Effects of medical ozone therapy on acetaminophen-induced nephrotoxicity in rats.

Abstract:

:Acetaminophen (APAP), also known as paracetamol, is the commonest cause of toxic ingestion in the world. Because overdose of APAP has life-threatening effects on kidney, treatment of APAP-induced nephrotoxicity has life-saving importance. Aim of the study was to evaluate the efficacy of medical ozone therapy in experimental model of APAP toxication. Twenty-one male Wistar rats (200-250 g) were randomly assigned into three groups containing seven rats each: Sham, control (only APAP treated), and APAP + ozone therapy groups. Rats were killed 48 hours after administration of APAP. Urea, creatinine levels in the blood, and malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) activity in renal tissue were measured. Kidney tissues were stained with hematoxylin and eosin for histological assessment. APAP administration deteriorated the renal functions and significantly elevated renal MDA levels and depleted SOD and GSH-Px activities. Ozone therapy significantly reduced the MDA level, increased the SOD and GSH-Px activities, and normalized the renal histology. In conclusion, our study results are consistent with encouraging data for ozone therapy on APAP-induced nephrotoxicity in rats by improving antioxidant mechanism and oxidative stress.

journal_name

Ren Fail

journal_title

Renal failure

authors

Demirbag S,Uysal B,Guven A,Cayci T,Ozler M,Ozcan A,Kaldirim U,Surer I,Korkmaz A

doi

10.3109/08860221003646352

subject

Has Abstract

pub_date

2010-05-01 00:00:00

pages

493-7

issue

4

eissn

0886-022X

issn

1525-6049

journal_volume

32

pub_type

杂志文章
  • Association of CYP3A variants with kidney transplant outcomes.

    abstract::Cyclosporine is used extensively in kidney transplantation and is a substrate for cytochrome P450 enzymes. The role of cytochrome p450 polymorphisms in kidney transplant outcome has not yet been fully elucidated. We investigate the clinical impact of single nucleotide polymorphisms in CYP3A4, CYP3A5, PPARα, and POR*28...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2015.1007013

    authors: Traynor C,Conlon P Jr,Phelan PJ,O'Kelly P,Elens L,McCormack M,Cavalleri G,Comber H,van Schaik RH,Conlon PJ

    更新日期:2015-05-01 00:00:00

  • Novel lncRNA XLOC_032768 protects against renal tubular epithelial cells apoptosis in renal ischemia-reperfusion injury by regulating FNDC3B/TGF-β1.

    abstract::Renal ischemia-reperfusion injury is a leading cause of acute kidney injury, but its underlying mechanism remains poorly understood and effective therapies are still lacking. Here, we identified lncRNA XLOC_032768 as a novel target in renal ischemia-reperfusion injury by analyzing differentially expressed genes of the...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2020.1818579

    authors: Zhou X,Li Y,Wu C,Yu W,Cheng F

    更新日期:2020-11-01 00:00:00

  • Renal cortical necrosis is a disappearing entity in obstetric acute kidney injury in developing countries: our three decade of experience from India.

    abstract:RATIONAL:Obstetrical complications are the commonest causes of Renal Cortical Necrosis (RCN). However, the overall incidence of RCN in obstetric acute kidney injury in developing countries has been decreasing in recent years. OBJECTIVE:The aim of this study was to evaluate the changing profile of RCN in obstetric AKI ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2015.1062340

    authors: Prakash J,Pant P,Singh AK,Sriniwas S,Singh VP,Singh U

    更新日期:2015-08-01 00:00:00

  • Differences in new-onset IgA nephropathy between young adults and the elderly.

    abstract:BACKGROUND:The goal of this study was to define the clinical and histological differences in new-onset IgA nephropathy between young adults and the elderly. METHODS:We retrospectively examined renal biopsy findings, clinical features at presentation and outcomes in 82 young adults (mean age 30.3+/-10.2 years) and 17 e...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860221003611687

    authors: Wen YK,Chen ML

    更新日期:2010-01-01 00:00:00

  • Spectrum of liver damage and correlation with clinical and laboratory parameters in HCV infected hemodialysis patients.

    abstract::There are conflicting results in studies concerning the best marker for liver histopathological features of HCV infection in HD patients. We planned a prospective study to follow HCV viremia and laboratory parameters of HD patients and correlate these with clinic features and histopathological findings. We included 68...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1081/jdi-100108192

    authors: Sezer S,Ozdemir BH,Arat Z,Turan M,Ozdemir NF,Haberal M

    更新日期:2001-11-01 00:00:00

  • Genomic distribution of 5-Hydroxymethylcytosine in mouse kidney and its relationship with gene expression.

    abstract::Ten-Eleven Translocation (TET) proteins oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytonsie (5hmC). Our recent work found a decline in global 5hmC level in mouse kidney insulted by ischemia reperfusion (IR). However, the genomic distribution of 5hmC in mouse kidney and its relationship with gene expression remai...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2016.1172973

    authors: Wang H,Huang N,Liu Y,Cang J,Xue Z

    更新日期:2016-07-01 00:00:00

  • Platelet parameters in children with upper urinary tract infection: is there a specific response?

    abstract::Although complete blood count is routinely ordered in most upper urinary tract infections (UTI), and information regarding the patient's platelet indices is made available without added cost, the relationship between platelet count and mean platelet volume (MPV) and specific platelet responses to different infectious ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220801947389

    authors: Catal F,Bavbek N,Bayrak O,Uz E,Isik B,Karabel M,Degirmencioglu H,Mete E,Akcay A

    更新日期:2008-01-01 00:00:00

  • Characterization of gentamicin-induced dysfunctions in vitro: the use of optimized primary cultures of rabbit proximal tubule cells.

    abstract::Compared to prior studies which frequently pinpoint the impairment of one parameter or function, this paper reports for the first time an extensive characterization of the toxic effects of gentamicin in a single model of primary cultured rabbit proximal tubule cells developed without insulin and glucose. Biochemical, ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229309054962

    authors: Monteil C,Leclere C,Fillastre JP,Morin JP

    更新日期:1993-01-01 00:00:00

  • Growth factors in metanephric development.

    abstract::During embryonic life, renal morphogenesis is characterized by a defined period of intense cellular activity, inductive-transformation of undifferentiated cells to polarized epithelia, in-growth of capillaries into an intricate parenchymal epithelial-mesenchymal mass, and finally the maturation into an organ with dive...

    journal_title:Renal failure

    pub_type: 杂志文章,评审

    doi:10.3109/08860229809045119

    authors: Wallner EI,Kumar A,Carone FA,Kanwar YS

    更新日期:1998-03-01 00:00:00

  • Influenza vaccination in chronic hemodialysis patients. The effect of zinc supplementation.

    abstract::Since influenza increases the mortality of chronically ill patients we decided to study the effectiveness of influenza vaccination in hemodialysis (HD) patients. Nineteen HD patients aged from 20 to 60 years, on unrestricted diet and with no febrile episode, were studied. Blood samples were collected before the intram...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229209047668

    authors: Grekas D,Alivanis P,Kotzadamis N,Kiriazopoulou V,Pyrpasopoulos M,Tourkantonis A

    更新日期:1992-01-01 00:00:00

  • Urinary transforming growth factor-beta1 excretion in renal allograft recipients during the early post-transplantation period.

    abstract:BACKGROUND:Transforming growth factor-beta1 (TGF-beta1), the major fibrogenic growth factor, is implicated in the pathogenesis of renal scarring in experimental and clinical nephropathies as well as in chronic allograft nephropathy. In this study we examined the pattern of changes of TGF-beta1 excretion in the urine an...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1081/jdi-120022547

    authors: Goumenos DS,Tsakas S,Karavias D,Savidaki I,Karatzas T,Vlachojannis JG

    更新日期:2003-07-01 00:00:00

  • Postpartum acute kidney injury: a review of 99 cases.

    abstract::Postpartum acute kidney injury (PPAKI) constitutes an important cause of obstetric AKI. It is associated with high maternal and fetal mortality in developing nations. The aim of this study is to survey the etiology and outcomes of PPAKI in a tertiary care Indian hospital. Ninety-nine patients, without prior comorbidit...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2016.1164015

    authors: Eswarappa M,Madhyastha PR,Puri S,Varma V,Bhandari A,Chennabassappa G

    更新日期:2016-07-01 00:00:00

  • Inhibition to DRP1 translocation can mitigate p38 MAPK-signaling pathway activation in GMC induced by hyperglycemia.

    abstract::Diabetic nephropathy (DN) is a serious complication of diabetes with a poorly defined etiology and limited treatment options. Early intervention is a key to preventing the progression of DN. Dynamin-related protein 1 (DRP1) regulates mitochondrial morphology by promoting its fission and is involved in the pathogenesis...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2015.1034607

    authors: Zhang L,Ji L,Tang X,Chen X,Li Z,Mi X,Yang L

    更新日期:2015-06-01 00:00:00

  • Event- and time-based prospective memory in hemodialysis patients.

    abstract:OBJECTIVE:The present study investigated whether hemodialysis (HD) patients exhibit future memory impairment (PM; the capability of remembering to perform expected future actions) and exploring relevant factors of PM task performance. METHODS:Sixty HD patients and 60 healthy controls matched by age are enrolled in the...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2020.1835673

    authors: Wang B,Li M,Tang F,Wang Y,Han Y,Lu W,Zhang L,Zhang L,Ni W,Zhang L,Zhang L

    更新日期:2020-11-01 00:00:00

  • An unusual cause of focal segmental glomerulosclerosis: psoriasis vulgaris.

    abstract::Psoriasis, being limited to the skin, is generally a chronic inflammatory disorder. Several glomerular diseases have been distinguished due to renal histological findings of psoriatic patients to date. The underlying pathogenetic mechanisms of these associations remain unclear because of the limited number of cases. W...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860221003778072

    authors: Ceri M,Kurultak I,Unverdi S,Altay M,Duranay M

    更新日期:2010-06-01 00:00:00

  • The effects of spironolactone on nephron function in patients with diabetic nephropathy.

    abstract::Increasing evidence suggests that circulating aldosterone per se contributes directly to renal and cardiovascular diseases. We sought to evaluate the effects of a three-month treatment with 25 mg spironolactone, an aldosterone receptor antagonist, on nephron function in 20 type II diabetic patients with persistent mic...

    journal_title:Renal failure

    pub_type: 临床试验,杂志文章

    doi:10.1080/08860220802389342

    authors: Ustundag A,Tugrul A,Ustundag S,Sut N,Demirkan B

    更新日期:2008-01-01 00:00:00

  • Coexisting glomerular IgA deposition and IgG-kappa multiple myeloma.

    abstract::Multiple myeloma (MM) is a common malignancy that often results in many kinds of kidney injuries for the abnormal monoclonal immunoglobulin. Here, we present an IgG-kappa type MM case accompanied by renal IgA deposition combined with IgG-kappa. The patient was treated with prednisone plus mycophenolate mofetil, and go...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2014.930656

    authors: Wang F,Xing T,Li J,Zhang ZG,Wang N

    更新日期:2014-09-01 00:00:00

  • Ten years' experience in subtotal parathyroidectomy of hemodialysis patients.

    abstract::Secondary hyperparathyroidism (SHP) is a frequent complication of long-term dialysis patients, and surgical parathyroidectomy remains necessary in patients resistant to medical therapy. The present paper reports single center results in subtotal parathyroidectomy, presenting diagnostic procedure, indications for parat...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:

    authors: Jovanovic DB,Pejanovic S,Vukovic L,Djukanovic L,Jankovic R,Kalezic N,Paunovic I,Zivaljevic V

    更新日期:2005-01-01 00:00:00

  • Higher urine heat shock protein 70/creatinine ratio in type 1 diabetes mellitus.

    abstract::Insidious progressive renal damage caused by type 1 diabetes mellitus (T1DM) begins in childhood before it becomes manifest in adult ages. Heat shock proteins (HSPs) regulate the cell response to any hazardous factors to prevent cell structure. The aim of the study is to determine whether urine levels of HSPs increase...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2015.1136893

    authors: Yilmaz A,Gedikbasi A,Yuruk Yildirim Z,Pehlivanoglu C,Seker B,Sucu A,Bundak R,Emre S

    更新日期:2016-01-01 00:00:00

  • Rhabdomyolysis and acute renal failure following cardioversion and cardiopulmonary resuscitation.

    abstract::A 39-year-old male suffered a myocardial infarction at work and cardiopulmonary resuscitation was initiated immediately. After 15 cardioversions, ventricular fibrillation converted to sinus rhythm. Rhabdomyolysis with a 100-fold increase of serum creatine kinase level and myoglobinuria with acute renal failure ensued,...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229509037645

    authors: Hojs R,Sinkovic A,Hojs-Fabjan T

    更新日期:1995-11-01 00:00:00

  • Evaluation of relationship between sexual functions, depression and quality of life in patients with chronic kidney disease at predialysis stage.

    abstract:AIM:The relation of chronic kidney disease (CKD) with metabolic, psychiatric and endocrinologic disorder is well-known. Depressive mood and sexual dysfunction are frequently observed as renal functions deteriorate. We aimed to analyze the relationship of sexual dysfunction, depressive mood and life quality in patients ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2014.990348

    authors: Esen B,Kahvecioglu S,Atay AE,Ozgen G,Okumus MM,Seyahi N,Sit D,Kadioglu P

    更新日期:2015-03-01 00:00:00

  • Unilateral renal venous thrombosis secondary to the use of vibration belt in a young woman.

    abstract::We report on the isolated unilateral renal venous thrombosis (RVT) detected in a young patient who used vibration belt to stay thin. Apart from her sickle cell trait, the patient presented no other clinical situations associated with RVT. ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2012.712848

    authors: Balal M,Paydas S,Inal M

    更新日期:2012-01-01 00:00:00

  • miR-15a-5p suppresses peritoneal fibrosis induced by peritoneal dialysis via targeting VEGF in rats.

    abstract:AIM:When peritoneal fibrosis (PF) causes ultrafiltration failure in peritoneal dialysis (PD) patients, PD has to be discontinued. Currently, there is no effective way to relieve PF. In this study, we aimed to determine whether miR-15a-5p is involved in PF and to determine the underlying mechanism. METHODS:Six normal r...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2020.1811123

    authors: He Q,Wen L,Wang L,Zhang Y,Yu W,Zhang F,Zhang W,Xiao J,Wen X,Zhao Z

    更新日期:2020-11-01 00:00:00

  • Regeneration of peritoneal mesothelium in a rat model of peritoneal fibrosis.

    abstract:BACKGROUND:Patients on long-term peritoneal dialysis develop progressive peritoneal fibrosis and loss of mesothelial layer. Regeneration of the mesothelium has been reported in the normal peritoneum but not the fibrotic peritoneum. Moreover, the origin of the regenerated mesothelial cells remains obscure. The aim of th...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220701741619

    authors: Nishioka Y,Miyazaki M,Abe K,Furusu A,Harada T,Ozono Y,Taguchi T,Koji T,Kohno S

    更新日期:2008-01-01 00:00:00

  • External dilator-assisted banding for high-flow hemodialysis arteriovenous fistula.

    abstract::Creation of arteriovenous fistula (AVF) may lead to left ventricle hypertrophy and predispose for development or worsening of heart failure. It was postulated to reduce access blood flow if exceeded 2 L/min or cardiac index was higher than 3.0 L/min/m(2). Numbers of techniques decreasing flow were described. The major...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2016.1184936

    authors: Letachowicz K,Kusztal M,Gołębiowski T,Letachowicz W,Weyde W,Klinger M

    更新日期:2016-08-01 00:00:00

  • Fasudil ameliorates rhabdomyolysis-induced acute kidney injury via inhibition of apoptosis.

    abstract::During times of war or natural disasters, rhabdomyolysis leading to acute kidney injury (AKI) can assume epidemic proportions. Fasudil attenuates ischemia/reperfusion-induced AKI. We investigated the therapeutic effect of an early application of fasudil on AKI induced by rhabdomyolysis and explored the potential mecha...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2011.601830

    authors: Wang YD,Zhang L,Cai GY,Zhang XG,Lv Y,Hong Q,Shi SZ,Yin Z,Liu XF,Chen XM

    更新日期:2011-01-01 00:00:00

  • Role of ticlopidine on adriamycin-induced nephropathy.

    abstract::The effect of ticlopidine on rats with adriamycin nephropathy was observed during 26 weeks. In the ticlopidine-treated nephrotic animals (TNG), proteinuria was less than in the untreated nephrotic animals (NG), but this difference was significant only at week 6 (TNG = 47.27 +/- 16.52 versus NG = 100.08 +/- 13.83 mg/24...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229909045185

    authors: Riyuzo MC,Soares VA

    更新日期:1999-09-01 00:00:00

  • Protection of Tanshinone IIA to human peritoneal mesothelial cells (HPMC) through delaying cellular senescence induced by high glucose.

    abstract:BACKGROUND:Long-term peritoneal exposure to high glucose in the peritoneal dialysis (PD) solution may potentiate the development of peritoneal fibrosis in PD patients. The most important factor leading to peritoneal fibrosis may be injury of human peritoneal mesothelial cells (HPMC). Little is known about senescence of...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2011.623497

    authors: Cao D,Zhang M,Jiang C,Xue L,Sun C

    更新日期:2012-01-01 00:00:00

  • Acute kidney injury in patients with pyogenic liver abscess.

    abstract::Incidence of acute kidney injury (AKI) in patients with pyogenic liver abscess is rare. In our study we found AKI in 32.6% of patients with liver abscess. Majority of the patients were in their fifties and sixties. As per acute kidney injury network trial criteria, renal failure was in stage 1 in 26.6%, stage 2 in 40%...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2011.569108

    authors: Sriramnaveen P,Sridhar A,Sandeep Y,Krishnakishore C,Sainaresh V,Manjusha Y,Sivakumar V

    更新日期:2011-01-01 00:00:00

  • Paradoxical body and kidney growth in potassium deficiency.

    abstract::In the growing animal, K deficiency (KD) retards body growth, but paradoxically stimulates renal growth. If KD persists, interstitial infiltrates appear and eventually tubulointerstitial fibrosis develops. In patients with chronic KD, renal cysts may form and with time tubulointerstitial disease with renal failure dev...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1081/jdi-100104718

    authors: Fervenza F,Tsao T,Rabkin R

    更新日期:2001-05-01 00:00:00