Abstract:
BACKGROUND/OBJECTIVE:Previous studies have shown that MPO -463G > A (rs2333227) might be associated with chronic kidney disease (CKD) susceptibility, but sample sizes of those studies are relatively small. Hence, we decided to perform a meta-analysis to evaluate the association. Methods/main results: Two investigators search databases systematically and independently. Odds ratios and 95% confidence intervals were used to pool the effect size. Four articles with 618 cases and 932 controls in total were included in our meta-analysis. CONCLUSIONS:MPO -463G > A was not associated with CKD susceptibility in recessive model and homozygote comparison. MPO -463G > A was associated with increased risk of CKD in allelic comparison, heterozygote comparison and dominant model, however, the results lacked stability. Owing to insufficient data, the association between MPO -463G > A and CKD cannot be fully confirmed.
journal_name
Ren Failjournal_title
Renal failureauthors
Qin J,Xing J,Li W,Zhang K,Wu Zdoi
10.1080/0886022X.2018.1499529subject
Has Abstractpub_date
2018-11-01 00:00:00pages
541-546issue
1eissn
0886-022Xissn
1525-6049journal_volume
40pub_type
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