Abstract:
:A 44-year-old man with acute renal failure and antineutrophil cytoplasmic antibodies (ANCA) positivity was described. The first renal biopsy specimen showed tubulointerstitial nephritis (TIN) with normal glomeruli. However, delayed recovery of renal function with low-dose steroid treatment for TIN prompted a second renal biopsy 1 month later; and the specimen demonstrated a dramatically different morphology, with necrotizing and crescentic glomerulonephritis. Improvement in renal function occurred, together with reduction of ANCA titers, following intensive immunosuppressive therapy. This case illustrates an unusual presentation of TIN in ANCA-associated renal vasculitis. The possible pathogenetic mechanism are discussed.
journal_name
Ren Failjournal_title
Renal failureauthors
Wen YK,Chen MLdoi
10.1080/08860220500531559subject
Has Abstractpub_date
2006-01-01 00:00:00pages
189-91issue
2eissn
0886-022Xissn
1525-6049journal_volume
28pub_type
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