Transformation from tubulointerstitial nephritis to crescentic glomerulonephritis: an unusual presentation of ANCA-associated renal vasculitis.

Abstract:

:A 44-year-old man with acute renal failure and antineutrophil cytoplasmic antibodies (ANCA) positivity was described. The first renal biopsy specimen showed tubulointerstitial nephritis (TIN) with normal glomeruli. However, delayed recovery of renal function with low-dose steroid treatment for TIN prompted a second renal biopsy 1 month later; and the specimen demonstrated a dramatically different morphology, with necrotizing and crescentic glomerulonephritis. Improvement in renal function occurred, together with reduction of ANCA titers, following intensive immunosuppressive therapy. This case illustrates an unusual presentation of TIN in ANCA-associated renal vasculitis. The possible pathogenetic mechanism are discussed.

journal_name

Ren Fail

journal_title

Renal failure

authors

Wen YK,Chen ML

doi

10.1080/08860220500531559

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

189-91

issue

2

eissn

0886-022X

issn

1525-6049

journal_volume

28

pub_type

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