LINC00528 regulates myocardial infarction by targeting the miR-143-3p/COX-2 axis.

Abstract:

:This study is aimed to explore the roles of LINC00528 in myocardial infarction (MI) progression. Quantitative real-time PCR showed that the expression of LINC00528 and COX-2 was upregulated while miR-143-3p expression was down-regulated in post-MI cells. In function assays, LINC00528 suppression promoted post-MI cells proliferation and reduced cell apoptosis in vitro. In mechanism, LINC00528 interacted with miR-143-3p in post-MI cells. COX-2 served as a target of miR-143-3p in post-MI cells. Besides, LINC00528 inhibition on COX-2 expression and post-MI cells progression could be partially abolished by miR-143-3p inhibitors. Therefore, our findings suggested that LINC00528 exerted its regulatory roles in MI via the miR-143-3p/COX-2 axis, which provided a potential therapeutic target for MI patients treatment.

journal_name

Bioengineered

journal_title

Bioengineered

authors

Liu K,Zhao D,Wang D

doi

10.1080/21655979.2019.1704535

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

11-18

issue

1

eissn

2165-5979

issn

2165-5987

journal_volume

11

pub_type

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