Tocilizumab treatment for nephrotic syndrome due to amyloidosis in Behcet's disease.


:Renal involvement is an unusual but significant Behcet´s disease (BD) complication and AA amyloidosis appears to be the most common etiology. IL-6 is a pro-inflammatory cytokine with an important role in AA amyloidosis development. Tocilizumab (TCZ) is a humanized anti-IL-6 receptor antibody that has emerged as an effective and specific treatment in AA amyloidosis secondary to chronic inflammatory disorders. We report on a patient diagnosed with BD who developed nephrotic syndrome caused by renal AA amyloidosis with an excellent response to TCZ therapy.


Ren Fail


Renal failure


Redondo-Pachón MD,Enríquez R,Sirvent AE,Andrada E,Noguera-Pons R,Millán I,Amorós F




Has Abstract


2013-01-01 00:00:00












  • Assessment of matrix Gla protein, Klotho gene polymorphisms, and oxidative stress in chronic kidney disease.

    abstract::Increased vascular calcification and oxidative stress are considered as extra renal risk factors at the pathogenesis cardiovascular events in chronic kidney disease (CKD). We investigated matrix Gla protein (MGP) (T-138C, Glu60X, Thr83Ala) and Klotho (Cys370Ser) gene polymorphisms, serum MGP levels, and oxidative stre...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Karsli Ceppioğlu S,Yurdun T,Canbakan M

    更新日期:2011-01-01 00:00:00

  • Ultrasound validation of Trendelenburg positioning to increase internal jugular vein cross-sectional area in chronic dialysis patients.

    abstract:BACKGROUND AND AIM:Trendelenburg positioning (TP) is a common approach used during internal jugular vein (IJV) cannulation. No evidence indicates that TP significantly increases the cross-sectional area (CSA) of the IJV or decreases the overlap between the carotid artery (CA) and the IJV in dialysis patients. The prima...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Nayman A,Onal IO,Apiliogullari S,Ozbek S,Saltali AO,Celik JB,Temizoz O,Celik G

    更新日期:2015-01-01 00:00:00

  • Effect of dialysis on erythrocyte membrane of chronically hemodialyzed patients.

    abstract::The present work examines the role of uremia and the effect of dialysis treatment on red blood cells (RBCs) membrane properties of hemodialysis patients. The results showed that, the uremic patients had a lower values of erythrocyte deformability than that of healthy control subject. The median osmotic fragility (MOF)...

    journal_title:Renal failure

    pub_type: 临床试验,杂志文章


    authors: Ibrahim FF,Ghannam MM,Ali FM

    更新日期:2002-11-01 00:00:00

  • Impact of immunofluorescence on the histological pattern of pediatric kidney biopsies from northern Pakistan.

    abstract::Kidney biopsy is an investigation for diagnosis and prognosis of a variety of nephritides. It also influences therapeutic options. Immunofluorescence (IMF) greatly adds in identifying the pathologies which may not be obvious on light microscopy (L/M), such as IgM, IgA nephropathy, pauci-immune glomerulonephritis, and ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Ali A,Ali MU,Ali MA

    更新日期:2011-01-01 00:00:00

  • Long-term efficacy and safety of quadruple therapy in childhood diffuse proliferative lupus nephritis.

    abstract::In this study, we evaluated the frequency, clinical presentation, treatment protocols, prognostic factors, and outcome in children with diffuse proliferative lupus nephritis (DPLN). Between June 1990 and December 2004, 46 patients were diagnosed to have systemic lupus erythematosus (SLE), and 26 of them (56.5%) were f...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Demircin G,Oner A,Erdoğan O,Delibaş A,Baysun S,Bülbül M,Bek K,Oksal A

    更新日期:2008-01-01 00:00:00

  • Proteomic analysis of peritoneal dialysate fluid in patients with dialysis-related peritonitis.

    abstract::The prognosis of uremia patients on continuous ambulatory peritoneal dialysis (CAPD) is related to frequent peritonitis rate. Frequent peritonitis will lead to peritoneum failure, making CAPD unfeasible. We have performed proteomic profiling of peritoneal dialysis effluent samples from a cross-section of CAPD patients...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Lin WT,Tsai CC,Chen CY,Lee WJ,Su CC,Wu YJ

    更新日期:2008-01-01 00:00:00

  • Cardiovascular surgery after renal transplantation--indications, complications and outcome.

    abstract:UNLABELLED:Cardiovascular diseases are the major cause of morbidity and mortality in renal transplant recipients. We report our experience in the treatment of patients with renal allograft who required cardiovascular surgery. METHODS:Indications for cardiovascular surgery, postoperative complications, and outcome were...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Basic-Jukic N,Ivanac-Jankovic R,Biocina B,Kes P

    更新日期:2015-07-01 00:00:00

  • Effect of fenoldopam on ischemia/reperfusion-induced apoptosis.

    abstract::Recently we demonstrated the effect of fenoldopam on ischemia/reperfusion (I/R) induced NFkappaB mediated pro-inflammatory signal transduction. However, the effect of fenoldopam on I/R-induced apoptosis is not known. We utilized a rat model of acute ischemic nephropathy to test the hypothesis that fenoldopam attenuate...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Aravindan N,Cata JP,Dougherty PM,Shaw AD

    更新日期:2006-01-01 00:00:00

  • Association of CYP3A variants with kidney transplant outcomes.

    abstract::Cyclosporine is used extensively in kidney transplantation and is a substrate for cytochrome P450 enzymes. The role of cytochrome p450 polymorphisms in kidney transplant outcome has not yet been fully elucidated. We investigate the clinical impact of single nucleotide polymorphisms in CYP3A4, CYP3A5, PPARα, and POR*28...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Traynor C,Conlon P Jr,Phelan PJ,O'Kelly P,Elens L,McCormack M,Cavalleri G,Comber H,van Schaik RH,Conlon PJ

    更新日期:2015-05-01 00:00:00

  • Renal failure and nephrotoxic drug-induced disturbances in rat kidney tissue.

    abstract::The injection to rats of glycerol, cisplatin, uranyl acetate, sodium dichromate, and mercuric chloride is followed on the third day by acute renal failure. A new approach for quantitative estimation of disturbance of excretory renal function is presented. The decrease in renal function due to uranyl acetate was 77%; s...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Natochin YV,Bakhteeva VT,Karpenko LA

    更新日期:1994-11-01 00:00:00

  • Salt sensitivity of blood pressure in non-dialysis patients with chronic kidney disease.

    abstract:BACKGROUND:Chronic kidney disease (CKD) is a world-wide public health problem. Hypertension is both a cause and a complication of CKD, and a risk factor for progression of kidney disease. The effect of salt intake on blood pressure (BP) and the salt sensitivity in non-dialysis patients with CKD were studied. METHODS:O...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Meng L,Fu B,Zhang T,Han Z,Yang M

    更新日期:2014-04-01 00:00:00

  • Bone mineral density in patients on maintenance hemodialysis and effect of chronic hepatitis C virus infection.

    abstract:OBJECTIVE:To determine the prevalence of osteopenia and osteoporosis in HD patients at our center; to investigate whether HCV infection affects BMD in hemodialysis patients; to test for correlations between bone mineral density (BMD) and clinical and laboratory parameters in this population. SUBJECTS AND METHODS:The s...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Yücel AE,Kart-Köseoglu H,Isiklar I,Kuruinci E,Ozdemir FN,Arslan H

    更新日期:2004-03-01 00:00:00

  • Cytomegalovirus disease in renal transplant recipients: a single-center experience.

    abstract:UNLABELLED:Cytomegalovirus (CMV) disease is an important complication and an independent risk factor for acute rejection and recipient morbidity-mortality. The aim of this study was to review the results of CMV disease in renal transplant recipients. METHOD:We have retrospectively analyzed CMV disease in 120 renal tra...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Cavdar C,Celtik A,Saglam F,Sifil A,Atila K,Celik A,Tosun P,Olmuscelik O,Bora S,Gulay H,Camsari T

    更新日期:2008-01-01 00:00:00

  • Protective effect of N-benzoyl-beta-alanine against cisplatin nephrotoxicity in rats.

    abstract::Prophylactic effects of N-benzoyl-beta-alanine (betamipron, BP), one of a series of N-acyl amino acids, were examined against cisplatin-induced nephrotoxicity. Male Wistar rats were injected i.p. with 6 mg/kg of cisplatin combined with an i.p. BP dose given at various times and various doses. Rats were sacrificed 5 da...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Tokunaga J,Kobayashi M,Nakamura C,Kitagawa A,Arimori K,Nakano M

    更新日期:1996-03-01 00:00:00

  • Relation between urinary cytology abnormalities and cyclosporine A therapy in bone marrow transplant recipients.

    abstract::The aim of the study was to determine the relationship, if any, between abnormalities in urinary cytology and the administration of cyclosporine A in bone marrow transplant recipients. Specific attention was given to the presence of tubular cells with round inclusions (TCRI). Two bone marrow transplant recipient group...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Sucic M,Boban D,Markovic-Glamocak M,Bogdanic V,Nemet D,Labar B,Cvoriscec D,Plavsic F,Stoos-Veic T,Mrsic M

    更新日期:1998-07-01 00:00:00

  • Acute renal failure due to hemorrhagic fever with renal syndrome.

    abstract::The aim of our study was to analyze the clinical course and outcome of acute renal failure (ARF) in patients with hemorrhagic fever with renal syndrome (HFRS). From 1983 to 1995, we treated 33 patients (27 males, 6 females) aged from 16 to 71 years. Half of patients were connected with work at a farm or in a forest. T...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Bren AF,Pavlovcic SK,Koselj M,Kovac J,Kandus A,Kveder R

    更新日期:1996-07-01 00:00:00

  • Early detection of acute tubular injury with diffusion-weighted magnetic resonance imaging in a rat model of myohemoglobinuric acute renal failure.

    abstract::We evaluated the feasibility of magnetic resonance imaging (MRI) for early detection of tubular injury by monitoring changes in the apparent diffusion coefficient (ADC) of renal water in a rat model of myohemoglobinuric glycerol-induced acute renal failure (ARF). Diffusion-weighted MRI was performed concurrently with ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Vexler VS,Roberts TP,Rosenau W

    更新日期:1996-01-01 00:00:00

  • High mobility group box 1 and tumor growth factor β: useful biomarkers in pediatric patients receiving peritoneal dialysis.

    abstract:BACKGROUND:Peritonitis, the most important limitation of peritoneal dialysis (PD), could be detected by biomarkers in dialysate effluent, representing a noninvasive method to indirectly assess the peritoneum status. The aim of our study was to test high mobility group box 1 (HMGB1) in PD patients, evaluating its role a...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Chimenz R,Lacquaniti A,Colavita L,Chirico V,Fede C,Buemi M,Fede C

    更新日期:2016-10-01 00:00:00

  • Two novel mutations affecting the same splice site of PKD1 correlate with different phenotypes in ADPKD.

    abstract::Genetic heterogeneity is the main factor for significant variation in the course of autosomal dominant polycystic kidney disease (ADPKD). PKD1 patients have more severe renal outcomes compared with PKD2 patients. Co-inheritance of a mutation in both genes is associated with more severe phenotypes than that found with ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Yu C,Li J,Yuan Z,Liu S,Zou L

    更新日期:2014-06-01 00:00:00

  • Occult HBV infection in continuous ambulatory peritoneal dialysis and hemodialysis patients.

    abstract:AIM:Occult hepatitis B virus (HBV) infection can be defined as the presence of HBV DNA in the liver and/or blood in the absence of detectable serum hepatitis B surface antigen (HBs Ag). There is a high prevalence of occult HBV infection in dialysis patients. This study investigated the prevalence of occult HBV infectio...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Sav T,Gursoy S,Torun E,Sav NM,Unal A,Oymak O,Utas C

    更新日期:2010-01-01 00:00:00

  • Gastrointestinal complications in patients with chronic kidney disease--a 5-year retrospective study from a tertiary referral center.

    abstract:BACKGROUND:Gastrointestinal complications are frequent in patients with renal disease and are responsible for substantial morbidity and mortality among these patients in developing countries. Many times, these patients are subjected to endoscopic evaluation and mucosal biopsies are taken for definitive diagnosis. This ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Thomas R,Panackal C,John M,Joshi H,Mathai S,Kattickaran J,Iqbal M

    更新日期:2013-01-01 00:00:00

  • Immune response after a single vaccination against 2009 influenza A H1N1 in hemodialysis patients.

    abstract:BACKGROUND:Influenza infection is a significant cause of morbidity and mortality in general population. Hemodialysis patients are considered at high risk of influenza infection given their altered immune status. Pandemic influenza virus is new for human beings, so it is hard to predict the response to infection or vacc...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Temiz G,Kasifoglu N,Kiris A,Ozturk S,Sahin G,Yalcin AU,Us T

    更新日期:2010-07-01 00:00:00

  • Carotid intima-media thickness is an independent predictor of all-cause mortality and cardiovascular morbidity in patients with diabetes mellitus type 2 and chronic kidney disease.

    abstract:BACKGROUND:Intima-Media-Thickness of the carotid artery wall (cIMT) is a strong predictor of cardiovascular (CV) disease. The aim of this study was to investigate the significance of cIMT as an independent prognostic factor for CV morbidity and mortality in patients with chronic kidney disease (CKD) and diabetes mellit...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Roumeliotis A,Roumeliotis S,Panagoutsos S,Theodoridis M,Argyriou C,Tavridou A,Georgiadis GS

    更新日期:2019-11-01 00:00:00

  • The predictive value of 131I-hippurate clearance in the prognosis of acute renal failure.

    abstract::The aim of this investigation was to study the validity of the radionuclide methods in the estimation of kidney function, for prognosis and follow-up of acute renal failure (ARF). In thirty-one ARF patients, the evaluation of glomerular filtration rate (GFR) by 99mTc-DTPA clearance and effective renal plasma flow (ERP...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Ilic S,Rajic M,Vlajkovic M,Bogicevic M,Stefanovic V

    更新日期:2000-01-01 00:00:00

  • Hemodynamic maladjustment and disease progression in nephrosis with FSGS.

    abstract::Idiopathic nephrotic syndrome (NS) associated with focal segmental glomerulosclerosis (FSGS) and severe renal function impairment is usually refractory to the conventional treatment and progresses to end-stage renal disease. Herein, we reported 10 patients with NS-FSGS who had initially had CCr 34 +/- 12 mL/min/1.73 m...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Futrakul N,Siriviriyakul P,Deekajorndej T,Futrakul P

    更新日期:2004-05-01 00:00:00

  • The differences of asymmetric dimethylarginine removal by different dialysis treatments.

    abstract:BACKGROUND:Asymmetric dimethylarginine (ADMA) as a uremia toxin is accumulated in end-stage renal disease (ESRD) patients. Elevated ADMA level has been shown to be predictive of cardiovascular diseases (CVDs) and all-cause mortality in ESRD. Therefore, we investigated the removal of ADMA by different dialysis treatment...

    journal_title:Renal failure

    pub_type: 杂志文章,随机对照试验


    authors: Zhang DL,Liu J,Liu S,Zhang Y,Liu WH

    更新日期:2010-01-01 00:00:00

  • The combination of sirolimus and cyclosporine does not delay initial renal graft function recovery.

    abstract:BACKGROUND:Sirolimus has been considered to be a non-nephrotoxic agent. It may delay graft function due to a potential hindrance of the recovery from acute tubular necrosis. It remains controversial as to whether the concomitant administration of sirolimus (SRL) with calcineurin inhibitors delays graft function in Asia...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Hsu HJ,Tian YC,Chen YC,Lai BC,Fang JT,Yang CW,Wu MS

    更新日期:2008-01-01 00:00:00

  • Detection of mature macrophages in urinary sediments: clinical significance in predicting progressive renal disease.

    abstract::The ability to predict the rate of progression of renal parenchymal disease may help in its clinical management. We undertook characterization of urinary macrophages obtained from patients with various renal diseases paying special attention to the differentiation from non-progressive to progressive renal diseases. A ...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Hotta O,Kitamura H,Taguma Y

    更新日期:1998-03-01 00:00:00

  • The association of overhydration with megafistulas in hemodialysis patients.

    abstract::Objectives: Diffuse enlargements of arteriovenous dialysis fistulas customarily attributed to either excessive arterial inflow or central outflow stenosis. The relationship between volume status and clinically enlarged (arteriovenous) fistula (CEF) formation in end-stage renal disease (ESRD) patients is not well under...

    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Tapolyai M,Faludi M,Berta K,Forró M,Zsom L,Pethő ÁG,Rosivall L,Fülöp T

    更新日期:2019-11-01 00:00:00

  • What has changed in the prevalence of hypertension in dialyzed children during the last decade?

    abstract:BACKGROUND:Hypertension very often accompanies progression of chronic kidney disease (CKD) in children. A cross-sectional analysis of hypertension prevalence in dialyzed children in Poland was designed with a comparison with the data previously recorded 10 years earlier. METHODS:Two cohorts of children were analyzed: ...

    journal_title:Renal failure

    pub_type: 杂志文章,多中心研究


    authors: Tkaczyk M,Stańczyk M,Miklaszewska M,Zachwieja K,Wierciński R,Stankiewicz R,Firszt-Adamczyk A,Zachwieja J,Borzęcka H,Zagożdżon I,Leszczyńska B,Medyńska A,Adamczyk P,Szczepańska M,Fendler W

    更新日期:2017-11-01 00:00:00