The role of mitofilin in left ventricular hypertrophy in hemodialysis patients.

Abstract:

:Left ventricular hypertrophy (LVH) is a common abnormality in hemodialysis (HD) patients. Mitochondrial dysfunction contributes to the progression of LVH. As an inner mitochondrial membrane structural protein, mitofilin plays a key role in maintaining mitochondrial structure and function. The aim of this study was to investigate the relationship between mitofilin and LVH in HD patients. A total of 98 HD patients and 32 healthy controls were included in the study. Serum N-terminal proBNP (NT-proBNP), endothelin-1 (ET-1), and atrial natriuretic peptide (ANP) were examined. The protein level of mitofilin and the mitochondrial DNA (mtDNA) copy number were estimated in peripheral blood mononuclear cells (PBMCs). The left ventricle mass index (LVMI) was evaluated in all participants, and the interaction between these variables and the LVMI was assessed. The LVMI was positively correlated with the NT-proBNP, ET-1, and ANP levels, and it was negatively correlated with mtDNA copy number and mitofilin levels. Multiple regression analysis showed that the NT-proBNP, ET-1, and ANP levels as well as mitofilin levels and mtDNA copy number were associated with the LVMI. Although further research of these associations is needed, this result suggests that LVH may affect the levels of mitofilin in HD patients.

journal_name

Ren Fail

journal_title

Renal failure

authors

Wu QS,He Q,He JQ,Chao J,Wang WY,Zhou Y,Lou JZ,Kong W,Chen JF

doi

10.1080/0886022X.2018.1456455

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

252-258

issue

1

eissn

0886-022X

issn

1525-6049

journal_volume

40

pub_type

杂志文章
  • Outcomes and APACHE II predictions for critically ill patients with acute renal failure requiring dialysis.

    abstract:BACKGROUND:Despite the widespread availability of dialytic and intensive care unit technology, the probability of early mortality in critically ill patients with acute renal failure (ARF) is still high, and the evaluation of the patients' prognosis has been difficult. The Acute Physiology and Chronic Health Evaluation ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1081/jdi-100001284

    authors: Chen YC,Hsu HH,Kao KC,Fang JT,Huang CC

    更新日期:2001-01-01 00:00:00

  • Transformation from tubulointerstitial nephritis to crescentic glomerulonephritis: an unusual presentation of ANCA-associated renal vasculitis.

    abstract::A 44-year-old man with acute renal failure and antineutrophil cytoplasmic antibodies (ANCA) positivity was described. The first renal biopsy specimen showed tubulointerstitial nephritis (TIN) with normal glomeruli. However, delayed recovery of renal function with low-dose steroid treatment for TIN prompted a second re...

    journal_title:Renal failure

    pub_type: 杂志文章,评审

    doi:10.1080/08860220500531559

    authors: Wen YK,Chen ML

    更新日期:2006-01-01 00:00:00

  • Which parameter is more influential on the development of arteriosclerosis in hemodialysis patients?

    abstract::Arteriosclerosis is characterized by stiffening of arteries. The incremental elastic modulus (Einc) measurement is a good marker of arterial wall stiffness. Metabolic, inflammatory and hemodynamic alterations cause structural changes and vascular complications in end stage renal disease. The aim of the present study w...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1081/jdi-120026036

    authors: Seyrek N,Balal M,Karayaylali I,Paydaş S,Aikimbaev K,Cetiner S,Seydaoglu G

    更新日期:2003-11-01 00:00:00

  • Therapeutic use of the natriuretic peptide ularitide in acute renal failure.

    abstract:BACKGROUND:Ularitide is a member of the natriuretic peptide family. This hormone exhibits an N-terminal extension by four amino acids compared with atrial natriuretic peptide. Ularitide was shown to exert strong diuretic and natriuretic effects when infused intravenously. Its main action sites are the glomerulum, induc...

    journal_title:Renal failure

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.3109/08860229909066972

    authors: Meyer M,Pfarr E,Schirmer G,Uberbacher HJ,Schöpe K,Böhm E,Flüge T,Mentz P,Scigalla P,Forssmann WG

    更新日期:1999-01-01 00:00:00

  • Long-term effects of small doses of calcitriol in hemodialysis patients with moderate secondary hyperparathyroidism.

    abstract::Prevention of secondary hyperparathyroidism (SHPTH) and treatment of the moderate cases by small p.os doses of Vitamin D has not been thoroughly investigated on the long term, while large doses of Vitamin D have been successful in the short term treatment of this entity. We administered calcitriol p.os 0.5-1.0 microgr...

    journal_title:Renal failure

    pub_type: 临床试验,杂志文章

    doi:10.3109/08860229909066984

    authors: Vlassopoulos D,Noussias C,Revenas K,Hadjilouka-Mantaka A,Arvanitis D,Tzortzis G,Hadjiconstantinou V

    更新日期:1999-03-01 00:00:00

  • Relation between exhaled nitric oxide and left ventricular performance in chronic hemodialysis patients.

    abstract:INTRODUCTION:End-stage renal disease is the most debilitating condition for patients with renal diseases. Cardiovascular disease is the leading cause of death in these patients. It has been shown that nitric oxide (NO) increases in renal failure and hemodialysis patients and could be correlated with cardiovascular dise...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2013.830225

    authors: Ansarin K,Toufan M,Namdar H,Etemadi J,Habibzadeh A,Valinejad M,Shoja MM,Ghabili K

    更新日期:2014-02-01 00:00:00

  • Intensification of peritoneal dialysis improves valacyclovir neurotoxicity.

    abstract::Valacyclovir induced neurotoxicity is a life-threatening complication, usually starting 24-48 h after drug-peak serum concentrations. The elderly with impaired renal function seem to be the most susceptible group to valacyclovir neurotoxicity. Although hemodialysis is considered the best method for rapid drug removal,...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2012.743914

    authors: Pipili C,Pantelias K,Deda E,Tsiamalos P,Kostis E,Grapsa E

    更新日期:2013-01-01 00:00:00

  • Retroperitoneal fibrosis secondary to different etiologies (hemilaminectomy and hypothyroidism): reports of two cases.

    abstract::Retroperitoneal fibrosis (RF) is a clinical entity characterized by the progressive proliferation of connective tissue that rarely forms a mass involving the periaortic area of the abdomen, which may be idiopathic as well as a result of an inflammatory process after aneurysmal dilatation of the aorta. This fibrotic ti...

    journal_title:Renal failure

    pub_type: 杂志文章,评审

    doi:10.1080/08860220701392322

    authors: Dişel U,Alpay NR,Paydas S

    更新日期:2007-01-01 00:00:00

  • Toward the optimal clinical use of the fraction excretion of solutes in oliguric azotemia.

    abstract::While the fractional excretion of solutes have long been considered excellent research tools to investigate tubular physiology, their clinical use has become common over the last 40 years in the diagnoses of many disorders; however, none have reached the clinical utility of the fractional excretion of sodium in the ab...

    journal_title:Renal failure

    pub_type: 杂志文章,评审

    doi:10.3109/0886022X.2010.517353

    authors: Diskin CJ,Stokes TJ,Dansby LM,Radcliff L,Carter TB

    更新日期:2010-01-01 00:00:00

  • Invasive and innovative nephrology.

    abstract:BACKGROUND:A nephrologist in the millennium offers comprehensive care to renal failure patients. Interventional nephrology plays a major role in this new approach. Overton Brooks Veterans Affairs Medical Center (OBVAMC) is the first federal health care provider in the nation offering such services. Lack of intervention...

    journal_title:Renal failure

    pub_type: 杂志文章,评审

    doi:

    authors: Vachharajani TJ,Atray NK

    更新日期:2005-01-01 00:00:00

  • Inhibitory factors of serum opsonic activity in serum from patients with chronic renal failure.

    abstract::We investigated the mechanism of impaired serum opsonic activity in patients suffering from chronic renal failure (CRF). Prehemodialysis pooled serum from CRF patients was fractionated using Sephadex G-50 gel chromatography, and the effects of the obtained fractions on serum opsonic activity were examined using lumino...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229709026268

    authors: Kikuchi T,Nigawara K,Sugawara K,Nakaji S,Abe T,Satoh H

    更新日期:1997-01-01 00:00:00

  • Novel lncRNA XLOC_032768 protects against renal tubular epithelial cells apoptosis in renal ischemia-reperfusion injury by regulating FNDC3B/TGF-β1.

    abstract::Renal ischemia-reperfusion injury is a leading cause of acute kidney injury, but its underlying mechanism remains poorly understood and effective therapies are still lacking. Here, we identified lncRNA XLOC_032768 as a novel target in renal ischemia-reperfusion injury by analyzing differentially expressed genes of the...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2020.1818579

    authors: Zhou X,Li Y,Wu C,Yu W,Cheng F

    更新日期:2020-11-01 00:00:00

  • Valvular calcification and left ventricular modifying in peritoneal dialysis patients.

    abstract:BACKGROUND:Cardiac valve calcification (CVC) and left ventricular (LV) alterations are frequent complication in end-stage renal disease (ESRD). We determined the prevalence of CVC and LV hypertrophy (LVH) in ESRD patients before renal replacement therapy and 12 months after peritoneal dialysis (PD). METHODS:A prospect...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2015.1073495

    authors: Rebić D,Rašić S,Hamzić-Mehmedbašić A,Džemidžić J,Kurtalić E

    更新日期:2015-01-01 00:00:00

  • Cytomegalovirus disease in renal transplant recipients: a single-center experience.

    abstract:UNLABELLED:Cytomegalovirus (CMV) disease is an important complication and an independent risk factor for acute rejection and recipient morbidity-mortality. The aim of this study was to review the results of CMV disease in renal transplant recipients. METHOD:We have retrospectively analyzed CMV disease in 120 renal tra...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220802064705

    authors: Cavdar C,Celtik A,Saglam F,Sifil A,Atila K,Celik A,Tosun P,Olmuscelik O,Bora S,Gulay H,Camsari T

    更新日期:2008-01-01 00:00:00

  • Can delivery dialysis dose affect survival of acute kidney injury patients?

    abstract:UNLABELLED:Intensity of dialysis dose in acute kidney injury (AKI) might benefit critically ill patients. The aim of this study was to evaluate the effect of intermittent hemodialysis (IHD) dose on mortality in patients with AKI. METHODS:Prospective observational study was performed on AKI patients treated with IHD. T...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2012.697444

    authors: Abrão JM,Ponce D,de Brito GA,Balbi AL

    更新日期:2012-01-01 00:00:00

  • Aquaporin-2 as a biomarker of distal renal tubular function using lithium as an experimental model.

    abstract::Aquaporin-2 protein levels can be detected in the urine of normal of subjects if measured after fluid deprivation. By contrast, in patients with nephrogenic diabetes insipidus caused by mutations in the aquaporin-2 gene, urine aquaporin-2 protein excretion cannot be detected. We propose that properly standardized meas...

    journal_title:Renal failure

    pub_type: 杂志文章,评审

    doi:10.3109/08860229909085095

    authors: Sisson D,Batlle D

    更新日期:1999-05-01 00:00:00

  • Specific alterations in gut microbiota in patients with chronic kidney disease: an updated systematic review.

    abstract:BACKGROUND:Emerging evidence demonstrates that gut dysbiosis is implicated in the pathogenesis of chronic kidney disease (CKD) with underlying mechanisms involving mucosal and/or systematic immunity or metabolic disorders. However, the profile of gut microbiota in patients with CKD has not been completely explored. ME...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2020.1864404

    authors: Zhao J,Ning X,Liu B,Dong R,Bai M,Sun S

    更新日期:2021-12-01 00:00:00

  • FK 506 reduces the injury experienced following renal ischemia and reperfusion.

    abstract::The effect of FK 506 pretreatment on renal ischemia and reperfusion (I/R) injury was investigated. Adult male rats were assigned to one of two groups (20 animals each). Group 1 (controls) received 0.5 mL saline while group 2 received FK 506 (0.3 mg/kg) intravenously 24 h prior to the induction of renal ischemia. After...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229209106630

    authors: Van Thiel DH,Sakr M,Zetti G,McClain C

    更新日期:1992-01-01 00:00:00

  • Evaluation of the protective effect of agmatine against cisplatin nephrotoxicity with 99mTc-DMSA renal scintigraphy and cystatin-C.

    abstract:BACKGROUND:The aim of the current study was to investigate whether agmatine (AGM) has a protective effect against cisplatin-induced nephrotoxicity. MATERIALS AND METHODS:Thirty-two rats were randomly divided into four groups: (1) Saline (control); (2) Cisplatin (CDDP; 7.5 mg/kg intraperitoneally); (3) Agmatine (AGM; 1...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2016.1227919

    authors: Salihoglu YS,Elri T,Gulle K,Can M,Aras M,Ozacmak HS,Cabuk M

    更新日期:2016-10-01 00:00:00

  • Acute renal failure due to nontraumatic rhabdomyolysis following binge drinking.

    abstract::Nontraumatic rhabdomyolysis is an important but under-recognized cause of acute renal failure. In alcoholics, rhabdomyolysis most frequently develop following muscle necrosis during alcohol-induced coma, but has also been described rarely in those without prolonged coma or seizures. We describe a patient who developed...

    journal_title:Renal failure

    pub_type: 杂志文章,评审

    doi:10.3109/08860229909045195

    authors: Muthukumar T,Jha V,Sud A,Wanchoo A,Bambery P,Sakhuja V

    更新日期:1999-09-01 00:00:00

  • Hypocomplementemia is associated with more severe renal disease and worse renal outcomes in patients with ANCA-associated vasculitis: a retrospective cohort study.

    abstract:BACKGROUND:The complement system has been recently proposed to play an important role in the pathogenesis of ANCA-associated vasculitis (AAV). This study evaluated the value of serum and kidney deposited C3 in predicting renal outcomes in AAV. METHODS:This was a retrospective study of 47 patients with AAV, who were ca...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2020.1803086

    authors: Chalkia A,Thomas K,Giannou P,Panagiotopoulos A,Hadziyannis E,Kapota A,Gakiopoulou H,Vassilopoulos D,Petras D

    更新日期:2020-11-01 00:00:00

  • The role of erythrocytes phosphatidylserine exposure in anemia in peritoneal dialysis patients.

    abstract:BACKGROUND:An increased red blood cell (RBC) phosphatidylserine (PS) exposure in uremic patients was found that could promote macrophage recognition and decrease RBC survival time. Furthermore, a reduced red cell life span was found to contribute anemia in patients with renal failure. It is therefore possible to hypoth...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220600839647

    authors: Bi SH,Cheng LT,Wang T

    更新日期:2006-01-01 00:00:00

  • Effects of a stroma-free hemoglobin and perfluorochemical combination on ultrastructure and function of the isolated rat kidney.

    abstract::Experimental perfusions of isolated rat kidneys were performed with flow rates adjusted to produce comparable glomerular filtration rates (GFR) in control and experimental groups. The experimental perfusate, consisting of Krebs-Ringer bicarbonate (KRB) containing 3.5% (uncrosslinked) stroma-free hemoglobin (SFH) plus ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229509037635

    authors: Millis RM,Barber JD,Anderson WA,Dehkordi O

    更新日期:1995-11-01 00:00:00

  • Morphine enhances renal cell carcinoma aggressiveness through promotes survivin level.

    abstract:BACKGROUND:Morphine is an opioid analgesic drug often used for pain relief in cancer patients. However, there is growing evidence that morphine may modulate tumor growth, progression and metastasis. Unfortunately, the results obtained by these studies are still contradictory. METHODS:In this study, we investigated the...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2016.1256322

    authors: Ma Y,Ren Z,Ma S,Yan W,He M,Wang D,Ding P

    更新日期:2017-11-01 00:00:00

  • The influence of mutant lactobacilli on serum creatinine and urea nitrogen concentrations and renal pathology in 5/6 nephrectomized rats.

    abstract:OBJECTIVES:To explore the capacity of mutant lactobacilli to remove creatinine (Cr) and urea nitrogen (UN) via the gastrointestinal tract and its effects on renal pathology in the 5/6 nephrectomized rat model of chronic renal failure. METHODS:Sixty Sprague-Dawley rats were randomly divided into a Sham group, a Model g...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2016.1227617

    authors: Wang F,Jiang YS,Liu F

    更新日期:2016-10-01 00:00:00

  • Development of hypertension in a pyelonephritis-induced model: the effect of salt intake and inability of renal sodium handling.

    abstract::The role of the kidney in the control of blood pressure has been convincingly demonstrated by several studies. Recent evidence has suggested that subtle acquired tubulointerstitial injury may cause a defect in sodium excretion function, thus leading to salt-sensitive hypertension. There are no reports, however, examin...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220600779058

    authors: de Magalhães Sartim R,Fantinato Menegon L,de Almeida AR,Rocha Gontijo JA,Aline Boer P

    更新日期:2006-01-01 00:00:00

  • Occult HBV infection in continuous ambulatory peritoneal dialysis and hemodialysis patients.

    abstract:AIM:Occult hepatitis B virus (HBV) infection can be defined as the presence of HBV DNA in the liver and/or blood in the absence of detectable serum hepatitis B surface antigen (HBs Ag). There is a high prevalence of occult HBV infection in dialysis patients. This study investigated the prevalence of occult HBV infectio...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860220903391242

    authors: Sav T,Gursoy S,Torun E,Sav NM,Unal A,Oymak O,Utas C

    更新日期:2010-01-01 00:00:00

  • A biotechnological T-shirt monitors the patient's heart during hemodialysis.

    abstract::Uremic patients are characterized by a "pro-arrhythmic substrate." Arrhythmia appearance during hemodialysis (HD) is an unexpected event with a high incidence of mortality and morbidity and difficult to record in patients repeatedly checked using electrocardiogram (ECG). Furthermore the carrying out of this important ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2012.673530

    authors: Lacquaniti A,Donato V,Lucisano S,Buemi A,Buemi M

    更新日期:2012-01-01 00:00:00

  • Anemia development and cardiovascular risk management in nonanemic stage 3 chronic kidney disease.

    abstract:BACKGROUND/AIM:There is little information on the development of anemia in the early stages of chronic kidney disease. The aim of this study was to analyze the onset of renal anemia in a cohort of initially nonanemic chronic kidney disease patients followed up in nephrology clinics. METHODS:This epidemiological, prosp...

    journal_title:Renal failure

    pub_type: 杂志文章,多中心研究

    doi:10.3109/08860220903216063

    authors: Portolés J,Castelao AM,Gorriz JL,Tato AM,de Alvaro F

    更新日期:2009-01-01 00:00:00

  • Low-dose intravenous iron administration in chronic hemodialysis patients treated with recombinant human erythropoietin.

    abstract::We conducted a prospective study to determine the effect of intravenous low-dose iron administration in chronic hemodialysis patients treated with recombinant human erythropoietin (rHuEPO). Sixteen hemodialysis patients (8 males and 8 females; mean age 63.1+/-9.8 years) on maintenance rHuEPO therapy were included in t...

    journal_title:Renal failure

    pub_type: 临床试验,杂志文章

    doi:10.1081/jdi-120004103

    authors: Harmankaya O,Eran A

    更新日期:2002-03-01 00:00:00