Characteristics of immune cell infiltration and associated diagnostic biomarkers in ulcerative colitis: results from bioinformatics analysis.

Abstract:

:Ulcerative colitis (UC) is a type of refractory and recurrent inflammatory disorder that occurs in colon and rectum. Immune cell infiltration plays a critical role in UC progression; therefore, this study aims to explore potential biomarkers for UC and to analyze characteristics of immune cell infiltration based on the bioinformatic analysis. In this study, 248 differentially expressed genes (DEGs) were screened, and the top 20 immune-related hub genes and pathways were assessed. Moreover, four candidate diagnostic biomarkers (DPP10, S100P, AMPD1, and ASS1) were identified and validated. Immune cell infiltration analysis identified 13 differentially infiltrated immune cells (IICs) in UC samples compared to normal samples, and the result showed that two IICs only expressed in UC samples. In addition, the present research found that DPP10 was negatively correlated with neutrophils, S100P exhibited a positive correlation with resting CD4 memory T cells, AMPD1 was positively correlated with M2 macrophages, and ASS1 was inversely associated with neutrophils and positively related to CD8 T cells. Taken together, these findings indicated that DPP10, S100P, AMPD1, and ASS1 may act as diagnostic biomarkers for UC, and that differential IICs may help to illustrate the progression of UC.

journal_name

Bioengineered

journal_title

Bioengineered

authors

Xue G,Hua L,Zhou N,Li J

doi

10.1080/21655979.2020.1863016

subject

Has Abstract

pub_date

2021-12-01 00:00:00

pages

252-265

issue

1

eissn

2165-5979

issn

2165-5987

journal_volume

12

pub_type

杂志文章
  • Driving biomass breakdown through engineered cellulosomes.

    abstract::Extraction of sugar is the rate-limiting step in converting unpretreated biomass into value-added products through microbial fermentation. Both anaerobic fungi and anaerobic bacteria have evolved to produce large multi-cellulase complexes referred to as cellulosomes, which are powerful machines for biomass deconstruct...

    journal_title:Bioengineered

    pub_type: 杂志文章,评审

    doi:10.1080/21655979.2015.1060379

    authors: Gilmore SP,Henske JK,O'Malley MA

    更新日期:2015-01-01 00:00:00

  • Development of an immune-related prognostic index associated with osteosarcoma.

    abstract::Tumor immunity is closely associated with the prognosis of tumors, including osteosarcoma (OS). The aim of the present study was to construct an immune-related prognostic index (PI) to predict the prognosis of OS. Herein, OS expression data were sourced from the Therapeutically Applicable Research to Generate Effectiv...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2020.1864096

    authors: Yin CD,Hou YL,Liu XR,He YS,Wang XP,Li CJ,Tan XH,Liu J

    更新日期:2021-12-01 00:00:00

  • Different construction strategies affected on the physiology of Pichia pastoris strains highly expressed lipase by transcriptional analysis of key genes.

    abstract::We demonstrated previously that expression of Rhizomucor miehei lipase (RML) in Pichia pastoris could be significantly increased by addition of gene propeptide, optimized signal peptide codons and manipulation of gene dosage. In this study, effects of various strategies on the protein synthesis and secretion pathways ...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2019.1614422

    authors: Huang J,Wang Q,Bu W,Chen L,Yang Z,Zheng W,Li Y,Li J

    更新日期:2019-12-01 00:00:00

  • Secretion of slow-folding proteins by a Type 1 secretion system.

    abstract::Protein production through dedicated secretion systems might offer an potential alternative to the conventional cytoplasmical expression. The application of Type 1 secretion systems of Gram-negative bacteria, however, where often not successful in the past for a wide range of proteins. Recently, two studies using the ...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.4161/bioe.20712

    authors: Schwarz CK,Lenders MH,Smits SH,Schmitt L

    更新日期:2012-09-01 00:00:00

  • Knock-down of a RING finger gene confers cold tolerance.

    abstract::The plant-specific RING-domain finger proteins play important roles in plant development and stress responses. We recently identified and functionally characterized a stress-induced gene OsSRFP1 (Oryza sativa Stress-related RING Finger Protein 1) from rice. We showed evidences of the biotechnological potential of the ...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2015.1131368

    authors: Fang H,Meng Q,Zhang H,Huang J

    更新日期:2016-01-01 00:00:00

  • Anti-microbial and anti-oxidant activities of Illicium verum, Crataegus oxyacantha ssp monogyna and Allium cepa red and white varieties.

    abstract::Illicium verum (badiane or star anise), Crataegus oxyacantha ssp monogyna (hawthorn) and Allium cepa (onion), have traditionnally been used as medicinal plants in Algeria. This study showed that the outer layer of onion is rich in flavonols with contents of 103 ± 7.90 µg/g DW (red variety) and 17.3 ± 0.69 µg/gDW (whit...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.4161/bioe.24435

    authors: Benmalek Y,Yahia OA,Belkebir A,Fardeau ML

    更新日期:2013-07-01 00:00:00

  • Engineering Saccharomyces cerevisiae for improvement in ethanol tolerance by accumulation of trehalose.

    abstract::A genetic recombinant Saccharomyces cerevisiae starter with high ethanol tolerance capacities was constructed. In this study, the gene of trehalose-6-phosphate synthase (encoded by tps1), which catalyzes the first step in trehalose synthesis, was cloned and overexpressed in S. cerevisiae. Moreover, the gene of neutral...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2016.1207019

    authors: Divate NR,Chen GH,Wang PM,Ou BR,Chung YC

    更新日期:2016-11-01 00:00:00

  • Analysis of gene expression on anodic porous alumina microarrays.

    abstract::This paper investigates the application of anodic porous alumina as an advancement on chip laboratory for gene expressions. The surface was prepared by a suitable electrolytic process to obtain a regular distribution of deep micrometric holes and printed bypen robot tips under standard conditions. The gene expression ...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.4161/bioe.25278

    authors: Nicolini C,Singh M,Spera R,Felli L

    更新日期:2013-09-01 00:00:00

  • Development and validation of a platform reduced intact mass method for process monitoring of monoclonal antibody glycosylation during routine manufacturing.

    abstract::N-linked glycosylation is a primary source of heterogeneity associated with recombinant monoclonal antibodies and plays a key role in a myriad of drug properties associated with biological function. The glycosylation profile of recombinant monoclonal antibodies is influenced by an array of cell culture inputs which mu...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2020.1842651

    authors: Schilling M,Feng P,Sosic Z,Traviglia SL

    更新日期:2020-12-01 00:00:00

  • Bioengineering for Organ Transplantation: Progress and Challenges.

    abstract::Organ transplantation can offer a curative option for patients with end stage organ failure. Unfortunately the treatment is severely limited by the availability of donor organs. Organ bioengineering could provide a solution to the worldwide critical organ shortage. The majority of protocols to date have employed the u...

    journal_title:Bioengineered

    pub_type: 杂志文章,评审

    doi:10.1080/21655979.2015.1081320

    authors: Welman T,Michel S,Segaren N,Shanmugarajah K

    更新日期:2015-01-01 00:00:00

  • Bioinformatics analysis to screen key prognostic genes in the breast cancer tumor microenvironment.

    abstract::Increasing evidence has shown that the tumor microenvironment (TME) plays an important role in tumor occurrence and development and can also affect patient prognosis. In this study, we screened key prognostic genes in the breast cancer (BC) TME by analyzing the immune and stromal scores of tumor samples to detect diff...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2020.1840731

    authors: Ye Q,Han X,Wu Z

    更新日期:2020-12-01 00:00:00

  • Shedding light on betL*: pPL2-lux mediated real-time analysis of betL* expression in Listeria monocytogenes.

    abstract::We propose a mechanism of action for the betL* mutation which is based on DNA topology. Removing a single thymine residue from the betL σ(A) promoter's -10 and -35 spacer results in a 'twist'-mediated activation of transcription which accounts for the osmotolerance phenotype observed for strains expressing betL*. ...

    journal_title:Bioengineered

    pub_type: 评论,杂志文章

    doi:10.1080/21655979.2016.1171438

    authors: Keane SM,Culligan EP,Hoffmann RF,Gahan CG,Hill C,Snelling WJ,Sleator RD

    更新日期:2016-04-02 00:00:00

  • Friction properties of biological functional materials: PVDF membranes.

    abstract::Touch is produced by sensations that include approaching, sliding, pressing, and temperature. This concept has become a target of research in biotechnology, especially in the field of bionic biology. This study measured sliding and pressing with traditional tactile sensors in order to improve a machine operator's judg...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2016.1227612

    authors: Chen L,Di C,Chen X,Li Z,Luo J

    更新日期:2017-01-02 00:00:00

  • Rhizobium etli asparaginase II: an alternative for acute lymphoblastic leukemia (ALL) treatment.

    abstract::Bacterial L-asparaginase has been a universal component of therapies for childhood acute lymphoblastic leukemia since the 1970s. Two principal enzymes derived from Escherichia coli and Erwinia chrysanthemi are the only options clinically approved to date. We recently reported a study of recombinant L-asparaginase (Ans...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.4161/bioe.21710

    authors: Huerta-Saquero A,Evangelista-Martínez Z,Moreno-Enriquez A,Perez-Rueda E

    更新日期:2013-01-01 00:00:00

  • Progress toward the development of polyvalent vaccination strategies against multiple viral infections in chickens using herpesvirus of turkeys as vector.

    abstract::Vaccination is the most cost effective strategy for the control and prevention of the plethora of viral diseases affecting poultry production. The major challenge for poultry vaccination is the design of vaccines that will protect against multiple pathogens via a single protective dose, delivered by mass vaccination. ...

    journal_title:Bioengineered

    pub_type: 评论,杂志文章

    doi:10.4161/bioe.20476

    authors: Iqbal M

    更新日期:2012-07-01 00:00:00

  • CHO-gmt5, a novel CHO glycosylation mutant for producing afucosylated and asialylated recombinant antibodies.

    abstract::Engineered zinc-finger nucleases (ZFNs) are powerful tools for creating double-stranded-breaks (DSBs) in genomic DNA in a site-specific manner. These DSBs generated by ZFNs can be repaired by homology-directed repair or nonhomologous end joining, in which the latter can be exploited to generate insertion or deletion m...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.4161/bioe.22262

    authors: Haryadi R,Zhang P,Chan KF,Song Z

    更新日期:2013-03-01 00:00:00

  • Isolation of a novel deep-sea Bacillus circulus strain and uniform design for optimization of its anti-aflatoxigenic bioactive metabolites production.

    abstract::The deep-sea bacterium strain FA13 was isolated from the sediment of the South Atlantic Ocean and identified as Bacillus circulans based on 16S ribosomal DNA sequence. Through liquid fermentation with five media, the cell-free supernatant fermented with ISP2 showed the highest inhibition activities against mycelial gr...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2019.1586055

    authors: Zhou Y,Wang J,Gao X,Wang K,Wang W,Wang Q,Yan P

    更新日期:2019-12-01 00:00:00

  • Activating transcription factor 3 (ATF3) regulates cell growth, apoptosis, invasion and collagen synthesis in keloid fibroblast through transforming growth factor beta (TGF-beta)/SMAD signaling pathway.

    abstract::The successful treatment of keloids is a great challenge in the plastic surgery field. Activating transcription factor 3 (ATF3) is discovered as an adaptive responsive gene, which plays a critical role in fibroblast activation. This study aimed to investigate the expression and biological role of ATF3 in the pathogene...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2020.1860491

    authors: Wang XM,Liu XM,Wang Y,Chen ZY

    更新日期:2021-12-01 00:00:00

  • Scarless assembly of unphosphorylated DNA fragments with a simplified DATEL method.

    abstract::Efficient assembly of multiple DNA fragments is a pivotal technology for synthetic biology. A scarless and sequence-independent DNA assembly method (DATEL) using thermal exonucleases has been developed recently. Here, we present a simplified DATEL (sDATEL) for efficient assembly of unphosphorylated DNA fragments with ...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2017.1308986

    authors: Ding W,Weng H,Jin P,Du G,Chen J,Kang Z

    更新日期:2017-05-04 00:00:00

  • CRISPR-Cas systems: ushering in the new genome editing era.

    abstract::In recent years there has been great progress with the implementation and utilization of Clustered Regularly Interspaced Palindromic Repeats (CRISPR) and CRISPR-associated protein (Cas) systems in the world of genetic engineering. Many forms of CRISPR-Cas9 have been developed as genome editing tools and techniques and...

    journal_title:Bioengineered

    pub_type: 杂志文章,评审

    doi:10.1080/21655979.2018.1470720

    authors: Perez Rojo F,Nyman RKM,Johnson AAT,Navarro MP,Ryan MH,Erskine W,Kaur P

    更新日期:2018-01-01 00:00:00

  • Implications of endophytic microbiota in Camellia sinensis: a review on current understanding and future insights.

    abstract::Endophytic fungi and bacteria are the most ubiquitous and representative commensal members that have been studied so far in various higher plants. Within colonization and interaction with their host plants, endophytic microbiota are reportedly to modulate not only the host's growth but also holobiont resilience to abi...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2020.1816788

    authors: Xie H,Feng X,Wang M,Wang Y,Kumar Awasthi M,Xu P

    更新日期:2020-12-01 00:00:00

  • Penaeus orientolis prawn freshness rapid determination method based on electronic nose and non-linear stochastic resonance technique.

    abstract::In this paper, Penaeus orientolis prawn freshness rapid determination method using electronic nose (e-nose) and non-linear data processing technique is studied. E-nose responses to prawns stored at 4 °C are measured. Meanwhile, physical/chemical indexes (firmness, pH, total volatile basic nitrogen (TVB-N), total viabl...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.4161/21655979.2014.993294

    authors: Wei L,Yuanyuan H,Yanping C,Jiaojiao J,Guohua H

    更新日期:2015-01-01 00:00:00

  • From biocontrol to cancer, probiotics and beyond.

    abstract::This invited commentary covers the period 1997-2012 and has seen changes in terminology that progressed from "basic" and "applied" to "translational" research. In the context of Bioengineered, these changes map readily onto the processes of identifying microbial characteristics appropriate for specific applications, i...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.4161/bioe.23251

    authors: Dunne C

    更新日期:2013-07-01 00:00:00

  • Bioengineering advancements, innovations and challenges on green synthesis of 2, 5-furan dicarboxylic acid.

    abstract::The major drawback of chemical transformations for the production of 2, 5-furan dicarboxylic acid (FDCA) implies the usage of hazardous chemicals, high temperature and high pressure from nonrenewable resources. Alternate to chemical methods, biological methods are promising. Microbial FDCA production is improved throu...

    journal_title:Bioengineered

    pub_type: 杂志文章,评审

    doi:10.1080/21655979.2019.1700093

    authors: Rajesh RO,Godan TK,Sindhu R,Pandey A,Binod P

    更新日期:2020-12-01 00:00:00

  • Bioengineering tools for the production of pharmaceuticals: current perspective and future outlook.

    abstract::The bioengineering tools have significant advantages through less time-consuming and utilized as a promising stage for the production of pharmaceutical bioproducts under the single platform. This review highlighted the advantages and current improvement in the plant, animal and microbial bioengineering tools and outli...

    journal_title:Bioengineered

    pub_type: 杂志文章,评审

    doi:10.1080/21655979.2019.1682108

    authors: Sarsaiya S,Shi J,Chen J

    更新日期:2019-12-01 00:00:00

  • Combining MPDL3280A with adoptive cell immunotherapy exerts better antitumor effects against cervical cancer.

    abstract::As the second most common gynecologic malignant tumors with a high mortality rate, cervical cancer jeopardizes women's life worldwide. The low cure rate in cervical cancer patients is mainly attributed to the lack of effective therapies. One feasible novel strategy is to develop immune-based approaches such as adoptiv...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2016.1230573

    authors: Zheng Y,Yang Y,Wu S,Zhu Y,Tang X,Liu X

    更新日期:2017-07-04 00:00:00

  • Synergistic effect of quorum sensing genes in biofilm development and PAHs degradation by a marine bacterium.

    abstract::Quorum sensing (QS) is a prevalently found intercellular signaling system in bacteria. QS system bestows behavioral coordination ability in bacteria at high population density. QS via acylated homoserine lactone (AHL) is extensively conserved in Gram-negative bacteria and plays crucial role in regulating many biologic...

    journal_title:Bioengineered

    pub_type: 评论,杂志文章

    doi:10.1080/21655979.2016.1174797

    authors: Kumari S,Mangwani N,Das S

    更新日期:2016-04-01 00:00:00

  • Rhizoremediation of Cu(II) ions from contaminated soil using plant growth promoting bacteria: an outlook on pyrolysis conditions on plant residues for methylene orange dye biosorption.

    abstract::Rhizoremediation is one of the most accepted, cost-effective bioremediation techniques focusing on the application of rhizospheric microorganisms in combination with plants for the remediation of organic and inorganic pollutants from the contaminated sites. This work focuses on isolation and identification of metal re...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2020.1728034

    authors: Yaashikaa PR,Senthil Kumar P,Varjani S,Saravanan A

    更新日期:2020-12-01 00:00:00

  • Enhanced catalytic efficiency of CotA-laccase by DNA shuffling.

    abstract::Bacterial CotA-laccases exhibit higher activity in alkaline pH and salt concentration conditions compared to laccases from white-rot fungi. They are considered as green catalysts in decolorizing of industrial dyes. However, CotA-laccases are limited due to the low yield and catalytic efficiency as the spore-bound natu...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2019.1621134

    authors: Ouyang F,Zhao M

    更新日期:2019-12-01 00:00:00

  • Clinical significance of serum MicroRNA-203 in patients with acute myeloid leukemia.

    abstract::This study aimed to detect serum miR-203 expression levels in AML and explore its potential clinical significance. Quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) was performed to measure the serum miR-203 levels in 134 patients with AML and 70 healthy controls. The results demonstrated that ser...

    journal_title:Bioengineered

    pub_type: 杂志文章,收录出版

    doi:10.1080/21655979.2019.1652490

    authors: Guo Y

    更新日期:2019-12-01 00:00:00