Abstract:
:Renal biopsy data indicate that tubular epithelial cells serve as a reservoir for HIV-1 infection. We studied the effect of HIV-1 gp120 envelope gene expression on tubular cell apoptosis. HIV-1 gp120 was expressed in a lentiviral vector pHR-CMV-IRES2-EGFP-DeltaB. This plasmid construct was used to produce pseudotyped virus using VSV-G envelope to enhance the tropism for efficient viral transduction. Human proximal tubular (HK-2) cells were transduced and assayed for cellular injury by trypan blue exclusion, Hoechst and PI staining, TUNEL, and cell cycle staging. HIV-1 gp120-transduced HK-2 cells showed cellular injury in a time-dependent manner. Gp120-transduced cells showed 2.5-fold greater apoptosis when compared with vector-transduced cells. Cell cycle analysis did not reveal any alteration between gp120-transduced cells and vector-transduced cells. Gp120-transduced cells showed higher expression of both Fas and FasL, whereas pretreatment with anti-FasL antibody partially inhibited gp120-induced tubular cell apoptosis. Similarly, pretreatment with caspase-8 inhibitor attenuated gp120-induced HK2 cell apoptosis. Moreover, gp120-transduced cells showed activation of caspase 8. These results suggest that HIV-1 gp120 expression induces tubular cell apoptosis through the extrinsic pathway by enhancing Fas and FasL expression and activation of caspase-8.
journal_name
Ren Failjournal_title
Renal failureauthors
Vashistha H,Husain M,Kumar D,Singhal PCdoi
10.1080/08860220902780101subject
Has Abstractpub_date
2009-01-01 00:00:00pages
303-12issue
4eissn
0886-022Xissn
1525-6049pii
911581138journal_volume
31pub_type
杂志文章相关文献
RENAL FAILURE文献大全abstract::Although sudden sensorineural hearing loss (SSNHL) affects chronic kidney disease (CKD) patients more frequently than non-CKD patients, few reports have described SSNHL in dialysis patients. We aimed to review the characteristics of SSNHL in chronic dialysis patients and evaluate treatment responses to steroid therapy...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2018.1450760
更新日期:2018-11-01 00:00:00
abstract::The nephrotoxicity of amikacin (AK) was prevented with pentoxifylline (PTX) in a rat model. Rats were received a single injection of AK (1.2 g/kg, i.p.) with or without PTX pretreatment (25 mg/kg, orally). Renal morphology was investigated by light microscopy. Tissue samples and trunk blood were also obtained to deter...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220802595492
更新日期:2009-01-01 00:00:00
abstract::Randomized control trials (RCTs) are considered as most rigors way of determining the cause-effect relationship of a treatment and outcome. Activation of rennin angiotensin aldosterone system (RAAS) is an important contributor to hypertension in hemodialysis patients. The prevalence of hypertension in hemodialysis pat...
journal_title:Renal failure
pub_type: 杂志文章,评审
doi:10.3109/0886022X.2016.1138833
更新日期:2016-01-01 00:00:00
abstract::Objective: The present study assesses whether phosphodiesterase type 5 (PDE-5) inhibitor or carnitine exert nephroprotective effects against clinical contrast-induced nephropathy (CIN).Materials and Methods: The present study consisted of three groups of CKD patients. The first group was control group, who were treate...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2019.1669459
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVES:To evaluate how chronic kidney disease (CKD) and diabetes mellitus (DM) influence in-hospital mortality in patients urgently admitted for acute heart failure (HF). METHODS:We used data from the Spanish "Minimum Basic Data Set" for 2006-2007 to evaluate clinical differences and crude mortality rates for pati...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2014.958974
更新日期:2014-11-01 00:00:00
abstract::Electrolyte disorders can alter cardiac ionic currents and depending on the changes can promote proarrhythmic effects. Potassium (K(+)) is the most common intracellular cation related to arrhythmic disorders. Hyperkalemia is mainly seen in the setting of impaired renal function. Severe hyperkalemia may lead to rhythm ...
journal_title:Renal failure
pub_type: 信件
doi:10.3109/0886022X.2011.653752
更新日期:2012-01-01 00:00:00
abstract::Cyclosporine is used extensively in kidney transplantation and is a substrate for cytochrome P450 enzymes. The role of cytochrome p450 polymorphisms in kidney transplant outcome has not yet been fully elucidated. We investigate the clinical impact of single nucleotide polymorphisms in CYP3A4, CYP3A5, PPARα, and POR*28...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2015.1007013
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:There are few reports on the safety and efficacy of long-term treatment with statins in patients with chronic renal disease and hyperlipidemia. We evaluated these subjects treated with fluvastatin. METHODS:After a 4-week run-in period, a total of 80 patients with diabetic nephropathy or chronic glomerulonep...
journal_title:Renal failure
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1081/jdi-120039826
更新日期:2004-07-01 00:00:00
abstract::Objective The objective of this study is to explore the efficacy and safety of mizoribine (MZR) in treating nephrotic syndrome patients afflicted with hepatitis B virus (HBV). Methods The present study included 36 nephrotic syndrome patients accompanied with HBV infection. A draft of MZR (150-200 mg/d), methylpredniso...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2016.1158035
更新日期:2016-06-01 00:00:00
abstract::The single dose administration of the aminonucleoside of puromycin (PAN) induces a nephrotic syndrome in rats characterized by massive proteinuria and progressive histologic changes. This model of acute parenchymal nephritis is thought to be mediated by the renal recruitment of monocytes and macrophages. To investigat...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229809045089
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVES:Chronic kidney disease (CKD) is a major risk factor for cardiovascular disease (CVD). We previously reported renal parenchymal damage in autopsy subjects with stroke or abdominal aortic aneurysm. The aim of this study is to evaluate the relationship between renal histology and clinical characteristics of pat...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2011.605531
更新日期:2011-01-01 00:00:00
abstract::Postpartum acute kidney injury (PPAKI) constitutes an important cause of obstetric AKI. It is associated with high maternal and fetal mortality in developing nations. The aim of this study is to survey the etiology and outcomes of PPAKI in a tertiary care Indian hospital. Ninety-nine patients, without prior comorbidit...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2016.1164015
更新日期:2016-07-01 00:00:00
abstract::Cardiovascular problems are a major cause of morbidity and mortality in patients with autosomal dominant polycystic kidney disease (ADPKD). Endothelial dysfunction (ED), which is an early manifestation of vascular injury, has been shown in patients with ADPKD. Statins have a beneficial effect in the reversal of ED. Th...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220601038892
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:The syndrome of rapid onset end-stage renal disease (SORO-ESRD) was first described in the journal Renal Failure in 2010. This is an acute precipitate unpredictable yet irreversible ESRD following acute kidney injury (AKI), as distinct from "classic" ESRD where chronic kidney disease (CKD)-ESRD progression w...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2015.1088336
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Morphine is an opioid analgesic drug often used for pain relief in cancer patients. However, there is growing evidence that morphine may modulate tumor growth, progression and metastasis. Unfortunately, the results obtained by these studies are still contradictory. METHODS:In this study, we investigated the...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2016.1256322
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:There are controversial reports in the prevalence of abnormal nighttime blood pressure fall in renal patients. It has been evaluated nocturnal BP in renal patients using 24 h blood pressure monitoring (ABPM) in comparison with nontreated control subjects either normotensives or hypertensives. DESIGN AND METH...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-120024297
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND:Emerging evidence demonstrates that gut dysbiosis is implicated in the pathogenesis of chronic kidney disease (CKD) with underlying mechanisms involving mucosal and/or systematic immunity or metabolic disorders. However, the profile of gut microbiota in patients with CKD has not been completely explored. ME...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2020.1864404
更新日期:2021-12-01 00:00:00
abstract::Herein, we report a case of acute kidney injury (AKI) due to diarrhea-induced acute tubular necrosis (ATN) in a patient with nephrotic syndrome secondary to biopsy-proven collapsing focal and segmental glomerulosclerosis (FSGS). The clinical picture mimicked rapidly progressive glomerulonephritis (RPGN) and motivated ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2010.501931
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to determine the effect of oral cholecalciferol treatment on vascular calcification, left ventricular mass index (LVMI) and other cardiac functions in dialysis patients. DESIGN AND METHODS:A six-month course of oral cholecalciferol treatment was recommended to dialysis patients with...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2015.1010416
更新日期:2015-05-01 00:00:00
abstract::Extensive ablation of renal mass in experimental animals leads to progressive glomerulosclerosis and chronic renal failure (CRF). Clinical studies are far from answering the question whether patients with reduced renal mass are at risk of developing progressive CRF. The aim of our study was to examine the morphologica...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229309054954
更新日期:1993-01-01 00:00:00
abstract::Objectives: To improve the mouse model of relief for unilateral ureteral obstruction (RUUO) and explore the pathological process of renal fibrosis after the obstruction was relieved. Methods: C57BL/6 mice in model group were randomly divided into RUUO group, improved RUUO group, and UUO group. After leaving Unilateral...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2019.1624263
更新日期:2019-11-01 00:00:00
abstract::Behçet's disease is a chronic systemic vasculitis with unknown etiology characterized by recurrent oral and genital ulcerations, ocular inflammation,having manifestations related to the skin and joints. Neurologic, pulmonary and gastrointestinal findings can also be observed during the course of the disease. In this r...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-120018734
更新日期:2003-03-01 00:00:00
abstract::Australia was an early pioneer of national integrated programs for the management of end-stage renal disease (ESRD). From being a leader in numbers of patients per population treated, it is now in the top 15. The Australian program has a high proportion of living patients with functioning transplants and a high propor...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229409044855
更新日期:1994-01-01 00:00:00
abstract:INTRODUCTION:Organic solvents are liquid substances commonly used in everyday life at home and in industrial workplaces. These solvents are found primarily in paint as thinner. Because other narcotics are hard to find, thinner is used as a narcotic especially among youngsters of low socioeconomic level. The aim of this...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2010.536290
更新日期:2011-01-01 00:00:00
abstract::In the growing animal, K deficiency (KD) retards body growth, but paradoxically stimulates renal growth. If KD persists, interstitial infiltrates appear and eventually tubulointerstitial fibrosis develops. In patients with chronic KD, renal cysts may form and with time tubulointerstitial disease with renal failure dev...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-100104718
更新日期:2001-05-01 00:00:00
abstract::Non-Shiga-like toxin-producing Escherichia coli (STEC) or atypical hemolytic uremic syndrome (aHUS) is observed in 5-10% of all hemolytic uremic syndrome (HUS) cases, and usually develops secondary to infections, malignancies, drugs, transplantation, pregnancy, and autoimmune disease. However, there has been no report...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2013.780978
更新日期:2013-01-01 00:00:00
abstract::To evaluate the efficacy of Silodosin as a medical expulsive therapy of ureteral stones, we searched PubMed, EMBASE, the Cochrane Library, and CBM up to June 2015. All randomized controlled trials (RCTs) were identified in which patients were randomized to receive Silodosin versus placebo or other therapies for ureter...
journal_title:Renal failure
pub_type: 杂志文章,meta分析,评审
doi:10.1080/0886022X.2016.1215221
更新日期:2016-10-01 00:00:00
abstract::We evaluated the feasibility of magnetic resonance imaging (MRI) for early detection of tubular injury by monitoring changes in the apparent diffusion coefficient (ADC) of renal water in a rat model of myohemoglobinuric glycerol-induced acute renal failure (ARF). Diffusion-weighted MRI was performed concurrently with ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229609052773
更新日期:1996-01-01 00:00:00
abstract:AIM:Bio-impedance analysis (BIA) is a preferred method for estimating the volume status. However, it cannot be utilized in daily practice. Since the assessment of the volume status is important and challenging for hemodialysis (HD) patients, the aim of study was to determine the volume status in chronic HD patients usi...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2016.1229968
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVES:In Taiwan, the widespread use of organophosphates (OPs) in agricultural and household environments results in numerous OP poisoning. To better understand the clinical significance of associated parameters on respiratory failure and patient outcome, we evaluate patients admitted to the Nephrology ward in our ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-120039816
更新日期:2004-07-01 00:00:00