The impact of location and patency of the arteriovenous fistula on quality of life of kidney transplant recipients.


BACKGROUND:Arteriovenous fistulae (AVFs) may remain patent after kidney transplantation (KTx), contributing to maladaptive cardiac remodeling. The flow in AVFs is associated with the diameter of its vessels and thus with the AVF location. The main objective of this study is to assess the influence of AVF location and its patency on the self-reported quality of life (QOL) of kidney transplant recipients (KTRs) with past history of hemodialysis. METHODS:To gain clinical data, during a scheduled visit, 353 KTRs were asked to fill out an anonymous questionnaire. From this group, 284 respondents were found eligible for analysis. The outcome was defined as prevalence of symptoms and health status, measured with the Left Ventricular Dysfunction-36 (LVD-36) Questionnaire in symptomatic patients. RESULTS:The hemodialysis patients (n = 243) were divided into two groups according to AVF location, i.e., DAVF - distally located AVF - (n = 174) and PAVF - proximally located AVF - (n = 69). The proportion of patients with heart failure (HF) was higher in PAVF group (24% vs. 12%, p = 0.0482). In the multivariable regression, PAVF, serum creatinine levels, and the presence of HF or coronary artery disease (CAD) remained independent predictors of lower functional capacity. Among patients with heart disease, the presence of active AVF was independently associated with worse functional outcome (higher LVD-36 scores). CONCLUSIONS:The influence of persistent PAVF in KTRs seems to be unfavorable, especially when coexisting with CAD or HF. Abbreviations: AVF arteriovenous fistula; BMI body mass index; CAD coronary artery disease; D-AVF distally-located arteriovenous fistula; EC exercise capacity; HD hemodialysis; HF heart failure; KTx kidney transplantation; KTR kidney transplant recipient; LVD-36 Left Ventricle Disfunction - 36; LVEF left ventricle ejection fraction; LVH left ventricle hypertrophy; NYHA New York Heart Association; P-AVF proximally located arteriovenous fistula; PD peritoneal dialysis; PRO patient-reported outcomes; QOL quality of life.


Ren Fail


Renal failure


Letachowicz K,Bardowska K,Królicki T,Kamińska D,Banasik M,Zajdel K,Mazanowska O,Madziarska K,Janczak D,Krajewska M




Has Abstract


2021-12-01 00:00:00












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    abstract::A 44-year-old man with acute renal failure and antineutrophil cytoplasmic antibodies (ANCA) positivity was described. The first renal biopsy specimen showed tubulointerstitial nephritis (TIN) with normal glomeruli. However, delayed recovery of renal function with low-dose steroid treatment for TIN prompted a second re...

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    abstract:BACKGROUND:The kidney is a major site for the inactivation, degradation, and clearance of a variety of peptide hormones. It has been shown that the uremia increases or decreases gastrointestinal system (GIS) hormones. Moreover, studies investigating the serum GIS hormones levels in chronic renal failure (CRF) were cond...

    journal_title:Renal failure

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    authors: Borazan A,Cavdar Z,Saglam F

    更新日期:2007-01-01 00:00:00

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    journal_title:Renal failure

    pub_type: 杂志文章


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    abstract::Neutrophil-lymphocyte ratio (NLR) is a marker of systemic inflammation that has been shown to predict mortality in patients with malignancies, ischemic heart disease and peripheral vascular disease. Its prognostic value in hemodialysis patients is unclear. The aims of this study were to: (i) explore the relationship b...

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    authors: Neuen BL,Leather N,Greenwood AM,Gunnarsson R,Cho Y,Mantha ML

    更新日期:2016-01-01 00:00:00

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    abstract::Hypertonic glycerol injection is one of the most frequently used models of experimental acute renal failure. Late structural changes such as interstitial fibrosis in the renal cortex and tubular atrophy have been detected after severe acute tubular necrosis (ATN). The aim of this study was to investigate the expressio...

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    authors: de Jesus Soares T,Costa RS,de Mattos Coelho R,Alves da Silva CG,Coimbra TM

    更新日期:2005-01-01 00:00:00

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    journal_title:Renal failure

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    authors: Aravindan N,Aravindan S,Riedel BJ,Weng HR,Shaw AD

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    更新日期:1998-07-01 00:00:00

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    journal_title:Renal failure

    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Huang B,Lai B,Xu L,Wang Y,Cao Y,Yan P,Chen J

    更新日期:2017-11-01 00:00:00

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    pub_type: 杂志文章


    authors: Altintepe L,Guney I,Tonbul Z,Türk S,Mazi M,Ağca E,Yeksan M

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    journal_title:Renal failure

    pub_type: 杂志文章,随机对照试验


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    pub_type: 杂志文章


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    更新日期:2002-09-01 00:00:00

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    pub_type: 临床试验,杂志文章


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    journal_title:Renal failure

    pub_type: 杂志文章


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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章


    authors: Simić-Ogrizović S,Radivojević D,Radovic M,Lezaic V,Mirković D,Babić D,Dukanović L

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    pub_type: 临床试验,杂志文章,随机对照试验


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    pub_type: 杂志文章


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    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Goumenos DS,Tsakas S,Karavias D,Savidaki I,Karatzas T,Vlachojannis JG

    更新日期:2003-07-01 00:00:00

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    journal_title:Renal failure

    pub_type: 杂志文章


    authors: Lai S,Coppola B,Dimko M,Galani A,Innico G,Frassetti N,Mariotti A

    更新日期:2014-02-01 00:00:00