Abstract:
:Gentamicin-induced nephrotoxicity results in necrosis of proximal tubular epithelial cells. In mammals, the injured nephron can be repaired by migration and division of surviving cells. We examined this repair process in the fresh-water goldfish, Carassius auratus. Fish were given a single intraperitoneal injection of 50 mg/kg gentamicin and sacrificed at 1, 4, 14, and 21 days. Injured nephrons showed regeneration along the basement membrane several days following gentamicin administration. In addition, 2-3 weeks following the injection, entirely new nephrons formed in the renal interstitium. Development of new nephrons in adult fish kidneys provides an excellent model for studying renal development and toxicity, and could provide insights into new therapies for chronic renal disease.
journal_name
Ren Failjournal_title
Renal failureauthors
Reimschuessel R,Williams Ddoi
10.3109/08860229509026246subject
Has Abstractpub_date
1995-03-01 00:00:00pages
101-6issue
2eissn
0886-022Xissn
1525-6049journal_volume
17pub_type
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