral vascular disease. Its prognostic value in hemodialysis patients is unclear. The aims of this study were to: (i) explore the relationship b...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2015.1104990

    authors: Neuen BL,Leather N,Greenwood AM,Gunnarsson R,Cho Y,Mantha ML

    更新日期:2016-01-01 00:00:00

  • The prognostic value of frozen section preimplantation graft biopsy in the outcome of renal transplantation.

    abstract:INTRODUCTION:Preimplantation biopsy provides a window on the state of the renal allograft. In this study, the prognostic value of frozen section preimplantation graft biopsy was estimated and compared to regularly processed formalin-fixed biopsy. MATERIALS AND METHODS:Seventy-four renal allograft recipients were studi...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860221003658241

    authors: Goumenos DS,Kalliakmani P,Tsamandas AC,Maroulis I,Savidaki E,Fokaefs E,Papachristou E,Karavias D,Vlachojannis JG

    更新日期:2010-05-01 00:00:00

  • Lespeflan, a bioflavonoid, and amidinotransferase interaction in mercury chloride intoxication.

    abstract::Amidinotransferase (transamidinase, L-arginine: glycine amidinotransferase, EC 2.1.4.1) is an enzyme that catalyses the first step in creatine synthesis primarily in the kidney and pancreas. The kidney is also the primary target organ for the toxic effect of mercury. Therefore, we studied the effect of acute uremic sy...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1081/jdi-200037149

    authors: Nikolic J,Sokolovic D

    更新日期:2004-11-01 00:00:00

  • Tacrolimus restores podocyte injury and stabilizes the expression of Cabin1 in 5/6 nephrectomized rats.

    abstract::Podocyte injury is a vital factor, which induces massive proteinuria. Studies have shown that tacrolimus (TAC) protected podocyte via stabilizing cytoskeleton. Our latest study indicates that calcineurin binding protein 1 (Cabin1) undergoes nuclear translocation during podocytes injury. Whether TAC targets on Cabin1 d...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2016.1148936

    authors: Wen Y,Liu L,Zhou P,Li H,Wang Z,Zhang Y,Liang J

    更新日期:2016-01-01 00:00:00

  • Influence of dialysis modality and membrane flux on quality of life in hemodialysis patients.

    abstract:BACKGROUND:The quality of life in patients undergoing hemodialysis is significantly disturbed. There are data that hemodiafiltration (HDF) may be more effective than conventional hemodialysis in the removal of uremic toxins and may reduce frequency and severity of intradialytic and postdialysis adverse symptoms in pati...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2012.684555

    authors: Knezevic MZ,Djordjevic VV,Radovanovic-Velickovic RM,Stankovic JJ,Cvetkovic TP,Djordjevic VM

    更新日期:2012-01-01 00:00:00

  • Development of new nephrons in adult kidneys following gentamicin-induced nephrotoxicity.

    abstract::Gentamicin-induced nephrotoxicity results in necrosis of proximal tubular epithelial cells. In mammals, the injured nephron can be repaired by migration and division of surviving cells. We examined this repair process in the fresh-water goldfish, Carassius auratus. Fish were given a single intraperitoneal injection of...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229509026246

    authors: Reimschuessel R,Williams D

    更新日期:1995-03-01 00:00:00

  • FK506 inhibits the mice glomerular mesangial cells proliferation by affecting the transforming growth factor-β and Smads signal pathways.

    abstract::Abstract TGF-β1 plays an important role in the pathogenesis of chronic renal diseases. Although the specific mechanism is unknown, a major factor is the potent fibrogenic activity of TGF-β1 in the chronic progression of renal diseases. TGF-β1 closely correlates with renal fibrosis in cooperation with several fibrosis-...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2014.882713

    authors: Qi R,Li W,Yu S

    更新日期:2014-05-01 00:00:00

  • Use of phosphonoformic acid to induce phosphaturia in chronic renal failure in rats.

    abstract::In chronic renal failure (CRF), phosphate (Pi) retention may lead to secondary hyperparathyroidism and progression to end-stage renal disease (ESRD). Dietary phosphorus restriction or phosphate binders can slow progression in experimental CRF. Conversely, diets high in phosphorus can accelerate the progression toward ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229609047712

    authors: Loghman-Adham M,Motock GT

    更新日期:1996-11-01 00:00:00

  • End-stage renal disease and its treatment in Latin America in the twenty-first century.

    abstract::The Latin American Society of Nephrology and Arterial Hypertension's Dialysis and Transplant Registry was chartered in 1991. It collects information on ESRD and its treatment in 20 countries of the region. The prevalence of patients on renal replacement therapy (RRT) increased from 129 pmp in 1992 to 447 pmp in 2004; ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220600925693

    authors: Cusumano A,Garcia-Garcia G,Di Gioia C,Hermida O,Lavorato C,Carreño CA,Torrico MP,Batista PB,Romão JE,Badal HP,Miranda SE,Gomez R,Calderon MC,Sanchez SH,Lopez MA,Moscoso J,Merino RL,Polo JV,Lopez A,Romero NJ,Garcia

    更新日期:2006-01-01 00:00:00

  • Melatonin with 1,25-dihydroxyvitamin D3 protects against apoptotic ischemia-reperfusion injury in the rat kidney.

    abstract::This study was designed to evaluate the preventive role of melatonin (Mel) and 1,25-dihydroxyvitamin D3 (VD3) in biochemical and apoptotic events leading to tissue injury and renal dysfunction after ischemia-reperfusion (I/R). Thirty male Wistar rats were divided into five groups: sham-operated, I/R, Mel + I/R, VD3 + ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2012.700887

    authors: Sinanoglu O,Sezgin G,Ozturk G,Tuncdemir M,Guney S,Aksungar FB,Yener N

    更新日期:2012-01-01 00:00:00

  • Postoperative hemolytic uremic syndrome with renal cortical necrosis following laparoscopic hemicolectomy.

    abstract::Non-Shiga-like toxin-producing Escherichia coli (STEC) or atypical hemolytic uremic syndrome (aHUS) is observed in 5-10% of all hemolytic uremic syndrome (HUS) cases, and usually develops secondary to infections, malignancies, drugs, transplantation, pregnancy, and autoimmune disease. However, there has been no report...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2013.780978

    authors: Lee JW,Won NH,Cho E,Kim MG,Jo SK,Cho WY,Kim HK

    更新日期:2013-01-01 00:00:00

  • Occult HBV infection in continuous ambulatory peritoneal dialysis and hemodialysis patients.

    abstract:AIM:Occult hepatitis B virus (HBV) infection can be defined as the presence of HBV DNA in the liver and/or blood in the absence of detectable serum hepatitis B surface antigen (HBs Ag). There is a high prevalence of occult HBV infection in dialysis patients. This study investigated the prevalence of occult HBV infectio...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860220903391242

    authors: Sav T,Gursoy S,Torun E,Sav NM,Unal A,Oymak O,Utas C

    更新日期:2010-01-01 00:00:00

  • Development of hypertension in a pyelonephritis-induced model: the effect of salt intake and inability of renal sodium handling.

    abstract::The role of the kidney in the control of blood pressure has been convincingly demonstrated by several studies. Recent evidence has suggested that subtle acquired tubulointerstitial injury may cause a defect in sodium excretion function, thus leading to salt-sensitive hypertension. There are no reports, however, examin...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220600779058

    authors: de Magalhães Sartim R,Fantinato Menegon L,de Almeida AR,Rocha Gontijo JA,Aline Boer P

    更新日期:2006-01-01 00:00:00

  • Renal cortical necrosis is a disappearing entity in obstetric acute kidney injury in developing countries: our three decade of experience from India.

    abstract:RATIONAL:Obstetrical complications are the commonest causes of Renal Cortical Necrosis (RCN). However, the overall incidence of RCN in obstetric acute kidney injury in developing countries has been decreasing in recent years. OBJECTIVE:The aim of this study was to evaluate the changing profile of RCN in obstetric AKI ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2015.1062340

    authors: Prakash J,Pant P,Singh AK,Sriniwas S,Singh VP,Singh U

    更新日期:2015-08-01 00:00:00

  • Resolving erythrocytosis and hypertension after open surgical extirpation of giant renal cyst measuring 30 cm: case report.

    abstract::The case of giant renal cyst measuring 30 cm, accompanied by abdominal swelling and erythrocytosis, is presented. A 45-year-old male presented with large abdominal mass, atrophic left kidney, hypertension, and erythrocytosis. The patient underwent multiple preoperative phlebotomies, open extirpation of the cyst, and n...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2011.552148

    authors: Pejcic T,Hadzi-Djokic J,Markovic B,Naumovic R

    更新日期:2011-01-01 00:00:00

  • Intermittent hirudin versus continuous heparin for anticoagulation in continuous renal replacement therapy.

    abstract:BACKGROUND:Besides possible bleeding complications a further problem in anticoagulation during continuous renal replacement therapy (CRRT) is the development of heparin-induced thrombocytopenia type II (HIT II) where further anticoagulation with heparin is contraindicated. The application of continuous hirudin as alter...

    journal_title:Renal failure

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1081/jdi-120039529

    authors: Hein OV,von Heymann C,Diehl T,Ziemer S,Ronco C,Morgera S,Siebert G,Kox WJ,Neumayer HH,Spies C

    更新日期:2004-05-01 00:00:00

  • Ozone therapy ameliorates tubulointerstitial inflammation by regulating TLR4 in adenine-induced CKD rats.

    abstract::Tubulointerstitium inflammation is a common pathway aggravating chronic kidney disease (CKD) progression and the mechanism is partly associated with excessive activation of toll-like receptor 4 (TLR4) in tubulointerstitium. Ozone therapy is demonstrated to alleviate inflammation in some experiments. The aim of this st...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2016.1143757

    authors: Chen Z,Liu X,Yu G,Chen H,Wang L,Wang Z,Qiu T,Weng X

    更新日期:2016-06-01 00:00:00

  • Familial Mediterranean fever and membranous glomerulonephritis: report of a case.

    abstract::Familial Mediterranean fever (FMF) is an autosomal recessive genetic disease characterized by recurrent attacks of fever and painful episodes of sterile polyserositis. Kidney involvement may occur as a result of secondary amyloidosis during the course of FMF. Previously, different types of glomerulopathies such as IgM...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860221003640090

    authors: Ceri M,Unverdi S,Altay M,Unverdi H,Ensari A,Duranay M

    更新日期:2010-01-01 00:00:00

  • Effect of cholecalciferol replacement on vascular calcification and left ventricular mass index in dialysis patients.

    abstract:OBJECTIVE:The aim of this study was to determine the effect of oral cholecalciferol treatment on vascular calcification, left ventricular mass index (LVMI) and other cardiac functions in dialysis patients. DESIGN AND METHODS:A six-month course of oral cholecalciferol treatment was recommended to dialysis patients with...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2015.1010416

    authors: Kidir V,Ersoy I,Altuntas A,Gultekin F,Inal S,Dagdeviren BH,Dogan A,Sezer MT

    更新日期:2015-05-01 00:00:00

  • Assessment of matrix Gla protein, Klotho gene polymorphisms, and oxidative stress in chronic kidney disease.

    abstract::Increased vascular calcification and oxidative stress are considered as extra renal risk factors at the pathogenesis cardiovascular events in chronic kidney disease (CKD). We investigated matrix Gla protein (MGP) (T-138C, Glu60X, Thr83Ala) and Klotho (Cys370Ser) gene polymorphisms, serum MGP levels, and oxidative stre...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2011.605534

    authors: Karsli Ceppioğlu S,Yurdun T,Canbakan M

    更新日期:2011-01-01 00:00:00

  • Salt sensitivity of blood pressure in non-dialysis patients with chronic kidney disease.

    abstract:BACKGROUND:Chronic kidney disease (CKD) is a world-wide public health problem. Hypertension is both a cause and a complication of CKD, and a risk factor for progression of kidney disease. The effect of salt intake on blood pressure (BP) and the salt sensitivity in non-dialysis patients with CKD were studied. METHODS:O...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2013.866008

    authors: Meng L,Fu B,Zhang T,Han Z,Yang M

    更新日期:2014-04-01 00:00:00

  • Effects of nitric oxide synthesis inhibition on FK506-induced nephrotoxicity in rats.

    abstract::This study was designed to evaluate the role of nitric oxide (NO) in FK506-induced nephrotoxicity by administering an inhibitor of NO synthesis, N omega-nitro-L-arginine methyl ester (L-NAME) to rats treated with FK506. After one week of treatment with FK506 (3.2 mg/kg/day, intramuscularly) and/or L-NAME (5 mg/100 mL ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1081/jdi-100001279

    authors: Wang L,Kubodera S,Ueno A,Takeda M

    更新日期:2001-01-01 00:00:00

  • Protective effect of N-benzoyl-beta-alanine against cisplatin nephrotoxicity in rats.

    abstract::Prophylactic effects of N-benzoyl-beta-alanine (betamipron, BP), one of a series of N-acyl amino acids, were examined against cisplatin-induced nephrotoxicity. Male Wistar rats were injected i.p. with 6 mg/kg of cisplatin combined with an i.p. BP dose given at various times and various doses. Rats were sacrificed 5 da...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229609052792

    authors: Tokunaga J,Kobayashi M,Nakamura C,Kitagawa A,Arimori K,Nakano M

    更新日期:1996-03-01 00:00:00

  • New options in the treatment of autosomal dominant polycystic kidney disease.

    abstract::Autosomal dominant polycystic disease (ADPKD) is one of the most common monogenic disorders, and globally is among the most common hereditary causes of end stage kidney disease. Until recently, the causes of this disease remained obscure. However, in the past decade there have been enormous advances in the understandi...

    journal_title:Renal failure

    pub_type: 杂志文章,评审

    doi:10.3109/0886022X.2015.1013404

    authors: Kazancioglu R,Gursu M

    更新日期:2015-05-01 00:00:00

  • Evaluation of renal clinicopathological changes in IgA nephropathy by urinary podocytes excretion and podocalyxin expression.

    abstract:OBJECTIVE:To explore the association of urinary podocyte excretion and renal expression of podocyte-specific marker podocalyxin (PCX) with clinicopathological changes in immunoglobulin A nephropathy (IgAN). METHODS:Morning urine samples from IgAN patients and healthy controls were collected. The expression of glomerul...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2011.643352

    authors: Jiang WL,Peng YM,Liu YH,Liu H,Chen GC,Xu XQ,Zhu XJ,Liu FY

    更新日期:2012-01-01 00:00:00

  • Toward the optimal clinical use of the fraction excretion of solutes in oliguric azotemia.

    abstract::While the fractional excretion of solutes have long been considered excellent research tools to investigate tubular physiology, their clinical use has become common over the last 40 years in the diagnoses of many disorders; however, none have reached the clinical utility of the fractional excretion of sodium in the ab...

    journal_title:Renal failure

    pub_type: 杂志文章,评审

    doi:10.3109/0886022X.2010.517353

    authors: Diskin CJ,Stokes TJ,Dansby LM,Radcliff L,Carter TB

    更新日期:2010-01-01 00:00:00

  • Synergistic action of inflammation and lipid dysmetabolism on kidney damage in rats.

    abstract::In kidney disease, inflammation and lipid dysmetabolism are often associated together, however, the effect and mechanism of inflammatory mediators and lipid dysmetabolism on kidney damage is still unclear. In this study, Wistar rats were randomized into four groups: normal diet + saline (Group N), high-fat diet (HF)+ ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2018.1450763

    authors: Wang Z,Huang W,Li H,Tang L,Sun H,Liu Q,Zhang L

    更新日期:2018-11-01 00:00:00

  • Long-term online hemodiafiltration does not reduce the frequency and severity of acquired cystic kidney disease in hemodialysis patients.

    abstract:BACKGROUND:Acquired cystic kidney disease (ACKD) is a frequent complication in chronic hemodialysis (HD) patients and a risk factor for renal cell carcinoma. Online hemodiafiltration (HDF) provides better clearance of middle molecular weight solutes, but its effect on ACKD has not been investigated. MATERIALS AND METH...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220903003412

    authors: Weng CJ,Chang MY,Chen YC,Tian YC,Fang JT,Yang CW

    更新日期:2009-01-01 00:00:00

  • Lack of relation between serum parathyroid hormone levels and erythrocyte osmotic fragility in pediatric patients on peritoneal dialysis.

    abstract::Secondary hyperparathyroidism and anemia are the hallmarks in uremic patients. It is suggested that parathyroid hormone increases erythrocyte osmotic fragility and induces hemolysis. The present study was undertaken to examine the possible relationship between erythrocyte osmotic fragility and secondary hyperparathyro...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1081/jdi-200037140

    authors: Koşan C,Sever L,Arisoy N

    更新日期:2004-11-01 00:00:00

  • Chronic renal disease in Kuwaiti nationals: a prospective study during the past 4 years.

    abstract::Our study is a prospective one conducted at Al-Amiri Hospital and including all new cases of chronic renal disease (CRD) seen at the capital area of Kuwait between 1 January 1999 and 30 December 2003. Diagnosis of CRD was based on clinical, laboratory, and radiological features. Kidney biopsies were done when indicate...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:

    authors: El-Reshaid W,El-Reshaid K,Kapoor M,Hakim A

    更新日期:2005-01-01 00:00:00