Pathological changes, TGF-β1 expression, and the effects of hepatocyte growth factor in 5/6 nephrectomized rats.

Abstract:

:Several studies have shown that hepatocyte growth factor (HGF) ameliorates chronic renal failure, but its mechanism of action is unclear. This study was designed to test the delivery of HGF in the PCI-neo vector, using the 5/6 nephrectomized rat as a model for chronic renal failure, and to confirm that this protective function is associated with decreased protein expression of transforming growth factor-beta1 (TGF-β1). Rats were randomly divided into the following groups: Control (untreated), PCI-neo (vector control), 5/6 nephrectomy, and PCI-neo-HGF. Rats were sacrificed at both the fifth and ninth week after 5/6 nephrectomy. Kidney specimens were used for pathological examination (hematoxylin-eosin staining), and detection of TGF-β1 protein (Western blot and immunohistochemistry) expression. Blood urea nitrogen, serum creatinine, and 24-h urinary protein excretion (UPE) were increased, renal interstitium was seriously injured, and TGF-β1 protein expression was elevated in 5/6 nephrectomized rats compared to control rats at either time point. Red blood cell and hemoglobin levels decreased in the ninth week after 5/6 nephrectomy. PCI-neo-HGF expression ameliorated the aforementioned changes and decreased TGF-β1 expression, not only in the fifth week, but also in the ninth week after surgery. The process of renal injury in the 5/6 nephrectomized rat was consistent with that of chronic renal failure. The increase in TGF-β1 expression was maintained after 5/6 nephrectomy. HGF relieved chronic renal failure, this protection was associated with down-regulation of TGF-β1 protein expression, and the protective effects were long-term and stable after 5/6 nephrectomy.

journal_name

Ren Fail

journal_title

Renal failure

authors

Wang HY,Yang LZ,Gu CM,Chen Y,Zhao Y,Zhao D,Li TS,Cui MJ

doi

10.3109/0886022X.2013.867797

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

393-9

issue

3

eissn

0886-022X

issn

1525-6049

journal_volume

36

pub_type

杂志文章
  • Peritoneal dialysis requirements following open-heart surgery in children with congenital heart disease.

    abstract::This article reviews our experience with 111 pediatric patients following open-heart surgery over 1-year period. Peritoneal dialysis was required in 34 of 111 children (30.6%). We randomly selected 33 patients who did not require peritoneal dialysis as control group. The indications of dialysis were oligoanuria and/or...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2010.493980

    authors: Baskin E,Gulleroglu KS,Saygili A,Aslamaci S,Varan B,Tokel K

    更新日期:2010-01-01 00:00:00

  • Use of alpha-lipoic acid in prevention of contrast-induced nephropathy in diabetic patients.

    abstract::In this prospective study, we aimed to determine the protective antioxidant role of alpha-lipoic acid (ALA) on development of contrast-induced nephropathy (CIN) in diabetic patients undergoing coronary angiography. Seventy-eight diabetic patients undergoing coronary angiography were included. Thirty-nine patients were...

    journal_title:Renal failure

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/0886022X.2013.790298

    authors: Cicek M,Yıldırır A,Okyay K,Yazici AC,Aydinalp A,Kanyilmaz S,Muderrisoglu H

    更新日期:2013-01-01 00:00:00

  • Use of phosphonoformic acid to induce phosphaturia in chronic renal failure in rats.

    abstract::In chronic renal failure (CRF), phosphate (Pi) retention may lead to secondary hyperparathyroidism and progression to end-stage renal disease (ESRD). Dietary phosphorus restriction or phosphate binders can slow progression in experimental CRF. Conversely, diets high in phosphorus can accelerate the progression toward ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229609047712

    authors: Loghman-Adham M,Motock GT

    更新日期:1996-11-01 00:00:00

  • Role of glutathione for cisplatin nephrotoxicity in young and adult rats.

    abstract::Investigations were done in 10- and 55-day-old Wistar rats. Glutathione (GSH) level in kidney was decreased by 8 mmol buthionine sulfoximine (BSO)/100 g BW. There was no effect on the renal function and nephrotoxicity of cisplatin (0.6 mg CP/100 g BW) in adult rats. In young rats BSO treatment was followed by nephroto...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229309046144

    authors: Appenroth D,Winnefeld K

    更新日期:1993-01-01 00:00:00

  • The association of serum inflammatory biomarkers with chronic kidney disease in hypertensive patients.

    abstract::A positive association between inflammation and chronic kidney disease (CKD) has been reported but the impact of hypertension on this relation remains unclear. The aim of this study is to investigate the association of various inflammation markers with risk of CKD in hypertensive patients. 387 hypertensive patients (m...

    journal_title:Renal failure

    pub_type: 临床试验,杂志文章

    doi:10.3109/0886022X.2014.890002

    authors: Xu TY,Zhang Y,Li Y,Zhu DL,Gao PJ

    更新日期:2014-06-01 00:00:00

  • Late onset renal failure and nephrotic syndrome after autologous stem cell transplant for Al amyloidosis.

    abstract::We present a patient with AL amyloidosis who had an autologous stem cell transplant (ASCT) over 9 years ago. She has since then developed slowly progressive renal insufficiency and the nephrotic syndrome. Hematologic evaluation has failed to identify recurrent disease and a renal biopsy demonstrated extensive amyloid ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2012.669320

    authors: Rifkin SI,Weinstein SS

    更新日期:2012-01-01 00:00:00

  • The incidence of acute kidney injury in patients with traumatic brain injury.

    abstract::There is limited information on the incidence of acute kidney injury (AKI) in patients with traumatic brain injury (TBI) although AKI may contribute to morbidity and mortality. We investigated the incidence of AKI in patients with moderate and severe TBI and the association of AKI with risk factors and outcomes in the...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2010.510234

    authors: Moore EM,Bellomo R,Nichol A,Harley N,Macisaac C,Cooper DJ

    更新日期:2010-01-01 00:00:00

  • Which echocardiographic parameter is a better marker of volume status in hemodialysis patients?

    abstract:AIM:Bio-impedance analysis (BIA) is a preferred method for estimating the volume status. However, it cannot be utilized in daily practice. Since the assessment of the volume status is important and challenging for hemodialysis (HD) patients, the aim of study was to determine the volume status in chronic HD patients usi...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2016.1229968

    authors: Sabaghian T,Hajibaratali B,Samavat S

    更新日期:2016-11-01 00:00:00

  • Protective effect of N-benzoyl-beta-alanine against cisplatin nephrotoxicity in rats.

    abstract::Prophylactic effects of N-benzoyl-beta-alanine (betamipron, BP), one of a series of N-acyl amino acids, were examined against cisplatin-induced nephrotoxicity. Male Wistar rats were injected i.p. with 6 mg/kg of cisplatin combined with an i.p. BP dose given at various times and various doses. Rats were sacrificed 5 da...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229609052792

    authors: Tokunaga J,Kobayashi M,Nakamura C,Kitagawa A,Arimori K,Nakano M

    更新日期:1996-03-01 00:00:00

  • Growth factors in metanephric development.

    abstract::During embryonic life, renal morphogenesis is characterized by a defined period of intense cellular activity, inductive-transformation of undifferentiated cells to polarized epithelia, in-growth of capillaries into an intricate parenchymal epithelial-mesenchymal mass, and finally the maturation into an organ with dive...

    journal_title:Renal failure

    pub_type: 杂志文章,评审

    doi:10.3109/08860229809045119

    authors: Wallner EI,Kumar A,Carone FA,Kanwar YS

    更新日期:1998-03-01 00:00:00

  • The prognostic value of frozen section preimplantation graft biopsy in the outcome of renal transplantation.

    abstract:INTRODUCTION:Preimplantation biopsy provides a window on the state of the renal allograft. In this study, the prognostic value of frozen section preimplantation graft biopsy was estimated and compared to regularly processed formalin-fixed biopsy. MATERIALS AND METHODS:Seventy-four renal allograft recipients were studi...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860221003658241

    authors: Goumenos DS,Kalliakmani P,Tsamandas AC,Maroulis I,Savidaki E,Fokaefs E,Papachristou E,Karavias D,Vlachojannis JG

    更新日期:2010-05-01 00:00:00

  • A case of idiopathic granulomatous interstitial nephritis with an unusually large granuloma.

    abstract::Granulomatous interstitial nephritis (GIN) is a rare disease. Contributing factors such as drugs, sarcoidosis, infections, and paraproteinemia have been reported, and when no obvious contributing factors can be identified, the disease is classified as idiopathic GIN. We managed a patient with idiopathic GIN with an un...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860220903391218

    authors: Kim SJ,Hee Sung S

    更新日期:2010-01-01 00:00:00

  • Evaluation of hemodialysis efficiency by an edema fluid model.

    abstract::The concentrations of urea, creatinine, and uric acid were measured in edema fluid and plasma during hemodialysis and 18 h after hemodialysis. The concentrations of these solutes in plasma were 15-17% lower than in the edema fluid after hemodialysis. Eighteen hours after hemodialysis, however, the concentrations in pl...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/08860229209039118

    authors: Shirai D,Kajimoto Y,Ochi S,Tanaka Y,Wada A,Yano F,Izumi M,Fujita Y,Nakahama H

    更新日期:1992-01-01 00:00:00

  • Osteoprotegerin and bone mineral density in hemodiafiltration patients.

    abstract::A newly identified cytokine, osteoprotegerin (OPG) appears to be involved in the regulation of bone remodeling. In vitro studies suggest that OPG, a soluble member of the TNF receptor family of proteins, inhibits osteoclastogenesis by interrupting the intercellular signaling between osteoblastic stromal cells and oste...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220500198698

    authors: Crisafulli A,Romeo A,Floccari F,Aloisi E,Atteritano M,Cincotta M,Aloisi C,Pizzoleo MA,Ruello A,Artemisia A,Valenti A,Frisina N,Teti D,Buemi M

    更新日期:2005-01-01 00:00:00

  • Nephro-oncology: a link in evolution.

    abstract::A multidisciplinary approach represents the best method to interact with patients. Neoplastic and renal diseases are closely related to each other because of an increased risk of cancer among individuals with end-stage renal disease and because of the high prevalence of renal failure in cancer patients. Physicians sho...

    journal_title:Renal failure

    pub_type: 杂志文章,评审

    doi:10.3109/0886022X.2015.1068514

    authors: Lacava V,Coppolino G,Puntorieri E,Cernaro V,Lupica R,Visconti L,Buemi A,Santoro D,Buemi M

    更新日期:2015-01-01 00:00:00

  • Development of hypertension in a pyelonephritis-induced model: the effect of salt intake and inability of renal sodium handling.

    abstract::The role of the kidney in the control of blood pressure has been convincingly demonstrated by several studies. Recent evidence has suggested that subtle acquired tubulointerstitial injury may cause a defect in sodium excretion function, thus leading to salt-sensitive hypertension. There are no reports, however, examin...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220600779058

    authors: de Magalhães Sartim R,Fantinato Menegon L,de Almeida AR,Rocha Gontijo JA,Aline Boer P

    更新日期:2006-01-01 00:00:00

  • Hepatocellular carcinoma after kidney transplantation: analysis of Hong Kong Renal Registry.

    abstract::Kidney transplant recipients have increased risk of cancers when compared with the general population. Hepatocellular carcinoma (HCC) is extremely important in Asia where hepatitis B virus (HBV) infection is endemic. The aim is to study the epidemiological and clinical aspects of all de novo HCC in our kidney transpla...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2014.899879

    authors: Cheung CY,Lam MF,Chow KM,Lee W,Cheng YL,Yuen SK,Wong PN,Mo KL,Leung KT,Wong SH,Ho YW,Chau KF

    更新日期:2014-07-01 00:00:00

  • Transformation from tubulointerstitial nephritis to crescentic glomerulonephritis: an unusual presentation of ANCA-associated renal vasculitis.

    abstract::A 44-year-old man with acute renal failure and antineutrophil cytoplasmic antibodies (ANCA) positivity was described. The first renal biopsy specimen showed tubulointerstitial nephritis (TIN) with normal glomeruli. However, delayed recovery of renal function with low-dose steroid treatment for TIN prompted a second re...

    journal_title:Renal failure

    pub_type: 杂志文章,评审

    doi:10.1080/08860220500531559

    authors: Wen YK,Chen ML

    更新日期:2006-01-01 00:00:00

  • Tocilizumab treatment for nephrotic syndrome due to amyloidosis in Behcet's disease.

    abstract::Renal involvement is an unusual but significant Behcet´s disease (BD) complication and AA amyloidosis appears to be the most common etiology. IL-6 is a pro-inflammatory cytokine with an important role in AA amyloidosis development. Tocilizumab (TCZ) is a humanized anti-IL-6 receptor antibody that has emerged as an eff...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2013.773913

    authors: Redondo-Pachón MD,Enríquez R,Sirvent AE,Andrada E,Noguera-Pons R,Millán I,Amorós F

    更新日期:2013-01-01 00:00:00

  • The role of prolidase activity in the diagnosis of uremic bone disease.

    abstract::The derangements in bone metabolism in patients with chronic renal failure (CRF) are summarized as uremic bone disease (UBD). In this study, we planned to determine the serum prolidase to compare it with the other biochemical markers. This study was performed on 44 patients (19 females, 25 males, mean age = 56.8 +/- 1...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220600577726

    authors: Evrenkaya TR,Atasoyu EM,Kara M,Unver S,Gultepe M

    更新日期:2006-01-01 00:00:00

  • Ozone therapy ameliorates tubulointerstitial inflammation by regulating TLR4 in adenine-induced CKD rats.

    abstract::Tubulointerstitium inflammation is a common pathway aggravating chronic kidney disease (CKD) progression and the mechanism is partly associated with excessive activation of toll-like receptor 4 (TLR4) in tubulointerstitium. Ozone therapy is demonstrated to alleviate inflammation in some experiments. The aim of this st...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2016.1143757

    authors: Chen Z,Liu X,Yu G,Chen H,Wang L,Wang Z,Qiu T,Weng X

    更新日期:2016-06-01 00:00:00

  • Vitamin D deficiency, insulin resistance, and ventricular hypertrophy in the early stages of chronic kidney disease.

    abstract:BACKGROUND:Chronic kidney disease (CKD) is associated with markedly increased cardiovascular (CV) risk. This increase is not fully explained by traditional CV risk factors but may in part be mediated by nontraditional risk factors, such as inadequate vitamin D (vit D) levels and insulin resistance (IR). Although IR is ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2013.832308

    authors: Lai S,Coppola B,Dimko M,Galani A,Innico G,Frassetti N,Mariotti A

    更新日期:2014-02-01 00:00:00

  • Comparing the frequency of hypertension determined by peri-dialysis measurement and ABPM in hemodialysis patients.

    abstract::Controlling blood pressure in hemodialysis patients is crucial but not always easy. The most common blood pressure measurement method is peri-dialysis measurement, but due to interdialytic blood pressure fluctuations, we are unsure if it is the proper way for evaluating blood pressure. Some studies have shown the supe...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2014.883933

    authors: Abbasi MR,Lessan-Pezeshki M,Najafi MT,Gatmiri SM,Karbakhsh M,Mohebi-Nejad A

    更新日期:2014-06-01 00:00:00

  • Successful treatment of severe iron intoxication with gastrointestinal decontamination, deferoxamine, and hemodialysis.

    abstract::Acute iron poisoning is a common and potentially serious problem in the pediatric population. Early recognition and treatment is crucial for a better outcome and to prevent morbidity and mortality. An 18-year-old female, who had accidental ingestion of 50 tablets of ferrous sulfate (100 mg of elemental iron per 335 mg...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2013.790299

    authors: Gumber MR,Kute VB,Shah PR,Vanikar AV,Patel HV,Balwani MR,Ghuge PP,Trivedi HL

    更新日期:2013-01-01 00:00:00

  • Wider intraoperative glycemic fluctuation increases risk of acute kidney injury after pediatric cardiac surgery.

    abstract:OBJECTIVE:The association between poor intraoperative glycemic control and postoperative acute kidney injury (AKI) in adult cardiac surgery has been observed, but data in the pediatrics remain unknown. We performed a hypothesis that intraoperative hyperglycemia and/or wider glycemic fluctuation were associated with the...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2018.1532908

    authors: Hu GH,Duan L,Jiang M,Zhang CL,Duan YY

    更新日期:2018-11-01 00:00:00

  • Potential of morin and hesperidin in the prevention of cisplatin-induced nephrotoxicity.

    abstract::Oxidative stress is one of the important mechanisms of cisplatin-induced nephrotoxicity. Therefore, this study was designed to explore the potential protective effects of morin and/or hesperidin on oxidative stress in cisplatin-induced nephrotoxicity. This study was performed on 42 Wistar rats. Rats were divided into ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2016.1209383

    authors: Kaltalioglu K,Coskun-Cevher S

    更新日期:2016-09-01 00:00:00

  • Cytomegalovirus disease in renal transplant recipients: a single-center experience.

    abstract:UNLABELLED:Cytomegalovirus (CMV) disease is an important complication and an independent risk factor for acute rejection and recipient morbidity-mortality. The aim of this study was to review the results of CMV disease in renal transplant recipients. METHOD:We have retrospectively analyzed CMV disease in 120 renal tra...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/08860220802064705

    authors: Cavdar C,Celtik A,Saglam F,Sifil A,Atila K,Celik A,Tosun P,Olmuscelik O,Bora S,Gulay H,Camsari T

    更新日期:2008-01-01 00:00:00

  • Normal mesenteric lymph ameliorates acute kidney injury following lipopolysaccharide challenge in mice.

    abstract:BACKGROUND:The kidney is one of the prior damaged organs subjected to severe infection and sepsis shock. Our previous studies have shown that the normal mesenteric lymph (NML) obtained from healthy dogs could alleviate multiple organ injuries following endotoxic shock. In the current study, we further investigated the ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.3109/0886022X.2014.938585

    authors: Zhao ZG,Zhang LM,Song W,Du HB,Cui H,Niu CY

    更新日期:2014-09-01 00:00:00

  • Low employment and low willingness of being reemployed in Chinese working-age maintained hemodialysis patients.

    abstract:AIM:Returning to society plays an important role in improving the quality of life in maintenance hemodialysis (MHD) patients, and retention of employment is one of the core enablers. The study is to assess the employment status and to determine the variables for unemployment in Chinese MHD patients. METHODS:Prevalent ...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1080/0886022X.2017.1361834

    authors: Huang B,Lai B,Xu L,Wang Y,Cao Y,Yan P,Chen J

    更新日期:2017-11-01 00:00:00

  • Low prevalence of hepatitis C virus infection in hemodialysis units: effect of isolation?

    abstract::Hepatitis C virus (HCV) infection has recently become the major cause of chronic liver disease among patients on chronic hemodialysis. The use of erythropoietin for treatment of anemia has reduced the number of blood transfusions, but the frequency of HCV infection has not declined in hemodialysis units. The exact mod...

    journal_title:Renal failure

    pub_type: 杂志文章

    doi:10.1081/jdi-120013968

    authors: Harmankaya O,Cetin B,Obek A,Seber E

    更新日期:2002-09-01 00:00:00