Characteristics of immune cell infiltration and associated diagnostic biomarkers in ulcerative colitis: results from bioinformatics analysis.

Abstract:

:Ulcerative colitis (UC) is a type of refractory and recurrent inflammatory disorder that occurs in colon and rectum. Immune cell infiltration plays a critical role in UC progression; therefore, this study aims to explore potential biomarkers for UC and to analyze characteristics of immune cell infiltration based on the bioinformatic analysis. In this study, 248 differentially expressed genes (DEGs) were screened, and the top 20 immune-related hub genes and pathways were assessed. Moreover, four candidate diagnostic biomarkers (DPP10, S100P, AMPD1, and ASS1) were identified and validated. Immune cell infiltration analysis identified 13 differentially infiltrated immune cells (IICs) in UC samples compared to normal samples, and the result showed that two IICs only expressed in UC samples. In addition, the present research found that DPP10 was negatively correlated with neutrophils, S100P exhibited a positive correlation with resting CD4 memory T cells, AMPD1 was positively correlated with M2 macrophages, and ASS1 was inversely associated with neutrophils and positively related to CD8 T cells. Taken together, these findings indicated that DPP10, S100P, AMPD1, and ASS1 may act as diagnostic biomarkers for UC, and that differential IICs may help to illustrate the progression of UC.

journal_name

Bioengineered

journal_title

Bioengineered

authors

Xue G,Hua L,Zhou N,Li J

doi

10.1080/21655979.2020.1863016

subject

Has Abstract

pub_date

2021-12-01 00:00:00

pages

252-265

issue

1

eissn

2165-5979

issn

2165-5987

journal_volume

12

pub_type

杂志文章
  • Bioinformatics analysis to screen key prognostic genes in the breast cancer tumor microenvironment.

    abstract::Increasing evidence has shown that the tumor microenvironment (TME) plays an important role in tumor occurrence and development and can also affect patient prognosis. In this study, we screened key prognostic genes in the breast cancer (BC) TME by analyzing the immune and stromal scores of tumor samples to detect diff...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2020.1840731

    authors: Ye Q,Han X,Wu Z

    更新日期:2020-12-01 00:00:00

  • Increased recovery and improved purity of PHA from recombinant Cupriavidus necator.

    abstract::A simple procedure for recovering biodegradable polymer from bacterial cells has been developed using economical and environmentally friendly solvent or chemicals. Recombinant bacterium, Cupriavidus necator harboring pBBR1MCS-C2 plasmid polyhydroxyalkanoate (PHA) synthase gene was used for the production of copolymer ...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.4161/bioe.22350

    authors: Anis SN,Iqbal NM,Kumar S,Al-Ashraf A

    更新日期:2013-03-01 00:00:00

  • Secretion of slow-folding proteins by a Type 1 secretion system.

    abstract::Protein production through dedicated secretion systems might offer an potential alternative to the conventional cytoplasmical expression. The application of Type 1 secretion systems of Gram-negative bacteria, however, where often not successful in the past for a wide range of proteins. Recently, two studies using the ...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.4161/bioe.20712

    authors: Schwarz CK,Lenders MH,Smits SH,Schmitt L

    更新日期:2012-09-01 00:00:00

  • Expression and purification of recombinant TAT-BoNT/A(1-448) under denaturing and native conditions.

    abstract::Botulinum toxin type A can temporarily inhibit muscle contraction. Currently, physicians administer this toxin as a bio-drug in treatment of some muscle contraction disorders. TAT-BoNT/A(1-448) is a functional recombinant protein derived from botulinum toxin light chain. Unlike the full length botulinum toxin, TAT-BoN...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2016.1201252

    authors: Saffarian P,Peerayeh SN,Amani J,Ebrahimi F,Sedighianrad H,Halabian R,Imani Fooladi AA

    更新日期:2016-11-01 00:00:00

  • Knock-down of a RING finger gene confers cold tolerance.

    abstract::The plant-specific RING-domain finger proteins play important roles in plant development and stress responses. We recently identified and functionally characterized a stress-induced gene OsSRFP1 (Oryza sativa Stress-related RING Finger Protein 1) from rice. We showed evidences of the biotechnological potential of the ...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2015.1131368

    authors: Fang H,Meng Q,Zhang H,Huang J

    更新日期:2016-01-01 00:00:00

  • Recombinant Lactococcus lactis fails to secrete bovine chymosine.

    abstract::Bovine chymosin is an important milk-clotting agent used in the manufacturing of cheeses. Currently, the production of recombinant proteins by genetically modified organisms is widespread, leading to greatly reduced costs. Lactococcus (L.) lactis, the model lactic acid bacterium, was considered a good candidate for he...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.4161/bioe.36327

    authors: Luerce TD,Azevedo MS,LeBlanc JG,Azevedo V,Miyoshi A,Pontes DS

    更新日期:2014-01-01 00:00:00

  • Cell suspension concentration monitoring by using a miniaturized serial high frequency SAWR sensor.

    abstract::In this paper, a miniaturized cell suspension concentration monitoring method was investigated. The sensing unit was a carbon screen-printed electrode (CSPE) in serial with a 433MHz vacuum-packaged surface acoustic wave resonator (SAWR). SAWR provided a stable and high operating frequency, which helps to keep the stab...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2015.1119342

    authors: Li J,Feng H,Fang Y

    更新日期:2015-01-01 00:00:00

  • miR-25 mediates metastasis and epithelial-mesenchymal-transition in human esophageal squamous cell carcinoma via regulation of E-cadherin signaling.

    abstract::MiR-25 is a well-documented oncogenic miRNA implicated in esophageal squamous cell carcinoma (ESCC) development, progression and metastasis. However, whether and how miR-25 is involved in the development and metastasis of ESCC remain un-addressed. By using qRT-PCR analysis to compare levels of miR-25 in ESCC tissues w...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2019.1687391

    authors: Liu B,Li X,Li C,Xu R,Sun X

    更新日期:2019-12-01 00:00:00

  • Chaperones in maturation of molybdoenzymes: Why specific is better than general?

    abstract::Molybdoenzymes play essential functions in living organisms and, as a result, in various geochemical cycles. It is thus crucial to understand how these complex proteins become highly efficient enzymes able to perform a wide range of catalytic activities. It has been established that specific chaperones are involved du...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2016.1218579

    authors: Lemaire ON,Bouillet S,Méjean V,Iobbi-Nivol C,Genest O

    更新日期:2017-03-04 00:00:00

  • Non-Fourier based thermal-mechanical tissue damage prediction for thermal ablation.

    abstract::Prediction of tissue damage under thermal loads plays important role for thermal ablation planning. A new methodology is presented in this paper by combing non-Fourier bio-heat transfer, constitutive elastic mechanics as well as non-rigid motion of dynamics to predict and analyze thermal distribution, thermal-induced ...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2016.1227609

    authors: Li X,Zhong Y,Smith J,Gu C

    更新日期:2017-01-02 00:00:00

  • The synthetic biology future.

    abstract::Herein, I track the evolution of synthetic biology from its earliest incarnations more than 50 years ago, through the DIYbio revolution, to the next 50 years. ...

    journal_title:Bioengineered

    pub_type: 社论

    doi:10.4161/bioe.28317

    authors: Sleator RD

    更新日期:2014-03-01 00:00:00

  • Study of detecting mechanism of carbon nanotubes gas sensor based on multi-stable stochastic resonance model.

    abstract::The detecting mechanism of carbon nanotubes gas sensor based on multi-stable stochastic resonance (MSR) model was studied in this paper. A numerically stimulating model based on MSR was established. And gas-ionizing experiment by adding electronic white noise to induce 1.65 MHz periodic component in the carbon nanotub...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2015.1058453

    authors: Jingyi Z

    更新日期:2015-01-01 00:00:00

  • An epithelial-mesenchymal transition-Related Long Non-Coding RNA signature to predict overall survival and immune microenvironment in Kidney Renal Clear Cell Carcinoma.

    abstract::Kidney renal clear cell carcinoma (ccRCC) is a malignant tumor originating from renal tubular epithelium, lncRNAs can regulate the occurrence and development of EMT by targeting EMT transcription factors. We constructed a new survival signature based on EMT-related differentially expressed lncRNAs obtained from The Ca...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2021.1880718

    authors: Cheng YB,Li S,Zhang YP,Zhu ZH,Zhao N

    更新日期:2021-01-31 00:00:00

  • Recent advances in synthetic biology of cyanobacteria for improved chemicals production.

    abstract::Cyanobacteria are Gram-negative photoautotrophic prokaryotes and have shown great importance to the Earth's ecology. Based on their capability in oxygenic photosynthesis and genetic merits, they can be engineered as microbial chassis for direct conversion of carbon dioxide to value-added biofuels and chemicals. In the...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2020.1837458

    authors: Wang F,Gao Y,Yang G

    更新日期:2020-12-01 00:00:00

  • Polyphosphate, cyclic AMP, guanosine tetraphosphate, and c-di-GMP reduce in vitro Lon activity.

    abstract::Lon protease is conserved from bacteria to humans and regulates cellular processes by degrading different classes of proteins including antitoxins, transcriptional activators, unfolded proteins, and free ribosomal proteins. Since we found that Lon has several putative cyclic diguanylate (c-di-GMP) binding sites and si...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.4161/bioe.29261

    authors: Osbourne DO,Soo VW,Konieczny I,Wood TK

    更新日期:2014-07-01 00:00:00

  • Engineering Saccharomyces cerevisiae for improvement in ethanol tolerance by accumulation of trehalose.

    abstract::A genetic recombinant Saccharomyces cerevisiae starter with high ethanol tolerance capacities was constructed. In this study, the gene of trehalose-6-phosphate synthase (encoded by tps1), which catalyzes the first step in trehalose synthesis, was cloned and overexpressed in S. cerevisiae. Moreover, the gene of neutral...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2016.1207019

    authors: Divate NR,Chen GH,Wang PM,Ou BR,Chung YC

    更新日期:2016-11-01 00:00:00

  • Production of L-carnitine-enriched edible filamentous fungal biomass through submerged cultivation.

    abstract::The edible filamentous fungi are hot candidate for future supply of functional food and feed with e.g. protein, essential amino acids, and compounds with immunostimulant activity. L-carnitine that plays a crucial role in energy metabolism represents a functional compound normally produced by Zygomycetes filamentous fu...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2020.1863618

    authors: Rousta N,Ferreira JA,Taherzadeh MJ

    更新日期:2021-12-01 00:00:00

  • From stale bread and brewers spent grain to a new food source using edible filamentous fungi.

    abstract::By-products from the food sector with a high load of organic matter present both a waste-handling problem related to expenses and to the environment, yet also an opportunity. This study aims to increase the value of stale bread and brewers spent grain (BSG) by re-introducing these residues to the food production chain...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2020.1768694

    authors: Gmoser R,Fristedt R,Larsson K,Undeland I,Taherzadeh MJ,Lennartsson PR

    更新日期:2020-12-01 00:00:00

  • Circular RNA circ-LRP6 facilitates Myc-driven tumorigenesis in esophageal squamous cell cancer.

    abstract::Circular RNA (circRNA) circ-LRP6 was recently proven to be a pivotal player in various human diseases. Nevertheless, its role in esophageal squamous cell cancer (ESCC) remains unknown. In the current study, we investigated the expression level, biological function and mechanism of circ-LRP6 in ESCC. Circ-LRP6 was sign...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2020.1809922

    authors: Wang J,Zhu W,Tao G,Wang W

    更新日期:2020-12-01 00:00:00

  • Rhizoremediation of Cu(II) ions from contaminated soil using plant growth promoting bacteria: an outlook on pyrolysis conditions on plant residues for methylene orange dye biosorption.

    abstract::Rhizoremediation is one of the most accepted, cost-effective bioremediation techniques focusing on the application of rhizospheric microorganisms in combination with plants for the remediation of organic and inorganic pollutants from the contaminated sites. This work focuses on isolation and identification of metal re...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2020.1728034

    authors: Yaashikaa PR,Senthil Kumar P,Varjani S,Saravanan A

    更新日期:2020-12-01 00:00:00

  • Fatty acid methyl ester analysis of Aspergillus fumigatus isolated from fruit pulps for biodiesel production using GC-MS spectrometry.

    abstract::In this study, a total of six fungal samples were isolated from apple, strawberry and orange pulp. DNA sequence analysis was used as molecular identification method. ITS region was aligned in DNA sequence analysis, and an algorithm sequence similarity was done using BLAST (Basic Local Alignment Search Tool) program to...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2020.1739379

    authors: Asci F,Aydin B,Akkus GU,Unal A,Erdogmus SF,Korcan SE,Jahan I

    更新日期:2020-12-01 00:00:00

  • Different construction strategies affected on the physiology of Pichia pastoris strains highly expressed lipase by transcriptional analysis of key genes.

    abstract::We demonstrated previously that expression of Rhizomucor miehei lipase (RML) in Pichia pastoris could be significantly increased by addition of gene propeptide, optimized signal peptide codons and manipulation of gene dosage. In this study, effects of various strategies on the protein synthesis and secretion pathways ...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2019.1614422

    authors: Huang J,Wang Q,Bu W,Chen L,Yang Z,Zheng W,Li Y,Li J

    更新日期:2019-12-01 00:00:00

  • A combination of experimental and numerical methods to investigate the role of strain rate on the mechanical properties and collagen fiber orientations of the healthy and atherosclerotic human coronary arteries.

    abstract::Atherosclerosis enables to alter not only the microstructural but also the physical properties of the arterial walls by plaque forming. Few studies so far have been conducted to calculate the isotropic or anisotropic mechanical properties of the healthy and atherosclerotic human coronary arteries. To date there is a p...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2016.1212134

    authors: Karimi A,Rahmati SM,Sera T,Kudo S,Navidbakhsh M

    更新日期:2017-03-04 00:00:00

  • CHO-gmt5, a novel CHO glycosylation mutant for producing afucosylated and asialylated recombinant antibodies.

    abstract::Engineered zinc-finger nucleases (ZFNs) are powerful tools for creating double-stranded-breaks (DSBs) in genomic DNA in a site-specific manner. These DSBs generated by ZFNs can be repaired by homology-directed repair or nonhomologous end joining, in which the latter can be exploited to generate insertion or deletion m...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.4161/bioe.22262

    authors: Haryadi R,Zhang P,Chan KF,Song Z

    更新日期:2013-03-01 00:00:00

  • Transformation of a Malaysian species of Nannochloropsis: gateway to construction of transgenic microalgae as vaccine delivery system to aquatic organisms.

    abstract:NANNOCHLOROPSIS:sp. is a green alga that is widely used in the aquaculture industry as a feed in Malaysia, but genetic engineering studies of this alga are still underexplored even though there is a growing interest in microalgae genetic engineering for various industrial purposes. This study aims to investigate the ef...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2020.1822106

    authors: Zainal Abidin AA,Suntarajh M,Balia Yusof ZN

    更新日期:2020-12-01 00:00:00

  • Genetic engineering of microorganisms for biodiesel production.

    abstract::Biodiesel, as one type of renewable energy, is an ideal substitute for petroleum-based diesel fuel and is usually made from triacylglycerides by transesterification with alcohols. Biodiesel production based on microbial fermentation aiming to establish more efficient, less-cost and sustainable biodiesel production str...

    journal_title:Bioengineered

    pub_type: 杂志文章,评审

    doi:10.4161/bioe.23114

    authors: Lin H,Wang Q,Shen Q,Zhan J,Zhao Y

    更新日期:2013-09-01 00:00:00

  • Friction properties of biological functional materials: PVDF membranes.

    abstract::Touch is produced by sensations that include approaching, sliding, pressing, and temperature. This concept has become a target of research in biotechnology, especially in the field of bionic biology. This study measured sliding and pressing with traditional tactile sensors in order to improve a machine operator's judg...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2016.1227612

    authors: Chen L,Di C,Chen X,Li Z,Luo J

    更新日期:2017-01-02 00:00:00

  • Regulatory roles of 24-epibrassinolide in tolerance of Acacia gerrardii Benth to salt stress.

    abstract::This experiment aimed to investigate the role of 24-epibrassinolide (EBL) against NaCl-induced salinity stress in Acacia gerrardii Benth. NaCl (200 mM) imparted deleterious effects on the growth and chlorophyll contents of A. gerrardii, but foliar application of EBL (1.0 mg/l; each plant received 2.5 ml) mitigated the...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2017.1297348

    authors: Abd Allah EF,Alqarawi AA,Hashem A,Wirth S,Egamberdieva D

    更新日期:2018-01-01 00:00:00

  • Use of bio-mimetic three-dimensional technology in therapeutics for heart disease.

    abstract::Due to the limited self-renewal capacity of cardiomyocytes, the mammalian heart exhibits impaired regeneration and insufficient ability to restore heart function after injury. Cardiovascular tissue engineering is currently considered as a promising alternative therapy to restore the structure and function of the faili...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.4161/bioe.27751

    authors: Serpooshan V,Zhao M,Metzler SA,Wei K,Shah PB,Wang A,Mahmoudi M,Malkovskiy AV,Rajadas J,Butte MJ,Bernstein D,Ruiz-Lozano P

    更新日期:2014-05-01 00:00:00

  • Enhanced catalytic efficiency of CotA-laccase by DNA shuffling.

    abstract::Bacterial CotA-laccases exhibit higher activity in alkaline pH and salt concentration conditions compared to laccases from white-rot fungi. They are considered as green catalysts in decolorizing of industrial dyes. However, CotA-laccases are limited due to the low yield and catalytic efficiency as the spore-bound natu...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2019.1621134

    authors: Ouyang F,Zhao M

    更新日期:2019-12-01 00:00:00