Development of new nephrons in adult kidneys following gentamicin-induced nephrotoxicity.

Abstract:

:Gentamicin-induced nephrotoxicity results in necrosis of proximal tubular epithelial cells. In mammals, the injured nephron can be repaired by migration and division of surviving cells. We examined this repair process in the fresh-water goldfish, Carassius auratus. Fish were given a single intraperitoneal injection of 50 mg/kg gentamicin and sacrificed at 1, 4, 14, and 21 days. Injured nephrons showed regeneration along the basement membrane several days following gentamicin administration. In addition, 2-3 weeks following the injection, entirely new nephrons formed in the renal interstitium. Development of new nephrons in adult fish kidneys provides an excellent model for studying renal development and toxicity, and could provide insights into new therapies for chronic renal disease.

journal_name

Ren Fail

journal_title

Renal failure

authors

Reimschuessel R,Williams D

doi

10.3109/08860229509026246

subject

Has Abstract

pub_date

1995-03-01 00:00:00

pages

101-6

issue

2

eissn

0886-022X

issn

1525-6049

journal_volume

17

pub_type

杂志文章
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