Beta2-microglobulin and alpha1-microglobulin as markers of Balkan endemic nephropathy, a worldwide disease.

Abstract:

BACKGROUND: Urine beta2-microglobulin (beta2-MG) was mainly used as a tubular marker of Balkan endemic nephropathy (BEN) but recently alpha1-microglobulin (alpha1-MG) was proposed for the diagnosis of BEN. In this study, the potential of urine beta2-MG, alpha1-MG, albumin, and total protein in the differentiation of BEN from healthy persons and patients with glomerulonephritis (GN) and nephrosclerosis (NS) was examined. METHODS: This study involved 47 patients with BEN, 36 with GN, 11 with NS, 30 healthy subjects from BEN families, and 46 healthy subjects from non-BEN families. RESULTS: In BEN patients area under the curve (AUC) for urine beta2-MG (0.828) and alpha1-MG (0.782) was higher than for urine albumin (0.740), but in GN patients AUC for urine protein (0.854) and albumin (0.872) was significantly higher than for the two low molecular weight proteins. AUC for all four urinary markers in NS patients was significantly lower than in BEN patients, ranging between 500 and 595. Median urine beta2-MG excretion in BEN patients was 17.5 times higher than in GN patients and 18.3 times higher than in controls; median alpha1-MG excretion was higher only 3.0 and 2.25 times, respectively. In the differentiation of BEN from healthy controls, beta2-MG had higher sensitivity and specificity at the cutoff levels (p < 0.001) than alpha1-MG (p < 0.05). In the differentiation of BEN from GN, beta2-MG was the best marker. CONCLUSION: All four urinary markers can be used for the differential diagnosis of BEN, beta2-MG being the best. Like in aristolochic acid nephropathy, beta2-MG seems to be an early marker of tubular damage in BEN.

journal_name

Ren Fail

journal_title

Renal failure

authors

Stefanović V,Djukanović L,Cukuranović R,Bukvić D,Ležaić V,Marić I,Ogrizovic SS,Jovanović I,Vlahovic P,Pešić I,Djordjević V

doi

10.3109/0886022X.2011.552152

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

176-83

issue

2

eissn

0886-022X

issn

1525-6049

journal_volume

33

pub_type

杂志文章
  • Chronic renal disease in Kuwaiti nationals: a prospective study during the past 4 years.

    abstract::Our study is a prospective one conducted at Al-Amiri Hospital and including all new cases of chronic renal disease (CRD) seen at the capital area of Kuwait between 1 January 1999 and 30 December 2003. Diagnosis of CRD was based on clinical, laboratory, and radiological features. Kidney biopsies were done when indicate...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:

    authors: El-Reshaid W,El-Reshaid K,Kapoor M,Hakim A

    更新日期:2005-01-01 00:00:00

  • Posttreatment with aminoguanidine attenuates renal ischemia/reperfusion injury in rats.

    abstract::Acute renal failure secondary to ischemia/reperfusion (I/R) injury is associated with significant mortality and morbidity. Aminoguanidine (AG), an inducible nitric oxide synthase inhibitor with antioxidant properties, has been reported beneficial in renal I/R injury. The aim of the present study was to investigate the...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220802546313

    authors: Onem Y,Ipcioglu OM,Haholu A,Sen H,Aydinoz S,Suleymanoglu S,Bilgi O,Akyol I

    更新日期:2009-01-01 00:00:00

  • Melatonin with 1,25-dihydroxyvitamin D3 protects against apoptotic ischemia-reperfusion injury in the rat kidney.

    abstract::This study was designed to evaluate the preventive role of melatonin (Mel) and 1,25-dihydroxyvitamin D3 (VD3) in biochemical and apoptotic events leading to tissue injury and renal dysfunction after ischemia-reperfusion (I/R). Thirty male Wistar rats were divided into five groups: sham-operated, I/R, Mel + I/R, VD3 + ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2012.700887

    authors: Sinanoglu O,Sezgin G,Ozturk G,Tuncdemir M,Guney S,Aksungar FB,Yener N

    更新日期:2012-01-01 00:00:00

  • Low-dose intravenous iron administration in chronic hemodialysis patients treated with recombinant human erythropoietin.

    abstract::We conducted a prospective study to determine the effect of intravenous low-dose iron administration in chronic hemodialysis patients treated with recombinant human erythropoietin (rHuEPO). Sixteen hemodialysis patients (8 males and 8 females; mean age 63.1+/-9.8 years) on maintenance rHuEPO therapy were included in t...

    journal_title:Renal failure

    pub_type: 临床试验,杂志文章

    doi:10.1081/jdi-120004103

    authors: Harmankaya O,Eran A

    更新日期:2002-03-01 00:00:00

  • Oxidation of albumin is enhanced in the presence of uremic toxins.

    abstract::Albumin has been considered a "sacrificial plasma antioxidant" due to the high reactivity of the protein sulfhydryl groups with oxidants such as hydrogen peroxide (H2O2) and hypochlorous acid (HOCl). Based on its large quantity and high turnover. It is considered as one of the most important plasma antioxidants for pr...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1081/jdi-100104738

    authors: Wratten ML,Sereni L,Tetta C

    更新日期:2001-05-01 00:00:00

  • A reference equation for objectively adjusting dwell volume to obtain more ultrafiltration in daily practice of peritoneal dialysis.

    abstract:OBJECTIVES:Few studies mention how to objectively adjust peritoneal dialysis (PD) dwell volume for adult continuous ambulatory peritoneal dialysis (CAPD) patients. We proposed a reference equation composed of parameters from the peritoneal equilibrium test (PET) for adjusting daily dialysate dwell volume to obtain more...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860220903541127

    authors: Chien CC,Wang HY,Chien TW,Kan WC,Su SB,Lin CY

    更新日期:2010-01-01 00:00:00

  • Relationship of serum cystatin C with C-reactive protein and apolipoprotein A1 in patients on hemodialysis.

    abstract::Cystatin C is considered an indicator of acute renal failure and also a risk factor of cardiovascular disease. This study was undertaken to examine the relationship of serum cystatin C with C-reactive protein (CRP), lipids, and lipid-related compounds in patients on hemodialysis (HD). Cystatin C, CRP, total cholestero...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220802212973

    authors: Samouilidou EC,Grapsa E

    更新日期:2008-01-01 00:00:00

  • Salt sensitivity of blood pressure in non-dialysis patients with chronic kidney disease.

    abstract:BACKGROUND:Chronic kidney disease (CKD) is a world-wide public health problem. Hypertension is both a cause and a complication of CKD, and a risk factor for progression of kidney disease. The effect of salt intake on blood pressure (BP) and the salt sensitivity in non-dialysis patients with CKD were studied. METHODS:O...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2013.866008

    authors: Meng L,Fu B,Zhang T,Han Z,Yang M

    更新日期:2014-04-01 00:00:00

  • Significant correlation between left ventricular systolic and diastolic dysfunction and decreased glomerular filtration rate.

    abstract::Cardiac dysfunction portends a poor prognosis in renal failure and vice versa. Functional abnormalities of heart in patients with renal insufficiency were frequently noted. The aim of this study is to assess the relationship between left ventricular systolic and diastolic function and renal function in patients with v...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2011.618792

    authors: Hsieh MC,Su HM,Wang SY,Tsai DH,Lin SD,Chen SC,Chen HC

    更新日期:2011-01-01 00:00:00

  • Lysosomal iron accumulation in diabetic nephropathy.

    abstract::Iron accumulates within proximal tubular lysosomes in several models of renal disease and may play a role in the progression of proteinuric chronic renal disease by the generation of reactive oxygen species. In this study, tubular iron was examined at an ultrastructural level by energy dispersive x-ray spectrometry in...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229409044877

    authors: Nankivell BJ,Tay YC,Boadle RA,Harris DC

    更新日期:1994-01-01 00:00:00

  • Rhabdomyolysis, acute renal failure, and multiple focal neuropathies after drinking alcohol soaked with centipede.

    abstract::Many Chinese like to drink alcohol soaked with creatures for promoting health. This study reports a 49-year-old male who presented with multiple focal neuropathies of the upper limbs, coagulopathy, erythematous swelling of the bilateral upper extremities and trunk with bullous skin lesions, and rhabdomyolysis associat...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1081/jdi-120028562

    authors: Wang IK,Hsu SP,Chi CC,Lee KF,Lin PY,Chang HW,Chuang FR

    更新日期:2004-01-01 00:00:00

  • Successful use of rituximab in fibrillary glomerulopathy.

    abstract::Fibrillary glomerulopathy (FG) can occur either alone or co-existing with other proteinuric glomerular disorders. FG has been associated with poor renal outcomes leading to End Stage Renal Disease (ESRD). Since FG is a relatively rare disorder, limited information is available concerning treatment protocols. We presen...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2014.918832

    authors: Chaudhary A,Gyamlani G,Cossey NL,Walker PD,Wall BM

    更新日期:2014-08-01 00:00:00

  • Urinary excretion of creatol, an in vivo biomarker of hydroxyl radical, in patients with chronic renal failure.

    abstract::Creatol (CTL) is a hydroxyl radical adduct of creatinine (Cr). The serum methylguanidine (MG) level and the MG/Cr molar ratio are reported to be biomarkers for oxidative stress. The aim of this study was to examine whether urinary excretion of CTL, another oxidative stress-related marker, is increased in patients with...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220701219863

    authors: Ienaga K,Nakamura K,Fujisawa T,Fukunaga Y,Nihei H,Narita M,Tomino Y,Sanaka T,Aoyagi K,Nakano K,Koide H

    更新日期:2007-01-01 00:00:00

  • Relation between urinary cytology abnormalities and cyclosporine A therapy in bone marrow transplant recipients.

    abstract::The aim of the study was to determine the relationship, if any, between abnormalities in urinary cytology and the administration of cyclosporine A in bone marrow transplant recipients. Specific attention was given to the presence of tubular cells with round inclusions (TCRI). Two bone marrow transplant recipient group...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229809045154

    authors: Sucic M,Boban D,Markovic-Glamocak M,Bogdanic V,Nemet D,Labar B,Cvoriscec D,Plavsic F,Stoos-Veic T,Mrsic M

    更新日期:1998-07-01 00:00:00

  • Paradoxical body and kidney growth in potassium deficiency.

    abstract::In the growing animal, K deficiency (KD) retards body growth, but paradoxically stimulates renal growth. If KD persists, interstitial infiltrates appear and eventually tubulointerstitial fibrosis develops. In patients with chronic KD, renal cysts may form and with time tubulointerstitial disease with renal failure dev...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1081/jdi-100104718

    authors: Fervenza F,Tsao T,Rabkin R

    更新日期:2001-05-01 00:00:00

  • Interleukin-22 attenuates renal tubular cells inflammation and fibrosis induced by TGF-β1 through Notch1 signaling pathway.

    abstract::Transforming growth factor-β1 (TGF-β1) is a crucial factor implicated in the development of renal inflammation and tubulointerstitial fibrosis (TIF). The cytokine interleukin 22 (IL-22) was previously reported to involve in the pathogenesis of chronic inflammatory diseases, however recent studies showed that IL-22 cou...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2020.1753538

    authors: Tang R,Xiao X,Lu Y,Li H,Zhou Q,Kwadwo Nuro-Gyina P,Li X

    更新日期:2020-11-01 00:00:00

  • Low-dose IL-2 expands CD4+ regulatory T cells with a suppressive function in vitro via the STAT5-dependent pathway in patients with chronic kidney diseases.

    abstract:BACKGROUND:Patients with chronic kidney disease (CKD) often have CD4+ regulatory T cells (Tregs) dysfunction and chronic inflammation. We aim to investigate the effect, function, and related mechanism of low-dose IL-2 on CD4+ regulatory T cells expansion in vitro from patients with CKD. METHODS:A total of 148 newly di...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2018.1456462

    authors: Li Y,Liu X,Wang W,Wang S,Zhang J,Jiang S,Wang Y,Li L,Li J,Zhang Y,Huang H

    更新日期:2018-11-01 00:00:00

  • Transformation from tubulointerstitial nephritis to crescentic glomerulonephritis: an unusual presentation of ANCA-associated renal vasculitis.

    abstract::A 44-year-old man with acute renal failure and antineutrophil cytoplasmic antibodies (ANCA) positivity was described. The first renal biopsy specimen showed tubulointerstitial nephritis (TIN) with normal glomeruli. However, delayed recovery of renal function with low-dose steroid treatment for TIN prompted a second re...

    journal_title:Renal failure

    pub_type: 杂志文章,评审

    doi:10.1080/08860220500531559

    authors: Wen YK,Chen ML

    更新日期:2006-01-01 00:00:00

  • Effect of cholecalciferol replacement on vascular calcification and left ventricular mass index in dialysis patients.

    abstract:OBJECTIVE:The aim of this study was to determine the effect of oral cholecalciferol treatment on vascular calcification, left ventricular mass index (LVMI) and other cardiac functions in dialysis patients. DESIGN AND METHODS:A six-month course of oral cholecalciferol treatment was recommended to dialysis patients with...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2015.1010416

    authors: Kidir V,Ersoy I,Altuntas A,Gultekin F,Inal S,Dagdeviren BH,Dogan A,Sezer MT

    更新日期:2015-05-01 00:00:00

  • Circulating purine compounds, uric acid, and xanthine oxidase/dehydrogenase relationship in essential hypertension and end stage renal disease.

    abstract::Purine nucleotide liberation and their metabolic rate of interconversion may be important in the development of hypertension and its renal consequences. In the present study, blood triphosphate (ATP), adenosine diphosphate (ADP), and adenosine monophosphate (AMP) breakdown pathway was evaluated in relation to uric aci...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2014.882240

    authors: Boban M,Kocic G,Radenkovic S,Pavlovic R,Cvetkovic T,Deljanin-Ilic M,Ilic S,Bobana MD,Djindjic B,Stojanovic D,Sokolovic D,Jevtovic-Stoimenov T

    更新日期:2014-05-01 00:00:00

  • Mortality risk factors in chronic renal failure patients after coronary artery bypass grafting.

    abstract::Perioperative risk during coronary artery bypass grafting (CABG) is high in patients with chronic renal disease. We aimed to determine postoperative two-year mortality and identify the preoperative risk factors of mortality during CABG surgery in hemodialysis (HD)-dependent and HD-non-dependent CRF patients. We includ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220701573525

    authors: Akman B,Bilgic A,Sasak G,Sezer S,Sezgin A,Arat Z,Ozdemir FN,Haberal M

    更新日期:2007-01-01 00:00:00

  • Development of new nephrons in adult kidneys following gentamicin-induced nephrotoxicity.

    abstract::Gentamicin-induced nephrotoxicity results in necrosis of proximal tubular epithelial cells. In mammals, the injured nephron can be repaired by migration and division of surviving cells. We examined this repair process in the fresh-water goldfish, Carassius auratus. Fish were given a single intraperitoneal injection of...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229509026246

    authors: Reimschuessel R,Williams D

    更新日期:1995-03-01 00:00:00

  • Relation between depression, some laboratory parameters, and quality of life in hemodialysis patients.

    abstract::Depression is common in patients with end-stage renal disease (ESRD) and is associated with increased mortality and morbidity. Several investigators have estimated that depression occurs in about 20% to 30% of dialysis patients. The aim of this study was to investigate the relationship between depression, some laborat...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220500242728

    authors: Dogan E,Erkoc R,Eryonucu B,Sayarlioglu H,Agargun MY

    更新日期:2005-01-01 00:00:00

  • Reversible renal failure due to bilateral renal sarcoma in a patient with acute myeloid leukemia.

    abstract::A 68-year-old male presented with acute myeloid leukemia, renal failure, hypokalemia, and enlarged kidneys on renal ultrasound. Renal biopsy revealed massive leukemic infiltration of the kidney. After systemic chemotherapy, the patient developed tumor lysis syndrome followed by a phase of proximal tubule dysfunction p...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220902972187

    authors: Rüger W,Kruip MJ,Betjes MG

    更新日期:2009-01-01 00:00:00

  • Role of CT scan in diagnosis of renal lymphangiectasia: our single-center experience.

    abstract:BACKGROUND:Renal lymphangiectasia is rarely reported benign renal disorder of lymphatic malformation. Though found incidentally; it presents with nonspecific symptoms and shows characteristic findings in radiological imaging studies. AIM:Here, we report eight patients with symptoms, laboratory and imaging findings com...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2017.1337584

    authors: Pandya VK,Sutariya HC,Gandhi SP,Khemchandani SI,Patel HV,Shah MK

    更新日期:2017-11-01 00:00:00

  • Effect of fenoldopam on ischemia/reperfusion-induced apoptosis.

    abstract::Recently we demonstrated the effect of fenoldopam on ischemia/reperfusion (I/R) induced NFkappaB mediated pro-inflammatory signal transduction. However, the effect of fenoldopam on I/R-induced apoptosis is not known. We utilized a rat model of acute ischemic nephropathy to test the hypothesis that fenoldopam attenuate...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220600583690

    authors: Aravindan N,Cata JP,Dougherty PM,Shaw AD

    更新日期:2006-01-01 00:00:00

  • Acute renal failure due to nontraumatic rhabdomyolysis following binge drinking.

    abstract::Nontraumatic rhabdomyolysis is an important but under-recognized cause of acute renal failure. In alcoholics, rhabdomyolysis most frequently develop following muscle necrosis during alcohol-induced coma, but has also been described rarely in those without prolonged coma or seizures. We describe a patient who developed...

    journal_title:Renal failure

    pub_type: 杂志文章,评审

    doi:10.3109/08860229909045195

    authors: Muthukumar T,Jha V,Sud A,Wanchoo A,Bambery P,Sakhuja V

    更新日期:1999-09-01 00:00:00

  • Renal stone disease and obesity: what is important for urologists and nephrologists?

    abstract::Currently, obesity has reached an epidemic stage and represents a challenge for health authorities across the globe. Certainly, with emergence of obesity epidemic, we started to see an increase in the prevalence of chronic kidney disease (CKD) and nephrolithiasis. Interestingly, epidemiologic studies have shown that t...

    journal_title:Renal failure

    pub_type: 杂志文章,评审

    doi:10.3109/0886022X.2012.723777

    authors: Ahmed MH,Ahmed HT,Khalil AA

    更新日期:2012-01-01 00:00:00

  • Postoperative hemolytic uremic syndrome with renal cortical necrosis following laparoscopic hemicolectomy.

    abstract::Non-Shiga-like toxin-producing Escherichia coli (STEC) or atypical hemolytic uremic syndrome (aHUS) is observed in 5-10% of all hemolytic uremic syndrome (HUS) cases, and usually develops secondary to infections, malignancies, drugs, transplantation, pregnancy, and autoimmune disease. However, there has been no report...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2013.780978

    authors: Lee JW,Won NH,Cho E,Kim MG,Jo SK,Cho WY,Kim HK

    更新日期:2013-01-01 00:00:00

  • A prospective study of hepatitis B vaccination - a comparison of responders versus nonresponders.

    abstract::Herein we present one of the largest single-center reports of the response of hemodialysis patients to a two-vaccine hepatitis B virus vaccination protocol in a European dialysis population. A hepatitis B recombinant DNA vaccine, HBvaxPRO, was given at a dose of 40 µg intramuscularly using a four-dose schedule at 0, 1...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2011.559300

    authors: Brown CM,Donlon S,O'Kelly P,Casey AM,Collier C,Conlon PJ,Walshe JJ

    更新日期:2011-01-01 00:00:00