Association between MPO-463G > A polymorphism and chronic kidney disease: a meta-analysis.

Abstract:

BACKGROUND/OBJECTIVE:Previous studies have shown that MPO -463G > A (rs2333227) might be associated with chronic kidney disease (CKD) susceptibility, but sample sizes of those studies are relatively small. Hence, we decided to perform a meta-analysis to evaluate the association. Methods/main results: Two investigators search databases systematically and independently. Odds ratios and 95% confidence intervals were used to pool the effect size. Four articles with 618 cases and 932 controls in total were included in our meta-analysis. CONCLUSIONS:MPO -463G > A was not associated with CKD susceptibility in recessive model and homozygote comparison. MPO -463G > A was associated with increased risk of CKD in allelic comparison, heterozygote comparison and dominant model, however, the results lacked stability. Owing to insufficient data, the association between MPO -463G > A and CKD cannot be fully confirmed.

journal_name

Ren Fail

journal_title

Renal failure

authors

Qin J,Xing J,Li W,Zhang K,Wu Z

doi

10.1080/0886022X.2018.1499529

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

541-546

issue

1

eissn

0886-022X

issn

1525-6049

journal_volume

40

pub_type

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