Abstract:
:A newly identified cytokine, osteoprotegerin (OPG) appears to be involved in the regulation of bone remodeling. In vitro studies suggest that OPG, a soluble member of the TNF receptor family of proteins, inhibits osteoclastogenesis by interrupting the intercellular signaling between osteoblastic stromal cells and osteoclast progenitors. As patients with chronic renal failure (CRF) often have renal osteodystrophy (ROD), we investigated the role of osteoprotegerin (OPG) in ROD, and investigated whether there was any relationship between serum OPG, intact parathyroid (PTH) (iPTH), vitamin D, and trabecular bone. Serum OPG combined with iPTH might be a useful tool in the noninvasive diagnosis of ROD, at least in cases in which the range of PTH values compromises reliable diagnosis. Thirty-six patients on maintenance hemodiafiltration (HDF) and a control group of 36 age and sex matched healthy subjects with no known metabolic bone disease were studied. The following assays were made on serum: iPTH, osteocalcin (BGP), bone alkaline phosphatase, 25(OH)-cholecalciferol, calcium, phosphate, OPG, IGF-1, estradiol, and free testosterone. Serum Ca++, P, B-ALP, BGP, IGF-1, iPTH, and OPG levels were significantly higher in HDF patients than in controls, while DXA measurements and quantitative ultrasound (QUS) parameters were significantly lower. On grouping patients according to their mean OPG levels, we observed significantly lower serum IGF-1, vitamin D3 concentrations, and lumbar spine and hip bone mineral density in the high OPG groups. No correlation was found between OPG and bone turnover markers, whereas a negative correlation was found between serum OPG and IGF-1 levels (r=-0.64, p=0.032). Serum iPTH concentrations were positively correlated with bone alkaline phosphatase (B-ALP) (r=0.69, p=0.038) and BGP (r=0.92, p<0.001). The findings made suggest that an increase in OPG levels may be a compensatory response to elevated bone loss. The low bone mineral density (BMD) levels found in the high OPG group might have been due to the significant decrease in serum IGF-1 and vitamin D3 observed. In conclusion, the findings made in the present study demonstrate that increased OPG in hemodiafiltration patients is only partly due to decreased renal clearance. As it may partly reflect a compensatory response to increased bone loss, this parameter might be helpful in the identification of patients with a marked reduction in trabecular BMD.
journal_name
Ren Failjournal_title
Renal failureauthors
Crisafulli A,Romeo A,Floccari F,Aloisi E,Atteritano M,Cincotta M,Aloisi C,Pizzoleo MA,Ruello A,Artemisia A,Valenti A,Frisina N,Teti D,Buemi Mdoi
10.1080/08860220500198698subject
Has Abstractpub_date
2005-01-01 00:00:00pages
531-9issue
5eissn
0886-022Xissn
1525-6049journal_volume
27pub_type
杂志文章相关文献
RENAL FAILURE文献大全abstract::Paraproteins or monoclonal proteins are the result of clonal B-cell or plasma cell proliferation of a malignant, premalignant or non-malignant nature. Monoclonal proteins may consist of intact immunoglobulin molecules or of heavy or light chains only. Depending on their rate of production and/or secretion they may acc...
journal_title:Renal failure
pub_type: 杂志文章,评审
doi:10.3109/08860229809045179
更新日期:1998-11-01 00:00:00
abstract::The use of colistin in the treatment of multidrug-resistant Gram-negative bacterial infections is restricted due to nephrotoxicity. We investigated the effects of aged black garlic extract (ABGE) on colistin-induced kidney injury in rats. Rats were assigned to four groups. Normal saline was intraperitoneally and intra...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2018.1561375
更新日期:2019-11-01 00:00:00
abstract::Non-Shiga-like toxin-producing Escherichia coli (STEC) or atypical hemolytic uremic syndrome (aHUS) is observed in 5-10% of all hemolytic uremic syndrome (HUS) cases, and usually develops secondary to infections, malignancies, drugs, transplantation, pregnancy, and autoimmune disease. However, there has been no report...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2013.780978
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate whether neutrophil gelatinase-associated lipocalin (NGAL) and interleukin-18 (IL-18) predict renal disfunction in patients with familial Mediterranean fever (FMF). METHODS:This prospective study consisted of 102 patients with FMF in attack-free period, and 40 matched he...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2013.865486
更新日期:2014-04-01 00:00:00
abstract::At least 372 people developed crush syndrome after they were injured by the Great Hanshin-Awaji Earthquake. Of these, 23 were transferred to Osaka City General Hospital from the disaster area. The serum creatinine kinase (CK) of each of the 23 patients exceeded 10,000 IU/L. Sixteen of these patients were treated with ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229709109037
更新日期:1997-09-01 00:00:00
abstract::Rhabdomyolysis is common clinical and laboratory syndrome resulting from skeletal muscle injury and acute renal failure is the most important complication. Acute renal failure is common in critically ill medical patients. The aim of our study was to determine the prevalence of rhabdomyolysis induced acute renal failur...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229909094161
更新日期:1999-11-01 00:00:00
abstract::Spontaneous nontraumatic rupture of the kidney (Wunderlich syndrome) is an extremely uncommon condition on hemodialysis. We report a case of 44-year-old hemodialysis patient presented with hemorrhagic shock and a right quadrant abdominal pain to the emergency department. There was no history of trauma. A kidney ruptur...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2012.706887
更新日期:2012-01-01 00:00:00
abstract:INTRODUCTION:End-stage renal disease is the most debilitating condition for patients with renal diseases. Cardiovascular disease is the leading cause of death in these patients. It has been shown that nitric oxide (NO) increases in renal failure and hemodialysis patients and could be correlated with cardiovascular dise...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2013.830225
更新日期:2014-02-01 00:00:00
abstract::Oxidative stress is one of the important mechanisms of cisplatin-induced nephrotoxicity. Therefore, this study was designed to explore the potential protective effects of morin and/or hesperidin on oxidative stress in cisplatin-induced nephrotoxicity. This study was performed on 42 Wistar rats. Rats were divided into ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2016.1209383
更新日期:2016-09-01 00:00:00
abstract::Heat stroke occurs in the desert area of Saudi Arabia quite frequently and manifest in different patterns including coagulopathy. Frequently encountered complications include renal or hepatic failure, rhabdomyolysis, acute respiratory distress syndrome (ARDS), disseminated intravascular coagulation (DIC), and seizure....
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-100107370
更新日期:2001-09-01 00:00:00
abstract:AIM:Returning to society plays an important role in improving the quality of life in maintenance hemodialysis (MHD) patients, and retention of employment is one of the core enablers. The study is to assess the employment status and to determine the variables for unemployment in Chinese MHD patients. METHODS:Prevalent ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2017.1361834
更新日期:2017-11-01 00:00:00
abstract::We studied gene expression for transforming growth factor (TGF)-alpha, epidermal growth factor (EGF), heparin binding (HB) EGF, and the EGF receptor following acute renal failure induced by mercuric chloride administration to gain insight into potential mechanisms of renal repair. Twenty four hours after HgCl2, 2 mg/k...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-100100884
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:The measurement of glomerular filtration rate (GFR) applying serum creatinine (Cr) does not reflect the GFR of patients accurately, and thus recently, studies on the measurement of GFR applying serum cystatin-C (Cys-C) have been conducted. We investigated the relationship between Cys-C and proteinuria in pat...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2012.672154
更新日期:2012-01-01 00:00:00
abstract::Hypertonic glycerol injection is one of the most frequently used models of experimental acute renal failure. Late structural changes such as interstitial fibrosis in the renal cortex and tubular atrophy have been detected after severe acute tubular necrosis (ATN). The aim of this study was to investigate the expressio...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220500244781
更新日期:2005-01-01 00:00:00
abstract::Herein, we report a case of acute kidney injury (AKI) due to diarrhea-induced acute tubular necrosis (ATN) in a patient with nephrotic syndrome secondary to biopsy-proven collapsing focal and segmental glomerulosclerosis (FSGS). The clinical picture mimicked rapidly progressive glomerulonephritis (RPGN) and motivated ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2010.501931
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Peritonitis, the most important limitation of peritoneal dialysis (PD), could be detected by biomarkers in dialysate effluent, representing a noninvasive method to indirectly assess the peritoneum status. The aim of our study was to test high mobility group box 1 (HMGB1) in PD patients, evaluating its role a...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2016.1216711
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:Acute hyperammonemia caused by urea cycle disorder is a medical emergency for which immediate managements should be taken to minimize permanent brain damage. Among different enzyme defects, ornithine transcarbamylase deficiency (OTC) is one of the most common enzyme defect in urea cycle disorders. We utilize...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-100101968
更新日期:2000-11-01 00:00:00
abstract::Controlling blood pressure in hemodialysis patients is crucial but not always easy. The most common blood pressure measurement method is peri-dialysis measurement, but due to interdialytic blood pressure fluctuations, we are unsure if it is the proper way for evaluating blood pressure. Some studies have shown the supe...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2014.883933
更新日期:2014-06-01 00:00:00
abstract:OBJECTIVE:There are controversial reports in the prevalence of abnormal nighttime blood pressure fall in renal patients. It has been evaluated nocturnal BP in renal patients using 24 h blood pressure monitoring (ABPM) in comparison with nontreated control subjects either normotensives or hypertensives. DESIGN AND METH...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-120024297
更新日期:2003-09-01 00:00:00
abstract:AIM:Oxidative stress (OS) and endothelial dysfunction are implicated in accelerated atherosclerosis in chronic kidney disease (CKD). We assessed endothelial function, OS, and carotid intimal medial thickness (CIMT) and their correlates in 44 CKD stage 5 patients (group III) before and after hemodialysis (HD), 40 patien...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2011.568138
更新日期:2011-01-01 00:00:00
abstract::Aims: The aim was to determine whether anti-neutrophil cytoplasmic antibody (ANCA)-positive serology in patients with lupus nephritis (LN) is associated with different clinicopathologic features and outcomes.Methods: In our retrospective analysis, 283 patients were enrolled between 2013 and 2018. Thirty-six patients w...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2020.1735416
更新日期:2020-11-01 00:00:00
abstract::During exercise, the plasma urate levels and urinary excretion increase due to the enhanced purine degradation in skeletal muscle. Although urate transporter-1 (URAT1) is the main transporter responsible for the reabsorption of filtered urate, potential changes in its activity and expression during exercise have not b...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2010.494805
更新日期:2010-01-01 00:00:00
abstract::The present study was undertaken to examine the role of arachidonic acid (AA) metabolites in hypoxia/reoxygenation (H/R)-induced renal cell injury in rabbit renal cortical slices using AA metabolic inhibitors. Inhibitors of cyclooxygenase (indomethacin and diclofenac sodium) and lipoxygenase pathways (nordihydroguaiar...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-100100860
更新日期:2000-03-01 00:00:00
abstract::In vascular smooth muscle, calcium overload is a highly pathogenic event, which increases with advancing age. An increase in the calcium content of arterial wall may be produced in rats by treatment with vitamin D3. The aim of this study was to evaluate the renal clearance of sulfanilamide (a model organic anion, pref...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-120021150
更新日期:2003-05-01 00:00:00
abstract::Objective: To study the efficacy and safety of sustained low-efficiency diafiltration (SLEDf) versus hemodialysis (HD) for patients with wasp stings who developed stage III acute kidney injury (AKI). Methods: We retrospectively analyzed the clinical data of consecutive patients who developed AKI following wasp stings....
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2019.1655449
更新日期:2019-11-01 00:00:00
abstract::Eight patients aged between 5 and 26 years developed rapid deterioration of renal function and became oliguric/anuric with duration ranging from 1 to 21 days. The initial functional assessment revealed severe degree of glomerular, tubular, and vascular dysfunctions. The magnitude of renal dysfunction was quantified an...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229609047678
更新日期:1996-07-01 00:00:00
abstract::Renal biopsy data indicate that tubular epithelial cells serve as a reservoir for HIV-1 infection. We studied the effect of HIV-1 gp120 envelope gene expression on tubular cell apoptosis. HIV-1 gp120 was expressed in a lentiviral vector pHR-CMV-IRES2-EGFP-DeltaB. This plasmid construct was used to produce pseudotyped ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220902780101
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Chronic kidney disease (CKD) is a world-wide public health problem. Hypertension is both a cause and a complication of CKD, and a risk factor for progression of kidney disease. The effect of salt intake on blood pressure (BP) and the salt sensitivity in non-dialysis patients with CKD were studied. METHODS:O...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2013.866008
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:There are little data on the incidence of acute renal failure (ARF) from India due to the absence of central registry. The etiology, course, and outcome of ARF differ in various parts of India. Significant trend changes were reported even within a same center over a period of time. AIM:To find out the epide...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220600689034
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:A nephrologist in the millennium offers comprehensive care to renal failure patients. Interventional nephrology plays a major role in this new approach. Overton Brooks Veterans Affairs Medical Center (OBVAMC) is the first federal health care provider in the nation offering such services. Lack of intervention...
journal_title:Renal failure
pub_type: 杂志文章,评审
doi:
更新日期:2005-01-01 00:00:00