Tocilizumab treatment for nephrotic syndrome due to amyloidosis in Behcet's disease.

Abstract:

:Renal involvement is an unusual but significant Behcet´s disease (BD) complication and AA amyloidosis appears to be the most common etiology. IL-6 is a pro-inflammatory cytokine with an important role in AA amyloidosis development. Tocilizumab (TCZ) is a humanized anti-IL-6 receptor antibody that has emerged as an effective and specific treatment in AA amyloidosis secondary to chronic inflammatory disorders. We report on a patient diagnosed with BD who developed nephrotic syndrome caused by renal AA amyloidosis with an excellent response to TCZ therapy.

journal_name

Ren Fail

journal_title

Renal failure

authors

Redondo-Pachón MD,Enríquez R,Sirvent AE,Andrada E,Noguera-Pons R,Millán I,Amorós F

doi

10.3109/0886022X.2013.773913

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

547-50

issue

4

eissn

0886-022X

issn

1525-6049

journal_volume

35

pub_type

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