Abstract:
AIM:To assess the utility of neutrophil gelatinase-associated lipocalin (NGAL) in both urine and serum as a follow-up marker for the discrimination of prerenal acute kidney injury (AKI) from intrinsic AKI in critically ill pediatric patients with established AKI at the time of patient presentation. PATIENTS AND METHODS:This was a prospective cohort study of a heterogeneous group of critically ill children in the pediatric intensive care unit (PICU). Serum creatinine (SCr) values were obtained daily as part of routine patient care. AKI was defined as a 50% or greater increase in SCr from baseline and classified as prerenal and intrinsic AKI. RESULTS:A total of 32 critically ill children (mean age: 105 ± 71.7 months, 56% female) with established AKI were included to the study. Area under curve (AUC) for urine and serum NGAL to distinguish prerenal AKI from intrinsic AKI was 0.94, 95% confidence interval (CI): 0.869-1.02 (p < 0.001) and 0.86, 95% CI: 0.71-1.02 (p = 0.002), respectively. CONCLUSION:In a heterogeneous group of critically ill children with established AKI, we found that NGAL in both urine and serum at the time of patient presentation discriminated intrinsic AKI from prerenal AKI.
journal_name
Ren Failjournal_title
Renal failureauthors
Polat M,Fidan K,Derinöz O,Gönen S,Söylemezoglu Odoi
10.3109/0886022X.2013.764273subject
Has Abstractpub_date
2013-01-01 00:00:00pages
352-6issue
3eissn
0886-022Xissn
1525-6049journal_volume
35pub_type
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