Abstract:
BACKGROUND:Human urotensin-II (hU-II) is one of the most potent vasoconstrictors in mammals. To our knowledge, there is no study about the role of U-II in childhood glomerulonephritis. We first determined the expression of h U-II in kidneys of children with chronic glomerular diseases. METHODS:Normal human kidneys were obtained from postmortem biopsies and compared with the kidney biopsy specimens of 24 children with membranoproliferative glomerulonephritis (MPGN) and 6 children with membranous GN. Kidney needle biopsies in 10% neutral buffered-formalin prior to routine processing through to embedded blocking sections were cut, and immunohistochemical reactions were performed on paraffin-embedded tissue by an avidin-biotin peroxidase complex method. The antibodies used in the present study were hU-II. The positivities were revealed as weak (+), moderate (++), and severe (+++), according to the color intensity. RESULTS:In kidneys of children with MPGN, differently fom the normal kidneys, more dense U-II immunoreactivity was seen in the glomerular basement membrane (GBM), glomerular mesangium, Bowman capsule, and tubules. Interestingly, we also observed U-II immunoreactivity in crescents. In children with MGN, U-II was mostly seen in GBM and Bowman capsule. CONCLUSION:Our findings suggest that U-II may have a possible autocrine/paracrine function in the kidneys, and may be an important target molecule in studying renal pathophysiology.
journal_name
Ren Failjournal_title
Renal failureauthors
Balat A,Karakök M,Yilmaz K,Kibar Ydoi
10.1080/08860220701392108subject
Has Abstractpub_date
2007-01-01 00:00:00pages
573-8issue
5eissn
0886-022Xissn
1525-6049pii
780773330journal_volume
29pub_type
杂志文章相关文献
RENAL FAILURE文献大全abstract::In chronic renal failure (CRF), phosphate (Pi) retention may lead to secondary hyperparathyroidism and progression to end-stage renal disease (ESRD). Dietary phosphorus restriction or phosphate binders can slow progression in experimental CRF. Conversely, diets high in phosphorus can accelerate the progression toward ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229609047712
更新日期:1996-11-01 00:00:00
abstract:BACKGROUND/OBJECTIVE:Previous studies have shown that MPO -463G > A (rs2333227) might be associated with chronic kidney disease (CKD) susceptibility, but sample sizes of those studies are relatively small. Hence, we decided to perform a meta-analysis to evaluate the association. Methods/main results: Two investigators ...
journal_title:Renal failure
pub_type: 杂志文章,meta分析
doi:10.1080/0886022X.2018.1499529
更新日期:2018-11-01 00:00:00
abstract::This study was designed to evaluate the seroprevalence of hepatitis G virus (HGV) infection, its impact, and its relationship with other hepatotropic viruses among chronic renal failure patients undergoing hemodialysis at the Lok Nayak Hospital, New Delhi. The study group consisted of 100 consecutive cases of patients...
journal_title:Renal failure
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::Thomas syndrome is a rare syndrome including Potter sequence, renal anomalies, heart defects, cleft palate with other oropharyngeal anomalies. Here, we report a newborn with Potter sequence, bilateral renal hypoplasia and cystic dysplasia, multiple cardiovascular malformations, long large ears, frontal bossing, small ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2011.585414
更新日期:2011-01-01 00:00:00
abstract::We studied gene expression for transforming growth factor (TGF)-alpha, epidermal growth factor (EGF), heparin binding (HB) EGF, and the EGF receptor following acute renal failure induced by mercuric chloride administration to gain insight into potential mechanisms of renal repair. Twenty four hours after HgCl2, 2 mg/k...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-100100884
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:Study the possible excretion of vitamin A in urine of critically ill patients complicated with acute renal failure. PATIENTS AND METHODS:Nine Intensive Care Unit patients, age 71.2 +/- 15.7 (mean +/- SD) with acute renal failure were studied. Urinary retinol, creatinine, protein, albumin, and serum creatinin...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-200031729
更新日期:2004-09-01 00:00:00
abstract:OBJECTIVE:To investigate the anti proteinuric effect of pentoxifylline in diabetic patients, we prospectively studied in 25 hypertensive type 2 diabetic patients with persistent microalbuminuria and normal renal function the impact of combining pentoxifylline with an angiotensin converting enzyme inhibitor, lisinopril,...
journal_title:Renal failure
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1081/jdi-120021159
更新日期:2003-05-01 00:00:00
abstract:BACKGROUND:Gastrointestinal complications are frequent in patients with renal disease and are responsible for substantial morbidity and mortality among these patients in developing countries. Many times, these patients are subjected to endoscopic evaluation and mucosal biopsies are taken for definitive diagnosis. This ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2012.731998
更新日期:2013-01-01 00:00:00
abstract:BACKGROUNDS/AIMS:Renal ischemia-reperfusion (IR) induces organ damage in remote organs. The aim of this study was to assess the role of leukocytes in the induction of liver damage after renal IR injury. METHODS:Inbred mice were subjected to either sham operation or bilateral renal IR injury (60 min ischemia followed b...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2010.541585
更新日期:2011-01-01 00:00:00
abstract:UNLABELLED:Intensity of dialysis dose in acute kidney injury (AKI) might benefit critically ill patients. The aim of this study was to evaluate the effect of intermittent hemodialysis (IHD) dose on mortality in patients with AKI. METHODS:Prospective observational study was performed on AKI patients treated with IHD. T...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2012.697444
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:To investigate the treatment efficacy of adefovir dipivoxil combined with a corticosteroid on hepatitis B virus-associated glomerulonephritis (HBV-GN). METHODS:A total of 38 patients with nephrotic syndrome induced by HBV-GN were treated for 36 weeks between 2010 and 2012. RESULTS:The efficacy analysis show...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2014.952745
更新日期:2014-10-01 00:00:00
abstract::TGF-beta1 has been demonstrated to be up-regulated in response to ischemic events both in animal models and in man. Demonstration of this up-regulation in the kidney following experimentally induced acute renal failure and in renal transplants complements similar findings in coronary and cerebral ischemia. Activation ...
journal_title:Renal failure
pub_type: 杂志文章,评审
doi:10.1081/jdi-120006767
更新日期:2002-07-01 00:00:00
abstract:OBJECTIVES:To show renal parenchymal injury depending on extracorporeal shock wave lithotripsy (ESWL). METHODS:The patients with one renal stone and in whom ESWL is planned among the patients in whom renal stone was determined. Their 24-h urine samples were collected just before and after the ESWL treatment. Cit (citr...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2013.766574
更新日期:2013-01-01 00:00:00
abstract::We evaluated the feasibility of magnetic resonance imaging (MRI) for early detection of tubular injury by monitoring changes in the apparent diffusion coefficient (ADC) of renal water in a rat model of myohemoglobinuric glycerol-induced acute renal failure (ARF). Diffusion-weighted MRI was performed concurrently with ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229609052773
更新日期:1996-01-01 00:00:00
abstract:AIM:Oxidative stress (OS) and endothelial dysfunction are implicated in accelerated atherosclerosis in chronic kidney disease (CKD). We assessed endothelial function, OS, and carotid intimal medial thickness (CIMT) and their correlates in 44 CKD stage 5 patients (group III) before and after hemodialysis (HD), 40 patien...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2011.568138
更新日期:2011-01-01 00:00:00
abstract::Nonalcoholic fatty liver disease (NAFLD) is associated with an increased prevalence of chronic kidney disease in patients with type 1 diabetes. The aim of this study was to explore the relationship between markers of NAFLD, namely concentrations of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alka...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2013.872569
更新日期:2014-04-01 00:00:00
abstract::Uncertainty of measurement is the numeric expression of the errors associated with all measurements taken in clinical laboratories. Serum creatinine concentration is the most common diagnostic marker for acute kidney injury. The goal of this study was to determine the effect of the uncertainty of measurement of serum ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2015.1117925
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to investigate the cancer incidence in patients with end-stage aristolochic acid nephropathy (AAN). METHODS:A total of 102 patients with end-stage AAN treated in our hospital between 2004 and 2013 were included in this study. The correlation of cancer incidence with age, gender...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2014.990347
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:The kidney is a major site for the inactivation, degradation, and clearance of a variety of peptide hormones. It has been shown that the uremia increases or decreases gastrointestinal system (GIS) hormones. Moreover, studies investigating the serum GIS hormones levels in chronic renal failure (CRF) were cond...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220701643799
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:A unique form of postinfectious glomerulonephritis (PIGN) with IgA-dominant deposition mimicking IgA nephropathy has been increasingly reported. METHODS:We compared the clinical and histological features of 12 patients with postinfectious IgA-dominant glomerulonephritis to 134 patients with idiopathic IgA n...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860221003753331
更新日期:2010-06-01 00:00:00
abstract::Genetic heterogeneity is the main factor for significant variation in the course of autosomal dominant polycystic kidney disease (ADPKD). PKD1 patients have more severe renal outcomes compared with PKD2 patients. Co-inheritance of a mutation in both genes is associated with more severe phenotypes than that found with ...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2014.890010
更新日期:2014-06-01 00:00:00
abstract::Arteriosclerosis is characterized by stiffening of arteries. The incremental elastic modulus (Einc) measurement is a good marker of arterial wall stiffness. Metabolic, inflammatory and hemodynamic alterations cause structural changes and vascular complications in end stage renal disease. The aim of the present study w...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-120026036
更新日期:2003-11-01 00:00:00
abstract::The aim of this investigation was to study the validity of the radionuclide methods in the estimation of kidney function, for prognosis and follow-up of acute renal failure (ARF). In thirty-one ARF patients, the evaluation of glomerular filtration rate (GFR) by 99mTc-DTPA clearance and effective renal plasma flow (ERP...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1081/jdi-100100899
更新日期:2000-01-01 00:00:00
abstract:AIM:The aim of this study was to evaluate the effects of curcumin in an experimental model of busulfan-induced renal toxicity with emphasis on importance of histological alterations. METHODS:In this study, we utilized 32 adult male Wistar rats (250 ± 10 g). All the animals were divided into four experimental groups ra...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2020.1818580
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:Cardiac valve calcification (CVC) and left ventricular (LV) alterations are frequent complication in end-stage renal disease (ESRD). We determined the prevalence of CVC and LV hypertrophy (LVH) in ESRD patients before renal replacement therapy and 12 months after peritoneal dialysis (PD). METHODS:A prospect...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/0886022X.2015.1073495
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Peritonitis, the most important limitation of peritoneal dialysis (PD), could be detected by biomarkers in dialysate effluent, representing a noninvasive method to indirectly assess the peritoneum status. The aim of our study was to test high mobility group box 1 (HMGB1) in PD patients, evaluating its role a...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2016.1216711
更新日期:2016-10-01 00:00:00
abstract::Aims: The aim was to determine whether anti-neutrophil cytoplasmic antibody (ANCA)-positive serology in patients with lupus nephritis (LN) is associated with different clinicopathologic features and outcomes.Methods: In our retrospective analysis, 283 patients were enrolled between 2013 and 2018. Thirty-six patients w...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/0886022X.2020.1735416
更新日期:2020-11-01 00:00:00
abstract::Rat renal cortical mitochondria were isolated from Wistar male rats weighing 80 to 120 g to investigate whether the source of oxygen free radicals was renal cortical mitochondria enhanced by gentamicin. In renal cortical mitochondria with or without the addition of gentamicin, DMSO, DFO, CAT, SOD, and MT1 were added s...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860229509036371
更新日期:1995-01-01 00:00:00
abstract:INTRODUCTION:Preimplantation biopsy provides a window on the state of the renal allograft. In this study, the prognostic value of frozen section preimplantation graft biopsy was estimated and compared to regularly processed formalin-fixed biopsy. MATERIALS AND METHODS:Seventy-four renal allograft recipients were studi...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.3109/08860221003658241
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:An increased red blood cell (RBC) phosphatidylserine (PS) exposure in uremic patients was found that could promote macrophage recognition and decrease RBC survival time. Furthermore, a reduced red cell life span was found to contribute anemia in patients with renal failure. It is therefore possible to hypoth...
journal_title:Renal failure
pub_type: 杂志文章
doi:10.1080/08860220600839647
更新日期:2006-01-01 00:00:00