The association of overhydration with megafistulas in hemodialysis patients.


:Objectives: Diffuse enlargements of arteriovenous dialysis fistulas customarily attributed to either excessive arterial inflow or central outflow stenosis. The relationship between volume status and clinically enlarged (arteriovenous) fistula (CEF) formation in end-stage renal disease (ESRD) patients is not well understood. Methods: We assessed the pre-dialysis bioimpedance spectroscopy-measured percentage of overhydration (OH%) in 13 prevalent dialysis patients with CEF development and negative angiography and compared the results with those of 52 control dialysis patients (CONTR). All patients were prevalent ESRD patients receiving thrice-weekly maintenance hemodiafiltration at an academic outpatient dialysis unit. Results: 10/13 CEF patients had OH% ≥15% as compared to 20/52 control patients (Chi square p: .02). The degree of OH% was 20.2 ± 7.4% among the CEF vs. 14.4 ± 7.1% in the control group (Student's t-test p: .01), representing 4.2 ± 3.2 vs. 2.8 ± 1.6 L of excess fluid pre-dialysis (p: .03). Patients with CEF development took an average of 1.7 ± 1.4 vs. 0.8 ± 0.8 (p: .002) antihypertensive medications compared to the CONTR patients, yet their blood pressure was higher: 156/91 vs. 141/78 mmHg (systolic/diastolic p: .03<.0001). We found no difference in fistula vintage, body mass index, age, diabetes status, or diuretic use. The odds ratio of having a CEF in patients with ≥15% OH status was 5.3 (95% CI: 1.3-21.7; p: .01), the Number Needed to Harm with overhydration was 4. Conclusions: There is an association between bioimpedance spectroscopy-measured overhydrated clinical state and the presence of CEF; either as an increased volume capacitance or as a potential cause.


Ren Fail


Renal failure


Tapolyai M,Faludi M,Berta K,Forró M,Zsom L,Pethő ÁG,Rosivall L,Fülöp T




Has Abstract


2019-11-01 00:00:00












  • Exercise-induced changes in renal URAT1 activity and expression in rats.

    abstract::During exercise, the plasma urate levels and urinary excretion increase due to the enhanced purine degradation in skeletal muscle. Although urate transporter-1 (URAT1) is the main transporter responsible for the reabsorption of filtered urate, potential changes in its activity and expression during exercise have not b...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Cirrik S,Yavuzer BU,Oner G

    更新日期:2010-01-01 00:00:00

  • The course of hypercalciuria and related markers of bone metabolism parameters associated with corticosteroid treatment.

    abstract:BACKGROUND AND OBJECTIVE:Prolonged corticosteroid (CS) use induces osteoporosis; the pathogenesis of this condition is multifactorial and includes CS-induced hypercalciuria. We investigated the course of hypercalciuria and related markers of bone metabolism parameters during and after the CS treatment. MATERIALS AND M...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Duzen O,Erkoc R,Begenik H,Soyoral YU,Aldemir MN

    更新日期:2012-01-01 00:00:00

  • Test of the recommended dialysis dose on one-year mortality of nondiabetic maintenance hemodialysis patients; observations from a single dialysis unit.

    abstract:BACKGROUND:The optimal delivered dialysis dose has been of a great interest for the last three decades, though a clear cut point has not been reached yet. We aimed to evaluate the relationship between one-year mortality and the delivered dialysis dose, which was recommended by Kidney Disease Outcomes Quality Initiative...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Sahutoglu T,Kara E,Ahbap E,Sakaci T,Koc Y,Basturk T,Sevinc M,Akgol C,Ucar ZA,Ozdemir Kayalar A,Caglayan FB,Unsal A

    更新日期:2016-09-01 00:00:00

  • Assessment of hemodialysis adequacy by ionic dialysance: comparison to standard method of urea removal.

    abstract:BACKGROUND:The hemodialysis adequacy is one of the most important issues influencing the survival of patients on maintenance hemodialysis (HD). Assessment of measuring the delivered dialysis dose using clearance x time/volume (Kt/V) index requires multiple blood sampling. New methods for assessment of dialysis dose bas...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Racki S,Zaputović L,Maleta I,Grzetić M,Mavrić Z,Devcić B,Vujicić B

    更新日期:2005-01-01 00:00:00

  • Relation between exhaled nitric oxide and left ventricular performance in chronic hemodialysis patients.

    abstract:INTRODUCTION:End-stage renal disease is the most debilitating condition for patients with renal diseases. Cardiovascular disease is the leading cause of death in these patients. It has been shown that nitric oxide (NO) increases in renal failure and hemodialysis patients and could be correlated with cardiovascular dise...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Ansarin K,Toufan M,Namdar H,Etemadi J,Habibzadeh A,Valinejad M,Shoja MM,Ghabili K

    更新日期:2014-02-01 00:00:00

  • Current evidence on the use of anti-RAAS agents in congenital or acquired solitary kidney.

    abstract:RATIONAL:The inhibition of renin-angiotensin-aldosterone system (RAAS) is a major strategy for slowing the progression of chronic kidney disease (CKD). The utility of anti-RAAS agents in patients with congenital or acquired solitary kidney is still controversial. OBJECTIVE:A systematic literature review was conducted....

    journal_title:Renal failure

    pub_type: 杂志文章,评审


    authors: Simeoni M,Armeni A,Summaria C,Cerantonio A,Fuiano G

    更新日期:2017-11-01 00:00:00

  • Can continuous intraperitoneal infusion of 125I-iothalamate and 131I-hippuran be used for measurement of GFR in conscious rats?

    abstract::We previously described a method to measure GFR in conscious spontaneously voiding rats. This method circumvents the need for anesthesia and for bladder instrumentation. It's main principle is the correction of renal 125I-iothalamate clearance for incomplete urine collection by the ratio of plasma and renal clearance ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: de Vries PA,Navis G,de Jong PE,de Zeeuw D

    更新日期:1998-03-01 00:00:00

  • Blood purification for crush syndrome.

    abstract::At least 372 people developed crush syndrome after they were injured by the Great Hanshin-Awaji Earthquake. Of these, 23 were transferred to Osaka City General Hospital from the disaster area. The serum creatinine kinase (CK) of each of the 23 patients exceeded 10,000 IU/L. Sixteen of these patients were treated with ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Shigemoto T,Rinka H,Matsuo Y,Kaji A,Tsukioka K,Ukai T,Shimaoka H

    更新日期:1997-09-01 00:00:00

  • Differential susceptibility to gentamicin toxicity within the proximal convoluted tubule.

    abstract::The proximal convoluted tubule (PCT) is the major target for injury in gentamicin nephrotoxicity but the necrosis is often patchy and focal. The PCT is structurally, functionally, and metabolically heterogeneous, and the possibility of differential vulnerability to gentamicin-induced necrosis based on this heterogenei...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Shanley PF,Burke TJ

    更新日期:1990-01-01 00:00:00

  • Effect of arachidonic acid metabolic inhibitors on hypoxia/reoxygenation-induced renal cell injury.

    abstract::The present study was undertaken to examine the role of arachidonic acid (AA) metabolites in hypoxia/reoxygenation (H/R)-induced renal cell injury in rabbit renal cortical slices using AA metabolic inhibitors. Inhibitors of cyclooxygenase (indomethacin and diclofenac sodium) and lipoxygenase pathways (nordihydroguaiar...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Kim YK,Hwang MY,Woo JS,Jung JS,Lee SH

    更新日期:2000-03-01 00:00:00

  • A repeat biopsy study in spontaneous crescentic glomerulonephritis mice.

    abstract:BACKGROUND:Spontaneous crescentic glomerulonephritis (SCG)/Kj mice are a candidate for suitable animal model of human pauci-immune crescentic glomerulonephritis (GN). In the present study, we used renal biopsy technique and analyzed time sequence correlations among crescent formation and glomerular neutrophil infiltrat...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Miyazawa S,Saiga K,Nemoto K,Mae T,Hotta O

    更新日期:2002-09-01 00:00:00

  • Early detection of acute tubular injury with diffusion-weighted magnetic resonance imaging in a rat model of myohemoglobinuric acute renal failure.

    abstract::We evaluated the feasibility of magnetic resonance imaging (MRI) for early detection of tubular injury by monitoring changes in the apparent diffusion coefficient (ADC) of renal water in a rat model of myohemoglobinuric glycerol-induced acute renal failure (ARF). Diffusion-weighted MRI was performed concurrently with ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Vexler VS,Roberts TP,Rosenau W

    更新日期:1996-01-01 00:00:00

  • The effects of adenosine A2B receptor inhibition on VEGF and nitric oxide axis-mediated renal function in diabetic nephropathy.

    abstract::Diabetic nephropathy (DN) is the most common cause of end-stage renal disease worldwide. The pathophysiologic mechanisms of diabetic nephropathy are incompletely understood but include overproduction of various growth factors and cytokines. Upregulation of vascular endothelial growth factor (VEGF) is a pathogenic even...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Patel L,Thaker A

    更新日期:2014-07-01 00:00:00

  • Tocilizumab treatment for nephrotic syndrome due to amyloidosis in Behcet's disease.

    abstract::Renal involvement is an unusual but significant Behcet´s disease (BD) complication and AA amyloidosis appears to be the most common etiology. IL-6 is a pro-inflammatory cytokine with an important role in AA amyloidosis development. Tocilizumab (TCZ) is a humanized anti-IL-6 receptor antibody that has emerged as an eff...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Redondo-Pachón MD,Enríquez R,Sirvent AE,Andrada E,Noguera-Pons R,Millán I,Amorós F

    更新日期:2013-01-01 00:00:00

  • The role of mitofilin in left ventricular hypertrophy in hemodialysis patients.

    abstract::Left ventricular hypertrophy (LVH) is a common abnormality in hemodialysis (HD) patients. Mitochondrial dysfunction contributes to the progression of LVH. As an inner mitochondrial membrane structural protein, mitofilin plays a key role in maintaining mitochondrial structure and function. The aim of this study was to ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Wu QS,He Q,He JQ,Chao J,Wang WY,Zhou Y,Lou JZ,Kong W,Chen JF

    更新日期:2018-11-01 00:00:00

  • Pathological changes, TGF-β1 expression, and the effects of hepatocyte growth factor in 5/6 nephrectomized rats.

    abstract::Several studies have shown that hepatocyte growth factor (HGF) ameliorates chronic renal failure, but its mechanism of action is unclear. This study was designed to test the delivery of HGF in the PCI-neo vector, using the 5/6 nephrectomized rat as a model for chronic renal failure, and to confirm that this protective...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Wang HY,Yang LZ,Gu CM,Chen Y,Zhao Y,Zhao D,Li TS,Cui MJ

    更新日期:2014-04-01 00:00:00

  • Two novel mutations affecting the same splice site of PKD1 correlate with different phenotypes in ADPKD.

    abstract::Genetic heterogeneity is the main factor for significant variation in the course of autosomal dominant polycystic kidney disease (ADPKD). PKD1 patients have more severe renal outcomes compared with PKD2 patients. Co-inheritance of a mutation in both genes is associated with more severe phenotypes than that found with ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Yu C,Li J,Yuan Z,Liu S,Zou L

    更新日期:2014-06-01 00:00:00

  • Acute toxic kidney injury.

    abstract::Substances toxic to the kidney are legion in the modern world. The sheer number and variety, their mutual interactions and, metabolism within the body are a challenge to research. Moreover, the kidney is especially prone to injury owing to its physiology. Acute kidney injury (AKI) induced by poisonous or primarily nep...

    journal_title:Renal failure

    pub_type: 杂志文章,评审


    authors: Petejova N,Martinek A,Zadrazil J,Teplan V

    更新日期:2019-11-01 00:00:00

  • Kidney function and histological damage in autopsy subjects with myocardial infarction.

    abstract:OBJECTIVES:Chronic kidney disease (CKD) is a major risk factor for cardiovascular disease (CVD). We previously reported renal parenchymal damage in autopsy subjects with stroke or abdominal aortic aneurysm. The aim of this study is to evaluate the relationship between renal histology and clinical characteristics of pat...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Niizuma S,Nakamura S,Ishibashi-Ueda H,Yoshihara F,Kawano Y

    更新日期:2011-01-01 00:00:00

  • Unusual clinic presentation of polyarteritis nodosa: involvement of axillary and brachial artery.

    abstract::Polyarteritis nodosa (PAN) is a necrotizing inflammatory vasculitis of small- and medium-sized muscular arteries. Multiple organs, especially the kidney, skin, peripheric nerves, striated muscles, and intestine, are affected. In this case report, a patient with renal and hepatic involvement and axillary and brachial a...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Kocyigit I,Koyuncu S,Mavili E,Unal A,Tokmak TT,Cilan H,Kavuncuoglu F,Oymak O,Utas C

    更新日期:2011-01-01 00:00:00

  • Chronic renal disease in Kuwaiti nationals: a prospective study during the past 4 years.

    abstract::Our study is a prospective one conducted at Al-Amiri Hospital and including all new cases of chronic renal disease (CRD) seen at the capital area of Kuwait between 1 January 1999 and 30 December 2003. Diagnosis of CRD was based on clinical, laboratory, and radiological features. Kidney biopsies were done when indicate...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: El-Reshaid W,El-Reshaid K,Kapoor M,Hakim A

    更新日期:2005-01-01 00:00:00

  • Adenylate cyclase responses and biochemical characterization of primary rabbit proximal tubular cell cultures and LLC-PK1 cells.

    abstract::Freshly isolated rabbit proximal tubules (PT), confluent primary rabbit proximal tubule cultures (PTC) and LLC-PK1 cells were characterised. Brushborder enzyme activities were lower in PTC than in LLC-PK1: ratios were 0.026 for alkaline phosphatase (AP), 0.458 for alanine aminopeptidase (AAP) and 0.514 for gamma-gluta...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Toutain H,Courjault F,Vauclin-Jacques N,Morin JP

    更新日期:1990-01-01 00:00:00

  • Hepatocellular carcinoma after kidney transplantation: analysis of Hong Kong Renal Registry.

    abstract::Kidney transplant recipients have increased risk of cancers when compared with the general population. Hepatocellular carcinoma (HCC) is extremely important in Asia where hepatitis B virus (HBV) infection is endemic. The aim is to study the epidemiological and clinical aspects of all de novo HCC in our kidney transpla...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Cheung CY,Lam MF,Chow KM,Lee W,Cheng YL,Yuen SK,Wong PN,Mo KL,Leung KT,Wong SH,Ho YW,Chau KF

    更新日期:2014-07-01 00:00:00

  • Low-dose cyclosporine in treatment of membranous nephropathy with nephrotic syndrome: effectiveness and renal safety.

    abstract:BACKGROUND:To observe effectiveness and renal safety of long-term low-dose cyclosporine in idiopathic membranous nephropathy (IMN). METHODS:Sixty-eight patients were enrolled in this prospective cohort study. Renal endpoint was defined as a decrease in eGFR ≥50% from baseline and a development of eGFR ≤60 ml/min/1.73m...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Yu X,Ruan L,Qu Z,Cui Z,Zhang Y,Wang X,Meng L,Liu X,Wang F,Zhang Y,Liu G,Yang L

    更新日期:2017-11-01 00:00:00

  • Acute renal failure due to acute rhabdomyolysis precipitated by MAST trousers and diflunisal.

    abstract::This report describes a patient who developed acute rhabdomyolysis and acute renal failure following the application of MAST trousers associated with an overdose of diflunisal. This association has not previously been reported. ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Pilmore H,Walker RJ

    更新日期:1993-01-01 00:00:00

  • Posttreatment with aminoguanidine attenuates renal ischemia/reperfusion injury in rats.

    abstract::Acute renal failure secondary to ischemia/reperfusion (I/R) injury is associated with significant mortality and morbidity. Aminoguanidine (AG), an inducible nitric oxide synthase inhibitor with antioxidant properties, has been reported beneficial in renal I/R injury. The aim of the present study was to investigate the...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Onem Y,Ipcioglu OM,Haholu A,Sen H,Aydinoz S,Suleymanoglu S,Bilgi O,Akyol I

    更新日期:2009-01-01 00:00:00

  • The role of Silodosin as a new medical expulsive therapy for ureteral stones: a meta-analysis.

    abstract::To evaluate the efficacy of Silodosin as a medical expulsive therapy of ureteral stones, we searched PubMed, EMBASE, the Cochrane Library, and CBM up to June 2015. All randomized controlled trials (RCTs) were identified in which patients were randomized to receive Silodosin versus placebo or other therapies for ureter...

    journal_title:Renal failure

    pub_type: 杂志文章,meta分析,评审


    authors: Ding H,Ning Z,Dai Y,Shang P,Yang L

    更新日期:2016-10-01 00:00:00

  • Evaluation of hemodialysis efficiency by an edema fluid model.

    abstract::The concentrations of urea, creatinine, and uric acid were measured in edema fluid and plasma during hemodialysis and 18 h after hemodialysis. The concentrations of these solutes in plasma were 15-17% lower than in the edema fluid after hemodialysis. Eighteen hours after hemodialysis, however, the concentrations in pl...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Shirai D,Kajimoto Y,Ochi S,Tanaka Y,Wada A,Yano F,Izumi M,Fujita Y,Nakahama H

    更新日期:1992-01-01 00:00:00

  • Renal cortical mitochondria are the source of oxygen free radicals enhanced by gentamicin.

    abstract::Rat renal cortical mitochondria were isolated from Wistar male rats weighing 80 to 120 g to investigate whether the source of oxygen free radicals was renal cortical mitochondria enhanced by gentamicin. In renal cortical mitochondria with or without the addition of gentamicin, DMSO, DFO, CAT, SOD, and MT1 were added s...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Yang CL,Du XH,Han YX

    更新日期:1995-01-01 00:00:00

  • The prognostic value of frozen section preimplantation graft biopsy in the outcome of renal transplantation.

    abstract:INTRODUCTION:Preimplantation biopsy provides a window on the state of the renal allograft. In this study, the prognostic value of frozen section preimplantation graft biopsy was estimated and compared to regularly processed formalin-fixed biopsy. MATERIALS AND METHODS:Seventy-four renal allograft recipients were studi...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Goumenos DS,Kalliakmani P,Tsamandas AC,Maroulis I,Savidaki E,Fokaefs E,Papachristou E,Karavias D,Vlachojannis JG

    更新日期:2010-05-01 00:00:00