Beta2-microglobulin and alpha1-microglobulin as markers of Balkan endemic nephropathy, a worldwide disease.


BACKGROUND: Urine beta2-microglobulin (beta2-MG) was mainly used as a tubular marker of Balkan endemic nephropathy (BEN) but recently alpha1-microglobulin (alpha1-MG) was proposed for the diagnosis of BEN. In this study, the potential of urine beta2-MG, alpha1-MG, albumin, and total protein in the differentiation of BEN from healthy persons and patients with glomerulonephritis (GN) and nephrosclerosis (NS) was examined. METHODS: This study involved 47 patients with BEN, 36 with GN, 11 with NS, 30 healthy subjects from BEN families, and 46 healthy subjects from non-BEN families. RESULTS: In BEN patients area under the curve (AUC) for urine beta2-MG (0.828) and alpha1-MG (0.782) was higher than for urine albumin (0.740), but in GN patients AUC for urine protein (0.854) and albumin (0.872) was significantly higher than for the two low molecular weight proteins. AUC for all four urinary markers in NS patients was significantly lower than in BEN patients, ranging between 500 and 595. Median urine beta2-MG excretion in BEN patients was 17.5 times higher than in GN patients and 18.3 times higher than in controls; median alpha1-MG excretion was higher only 3.0 and 2.25 times, respectively. In the differentiation of BEN from healthy controls, beta2-MG had higher sensitivity and specificity at the cutoff levels (p < 0.001) than alpha1-MG (p < 0.05). In the differentiation of BEN from GN, beta2-MG was the best marker. CONCLUSION: All four urinary markers can be used for the differential diagnosis of BEN, beta2-MG being the best. Like in aristolochic acid nephropathy, beta2-MG seems to be an early marker of tubular damage in BEN.


Ren Fail


Renal failure


Stefanović V,Djukanović L,Cukuranović R,Bukvić D,Ležaić V,Marić I,Ogrizovic SS,Jovanović I,Vlahovic P,Pešić I,Djordjević V




Has Abstract


2011-01-01 00:00:00












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    abstract:BACKGROUND:In this study, it was aimed to determine the effects of alfuzosin on experimentally generated unilateral partial ureteropelvic junction obstruction (UPO) in rats. MATERIALS AND METHODS:Thirty Long-Evans rats were randomly allocated into five groups. In control group (C), nothing was performed; in group Sham...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Kose F,Turkyilmaz Z,Sonmez K,Karabulut R,Poyraz A,Gulbahar O,Aral A,Damar C,Kaya C,Can Basaklar A

    更新日期:2016-09-01 00:00:00

  • Sudden onset of nephrotic syndrome in an asymptomatic Fabry patient: a case report.

    abstract:BACKGROUND:Fabry disease (FD) is an X-linked lysosomal storage disorder caused by the mutation of the GLA gene, encoding the α-galactosidase, which is responsible for the catabolism of neutral glycosphingolipids. Microalbuminuria or low-grade proteinuria, and continuously progressive renal failure are common manifestat...

    journal_title:Renal failure

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    authors: Zhang R,Chen Z,Lang Y,Shao S,Cai Y,You Q,Sun Y,Wang S,Shi X,Liu Z,Guo W,Han Y,Shao L

    更新日期:2020-11-01 00:00:00

  • Angiotensin II and endothelin in the renal cortex during the evolution of glycerol-induced acute tubular necrosis.

    abstract::Hypertonic glycerol injection is one of the most frequently used models of experimental acute renal failure. Late structural changes such as interstitial fibrosis in the renal cortex and tubular atrophy have been detected after severe acute tubular necrosis (ATN). The aim of this study was to investigate the expressio...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: de Jesus Soares T,Costa RS,de Mattos Coelho R,Alves da Silva CG,Coimbra TM

    更新日期:2005-01-01 00:00:00

  • Elevated plasma levels of PAI-1 predict cardiovascular events and cardiovascular mortality in prevalent peritoneal dialysis patients.

    abstract:BACKGROUND:Elevated plasminogen activator inhibitor-1 (PAI-1) levels are associated with increased cardiovascular (CV) risk in the general population. It has been shown that peritoneal dialysis (PD) patients have increased plasma levels of PAI-1. The aim of this study was to investigate whether PAI-1 independently pred...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Arikan H,Koc M,Tuglular S,Ozener C,Akoglu E

    更新日期:2009-01-01 00:00:00

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    abstract:BACKGROUND:Influenza infection is a significant cause of morbidity and mortality in general population. Hemodialysis patients are considered at high risk of influenza infection given their altered immune status. Pandemic influenza virus is new for human beings, so it is hard to predict the response to infection or vacc...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Temiz G,Kasifoglu N,Kiris A,Ozturk S,Sahin G,Yalcin AU,Us T

    更新日期:2010-07-01 00:00:00

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    abstract:BACKGROUND:Previous studies have demonstrated the role of inflammation in diabetic nephropathy (DN). Neutrophil to lymphocyte ratio (NLR) rather than other white cell parameters was found to be a useful inflammatory marker to predict adverse outcomes in medical and surgical conditions. Nevertheless, the value of NLR in...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Azab B,Daoud J,Naeem FB,Nasr R,Ross J,Ghimire P,Siddiqui A,Azzi N,Rihana N,Abdallah M,Azzi N,Patel P,Kleiner M,El-Sayegh S

    更新日期:2012-01-01 00:00:00

  • Evaluation of the process of recycling and renal parenchymal injury after eswl with metabolites excreted in the urine.

    abstract:OBJECTIVES:To show renal parenchymal injury depending on extracorporeal shock wave lithotripsy (ESWL). METHODS:The patients with one renal stone and in whom ESWL is planned among the patients in whom renal stone was determined. Their 24-h urine samples were collected just before and after the ESWL treatment. Cit (citr...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Ceylan C,Dogan S,Saydam G,Kocak MZ,Doluoglu OG

    更新日期:2013-01-01 00:00:00

  • Radial augmentation index may be an effective predictor of vascular calcification in patients on peritoneal dialysis.

    abstract::Vascular calcification (VC) is an important promoter of cardiovascular disease (CVD) in patients undergoing peritoneal dialysis (PD). Several indices can be used to evaluate VC, including the abdominal aortic calcification index (AACI) and carotid artery intima-media thickness (IMT); however, simpler and lesser expens...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Yang N,Yang W,Cui W,Zhou D,Du X,Li L

    更新日期:2020-11-01 00:00:00

  • Intermittent hirudin versus continuous heparin for anticoagulation in continuous renal replacement therapy.

    abstract:BACKGROUND:Besides possible bleeding complications a further problem in anticoagulation during continuous renal replacement therapy (CRRT) is the development of heparin-induced thrombocytopenia type II (HIT II) where further anticoagulation with heparin is contraindicated. The application of continuous hirudin as alter...

    journal_title:Renal failure

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Hein OV,von Heymann C,Diehl T,Ziemer S,Ronco C,Morgera S,Siebert G,Kox WJ,Neumayer HH,Spies C

    更新日期:2004-05-01 00:00:00

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    abstract:BACKGROUND:Previous studies have found significant stressors experienced by nurses working in hemodialysis units. The purpose of this study was to determine the burnout levels of hemodialysis nurses working in hemodialysis units and their relation with some sociodemographic variables. METHODS:The study was conducted b...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Kavurmacı M,Cantekin I,Tan M

    更新日期:2014-08-01 00:00:00

  • The association of overhydration with megafistulas in hemodialysis patients.

    abstract::Objectives: Diffuse enlargements of arteriovenous dialysis fistulas customarily attributed to either excessive arterial inflow or central outflow stenosis. The relationship between volume status and clinically enlarged (arteriovenous) fistula (CEF) formation in end-stage renal disease (ESRD) patients is not well under...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Tapolyai M,Faludi M,Berta K,Forró M,Zsom L,Pethő ÁG,Rosivall L,Fülöp T

    更新日期:2019-11-01 00:00:00

  • Relationship between renal function and blood level of chromogranin A.

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    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Tramonti G,Ferdeghini M,Annichiarico C,Norpoth M,Donadio C,Bianchi R,Bianchi C

    更新日期:2001-05-01 00:00:00

  • Lack of relation between serum parathyroid hormone levels and erythrocyte osmotic fragility in pediatric patients on peritoneal dialysis.

    abstract::Secondary hyperparathyroidism and anemia are the hallmarks in uremic patients. It is suggested that parathyroid hormone increases erythrocyte osmotic fragility and induces hemolysis. The present study was undertaken to examine the possible relationship between erythrocyte osmotic fragility and secondary hyperparathyro...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Koşan C,Sever L,Arisoy N

    更新日期:2004-11-01 00:00:00

  • Comparing the frequency of hypertension determined by peri-dialysis measurement and ABPM in hemodialysis patients.

    abstract::Controlling blood pressure in hemodialysis patients is crucial but not always easy. The most common blood pressure measurement method is peri-dialysis measurement, but due to interdialytic blood pressure fluctuations, we are unsure if it is the proper way for evaluating blood pressure. Some studies have shown the supe...

    journal_title:Renal failure

    pub_type: 杂志文章


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    更新日期:2014-06-01 00:00:00

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    abstract:BACKGROUND:The kidney is one of the prior damaged organs subjected to severe infection and sepsis shock. Our previous studies have shown that the normal mesenteric lymph (NML) obtained from healthy dogs could alleviate multiple organ injuries following endotoxic shock. In the current study, we further investigated the ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Zhao ZG,Zhang LM,Song W,Du HB,Cui H,Niu CY

    更新日期:2014-09-01 00:00:00

  • Which parameter is more influential on the development of arteriosclerosis in hemodialysis patients?

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    pub_type: 杂志文章


    authors: Seyrek N,Balal M,Karayaylali I,Paydaş S,Aikimbaev K,Cetiner S,Seydaoglu G

    更新日期:2003-11-01 00:00:00

  • The differences of asymmetric dimethylarginine removal by different dialysis treatments.

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    journal_title:Renal failure

    pub_type: 杂志文章,随机对照试验


    authors: Zhang DL,Liu J,Liu S,Zhang Y,Liu WH

    更新日期:2010-01-01 00:00:00

  • Analysis of potential risk factors for cancer incidence in patients with aristolochic acid nephropathy from Wenzhou, China.

    abstract:BACKGROUND:The purpose of this study was to investigate the cancer incidence in patients with end-stage aristolochic acid nephropathy (AAN). METHODS:A total of 102 patients with end-stage AAN treated in our hospital between 2004 and 2013 were included in this study. The correlation of cancer incidence with age, gender...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Sun M,Zhang J,Zheng C,Liu Y,Lin F,Xu F,Chen C

    更新日期:2015-03-01 00:00:00

  • Relation between urinary cytology abnormalities and cyclosporine A therapy in bone marrow transplant recipients.

    abstract::The aim of the study was to determine the relationship, if any, between abnormalities in urinary cytology and the administration of cyclosporine A in bone marrow transplant recipients. Specific attention was given to the presence of tubular cells with round inclusions (TCRI). Two bone marrow transplant recipient group...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Sucic M,Boban D,Markovic-Glamocak M,Bogdanic V,Nemet D,Labar B,Cvoriscec D,Plavsic F,Stoos-Veic T,Mrsic M

    更新日期:1998-07-01 00:00:00

  • A repeat biopsy study in spontaneous crescentic glomerulonephritis mice.

    abstract:BACKGROUND:Spontaneous crescentic glomerulonephritis (SCG)/Kj mice are a candidate for suitable animal model of human pauci-immune crescentic glomerulonephritis (GN). In the present study, we used renal biopsy technique and analyzed time sequence correlations among crescent formation and glomerular neutrophil infiltrat...

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    pub_type: 杂志文章


    authors: Miyazawa S,Saiga K,Nemoto K,Mae T,Hotta O

    更新日期:2002-09-01 00:00:00

  • Acute renal failure due to nontraumatic rhabdomyolysis following binge drinking.

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    journal_title:Renal failure

    pub_type: 杂志文章,评审


    authors: Muthukumar T,Jha V,Sud A,Wanchoo A,Bambery P,Sakhuja V

    更新日期:1999-09-01 00:00:00

  • Genomic distribution of 5-Hydroxymethylcytosine in mouse kidney and its relationship with gene expression.

    abstract::Ten-Eleven Translocation (TET) proteins oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytonsie (5hmC). Our recent work found a decline in global 5hmC level in mouse kidney insulted by ischemia reperfusion (IR). However, the genomic distribution of 5hmC in mouse kidney and its relationship with gene expression remai...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Wang H,Huang N,Liu Y,Cang J,Xue Z

    更新日期:2016-07-01 00:00:00

  • Dysregulated microRNAs involved in contrast-induced acute kidney injury in rat and human.

    abstract:BACKGROUND:Contrast-induced nephropathy (CIN) is a complex syndrome of acute nephropathy that occurs following infusion of intravascular contrast agents, and is associated with an increased risk for adverse cardiovascular events. While there is no ideal biomarker for making an early diagnosis of CIN, we hypothesized th...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Gutiérrez-Escolano A,Santacruz-Vázquez E,Gómez-Pérez F

    更新日期:2015-01-01 00:00:00

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    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Baskin E,Gulleroglu KS,Saygili A,Aslamaci S,Varan B,Tokel K

    更新日期:2010-01-01 00:00:00

  • Malnutrition in the elderly patient on dialysis.

    abstract::Approximately one-third of all dialysis patients have mild to moderate malnutrition, while 6-8% have severe malnutrition, which is associated with increased morbidity and mortality rates and numerous pre-existing factors directly correlated with, or existing prior to, replacement hemodialysis. However, moderate to sev...

    journal_title:Renal failure

    pub_type: 杂志文章,评审


    authors: Lacquaniti A,Bolignano D,Campo S,Perrone C,Donato V,Fazio MR,Buemi A,Sturiale A,Buemi M

    更新日期:2009-01-01 00:00:00

  • Coumadin-induced renal and retroperitoneal hemorrhage.

    abstract:PRINCIPLES:Coumadin-induced renal and retroperitoneal hemorrhages are rare. Clinical and laboratory findings are not specific for the diagnosis. Computed tomography (CT) has some advantages in the evaluation of these patients. The aim of this study is to report our experience regarding renal and retroperitoneal hemorrh...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Danaci M,Kesici GE,Kesici H,Polat C,Belet U

    更新日期:2006-01-01 00:00:00

  • Primary disseminated form of Ewing sarcoma in association with hypercalcemia and acute renal failure.

    abstract::We present a case of an extremely rare form of Ewing sarcoma--primary disseminated, with fulminating course, severe hypercalcemia, extensive calcium deposition in parenchymatous organs, including kidneys, and acute renal failure as a clinical consequence. Correction of hypercalcemia was followed by prompt restoration ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Lozance LA,Zafirovska KG,Bogdanovska SV,Zafirovski GJ

    更新日期:1994-01-01 00:00:00

  • Intensification of peritoneal dialysis improves valacyclovir neurotoxicity.

    abstract::Valacyclovir induced neurotoxicity is a life-threatening complication, usually starting 24-48 h after drug-peak serum concentrations. The elderly with impaired renal function seem to be the most susceptible group to valacyclovir neurotoxicity. Although hemodialysis is considered the best method for rapid drug removal,...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Pipili C,Pantelias K,Deda E,Tsiamalos P,Kostis E,Grapsa E

    更新日期:2013-01-01 00:00:00

  • Factors related to pulse wave velocity and augmentation index in chronic hemodialysis patients.

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    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Celik G,Demirci MS,Tumuklu M,Ascı G,Sipahi S,Toz H,Bascı A,Ok E

    更新日期:2011-01-01 00:00:00

  • Modification of the Schwartz equations for children increases their accuracy at eGFR > 60 mL/min/1.73 m(2).

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    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Zachwieja K,Korohoda P,Kwinta-Rybicka J,Miklaszewska M,Moczulska A,Bugajska J,Berska J,Drożdż D,Pietrzyk JA

    更新日期:2016-06-01 00:00:00