The association of serum inflammatory biomarkers with chronic kidney disease in hypertensive patients.


:A positive association between inflammation and chronic kidney disease (CKD) has been reported but the impact of hypertension on this relation remains unclear. The aim of this study is to investigate the association of various inflammation markers with risk of CKD in hypertensive patients. 387 hypertensive patients (mean age 55.5 years) were recruited. Serum matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1(TIMP-1), high-sensitivity C-reactive protein (hsCRP) and osteopontin (OPN) were measured by ELISA. CKD was diagnosed either as evidence of kidney damage, including microalbuminuria, or by low glomerular filtration rate (GFR) (<60 mL/min/1.73 m(2)), which was estimated using the Modification of Diet in Renal Disease (MDRD) abbreviated equation. Compared with the reference groups (eGFR ≥ 60 mL/min/1.73 m(2)), the serum levels of TIMP-1, OPN, hsCRP were significantly higher, and the MMP-9/TIMP-1 ratio was lower in the risk group (eGFR < 60 mL/min/1.73 m(2)). Multiple logistic regression analysis showed that TIMP-1, MMP-9/TIMP-1 ratio, OPN and hsCRP were associated with low GFR separately after adjustment, whereas MMP-9/TIMP-1 ratio, OPN and hsCRP were associated with microalbuminuria. The significant association of MMP-9/TIMP-1 ratio and OPN with low GFR and microalbuminuria persisted after additional adjustment for other studied inflammatory biomarkers. Our data suggest that inflammation is strongly and independently associated with renal damage in hypertensive patients. MMP-9/TIMP-1 ratio and OPN may serve as novel risk factors and therapeutic targets for the treatment of CKD in hypertensive patients.


Ren Fail


Renal failure


Xu TY,Zhang Y,Li Y,Zhu DL,Gao PJ




Has Abstract


2014-06-01 00:00:00












  • The predictive value of 131I-hippurate clearance in the prognosis of acute renal failure.

    abstract::The aim of this investigation was to study the validity of the radionuclide methods in the estimation of kidney function, for prognosis and follow-up of acute renal failure (ARF). In thirty-one ARF patients, the evaluation of glomerular filtration rate (GFR) by 99mTc-DTPA clearance and effective renal plasma flow (ERP...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Ilic S,Rajic M,Vlajkovic M,Bogicevic M,Stefanovic V

    更新日期:2000-01-01 00:00:00

  • Cold preservation mediated renal injury: involvement of mitochondrial oxidative stress.

    abstract::Cold preservation has greatly facilitated the use of cadaveric kidneys for renal transplantation, but, clearly, damage occurs during both the preservation episode and the reperfusion phase (following transplantation). The aims of this study were twofold: to develop an in vivo model that was capable of evaluating renal...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Saba H,Munusamy S,Macmillan-Crow LA

    更新日期:2008-01-01 00:00:00

  • Left ventricle ejection fraction may predict mortality in renal transplant patients.

    abstract:PURPOSE:Mortality is a major problem in renal transplant patients, and appropriate preoperative evaluation is very important. We retrospectively reviewed the left ventricle ejection fraction (LVEF) of renal transplant patients. MATERIAL AND METHODS:The clinical records of 1763 patients who had preoperative LVEF result...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Ozkul F,Kasim Arik M,Erbiş H,Akbaş A,Yilmaz VT,Barutcu A,Ali Osmanoğlu I,Kocak H

    更新日期:2016-11-01 00:00:00

  • The protective effect and mechanism of rapamycin in the rat model of IgA nephropathy.

    abstract:BACKGROUND:The pathogenesis of the development of IgA nephropathy has not been clear up to now. At present, some studies revealed that the mTOR pathway may participate in IgA nephropathy; however, the mechanism has not been systematically studied. In this study, we established an IgAN rat model to investigate the prote...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Guo N,Liu S,Bow LM,Cui X,Zhang L,Xu S,Lu S,Tian J

    更新日期:2019-11-01 00:00:00

  • Polyneuropathy due to cyclosporine A in patients with renal transplantation: a case report.

    abstract:BACKGROUND:Calcineurin inhibitor cyclosporine A (CsA) is a potent immunosuppressive agent. The side effects of CsA include nephrotoxicity, hypertension, hypertrichosis, infection, hyperpotassemia, and, to a lower extent, neuropathy. OBJECTIVES:In this case report, we aimed to present a renal transplant patient with po...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Sayin R,Soyoral YU,Erkoc R

    更新日期:2011-01-01 00:00:00

  • Safety and efficacy of mizoribine treatment in nephrotic syndrome complicated with hepatitis B virus infection: a clinical study.

    abstract::Objective The objective of this study is to explore the efficacy and safety of mizoribine (MZR) in treating nephrotic syndrome patients afflicted with hepatitis B virus (HBV). Methods The present study included 36 nephrotic syndrome patients accompanied with HBV infection. A draft of MZR (150-200 mg/d), methylpredniso...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Liu J,Zhang K,Ji Y,Zhang W,Li W,Yong Q,Wang J,Sun J,Zhang H

    更新日期:2016-06-01 00:00:00

  • Differential susceptibility to gentamicin toxicity within the proximal convoluted tubule.

    abstract::The proximal convoluted tubule (PCT) is the major target for injury in gentamicin nephrotoxicity but the necrosis is often patchy and focal. The PCT is structurally, functionally, and metabolically heterogeneous, and the possibility of differential vulnerability to gentamicin-induced necrosis based on this heterogenei...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Shanley PF,Burke TJ

    更新日期:1990-01-01 00:00:00

  • The effect of alfuzosin on renal resistive index, urinary electrolytes and β2 microglobulin levels and TGF β-1 levels of kidney tissue in rats with unilateral ureteropelvic junction obstruction.

    abstract:BACKGROUND:In this study, it was aimed to determine the effects of alfuzosin on experimentally generated unilateral partial ureteropelvic junction obstruction (UPO) in rats. MATERIALS AND METHODS:Thirty Long-Evans rats were randomly allocated into five groups. In control group (C), nothing was performed; in group Sham...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Kose F,Turkyilmaz Z,Sonmez K,Karabulut R,Poyraz A,Gulbahar O,Aral A,Damar C,Kaya C,Can Basaklar A

    更新日期:2016-09-01 00:00:00

  • Oral glucose tolerance test after high-dose i.v. biotin administration in normoglucemic hemodialysis patients.

    abstract::Abnormal glucose metabolism in uremia may result from a complex interplay between decreased insulin secretion and insulin resistance. Recent studies report beneficial effect of biotin administration in glucose metabolism in diabetic animals and in a small number of patients with diabetes mellitus. The aim of the prese...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Koutsikos D,Fourtounas C,Kapetanaki A,Agroyannis B,Tzanatos H,Rammos G,Kopelias I,Bosiolis B,Bovoleti O,Darema M,Sallum G

    更新日期:1996-01-01 00:00:00

  • Outcomes of normotensive IgA nephropathy patients with mild proteinuria who have impaired renal function.

    abstract::Purpose: Typically, IgA nephropathy is a slowly progressive type of glomerulonephritis. High-grade proteinuria and hypertension are predictors of reduced kidney function. However, we found some normotensive patients with mild proteinuria could exhibit impaired renal function at the time of IgAN diagnosis. We therefore...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Tan M,Fang J,Xu Q,Zhang C,Zou G,Wang M,Li W

    更新日期:2019-11-01 00:00:00

  • Current evidence on the use of anti-RAAS agents in congenital or acquired solitary kidney.

    abstract:RATIONAL:The inhibition of renin-angiotensin-aldosterone system (RAAS) is a major strategy for slowing the progression of chronic kidney disease (CKD). The utility of anti-RAAS agents in patients with congenital or acquired solitary kidney is still controversial. OBJECTIVE:A systematic literature review was conducted....

    journal_title:Renal failure

    pub_type: 杂志文章,评审


    authors: Simeoni M,Armeni A,Summaria C,Cerantonio A,Fuiano G

    更新日期:2017-11-01 00:00:00

  • Association of the angiotensinogen M235T and APO E gene polymorphisms in Turkish type 2 diabetic patients with and without nephropathy.

    abstract:BACKGROUND:Diabetic nephropathy (DN) is a leading cause of diabetes-related morbidity and mortality. The aim of this study was to evaluate the relationship of AGT M235T and apoprotein E (APO E) gene polymorphism with DN in Turkish patients of Type 2 diabetes, and to compare genotype and allele distributions among DN pa...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Reis KA,Ebinç FA,Koç E,Demirci H,Erten Y,Güz G,Derici UB,Bali M,Söylemezoğlu O,Arınsoy T,Sindel S

    更新日期:2011-01-01 00:00:00

  • Effects of pentoxifylline on amikacin-induced nephrotoxicity in rats.

    abstract::The nephrotoxicity of amikacin (AK) was prevented with pentoxifylline (PTX) in a rat model. Rats were received a single injection of AK (1.2 g/kg, i.p.) with or without PTX pretreatment (25 mg/kg, orally). Renal morphology was investigated by light microscopy. Tissue samples and trunk blood were also obtained to deter...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Ozer MK,Asci H,Oncu M,Yesilot S,Savran M,Bayram D,Cicek E

    更新日期:2009-01-01 00:00:00

  • Potential of morin and hesperidin in the prevention of cisplatin-induced nephrotoxicity.

    abstract::Oxidative stress is one of the important mechanisms of cisplatin-induced nephrotoxicity. Therefore, this study was designed to explore the potential protective effects of morin and/or hesperidin on oxidative stress in cisplatin-induced nephrotoxicity. This study was performed on 42 Wistar rats. Rats were divided into ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Kaltalioglu K,Coskun-Cevher S

    更新日期:2016-09-01 00:00:00

  • The incidence of acute kidney injury in patients with traumatic brain injury.

    abstract::There is limited information on the incidence of acute kidney injury (AKI) in patients with traumatic brain injury (TBI) although AKI may contribute to morbidity and mortality. We investigated the incidence of AKI in patients with moderate and severe TBI and the association of AKI with risk factors and outcomes in the...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Moore EM,Bellomo R,Nichol A,Harley N,Macisaac C,Cooper DJ

    更新日期:2010-01-01 00:00:00

  • Syndrome of rapid onset ESRD accounted for high hemodialysis catheter use--results of a 13-year Mayo Clinic incident hemodialysis study.

    abstract:BACKGROUND:The syndrome of rapid onset end-stage renal disease (SORO-ESRD) was first described in the journal Renal Failure in 2010. This is an acute precipitate unpredictable yet irreversible ESRD following acute kidney injury (AKI), as distinct from "classic" ESRD where chronic kidney disease (CKD)-ESRD progression w...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Onuigbo M,Agbasi N

    更新日期:2015-01-01 00:00:00

  • Is there an association of hepatitis B virus infection with minimal change disease of nephrotic syndrome? A clinical observational report.

    abstract::The rate of hepatitis B virus (HBV) infection is high in the Chinese population, and the implications of HBV infection are widely recognized, and membranous nephropathy is the most common renal lesion to be associated with HBV infection. Minimal change disease (MCD) is one of the most important histopathological chara...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Zhou TB,Jiang ZP

    更新日期:2015-04-01 00:00:00

  • Association between MPO-463G > A polymorphism and chronic kidney disease: a meta-analysis.

    abstract:BACKGROUND/OBJECTIVE:Previous studies have shown that MPO -463G > A (rs2333227) might be associated with chronic kidney disease (CKD) susceptibility, but sample sizes of those studies are relatively small. Hence, we decided to perform a meta-analysis to evaluate the association. Methods/main results: Two investigators ...

    journal_title:Renal failure

    pub_type: 杂志文章,meta分析


    authors: Qin J,Xing J,Li W,Zhang K,Wu Z

    更新日期:2018-11-01 00:00:00

  • Secondary hyperparathyroidism and brown tumor in dialyzed patients.

    abstract::Secondary hyperparathyroidism is one of the most common complications of chronic renal failure (CRF). Its pathogenesis is multifactorial and still not completely understood. Pathological mechanism of hypocalcemia, hyperphosphatemia and calcitriol deficiency are basic characteristics of CRF and main reason for morpholo...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Jeren-Strujić B,Rozman B,Lambasa S,Jeren T,Marković M,Raos V

    更新日期:2001-03-01 00:00:00

  • Endothelin-1 and nitric oxide in patients on chronic hemodialysis.

    abstract:AIM:To establish the role of endothelin-1 and nitric oxide in the pathogenesis of hypertension in patients on chronic hemodialysis by correlating endothelin-1 and NO plasma concentrations to the level of arterial hypertension with respect to angiotensin-converting enzyme (ACE) inhibitor therapy. METHODS:We determined ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Tomić M,Galesić K,Markota I

    更新日期:2008-01-01 00:00:00

  • Acute renal failure due to acute rhabdomyolysis precipitated by MAST trousers and diflunisal.

    abstract::This report describes a patient who developed acute rhabdomyolysis and acute renal failure following the application of MAST trousers associated with an overdose of diflunisal. This association has not previously been reported. ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Pilmore H,Walker RJ

    更新日期:1993-01-01 00:00:00

  • Expression of both matrix metalloproteinase-2 and its tissue inhibitor-2 in tunica media of radial artery in uremic patients.

    abstract:OBJECTIVE:To investigate the expression and clinical significance of both matrix metalloproteinase-2 (MMP-2) and its tissue inhibitor (tissue inhibitor of metalloproteinase-2 (TIMP-2)) in tunica media of radial artery in uremic patients. METHODS:The modified radial arteries from 80 uremic patients during internal arte...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Shan A,Zhou C,He Y,Feng W,Chen G,Zhong G

    更新日期:2013-01-01 00:00:00

  • Erythropoietin production in patients with chronic renal failure.

    abstract::Studies were performed to reexamine the response of erythropoietin (Epo) production to acute hypoxic stimuli in patients with end-stage renal disease (ESRD). In the absence of acute bleeding or hypoxia, the serum Epo level in ESRD was similar to that of normal subjects despite severe anemia. In 11 dialysis patients wi...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Kato A,Hishida A,Kumagai H,Furuya R,Nakajima T,Honda N

    更新日期:1994-01-01 00:00:00

  • Association of CYP3A variants with kidney transplant outcomes.

    abstract::Cyclosporine is used extensively in kidney transplantation and is a substrate for cytochrome P450 enzymes. The role of cytochrome p450 polymorphisms in kidney transplant outcome has not yet been fully elucidated. We investigate the clinical impact of single nucleotide polymorphisms in CYP3A4, CYP3A5, PPARα, and POR*28...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Traynor C,Conlon P Jr,Phelan PJ,O'Kelly P,Elens L,McCormack M,Cavalleri G,Comber H,van Schaik RH,Conlon PJ

    更新日期:2015-05-01 00:00:00

  • Acute renal failure and pregnancy: a seventeen-year experience of a Tunisian intensive care unit.

    abstract:PURPOSE:To describe the epidemiologic features of acute renal failure related to pregnancy (PRARF) and to evaluate its prognostic impact. METHODS:Retrospective study conducted in a Tunisian intensive care unit over a period of 17 years (1995-2011). Women were included if they were more than 20 weeks pregnant and were ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Bouaziz M,Chaari A,Turki O,Dammak H,Chelly H,Ammar R,Nasri A,Ben Algia N,Bahloul M,Ben Hamida C

    更新日期:2013-10-01 00:00:00

  • Glomerular alterations in experimental oliguric and nonoliguric acute renal failure.

    abstract::Studies were performed in oliguric and nonoliguric forms of uranyl acetate (UA)-induced and ischemic acute renal failure (ARF) to examine whether a reduction in GFR is correlated with glomerular morphologic alterations. UA-induced nonoliguric and oliguric ARF were induced in rabbits by i.v. injections of 0.9 and 2 mg/...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Kato A,Hishida A,Kobayashi S,Honda N

    更新日期:1993-01-01 00:00:00

  • Outcomes and APACHE II predictions for critically ill patients with acute renal failure requiring dialysis.

    abstract:BACKGROUND:Despite the widespread availability of dialytic and intensive care unit technology, the probability of early mortality in critically ill patients with acute renal failure (ARF) is still high, and the evaluation of the patients' prognosis has been difficult. The Acute Physiology and Chronic Health Evaluation ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Chen YC,Hsu HH,Kao KC,Fang JT,Huang CC

    更新日期:2001-01-01 00:00:00

  • Enhanced urinary adiponectin excretion in IgA-nephropathy patients with proteinuria.

    abstract::Adiponectin is secreted specifically by adipose tissue. It was reported that the serum adiponectin level was markedly increased in patients with end-stage renal disease and was positively associated with abnormal renal function in type 2 diabetes. Recently, we found that urinary adiponectin level was significantly inc...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Shimotomai T,Kakei M,Narita T,Koshimura J,Hosoba M,Kato M,Komatsuda A,Ito S

    更新日期:2005-01-01 00:00:00

  • Urinary transforming growth factor-beta1 excretion in renal allograft recipients during the early post-transplantation period.

    abstract:BACKGROUND:Transforming growth factor-beta1 (TGF-beta1), the major fibrogenic growth factor, is implicated in the pathogenesis of renal scarring in experimental and clinical nephropathies as well as in chronic allograft nephropathy. In this study we examined the pattern of changes of TGF-beta1 excretion in the urine an...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Goumenos DS,Tsakas S,Karavias D,Savidaki I,Karatzas T,Vlachojannis JG

    更新日期:2003-07-01 00:00:00

  • Thrombotic thrombocytopenic purpura (TTP): initial treatment with plasma exchange plus steroids and immunosuppressive agents for relapsing cases.

    abstract:BACKGROUND:The thrombotic thrombocytopenic purpura (TTP) is a rare disorder with a high mortality rate if untreated or delayed therapy. Whether immediate diagnosis and promptly treated with plasma exchange can change the grave prognosis? METHOD:Retrospective analysis was performed on clinical characteristics and treat...

    journal_title:Renal failure

    pub_type: 临床试验,杂志文章


    authors: Yang CW,Chen YC,Dunn P,Chang MY,Fang JT,Huang CC

    更新日期:2003-01-01 00:00:00