Bcıı--RFLP profiles for serum amiloid A1 and mutated MEFV gene prevalence in chronic renal failure patients requiring long-term hemodialysis.


BACKGROUND AND AIM:There is an increased mortality risk in long-term hemodialysis patients of renal failure due to the chronic inflammation. The relationship between the chronic renal failure (CRF) and the role of familial genetic markers remains incompletely understood. In the current study, it was aimed to find out the prevalence of common MEFV gene mutations and BcII polymorphism in serum amyloid A1 (SAA1) gene in chronic renal patients (CRF) who require long-term hemodialysis. METHOD:Current cohort includes 242 CRF patients and 245 healthy individuals from the same population. Total genomic DNA was isolated from peripheral blood-EDTA samples and genotyping of target MEFV gene was carried out by reverse hybridization Strip Assay and real-time techniques. The SAA1 gene was genotyped by the BclI-RFLP method. RESULTS:Increased mutated MEFV genotypes were found in current CRF patients when compared with the control group from the same ethnicity and the difference was statistically significant (Table 2) (OR: 4.9401, 95% CI: 3.0694-7.9509), p<0.0001. The most frequent point mutations were M694V and E148Q. The mutated T allel frequency in the SAA1 gene was also different when compared with the healthy controls and the difference was found to be statistically significant (χ2: 13.18; p=0.000). CONCLUSIONS:The current results indicate the germ-line mutations in both genetic biomarkers (MEFV and SAA1 genes) that are related to inflammation and amyloidosis processes may play a crucial role in CRF pathogenesis due to the long-term chronic inflammation.


Ren Fail


Renal failure


Ozdemir O,Kayatas M,Cetinkaya S,Yildirim ME,Silan F,Kurtulgan HK,Koksal B,Urfali M,Candan F




Has Abstract


2015-03-01 00:00:00












  • A novel rodent model of severe renal ischemia reperfusion injury.

    abstract::Renal ischemia reperfusion injury (IRI) is a major problem, currently without treatments in clinical use. This reflects the failure of animal models to mimic the severity of IRI observed in clinical practice. Most described models lack both the ability to inflict a permanent reduction in renal function and the sensiti...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Whalen H,Shiels P,Littlejohn M,Clancy M

    更新日期:2016-11-01 00:00:00

  • Influenza vaccination in chronic hemodialysis patients. The effect of zinc supplementation.

    abstract::Since influenza increases the mortality of chronically ill patients we decided to study the effectiveness of influenza vaccination in hemodialysis (HD) patients. Nineteen HD patients aged from 20 to 60 years, on unrestricted diet and with no febrile episode, were studied. Blood samples were collected before the intram...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Grekas D,Alivanis P,Kotzadamis N,Kiriazopoulou V,Pyrpasopoulos M,Tourkantonis A

    更新日期:1992-01-01 00:00:00

  • Mortality risk factors in chronic renal failure patients after coronary artery bypass grafting.

    abstract::Perioperative risk during coronary artery bypass grafting (CABG) is high in patients with chronic renal disease. We aimed to determine postoperative two-year mortality and identify the preoperative risk factors of mortality during CABG surgery in hemodialysis (HD)-dependent and HD-non-dependent CRF patients. We includ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Akman B,Bilgic A,Sasak G,Sezer S,Sezgin A,Arat Z,Ozdemir FN,Haberal M

    更新日期:2007-01-01 00:00:00

  • Spectrum of liver damage and correlation with clinical and laboratory parameters in HCV infected hemodialysis patients.

    abstract::There are conflicting results in studies concerning the best marker for liver histopathological features of HCV infection in HD patients. We planned a prospective study to follow HCV viremia and laboratory parameters of HD patients and correlate these with clinic features and histopathological findings. We included 68...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Sezer S,Ozdemir BH,Arat Z,Turan M,Ozdemir NF,Haberal M

    更新日期:2001-11-01 00:00:00

  • Leukocyte involvement in renal reperfusion-induced liver damage.

    abstract:BACKGROUNDS/AIMS:Renal ischemia-reperfusion (IR) induces organ damage in remote organs. The aim of this study was to assess the role of leukocytes in the induction of liver damage after renal IR injury. METHODS:Inbred mice were subjected to either sham operation or bilateral renal IR injury (60 min ischemia followed b...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Khastar H,Kadkhodaee M,Sadeghipour HR,Seifi B,Hadjati J,Delavari F,Soleimani M

    更新日期:2011-01-01 00:00:00

  • Significant benefits after renal transplantation in patients with chronic heart failure and chronic kidney disease.

    abstract:BACKGROUND:Chronic heart failure (CHF) and chronic kidney disease (CKD) are serious medical conditions with significant morbidity and mortality and often coexist. Because of perioperative risks in these patients, they may not be considered a candidate for renal transplantation (RTx). MATERIAL AND METHODS:We compare re...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Kute VB,Vanikar AV,Patel HV,Gumber MR,Shah PR,Engineer DP,Balwani MR,Gautam RS,Modi PR,Shah VR,Trivedi HL

    更新日期:2014-07-01 00:00:00

  • Role of glutathione for cisplatin nephrotoxicity in young and adult rats.

    abstract::Investigations were done in 10- and 55-day-old Wistar rats. Glutathione (GSH) level in kidney was decreased by 8 mmol buthionine sulfoximine (BSO)/100 g BW. There was no effect on the renal function and nephrotoxicity of cisplatin (0.6 mg CP/100 g BW) in adult rats. In young rats BSO treatment was followed by nephroto...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Appenroth D,Winnefeld K

    更新日期:1993-01-01 00:00:00

  • Interleukin-17 promotes the production of underglycosylated IgA1 in DAKIKI cells.

    abstract:BACKGROUND:Interleukin 17 (IL-17) plays an important role in the pathogenesis of autoimmune diseases and might be associated with IgA nephropathy (IgAN). This study aimed to investigate the effect of IL-17 on autoimmune pathogenesis in IgA nephropathy. METHODS:DAKIKI cells were cultured and stimulated with IL-17 to pe...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Lin JR,Wen J,Zhang H,Wang L,Gou FF,Yang M,Fan JM

    更新日期:2018-11-01 00:00:00

  • Role of CT scan in diagnosis of renal lymphangiectasia: our single-center experience.

    abstract:BACKGROUND:Renal lymphangiectasia is rarely reported benign renal disorder of lymphatic malformation. Though found incidentally; it presents with nonspecific symptoms and shows characteristic findings in radiological imaging studies. AIM:Here, we report eight patients with symptoms, laboratory and imaging findings com...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Pandya VK,Sutariya HC,Gandhi SP,Khemchandani SI,Patel HV,Shah MK

    更新日期:2017-11-01 00:00:00

  • Effects of a stroma-free hemoglobin and perfluorochemical combination on ultrastructure and function of the isolated rat kidney.

    abstract::Experimental perfusions of isolated rat kidneys were performed with flow rates adjusted to produce comparable glomerular filtration rates (GFR) in control and experimental groups. The experimental perfusate, consisting of Krebs-Ringer bicarbonate (KRB) containing 3.5% (uncrosslinked) stroma-free hemoglobin (SFH) plus ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Millis RM,Barber JD,Anderson WA,Dehkordi O

    更新日期:1995-11-01 00:00:00

  • Protective effect of curcumin on busulfan-induced renal toxicity in male rats.

    abstract:AIM:The aim of this study was to evaluate the effects of curcumin in an experimental model of busulfan-induced renal toxicity with emphasis on importance of histological alterations. METHODS:In this study, we utilized 32 adult male Wistar rats (250 ± 10 g). All the animals were divided into four experimental groups ra...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Abdollahifar MA,Ebrahimi V,Aliaghaei A,Raoofi A,Khosravi A,Hasani A,Mehdizadeh A,Asadi M

    更新日期:2020-11-01 00:00:00

  • Is there an association of hepatitis B virus infection with minimal change disease of nephrotic syndrome? A clinical observational report.

    abstract::The rate of hepatitis B virus (HBV) infection is high in the Chinese population, and the implications of HBV infection are widely recognized, and membranous nephropathy is the most common renal lesion to be associated with HBV infection. Minimal change disease (MCD) is one of the most important histopathological chara...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Zhou TB,Jiang ZP

    更新日期:2015-04-01 00:00:00

  • Comparison of insulin resistance in the various stages of chronic kidney disease and inflammation.

    abstract:OBJECTIVE:In this study, we compared predialysis and dialysis patients with the controls in terms of insulin resistance and evaluated the association with inflammation that is a risk factor for cardiovascular disease. MATERIALS AND METHODS:A total of 134 non-diabetic patients with controls (n=33), predialysis (n=29) a...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Akalın N,Köroğlu M,Harmankaya Ö,Akay H,Kumbasar B

    更新日期:2015-03-01 00:00:00

  • The effect of cholesterol overload on mouse kidney and kidney-derived cells.

    abstract:INTRODUCTION:Dyslipidemia is one of the onset and risk factors of chronic kidney disease and renal function drop is seen in lipoprotein abnormal animal models. However, the detailed molecular mechanism of renal lipotoxicity has not been clarified. Therefore, the present study aimed to investigate the influence of chole...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Honzumi S,Takeuchi M,Kurihara M,Fujiyoshi M,Uchida M,Watanabe K,Suzuki T,Ishii I

    更新日期:2018-11-01 00:00:00

  • Infection-related hospitalization after intensive immunosuppressive therapy among lupus nephritis and ANCA glomerulonephritis patients.

    abstract::Introduction: This study aimed to investigate the clinical characteristics, risk factors, and outcomes of infection-related hospitalization (IRH) in patients with lupus nephritis (LN) and ANCA glomerulonephritis after intensive immunosuppressive therapy.Methods: Patients diagnosed with LN or ANCA glomerulonephritis wh...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Yin P,Li J,Wen Q,Qiu Y,Liang W,Wang J,Yu J,Zhong Z,Yang X,Yu X,Ye Q,Huang F

    更新日期:2020-11-01 00:00:00

  • Oral glucose tolerance test after high-dose i.v. biotin administration in normoglucemic hemodialysis patients.

    abstract::Abnormal glucose metabolism in uremia may result from a complex interplay between decreased insulin secretion and insulin resistance. Recent studies report beneficial effect of biotin administration in glucose metabolism in diabetic animals and in a small number of patients with diabetes mellitus. The aim of the prese...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Koutsikos D,Fourtounas C,Kapetanaki A,Agroyannis B,Tzanatos H,Rammos G,Kopelias I,Bosiolis B,Bovoleti O,Darema M,Sallum G

    更新日期:1996-01-01 00:00:00

  • Early manifestation of nephropathy in rats with arterial calcinosis.

    abstract::In vascular smooth muscle, calcium overload is a highly pathogenic event, which increases with advancing age. An increase in the calcium content of arterial wall may be produced in rats by treatment with vitamin D3. The aim of this study was to evaluate the renal clearance of sulfanilamide (a model organic anion, pref...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Quaglia NB,Brandoni A,Ferri A,Torres AM

    更新日期:2003-05-01 00:00:00

  • Successful use of rituximab in fibrillary glomerulopathy.

    abstract::Fibrillary glomerulopathy (FG) can occur either alone or co-existing with other proteinuric glomerular disorders. FG has been associated with poor renal outcomes leading to End Stage Renal Disease (ESRD). Since FG is a relatively rare disorder, limited information is available concerning treatment protocols. We presen...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Chaudhary A,Gyamlani G,Cossey NL,Walker PD,Wall BM

    更新日期:2014-08-01 00:00:00

  • Hepatitis G virus infection in hemodialysis patients from urban Delhi.

    abstract::This study was designed to evaluate the seroprevalence of hepatitis G virus (HGV) infection, its impact, and its relationship with other hepatotropic viruses among chronic renal failure patients undergoing hemodialysis at the Lok Nayak Hospital, New Delhi. The study group consisted of 100 consecutive cases of patients...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Kumar D,Arora A,Singh NP,Kohli R,Kar P,Das BC

    更新日期:2005-01-01 00:00:00

  • Modification of the Schwartz equations for children increases their accuracy at eGFR > 60 mL/min/1.73 m(2).

    abstract:AIM:Estimation of eGFR in children with normal kidney function using the Schwartz equations results in underestimating real GFR. MATERIALS AND METHODS:We propose modification of three Schwartz equations - two based on creatinine concentration (eGFRScrBS bedside) and (eGFRScr) and one 3-marker based on creatinine, urea...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Zachwieja K,Korohoda P,Kwinta-Rybicka J,Miklaszewska M,Moczulska A,Bugajska J,Berska J,Drożdż D,Pietrzyk JA

    更新日期:2016-06-01 00:00:00

  • External dilator-assisted banding for high-flow hemodialysis arteriovenous fistula.

    abstract::Creation of arteriovenous fistula (AVF) may lead to left ventricle hypertrophy and predispose for development or worsening of heart failure. It was postulated to reduce access blood flow if exceeded 2 L/min or cardiac index was higher than 3.0 L/min/m(2). Numbers of techniques decreasing flow were described. The major...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Letachowicz K,Kusztal M,Gołębiowski T,Letachowicz W,Weyde W,Klinger M

    更新日期:2016-08-01 00:00:00

  • Lysosomal iron accumulation in diabetic nephropathy.

    abstract::Iron accumulates within proximal tubular lysosomes in several models of renal disease and may play a role in the progression of proteinuric chronic renal disease by the generation of reactive oxygen species. In this study, tubular iron was examined at an ultrastructural level by energy dispersive x-ray spectrometry in...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Nankivell BJ,Tay YC,Boadle RA,Harris DC

    更新日期:1994-01-01 00:00:00

  • Dysregulated microRNAs involved in contrast-induced acute kidney injury in rat and human.

    abstract:BACKGROUND:Contrast-induced nephropathy (CIN) is a complex syndrome of acute nephropathy that occurs following infusion of intravascular contrast agents, and is associated with an increased risk for adverse cardiovascular events. While there is no ideal biomarker for making an early diagnosis of CIN, we hypothesized th...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Gutiérrez-Escolano A,Santacruz-Vázquez E,Gómez-Pérez F

    更新日期:2015-01-01 00:00:00

  • Higher thrombin activatable fibrinolysis inhibitor levels are associated with inflammation in attack-free familial Mediterranean fever patients.

    abstract:BACKGROUND:Coagulation abnormalities have been reported in familial Mediterranean fever (FMF) patients with amyloidosis and nephrotic syndrome; but there is not enough data about the continuity of the thrombogenic activity in FMF patients in clinical remission. The purpose of this study was to assess thrombin activatab...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Bavbek N,Ceri M,Akdeniz D,Kargili A,Duranay M,Erdemli K,Akcay A,Guz G

    更新日期:2014-06-01 00:00:00

  • The association of overhydration with megafistulas in hemodialysis patients.

    abstract::Objectives: Diffuse enlargements of arteriovenous dialysis fistulas customarily attributed to either excessive arterial inflow or central outflow stenosis. The relationship between volume status and clinically enlarged (arteriovenous) fistula (CEF) formation in end-stage renal disease (ESRD) patients is not well under...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Tapolyai M,Faludi M,Berta K,Forró M,Zsom L,Pethő ÁG,Rosivall L,Fülöp T

    更新日期:2019-11-01 00:00:00

  • Low-dose IL-2 expands CD4+ regulatory T cells with a suppressive function in vitro via the STAT5-dependent pathway in patients with chronic kidney diseases.

    abstract:BACKGROUND:Patients with chronic kidney disease (CKD) often have CD4+ regulatory T cells (Tregs) dysfunction and chronic inflammation. We aim to investigate the effect, function, and related mechanism of low-dose IL-2 on CD4+ regulatory T cells expansion in vitro from patients with CKD. METHODS:A total of 148 newly di...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Li Y,Liu X,Wang W,Wang S,Zhang J,Jiang S,Wang Y,Li L,Li J,Zhang Y,Huang H

    更新日期:2018-11-01 00:00:00

  • Predictive value of bedside effective renal plasma flow for renal recovery in severe acute renal failure.

    abstract::Single injection, single blood sample, effective renal plasma flow (ERPF) estimated by 131I-orthoiodohippurate can be performed accurately and conveniently without urine collection at the bedside. The purpose of this study was to determine if ERPF early in the course of severe acute renal failure (ARF) predicts recove...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Holland MD,Galla JH,Dubovsky EV,Luke RG

    更新日期:1987-01-01 00:00:00

  • Tubular cell HIV-1 gp120 expression induces caspase 8 activation and apoptosis.

    abstract::Renal biopsy data indicate that tubular epithelial cells serve as a reservoir for HIV-1 infection. We studied the effect of HIV-1 gp120 envelope gene expression on tubular cell apoptosis. HIV-1 gp120 was expressed in a lentiviral vector pHR-CMV-IRES2-EGFP-DeltaB. This plasmid construct was used to produce pseudotyped ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Vashistha H,Husain M,Kumar D,Singhal PC

    更新日期:2009-01-01 00:00:00

  • Salt sensitivity of blood pressure in non-dialysis patients with chronic kidney disease.

    abstract:BACKGROUND:Chronic kidney disease (CKD) is a world-wide public health problem. Hypertension is both a cause and a complication of CKD, and a risk factor for progression of kidney disease. The effect of salt intake on blood pressure (BP) and the salt sensitivity in non-dialysis patients with CKD were studied. METHODS:O...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Meng L,Fu B,Zhang T,Han Z,Yang M

    更新日期:2014-04-01 00:00:00

  • Acute renal failure caused by nontraumatic rhabdomyolysis.

    abstract::Nontraumatic rhabdomyolysis may be associated with severe metabolic disturbances. In particular, previous literature has described a 8-20% incidence of acute renal failure in rhabdomyolysis. The aim of this study was to evaluate our experience on 11 patients with acute renal failure treated by high-efficiency daily he...

    journal_title:Renal failure

    pub_type: 临床试验,杂志文章


    authors: Tozzo C,Mazzarella V,Splendiani G,Casciani CU

    更新日期:1997-05-01 00:00:00