Bcıı--RFLP profiles for serum amiloid A1 and mutated MEFV gene prevalence in chronic renal failure patients requiring long-term hemodialysis.

Abstract:

BACKGROUND AND AIM:There is an increased mortality risk in long-term hemodialysis patients of renal failure due to the chronic inflammation. The relationship between the chronic renal failure (CRF) and the role of familial genetic markers remains incompletely understood. In the current study, it was aimed to find out the prevalence of common MEFV gene mutations and BcII polymorphism in serum amyloid A1 (SAA1) gene in chronic renal patients (CRF) who require long-term hemodialysis. METHOD:Current cohort includes 242 CRF patients and 245 healthy individuals from the same population. Total genomic DNA was isolated from peripheral blood-EDTA samples and genotyping of target MEFV gene was carried out by reverse hybridization Strip Assay and real-time techniques. The SAA1 gene was genotyped by the BclI-RFLP method. RESULTS:Increased mutated MEFV genotypes were found in current CRF patients when compared with the control group from the same ethnicity and the difference was statistically significant (Table 2) (OR: 4.9401, 95% CI: 3.0694-7.9509), p<0.0001. The most frequent point mutations were M694V and E148Q. The mutated T allel frequency in the SAA1 gene was also different when compared with the healthy controls and the difference was found to be statistically significant (χ2: 13.18; p=0.000). CONCLUSIONS:The current results indicate the germ-line mutations in both genetic biomarkers (MEFV and SAA1 genes) that are related to inflammation and amyloidosis processes may play a crucial role in CRF pathogenesis due to the long-term chronic inflammation.

journal_name

Ren Fail

journal_title

Renal failure

authors

Ozdemir O,Kayatas M,Cetinkaya S,Yildirim ME,Silan F,Kurtulgan HK,Koksal B,Urfali M,Candan F

doi

10.3109/0886022X.2014.982954

subject

Has Abstract

pub_date

2015-03-01 00:00:00

pages

292-6

issue

2

eissn

0886-022X

issn

1525-6049

journal_volume

37

pub_type

杂志文章
  • Influence of dialysis modality and membrane flux on quality of life in hemodialysis patients.

    abstract:BACKGROUND:The quality of life in patients undergoing hemodialysis is significantly disturbed. There are data that hemodiafiltration (HDF) may be more effective than conventional hemodialysis in the removal of uremic toxins and may reduce frequency and severity of intradialytic and postdialysis adverse symptoms in pati...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2012.684555

    authors: Knezevic MZ,Djordjevic VV,Radovanovic-Velickovic RM,Stankovic JJ,Cvetkovic TP,Djordjevic VM

    更新日期:2012-01-01 00:00:00

  • A reference equation for objectively adjusting dwell volume to obtain more ultrafiltration in daily practice of peritoneal dialysis.

    abstract:OBJECTIVES:Few studies mention how to objectively adjust peritoneal dialysis (PD) dwell volume for adult continuous ambulatory peritoneal dialysis (CAPD) patients. We proposed a reference equation composed of parameters from the peritoneal equilibrium test (PET) for adjusting daily dialysate dwell volume to obtain more...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860220903541127

    authors: Chien CC,Wang HY,Chien TW,Kan WC,Su SB,Lin CY

    更新日期:2010-01-01 00:00:00

  • Superior prognostic value of soluble suppression of tumorigenicity 2 for the short-term mortality of maintenance hemodialysis patients compared with NT-proBNP: a prospective cohort study.

    abstract::Background: Both soluble suppression of tumorigenicity 2 (sST2) and N-terminal pro-brain natriuretic peptide (NT-proBNP) are promising biomarkers associated with the adverse clinical outcomes of dialysis patients. Our research aims at exploring and comparing the roles of sST2 and NT-proBNP in predicting the short-term...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2020.1767648

    authors: Wang Z,Chen Z,Yu H,Ma X,Zhang C,Qu B,Zhang W,Chen X

    更新日期:2020-11-01 00:00:00

  • Lupus nephritis at the University Hospital of the West Indies, Kingston, Jamaica: a 10-year experience.

    abstract::The case records of 75 patients who had systemic lupus erythematosus (SLE) and renal involvement on renal histology were reviewed. There were 70 females and 5 males, with a ratio of 14:1. The majority of the patients were in their second and third decades of life. SLE nephritis was distinctly uncommon in patients belo...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229009066962

    authors: Williams W,Shah D

    更新日期:1990-01-01 00:00:00

  • Safety and efficacy of mizoribine treatment in nephrotic syndrome complicated with hepatitis B virus infection: a clinical study.

    abstract::Objective The objective of this study is to explore the efficacy and safety of mizoribine (MZR) in treating nephrotic syndrome patients afflicted with hepatitis B virus (HBV). Methods The present study included 36 nephrotic syndrome patients accompanied with HBV infection. A draft of MZR (150-200 mg/d), methylpredniso...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2016.1158035

    authors: Liu J,Zhang K,Ji Y,Zhang W,Li W,Yong Q,Wang J,Sun J,Zhang H

    更新日期:2016-06-01 00:00:00

  • Effect of fenoldopam on ischemia/reperfusion-induced apoptosis.

    abstract::Recently we demonstrated the effect of fenoldopam on ischemia/reperfusion (I/R) induced NFkappaB mediated pro-inflammatory signal transduction. However, the effect of fenoldopam on I/R-induced apoptosis is not known. We utilized a rat model of acute ischemic nephropathy to test the hypothesis that fenoldopam attenuate...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220600583690

    authors: Aravindan N,Cata JP,Dougherty PM,Shaw AD

    更新日期:2006-01-01 00:00:00

  • Indwelling hemodialysis catheterization by transthoracic way.

    abstract::Chronic kidney failure can be described as a chronic and progressive disfunction in metabolic-endocrine function and in adjustment of fluid-electrolyte balance of kidney, as a result of reducing of glomerular filtration value. Besides being a medical issue, chronic kidney failure affects social, economic, and psycholo...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2015.1006115

    authors: Yildiz Z,Tort M,Çalik ES,Arslan Ü,Kaygin MA

    更新日期:2015-04-01 00:00:00

  • Retroperitoneal fibrosis secondary to different etiologies (hemilaminectomy and hypothyroidism): reports of two cases.

    abstract::Retroperitoneal fibrosis (RF) is a clinical entity characterized by the progressive proliferation of connective tissue that rarely forms a mass involving the periaortic area of the abdomen, which may be idiopathic as well as a result of an inflammatory process after aneurysmal dilatation of the aorta. This fibrotic ti...

    journal_title:Renal failure

    pub_type: 杂志文章,评审

    doi:10.1080/08860220701392322

    authors: Dişel U,Alpay NR,Paydas S

    更新日期:2007-01-01 00:00:00

  • Left ventricle ejection fraction may predict mortality in renal transplant patients.

    abstract:PURPOSE:Mortality is a major problem in renal transplant patients, and appropriate preoperative evaluation is very important. We retrospectively reviewed the left ventricle ejection fraction (LVEF) of renal transplant patients. MATERIAL AND METHODS:The clinical records of 1763 patients who had preoperative LVEF result...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2016.1194162

    authors: Ozkul F,Kasim Arik M,Erbiş H,Akbaş A,Yilmaz VT,Barutcu A,Ali Osmanoğlu I,Kocak H

    更新日期:2016-11-01 00:00:00

  • Unilateral nephrectomy and progression of renal failure.

    abstract::Extensive ablation of renal mass in experimental animals leads to progressive glomerulosclerosis and chronic renal failure (CRF). Clinical studies are far from answering the question whether patients with reduced renal mass are at risk of developing progressive CRF. The aim of our study was to examine the morphologica...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229309054954

    authors: Buccianti G,Lorenz M,Cresseri D,Bianchi ML,Valenti G,Cicchetti F,Francucci BM

    更新日期:1993-01-01 00:00:00

  • Long-term efficacy and safety of quadruple therapy in childhood diffuse proliferative lupus nephritis.

    abstract::In this study, we evaluated the frequency, clinical presentation, treatment protocols, prognostic factors, and outcome in children with diffuse proliferative lupus nephritis (DPLN). Between June 1990 and December 2004, 46 patients were diagnosed to have systemic lupus erythematosus (SLE), and 26 of them (56.5%) were f...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220802132171

    authors: Demircin G,Oner A,Erdoğan O,Delibaş A,Baysun S,Bülbül M,Bek K,Oksal A

    更新日期:2008-01-01 00:00:00

  • A Behçet case with renal amyloidosis.

    abstract::Behçet's disease is a chronic systemic vasculitis with unknown etiology characterized by recurrent oral and genital ulcerations, ocular inflammation,having manifestations related to the skin and joints. Neurologic, pulmonary and gastrointestinal findings can also be observed during the course of the disease. In this r...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1081/jdi-120018734

    authors: Nadir I,Gültekin F,Yönem O,Yildiz E

    更新日期:2003-03-01 00:00:00

  • Glomerular alterations in experimental oliguric and nonoliguric acute renal failure.

    abstract::Studies were performed in oliguric and nonoliguric forms of uranyl acetate (UA)-induced and ischemic acute renal failure (ARF) to examine whether a reduction in GFR is correlated with glomerular morphologic alterations. UA-induced nonoliguric and oliguric ARF were induced in rabbits by i.v. injections of 0.9 and 2 mg/...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229309046155

    authors: Kato A,Hishida A,Kobayashi S,Honda N

    更新日期:1993-01-01 00:00:00

  • Urinary excretion of creatol, an in vivo biomarker of hydroxyl radical, in patients with chronic renal failure.

    abstract::Creatol (CTL) is a hydroxyl radical adduct of creatinine (Cr). The serum methylguanidine (MG) level and the MG/Cr molar ratio are reported to be biomarkers for oxidative stress. The aim of this study was to examine whether urinary excretion of CTL, another oxidative stress-related marker, is increased in patients with...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220701219863

    authors: Ienaga K,Nakamura K,Fujisawa T,Fukunaga Y,Nihei H,Narita M,Tomino Y,Sanaka T,Aoyagi K,Nakano K,Koide H

    更新日期:2007-01-01 00:00:00

  • Effect of hormone replacement therapy on CD4+ and CD8+ numbers, CD4+/CD8+ ratio, and immunoglobulin levels in hemodialysis patients.

    abstract::Uremia induces a suppression of the immune status. A large clinical literature suggests that estradiol (E2) plays a critical role in immune function. A large proportion of women hemodialysis patients faced early menopause and inadequate estrogen levels. The aim of the present study is to evaluate the effect of hormone...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:

    authors: Dogan E,Erkoc R,Demir C,Sayarlioglu H,Dilek I,Sayarlioglu M

    更新日期:2005-01-01 00:00:00

  • Early manifestation of nephropathy in rats with arterial calcinosis.

    abstract::In vascular smooth muscle, calcium overload is a highly pathogenic event, which increases with advancing age. An increase in the calcium content of arterial wall may be produced in rats by treatment with vitamin D3. The aim of this study was to evaluate the renal clearance of sulfanilamide (a model organic anion, pref...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1081/jdi-120021150

    authors: Quaglia NB,Brandoni A,Ferri A,Torres AM

    更新日期:2003-05-01 00:00:00

  • Cardiovascular surgery after renal transplantation--indications, complications and outcome.

    abstract:UNLABELLED:Cardiovascular diseases are the major cause of morbidity and mortality in renal transplant recipients. We report our experience in the treatment of patients with renal allograft who required cardiovascular surgery. METHODS:Indications for cardiovascular surgery, postoperative complications, and outcome were...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2015.1052950

    authors: Basic-Jukic N,Ivanac-Jankovic R,Biocina B,Kes P

    更新日期:2015-07-01 00:00:00

  • A comparison of sevelamer hydrochloride with calcium acetate on biomarkers of bone turnover in hemodialysis patients.

    abstract:OBJECTIVE:To evaluate the influence of sevelamer hydrochloride and calcium acetate on biomarkers of bone turnover in patients with hyperphosphatemia receiving hemodialysis. METHODS:In this prospective, open-label, randomized, active-controlled study, 70 patients (38 men and 32 women) with hyperphosphatemia (serum phos...

    journal_title:Renal failure

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/08860220600925388

    authors: Liu YL,Lin HH,Yu CC,Kuo HL,Yang YF,Chou CY,Lin PW,Liu JH,Liao PY,Huang CC

    更新日期:2006-01-01 00:00:00

  • Ten years' experience in subtotal parathyroidectomy of hemodialysis patients.

    abstract::Secondary hyperparathyroidism (SHP) is a frequent complication of long-term dialysis patients, and surgical parathyroidectomy remains necessary in patients resistant to medical therapy. The present paper reports single center results in subtotal parathyroidectomy, presenting diagnostic procedure, indications for parat...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:

    authors: Jovanovic DB,Pejanovic S,Vukovic L,Djukanovic L,Jankovic R,Kalezic N,Paunovic I,Zivaljevic V

    更新日期:2005-01-01 00:00:00

  • Endothelial function and oxidative stress in chronic kidney disease of varying severity and the effect of acute hemodialysis.

    abstract:AIM:Oxidative stress (OS) and endothelial dysfunction are implicated in accelerated atherosclerosis in chronic kidney disease (CKD). We assessed endothelial function, OS, and carotid intimal medial thickness (CIMT) and their correlates in 44 CKD stage 5 patients (group III) before and after hemodialysis (HD), 40 patien...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2011.568138

    authors: Khaira A,Mahajan S,Kumar A,Saraya A,Tiwari SC,Prakash S,Gupta A,Bhowmik D,Agarwal SK

    更新日期:2011-01-01 00:00:00

  • Intermittent hirudin versus continuous heparin for anticoagulation in continuous renal replacement therapy.

    abstract:BACKGROUND:Besides possible bleeding complications a further problem in anticoagulation during continuous renal replacement therapy (CRRT) is the development of heparin-induced thrombocytopenia type II (HIT II) where further anticoagulation with heparin is contraindicated. The application of continuous hirudin as alter...

    journal_title:Renal failure

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1081/jdi-120039529

    authors: Hein OV,von Heymann C,Diehl T,Ziemer S,Ronco C,Morgera S,Siebert G,Kox WJ,Neumayer HH,Spies C

    更新日期:2004-05-01 00:00:00

  • The role of mitofilin in left ventricular hypertrophy in hemodialysis patients.

    abstract::Left ventricular hypertrophy (LVH) is a common abnormality in hemodialysis (HD) patients. Mitochondrial dysfunction contributes to the progression of LVH. As an inner mitochondrial membrane structural protein, mitofilin plays a key role in maintaining mitochondrial structure and function. The aim of this study was to ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2018.1456455

    authors: Wu QS,He Q,He JQ,Chao J,Wang WY,Zhou Y,Lou JZ,Kong W,Chen JF

    更新日期:2018-11-01 00:00:00

  • Malnutrition in the elderly patient on dialysis.

    abstract::Approximately one-third of all dialysis patients have mild to moderate malnutrition, while 6-8% have severe malnutrition, which is associated with increased morbidity and mortality rates and numerous pre-existing factors directly correlated with, or existing prior to, replacement hemodialysis. However, moderate to sev...

    journal_title:Renal failure

    pub_type: 杂志文章,评审

    doi:10.1080/08860220802669891

    authors: Lacquaniti A,Bolignano D,Campo S,Perrone C,Donato V,Fazio MR,Buemi A,Sturiale A,Buemi M

    更新日期:2009-01-01 00:00:00

  • Association between MPO-463G > A polymorphism and chronic kidney disease: a meta-analysis.

    abstract:BACKGROUND/OBJECTIVE:Previous studies have shown that MPO -463G > A (rs2333227) might be associated with chronic kidney disease (CKD) susceptibility, but sample sizes of those studies are relatively small. Hence, we decided to perform a meta-analysis to evaluate the association. Methods/main results: Two investigators ...

    journal_title:Renal failure

    pub_type: 杂志文章,meta分析

    doi:10.1080/0886022X.2018.1499529

    authors: Qin J,Xing J,Li W,Zhang K,Wu Z

    更新日期:2018-11-01 00:00:00

  • Efficacy of adefovir dipivoxil combined with a corticosteroid in 38 cases of nephrotic syndrome induced by hepatitis B virus-associated glomerulonephritis.

    abstract:OBJECTIVE:To investigate the treatment efficacy of adefovir dipivoxil combined with a corticosteroid on hepatitis B virus-associated glomerulonephritis (HBV-GN). METHODS:A total of 38 patients with nephrotic syndrome induced by HBV-GN were treated for 36 weeks between 2010 and 2012. RESULTS:The efficacy analysis show...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2014.952745

    authors: Li H,Yuan X,Qiu L,Zhou Q,Xiao P

    更新日期:2014-10-01 00:00:00

  • Continuous arteriovenous hemodiafiltration in the acute treatment of hyperammonaemia due to ornithine transcarbamylase deficiency.

    abstract:BACKGROUND:Acute hyperammonemia caused by urea cycle disorder is a medical emergency for which immediate managements should be taken to minimize permanent brain damage. Among different enzyme defects, ornithine transcarbamylase deficiency (OTC) is one of the most common enzyme defect in urea cycle disorders. We utilize...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1081/jdi-100101968

    authors: Chen CY,Chen YC,Fang JT,Huang CC

    更新日期:2000-11-01 00:00:00

  • Low-dose IL-2 expands CD4+ regulatory T cells with a suppressive function in vitro via the STAT5-dependent pathway in patients with chronic kidney diseases.

    abstract:BACKGROUND:Patients with chronic kidney disease (CKD) often have CD4+ regulatory T cells (Tregs) dysfunction and chronic inflammation. We aim to investigate the effect, function, and related mechanism of low-dose IL-2 on CD4+ regulatory T cells expansion in vitro from patients with CKD. METHODS:A total of 148 newly di...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2018.1456462

    authors: Li Y,Liu X,Wang W,Wang S,Zhang J,Jiang S,Wang Y,Li L,Li J,Zhang Y,Huang H

    更新日期:2018-11-01 00:00:00

  • End-stage renal disease and its treatment in Latin America in the twenty-first century.

    abstract::The Latin American Society of Nephrology and Arterial Hypertension's Dialysis and Transplant Registry was chartered in 1991. It collects information on ESRD and its treatment in 20 countries of the region. The prevalence of patients on renal replacement therapy (RRT) increased from 129 pmp in 1992 to 447 pmp in 2004; ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220600925693

    authors: Cusumano A,Garcia-Garcia G,Di Gioia C,Hermida O,Lavorato C,Carreño CA,Torrico MP,Batista PB,Romão JE,Badal HP,Miranda SE,Gomez R,Calderon MC,Sanchez SH,Lopez MA,Moscoso J,Merino RL,Polo JV,Lopez A,Romero NJ,Garcia

    更新日期:2006-01-01 00:00:00

  • Proteomic analysis of peritoneal dialysate fluid in patients with dialysis-related peritonitis.

    abstract::The prognosis of uremia patients on continuous ambulatory peritoneal dialysis (CAPD) is related to frequent peritonitis rate. Frequent peritonitis will lead to peritoneum failure, making CAPD unfeasible. We have performed proteomic profiling of peritoneal dialysis effluent samples from a cross-section of CAPD patients...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220802248969

    authors: Lin WT,Tsai CC,Chen CY,Lee WJ,Su CC,Wu YJ

    更新日期:2008-01-01 00:00:00

  • Relationships between brain natriuretic peptide, troponin I and QT dispersion in asymptomatic dialysis patients.

    abstract:OBJECTIVES:The relationships between increased wall stress, myocyte death, and ventricular repolarization instability in patients with heart failure were reported. DESIGN AND METHODS:The relationships between brain natriuretic peptide (BNP), a predictor of increased wall stress of hearth; troponin I (cTnI), a predicto...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220601098953

    authors: Taskapan MC,Taskapan H,Ulutas O,Orhan M,Sahin I

    更新日期:2007-01-01 00:00:00