Significant benefits after renal transplantation in patients with chronic heart failure and chronic kidney disease.

Abstract:

BACKGROUND:Chronic heart failure (CHF) and chronic kidney disease (CKD) are serious medical conditions with significant morbidity and mortality and often coexist. Because of perioperative risks in these patients, they may not be considered a candidate for renal transplantation (RTx). MATERIAL AND METHODS:We compare retrospectively RTx outcomes [graft/patient survival, rejection rates and adverse cardiac events] in study group [low left ventricular ejection fraction (LVEF) ≤ 45% by echocardiogram, n = 63] and control group [normal LVEF ≥ 50%, n = 537] from a developing country. RESULTS:The mean EF was 35 ± 5.6 and 57 ± 3% for the study and control groups, respectively (p < 0.001). Majority of these patients (98%) showed normalization of LVEF post-transplant. The median EF was 60% at 1-3 months post-transplant. No difference was noted in graft survival, patient survival, rejection rates, serum creatinine and adverse cardiac events of study group at 1.3-year mean follow-up compared to control group. Outcome was not adversely affected by preexisting LV dysfunction. The study and control groups had nearly similar percent of patients with established CAD but significantly more hospitalization for CHF pre RTx in the study group compared with the control group. CONCLUSION:RTx may play a role in reversing LV systolic dysfunction. Once thought by many to be a contraindication for renal transplantation, this appears not to be the case. The outcomes between the 2 groups are comparable and transplant is an option for even low EF patients.

journal_name

Ren Fail

journal_title

Renal failure

authors

Kute VB,Vanikar AV,Patel HV,Gumber MR,Shah PR,Engineer DP,Balwani MR,Gautam RS,Modi PR,Shah VR,Trivedi HL

doi

10.3109/0886022X.2014.899474

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

854-8

issue

6

eissn

0886-022X

issn

1525-6049

journal_volume

36

pub_type

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