Oral glucose tolerance test after high-dose i.v. biotin administration in normoglucemic hemodialysis patients.

Abstract:

:Abnormal glucose metabolism in uremia may result from a complex interplay between decreased insulin secretion and insulin resistance. Recent studies report beneficial effect of biotin administration in glucose metabolism in diabetic animals and in a small number of patients with diabetes mellitus. The aim of the present study was to evaluate the response of oral glucose tolerance test (OGTT) to the i.v. administration of large doses of biotin in hemodialysis patients. Eleven hemodialysis patients aged 56.90 +/- 11.20 (32-76) years on regular hemodialysis thrice a week for 2.72 +/- 1.79 (1-7) years were studied. Fasting venous plasma glucose, glucosylated hemoglobin (%GH), and plasma glucose concentration 2 h after the administration of a 75-g glucose load were measured before, and 2 weeks and 2 months after administration of 50 mg of biotin i.v. postdialysis, and after a 2-month washout period. During the study, dialysis schedule and patients' medication, diet, and dry weight were kept unchanged. OGTT was abnormal in 4 patients before biotin administration and became normal in 3 patients (75%). Our results offer support to the findings of other studies about the beneficial effect of biotin in experimental or clinical diabetes mellitus, and argue for the involvement of biotin in glucose metabolism.

journal_name

Ren Fail

journal_title

Renal failure

authors

Koutsikos D,Fourtounas C,Kapetanaki A,Agroyannis B,Tzanatos H,Rammos G,Kopelias I,Bosiolis B,Bovoleti O,Darema M,Sallum G

doi

10.3109/08860229609052783

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

131-7

issue

1

eissn

0886-022X

issn

1525-6049

journal_volume

18

pub_type

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