Abstract:
:A positive association between inflammation and chronic kidney disease (CKD) has been reported but the impact of hypertension on this relation remains unclear. The aim of this study is to investigate the association of various inflammation markers with risk of CKD in hypertensive patients. 387 hypertensive patients (mean age 55.5 years) were recruited. Serum matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1(TIMP-1), high-sensitivity C-reactive protein (hsCRP) and osteopontin (OPN) were measured by ELISA. CKD was diagnosed either as evidence of kidney damage, including microalbuminuria, or by low glomerular filtration rate (GFR) (<60 mL/min/1.73 m(2)), which was estimated using the Modification of Diet in Renal Disease (MDRD) abbreviated equation. Compared with the reference groups (eGFR ≥ 60 mL/min/1.73 m(2)), the serum levels of TIMP-1, OPN, hsCRP were significantly higher, and the MMP-9/TIMP-1 ratio was lower in the risk group (eGFR < 60 mL/min/1.73 m(2)). Multiple logistic regression analysis showed that TIMP-1, MMP-9/TIMP-1 ratio, OPN and hsCRP were associated with low GFR separately after adjustment, whereas MMP-9/TIMP-1 ratio, OPN and hsCRP were associated with microalbuminuria. The significant association of MMP-9/TIMP-1 ratio and OPN with low GFR and microalbuminuria persisted after additional adjustment for other studied inflammatory biomarkers. Our data suggest that inflammation is strongly and independently associated with renal damage in hypertensive patients. MMP-9/TIMP-1 ratio and OPN may serve as novel risk factors and therapeutic targets for the treatment of CKD in hypertensive patients.
journal_name
Ren Failjournal_title
Renal failureauthors
Xu TY,Zhang Y,Li Y,Zhu DL,Gao PJdoi
10.3109/0886022X.2014.890002subject
Has Abstractpub_date
2014-06-01 00:00:00pages
666-72issue
5eissn
0886-022Xissn
1525-6049journal_volume
36pub_type
临床试验,杂志文章相关文献
RENAL FAILURE文献大全abstract::Glycine has been shown to protect against cisplatin (CP) nephrotoxicity in rats and to enhance the in vitro expression of heat-shock protein (hsp) 70 in renal epithelial cells following sublethal heat shock. We hypothesized that the protective effect of glycine against CP nephrotoxicity may be due to an up-regulation ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229709026258
更新日期:1997-01-01 00:00:00
abstract::This report describes a patient who developed acute rhabdomyolysis and acute renal failure following the application of MAST trousers associated with an overdose of diflunisal. This association has not previously been reported. ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229309069415
更新日期:1993-01-01 00:00:00
abstract::Secondary hyperparathyroidism (SHP) is a frequent complication of long-term dialysis patients, and surgical parathyroidectomy remains necessary in patients resistant to medical therapy. The present paper reports single center results in subtotal parathyroidectomy, presenting diagnostic procedure, indications for parat...
journal_title:Renal failure
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::Kidney biopsy is an investigation for diagnosis and prognosis of a variety of nephritides. It also influences therapeutic options. Immunofluorescence (IMF) greatly adds in identifying the pathologies which may not be obvious on light microscopy (L/M), such as IgM, IgA nephropathy, pauci-immune glomerulonephritis, and ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2011.589944
更新日期:2011-01-01 00:00:00
abstract::Transforming growth factor-β1 (TGF-β1) is a crucial factor implicated in the development of renal inflammation and tubulointerstitial fibrosis (TIF). The cytokine interleukin 22 (IL-22) was previously reported to involve in the pathogenesis of chronic inflammatory diseases, however recent studies showed that IL-22 cou...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2020.1753538
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVES:To explore the capacity of mutant lactobacilli to remove creatinine (Cr) and urea nitrogen (UN) via the gastrointestinal tract and its effects on renal pathology in the 5/6 nephrectomized rat model of chronic renal failure. METHODS:Sixty Sprague-Dawley rats were randomly divided into a Sham group, a Model g...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2016.1227617
更新日期:2016-10-01 00:00:00
abstract:UNLABELLED:Cardiovascular diseases are the major cause of morbidity and mortality in renal transplant recipients. We report our experience in the treatment of patients with renal allograft who required cardiovascular surgery. METHODS:Indications for cardiovascular surgery, postoperative complications, and outcome were...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2015.1052950
更新日期:2015-07-01 00:00:00
abstract::In the acute phase of ischemic renal failure, the severe depression of the glomerular filtration rate (GFR) is due to obstruction of the tubules by cells and cell debris rejected from the proximal tubules, a blockade which can be prevented at least partly, by treatment with osmotic diuretics. The isosthenuria, the sec...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229209106632
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Despite the widespread availability of dialytic and intensive care unit technology, the probability of early mortality in critically ill patients with acute renal failure (ARF) is still high, and the evaluation of the patients' prognosis has been difficult. The Acute Physiology and Chronic Health Evaluation ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-100001284
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Calcineurin inhibitor cyclosporine A (CsA) is a potent immunosuppressive agent. The side effects of CsA include nephrotoxicity, hypertension, hypertrichosis, infection, hyperpotassemia, and, to a lower extent, neuropathy. OBJECTIVES:In this case report, we aimed to present a renal transplant patient with po...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2011.573893
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Hemodialysis (HD) patients often experience cardiovascular events, that might be related to altered calcium-phosphate metabolism, dyslipidemia, and chronic inflammation in addition to hypertension. Sevelamer, a non-calcium-containing phosphate binder, may improve the lipid profile of HD patients. However, th...
journal_title:Renal failure
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVE:In order to evaluate the clinical and pathological characteristics of diuretics associated acute kidney injury (AKI) and its management. METHODS:We performed a retrospective study including 131 cases that diagnosed as diuretics associated AKI from 1 January 1999 to 1 January 2010 in Ruijin Hospital affiliate...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2014.917560
更新日期:2014-08-01 00:00:00
abstract:OBJECTIVES:To show renal parenchymal injury depending on extracorporeal shock wave lithotripsy (ESWL). METHODS:The patients with one renal stone and in whom ESWL is planned among the patients in whom renal stone was determined. Their 24-h urine samples were collected just before and after the ESWL treatment. Cit (citr...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2013.766574
更新日期:2013-01-01 00:00:00
abstract::The injection to rats of glycerol, cisplatin, uranyl acetate, sodium dichromate, and mercuric chloride is followed on the third day by acute renal failure. A new approach for quantitative estimation of disturbance of excretory renal function is presented. The decrease in renal function due to uranyl acetate was 77%; s...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229409044898
更新日期:1994-11-01 00:00:00
abstract:BACKGROUND:Serious hyperkalemia was reported in 10% of chronic hemodialysis (HD) patients that could lead to arrhythmia and death. Angiotensin-converting enzyme inhibitors (ACE-I) and angiotensin II receptor blockers (ARB) are well accepted for cardio-protective benefits. The relationship between renin-angiotensin syst...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860220903216147
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Acute hyperammonemia caused by urea cycle disorder is a medical emergency for which immediate managements should be taken to minimize permanent brain damage. Among different enzyme defects, ornithine transcarbamylase deficiency (OTC) is one of the most common enzyme defect in urea cycle disorders. We utilize...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-100101968
更新日期:2000-11-01 00:00:00
abstract::Pentoxifylline (PTX) has been reported to inhibit TNF-alpha production and prevent several types of acute renal failure. This study was undertaken to determine the effect of PTX on the cisplatin-induced acute renal failure in rabbits. Rabbits received a single injection of cisplatin (5 mg/kg, i.p.) with or without PTX...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-120026026
更新日期:2003-11-01 00:00:00
abstract::Secondary hyperparathyroidism is one of the most common complications of chronic renal failure (CRF). Its pathogenesis is multifactorial and still not completely understood. Pathological mechanism of hypocalcemia, hyperphosphatemia and calcitriol deficiency are basic characteristics of CRF and main reason for morpholo...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-100103500
更新日期:2001-03-01 00:00:00
abstract:BACKGROUND:The pathogenesis of the development of IgA nephropathy has not been clear up to now. At present, some studies revealed that the mTOR pathway may participate in IgA nephropathy; however, the mechanism has not been systematically studied. In this study, we established an IgAN rat model to investigate the prote...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2019.1577257
更新日期:2019-11-01 00:00:00
abstract::Postpartum acute kidney injury (PPAKI) constitutes an important cause of obstetric AKI. It is associated with high maternal and fetal mortality in developing nations. The aim of this study is to survey the etiology and outcomes of PPAKI in a tertiary care Indian hospital. Ninety-nine patients, without prior comorbidit...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2016.1164015
更新日期:2016-07-01 00:00:00
abstract::Cold preservation has greatly facilitated the use of cadaveric kidneys for renal transplantation, but, clearly, damage occurs during both the preservation episode and the reperfusion phase (following transplantation). The aims of this study were twofold: to develop an in vivo model that was capable of evaluating renal...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220701813327
更新日期:2008-01-01 00:00:00
abstract::Fibrillary glomerulopathy (FG) can occur either alone or co-existing with other proteinuric glomerular disorders. FG has been associated with poor renal outcomes leading to End Stage Renal Disease (ESRD). Since FG is a relatively rare disorder, limited information is available concerning treatment protocols. We presen...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2014.918832
更新日期:2014-08-01 00:00:00
abstract:INTRODUCTION:In this study, the cause of rapidly deteriorating renal functions in a follow-up period of a 65-year-old female patient, who applied with nephrotic syndrome findings and diagnosed as membranous nephropathy, is presented. CASE REPORT:A 65-year-old patient with findings of nephrotic syndrome had normal kidn...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220802064804
更新日期:2008-01-01 00:00:00
abstract:AIM:The aim of the present study was to investigate the value of the urine cell glycoprotein 1 (PC-1), aminopeptidase N (APN), N-acetyl-beta-D-glucosaminidase (NAGA), and dipeptidylpeptidase IV (DPP IV) in the evaluation of tubular damage in patients with primary glomerulonephritis, diabetic nephropathy, and lupus neph...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220802359048
更新日期:2008-01-01 00:00:00
abstract::A growing body of evidence supports the notion that calcium antagonists exert a renal protective effect. Calcium antagonists may play an important future role in renal hemodynamics related to their reversal of renal vasoconstrictors. Calcium antagonists are also capable of blocking intracellular calcium overload induc...
journal_title:Renal failure
pub_type: 杂志文章,评审
doi:10.3109/08860229309054944
更新日期:1993-01-01 00:00:00
abstract::Oxygen metabolites play an important role in the pathogenesis of myoglobinuric acute renal failure (ARF). Previously, we have reported a down regulation of peroxisome proliferator activated receptor gamma (PPARgamma) in glycerol-induced ARF, and the induction of PPARgamma has been shown to provide renal protection. In...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220701573483
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Coagulation abnormalities have been reported in familial Mediterranean fever (FMF) patients with amyloidosis and nephrotic syndrome; but there is not enough data about the continuity of the thrombogenic activity in FMF patients in clinical remission. The purpose of this study was to assess thrombin activatab...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2014.886935
更新日期:2014-06-01 00:00:00
abstract::Adiponectin is secreted specifically by adipose tissue. It was reported that the serum adiponectin level was markedly increased in patients with end-stage renal disease and was positively associated with abnormal renal function in type 2 diabetes. Recently, we found that urinary adiponectin level was significantly inc...
journal_title:Renal failure
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::This article reviews our experience with 111 pediatric patients following open-heart surgery over 1-year period. Peritoneal dialysis was required in 34 of 111 children (30.6%). We randomly selected 33 patients who did not require peritoneal dialysis as control group. The indications of dialysis were oligoanuria and/or...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2010.493980
更新日期:2010-01-01 00:00:00
abstract::The present study was undertaken to examine the role of arachidonic acid (AA) metabolites in hypoxia/reoxygenation (H/R)-induced renal cell injury in rabbit renal cortical slices using AA metabolic inhibitors. Inhibitors of cyclooxygenase (indomethacin and diclofenac sodium) and lipoxygenase pathways (nordihydroguaiar...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-100100860
更新日期:2000-03-01 00:00:00