Neutrophil gelatinase-associated lipocalin as a follow-up marker in critically ill pediatric patients with established acute kidney injury.

Abstract:

AIM:To assess the utility of neutrophil gelatinase-associated lipocalin (NGAL) in both urine and serum as a follow-up marker for the discrimination of prerenal acute kidney injury (AKI) from intrinsic AKI in critically ill pediatric patients with established AKI at the time of patient presentation. PATIENTS AND METHODS:This was a prospective cohort study of a heterogeneous group of critically ill children in the pediatric intensive care unit (PICU). Serum creatinine (SCr) values were obtained daily as part of routine patient care. AKI was defined as a 50% or greater increase in SCr from baseline and classified as prerenal and intrinsic AKI. RESULTS:A total of 32 critically ill children (mean age: 105 ± 71.7 months, 56% female) with established AKI were included to the study. Area under curve (AUC) for urine and serum NGAL to distinguish prerenal AKI from intrinsic AKI was 0.94, 95% confidence interval (CI): 0.869-1.02 (p < 0.001) and 0.86, 95% CI: 0.71-1.02 (p = 0.002), respectively. CONCLUSION:In a heterogeneous group of critically ill children with established AKI, we found that NGAL in both urine and serum at the time of patient presentation discriminated intrinsic AKI from prerenal AKI.

journal_name

Ren Fail

journal_title

Renal failure

authors

Polat M,Fidan K,Derinöz O,Gönen S,Söylemezoglu O

doi

10.3109/0886022X.2013.764273

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

352-6

issue

3

eissn

0886-022X

issn

1525-6049

journal_volume

35

pub_type

杂志文章
  • Successful treatment of severe iron intoxication with gastrointestinal decontamination, deferoxamine, and hemodialysis.

    abstract::Acute iron poisoning is a common and potentially serious problem in the pediatric population. Early recognition and treatment is crucial for a better outcome and to prevent morbidity and mortality. An 18-year-old female, who had accidental ingestion of 50 tablets of ferrous sulfate (100 mg of elemental iron per 335 mg...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2013.790299

    authors: Gumber MR,Kute VB,Shah PR,Vanikar AV,Patel HV,Balwani MR,Ghuge PP,Trivedi HL

    更新日期:2013-01-01 00:00:00

  • Modification of the Schwartz equations for children increases their accuracy at eGFR > 60 mL/min/1.73 m(2).

    abstract:AIM:Estimation of eGFR in children with normal kidney function using the Schwartz equations results in underestimating real GFR. MATERIALS AND METHODS:We propose modification of three Schwartz equations - two based on creatinine concentration (eGFRScrBS bedside) and (eGFRScr) and one 3-marker based on creatinine, urea...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2016.1163152

    authors: Zachwieja K,Korohoda P,Kwinta-Rybicka J,Miklaszewska M,Moczulska A,Bugajska J,Berska J,Drożdż D,Pietrzyk JA

    更新日期:2016-06-01 00:00:00

  • The significance of serum levels of soluble interleukin-2 receptor in patients undergoing maintenance hemodialysis.

    abstract::Background: Elevated serum levels of sIL-2R are commonly observed in patients undergoing maintenance hemodialysis (MHD). However, the clinical implications in these subjects are unclear. This study is aimed to assess the significance of elevated sIL-2R levels in MHD patients.Methods: A total of 382 MHD patients were f...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2020.1761388

    authors: Chen X,Li Y,Ding X,Zou J,Shen B,Liu Z,Lv W,Cao X,Xiang F

    更新日期:2020-11-01 00:00:00

  • The association of overhydration with megafistulas in hemodialysis patients.

    abstract::Objectives: Diffuse enlargements of arteriovenous dialysis fistulas customarily attributed to either excessive arterial inflow or central outflow stenosis. The relationship between volume status and clinically enlarged (arteriovenous) fistula (CEF) formation in end-stage renal disease (ESRD) patients is not well under...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2019.1614954

    authors: Tapolyai M,Faludi M,Berta K,Forró M,Zsom L,Pethő ÁG,Rosivall L,Fülöp T

    更新日期:2019-11-01 00:00:00

  • Effect of fenoldopam on ischemia/reperfusion-induced apoptosis.

    abstract::Recently we demonstrated the effect of fenoldopam on ischemia/reperfusion (I/R) induced NFkappaB mediated pro-inflammatory signal transduction. However, the effect of fenoldopam on I/R-induced apoptosis is not known. We utilized a rat model of acute ischemic nephropathy to test the hypothesis that fenoldopam attenuate...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220600583690

    authors: Aravindan N,Cata JP,Dougherty PM,Shaw AD

    更新日期:2006-01-01 00:00:00

  • The association of serum inflammatory biomarkers with chronic kidney disease in hypertensive patients.

    abstract::A positive association between inflammation and chronic kidney disease (CKD) has been reported but the impact of hypertension on this relation remains unclear. The aim of this study is to investigate the association of various inflammation markers with risk of CKD in hypertensive patients. 387 hypertensive patients (m...

    journal_title:Renal failure

    pub_type: 临床试验,杂志文章

    doi:10.3109/0886022X.2014.890002

    authors: Xu TY,Zhang Y,Li Y,Zhu DL,Gao PJ

    更新日期:2014-06-01 00:00:00

  • Psychological aspects of disasters.

    abstract::This article describes several topics necessary for understanding the psychological impact of disasters. Topics discussed include characteristics of disaster that impact psychological response, stages of response, factors influencing individual and collective trauma, and important aspects of psychological intervention...

    journal_title:Renal failure

    pub_type: 杂志文章,评审

    doi:10.3109/08860229709109027

    authors: Flynn BW

    更新日期:1997-09-01 00:00:00

  • Which echocardiographic parameter is a better marker of volume status in hemodialysis patients?

    abstract:AIM:Bio-impedance analysis (BIA) is a preferred method for estimating the volume status. However, it cannot be utilized in daily practice. Since the assessment of the volume status is important and challenging for hemodialysis (HD) patients, the aim of study was to determine the volume status in chronic HD patients usi...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2016.1229968

    authors: Sabaghian T,Hajibaratali B,Samavat S

    更新日期:2016-11-01 00:00:00

  • Effects of nitric oxide synthesis inhibition on FK506-induced nephrotoxicity in rats.

    abstract::This study was designed to evaluate the role of nitric oxide (NO) in FK506-induced nephrotoxicity by administering an inhibitor of NO synthesis, N omega-nitro-L-arginine methyl ester (L-NAME) to rats treated with FK506. After one week of treatment with FK506 (3.2 mg/kg/day, intramuscularly) and/or L-NAME (5 mg/100 mL ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1081/jdi-100001279

    authors: Wang L,Kubodera S,Ueno A,Takeda M

    更新日期:2001-01-01 00:00:00

  • A systematic review on randomized control trials on rennin angiotensin aldosterone system inhibitors role in managing hypertension among hemodialysis patients.

    abstract::Randomized control trials (RCTs) are considered as most rigors way of determining the cause-effect relationship of a treatment and outcome. Activation of rennin angiotensin aldosterone system (RAAS) is an important contributor to hypertension in hemodialysis patients. The prevalence of hypertension in hemodialysis pat...

    journal_title:Renal failure

    pub_type: 杂志文章,评审

    doi:10.3109/0886022X.2016.1138833

    authors: Aftab RA,Khan AH,Adnan AS,Jannah N

    更新日期:2016-01-01 00:00:00

  • Mortality risk factors in chronic renal failure patients after coronary artery bypass grafting.

    abstract::Perioperative risk during coronary artery bypass grafting (CABG) is high in patients with chronic renal disease. We aimed to determine postoperative two-year mortality and identify the preoperative risk factors of mortality during CABG surgery in hemodialysis (HD)-dependent and HD-non-dependent CRF patients. We includ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220701573525

    authors: Akman B,Bilgic A,Sasak G,Sezer S,Sezgin A,Arat Z,Ozdemir FN,Haberal M

    更新日期:2007-01-01 00:00:00

  • Tubular cell HIV-1 gp120 expression induces caspase 8 activation and apoptosis.

    abstract::Renal biopsy data indicate that tubular epithelial cells serve as a reservoir for HIV-1 infection. We studied the effect of HIV-1 gp120 envelope gene expression on tubular cell apoptosis. HIV-1 gp120 was expressed in a lentiviral vector pHR-CMV-IRES2-EGFP-DeltaB. This plasmid construct was used to produce pseudotyped ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220902780101

    authors: Vashistha H,Husain M,Kumar D,Singhal PC

    更新日期:2009-01-01 00:00:00

  • Proteomic analysis of peritoneal dialysate fluid in patients with dialysis-related peritonitis.

    abstract::The prognosis of uremia patients on continuous ambulatory peritoneal dialysis (CAPD) is related to frequent peritonitis rate. Frequent peritonitis will lead to peritoneum failure, making CAPD unfeasible. We have performed proteomic profiling of peritoneal dialysis effluent samples from a cross-section of CAPD patients...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220802248969

    authors: Lin WT,Tsai CC,Chen CY,Lee WJ,Su CC,Wu YJ

    更新日期:2008-01-01 00:00:00

  • Hemodynamic maladjustment and disease progression in nephrosis with FSGS.

    abstract::Idiopathic nephrotic syndrome (NS) associated with focal segmental glomerulosclerosis (FSGS) and severe renal function impairment is usually refractory to the conventional treatment and progresses to end-stage renal disease. Herein, we reported 10 patients with NS-FSGS who had initially had CCr 34 +/- 12 mL/min/1.73 m...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1081/jdi-120039520

    authors: Futrakul N,Siriviriyakul P,Deekajorndej T,Futrakul P

    更新日期:2004-05-01 00:00:00

  • Transforming growth factor-beta1 (TGF-beta1): a potential recovery signal in the post-ischemic kidney.

    abstract::TGF-beta1 has been demonstrated to be up-regulated in response to ischemic events both in animal models and in man. Demonstration of this up-regulation in the kidney following experimentally induced acute renal failure and in renal transplants complements similar findings in coronary and cerebral ischemia. Activation ...

    journal_title:Renal failure

    pub_type: 杂志文章,评审

    doi:10.1081/jdi-120006767

    authors: Docherty NG,Pérez-Barriocanal F,Balboa NE,López-Novoa JM

    更新日期:2002-07-01 00:00:00

  • Correlation between asymptomatic leukocyturia and urinary N-acetyl-β-d-glucosaminidase in women.

    abstract::Urinary N-acetyl-β-d-glucosaminidase (NAG) has been suggested as a marker for early diabetic nephropathy. This study aimed to prospectively investigate the relationship between asymptomatic leukocyturia (ASL) and NAG in women. One hundred and five female outpatients aged 31-86 years were selected for a 10-year follow-...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2012.713278

    authors: Sekimizu K,Suzuki T,Igari Y,Okazaki M,Hashimoto M,Suzuki K,Ouchi M,Watanabe K,Nakano H,Oba K

    更新日期:2012-01-01 00:00:00

  • Hepatocellular carcinoma after kidney transplantation: analysis of Hong Kong Renal Registry.

    abstract::Kidney transplant recipients have increased risk of cancers when compared with the general population. Hepatocellular carcinoma (HCC) is extremely important in Asia where hepatitis B virus (HBV) infection is endemic. The aim is to study the epidemiological and clinical aspects of all de novo HCC in our kidney transpla...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2014.899879

    authors: Cheung CY,Lam MF,Chow KM,Lee W,Cheng YL,Yuen SK,Wong PN,Mo KL,Leung KT,Wong SH,Ho YW,Chau KF

    更新日期:2014-07-01 00:00:00

  • A case of idiopathic granulomatous interstitial nephritis with an unusually large granuloma.

    abstract::Granulomatous interstitial nephritis (GIN) is a rare disease. Contributing factors such as drugs, sarcoidosis, infections, and paraproteinemia have been reported, and when no obvious contributing factors can be identified, the disease is classified as idiopathic GIN. We managed a patient with idiopathic GIN with an un...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860220903391218

    authors: Kim SJ,Hee Sung S

    更新日期:2010-01-01 00:00:00

  • Effects of prolonged infusion of the natriuretic peptides Escherichia coli enterotoxin and atrial natriuretic peptide on the outcome of acute ischemic renal failure in the rat.

    abstract::Atrial Natriuretic Peptide (ANP), has protective effect on the outcome of acute renal failure in animals when infused over short periods of time. Escherichia Coli heat-stable enterotoxin (STa) acts on a particulate guanylate cyclase receptors leading to an increase in cytosolic cGMP similar to ANP. STa has longer dura...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1081/jdi-100100850

    authors: Abdulla HM

    更新日期:2000-01-01 00:00:00

  • Bacterial colonization in hemodialysis temporary dual lumen catheters: a prospective study.

    abstract:AIMS:The use of hemodialysis temporary dual-lumen catheters is often complicated by infections, which may be a significant cause of death among patients with end stage renal disease (ESRD). The aim of this study was to assess the incidence of bacteremia and bacterial colonization related to non-tunneled, non-cuffed, du...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220701741940

    authors: de Freitas LW,Neto MM,Nascimento MM,Figueiredo JF

    更新日期:2008-01-01 00:00:00

  • Acute renal failure due to hemorrhagic fever with renal syndrome.

    abstract::The aim of our study was to analyze the clinical course and outcome of acute renal failure (ARF) in patients with hemorrhagic fever with renal syndrome (HFRS). From 1983 to 1995, we treated 33 patients (27 males, 6 females) aged from 16 to 71 years. Half of patients were connected with work at a farm or in a forest. T...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229609047688

    authors: Bren AF,Pavlovcic SK,Koselj M,Kovac J,Kandus A,Kveder R

    更新日期:1996-07-01 00:00:00

  • Rhabdomyolysis and acute renal failure following cardioversion and cardiopulmonary resuscitation.

    abstract::A 39-year-old male suffered a myocardial infarction at work and cardiopulmonary resuscitation was initiated immediately. After 15 cardioversions, ventricular fibrillation converted to sinus rhythm. Rhabdomyolysis with a 100-fold increase of serum creatine kinase level and myoglobinuria with acute renal failure ensued,...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229509037645

    authors: Hojs R,Sinkovic A,Hojs-Fabjan T

    更新日期:1995-11-01 00:00:00

  • Familial Mediterranean fever and membranous glomerulonephritis: report of a case.

    abstract::Familial Mediterranean fever (FMF) is an autosomal recessive genetic disease characterized by recurrent attacks of fever and painful episodes of sterile polyserositis. Kidney involvement may occur as a result of secondary amyloidosis during the course of FMF. Previously, different types of glomerulopathies such as IgM...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860221003640090

    authors: Ceri M,Unverdi S,Altay M,Unverdi H,Ensari A,Duranay M

    更新日期:2010-01-01 00:00:00

  • Sudden onset of nephrotic syndrome in an asymptomatic Fabry patient: a case report.

    abstract:BACKGROUND:Fabry disease (FD) is an X-linked lysosomal storage disorder caused by the mutation of the GLA gene, encoding the α-galactosidase, which is responsible for the catabolism of neutral glycosphingolipids. Microalbuminuria or low-grade proteinuria, and continuously progressive renal failure are common manifestat...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2020.1818578

    authors: Zhang R,Chen Z,Lang Y,Shao S,Cai Y,You Q,Sun Y,Wang S,Shi X,Liu Z,Guo W,Han Y,Shao L

    更新日期:2020-11-01 00:00:00

  • Event- and time-based prospective memory in hemodialysis patients.

    abstract:OBJECTIVE:The present study investigated whether hemodialysis (HD) patients exhibit future memory impairment (PM; the capability of remembering to perform expected future actions) and exploring relevant factors of PM task performance. METHODS:Sixty HD patients and 60 healthy controls matched by age are enrolled in the...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2020.1835673

    authors: Wang B,Li M,Tang F,Wang Y,Han Y,Lu W,Zhang L,Zhang L,Ni W,Zhang L,Zhang L

    更新日期:2020-11-01 00:00:00

  • Endothelin-1 and nitric oxide in patients on chronic hemodialysis.

    abstract:AIM:To establish the role of endothelin-1 and nitric oxide in the pathogenesis of hypertension in patients on chronic hemodialysis by correlating endothelin-1 and NO plasma concentrations to the level of arterial hypertension with respect to angiotensin-converting enzyme (ACE) inhibitor therapy. METHODS:We determined ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220802356218

    authors: Tomić M,Galesić K,Markota I

    更新日期:2008-01-01 00:00:00

  • Idiopathic sudden sensorineural hearing loss in dialysis patients.

    abstract::Although sudden sensorineural hearing loss (SSNHL) affects chronic kidney disease (CKD) patients more frequently than non-CKD patients, few reports have described SSNHL in dialysis patients. We aimed to review the characteristics of SSNHL in chronic dialysis patients and evaluate treatment responses to steroid therapy...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2018.1450760

    authors: Kang SM,Lim HW,Yu H

    更新日期:2018-11-01 00:00:00

  • Safety and efficacy of fluvastatin in hyperlipidemic patients with chronic renal disease.

    abstract:BACKGROUND:There are few reports on the safety and efficacy of long-term treatment with statins in patients with chronic renal disease and hyperlipidemia. We evaluated these subjects treated with fluvastatin. METHODS:After a 4-week run-in period, a total of 80 patients with diabetic nephropathy or chronic glomerulonep...

    journal_title:Renal failure

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1081/jdi-120039826

    authors: Yasuda G,Kuji T,Hasegawa K,Ogawa N,Shimura G,Ando D,Umemura S

    更新日期:2004-07-01 00:00:00

  • Evaluation of volume overload by bioelectrical impedance analysis, NT-proBNP and inferior vena cava diameter in patients with stage 3&4 and 5 chronic kidney disease.

    abstract:BACKGROUND:Determination of fluid overload is important in chronic kidney disease. Early diagnosis and treatment of volume overload may decrease morbidity and mortality. We aimed to determine body composition by using bioelectrical impedance analysis, and studying other clinical characteristics, inferior vena cava diam...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2013.875815

    authors: Yilmaz Z,Yildirim Y,Oto F,Aydin FY,Aydin E,Kadiroglu AK,Yilmaz ME

    更新日期:2014-05-01 00:00:00

  • Epidemiologic trend changes in acute renal failure--a tertiary center experience from South India.

    abstract:BACKGROUND:There are little data on the incidence of acute renal failure (ARF) from India due to the absence of central registry. The etiology, course, and outcome of ARF differ in various parts of India. Significant trend changes were reported even within a same center over a period of time. AIM:To find out the epide...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220600689034

    authors: Jayakumar M,Prabahar MR,Fernando EM,Manorajan R,Venkatraman R,Balaraman V

    更新日期:2006-01-01 00:00:00