Abstract:
:This study is aimed to explore the roles of LINC00528 in myocardial infarction (MI) progression. Quantitative real-time PCR showed that the expression of LINC00528 and COX-2 was upregulated while miR-143-3p expression was down-regulated in post-MI cells. In function assays, LINC00528 suppression promoted post-MI cells proliferation and reduced cell apoptosis in vitro. In mechanism, LINC00528 interacted with miR-143-3p in post-MI cells. COX-2 served as a target of miR-143-3p in post-MI cells. Besides, LINC00528 inhibition on COX-2 expression and post-MI cells progression could be partially abolished by miR-143-3p inhibitors. Therefore, our findings suggested that LINC00528 exerted its regulatory roles in MI via the miR-143-3p/COX-2 axis, which provided a potential therapeutic target for MI patients treatment.
journal_name
Bioengineeredjournal_title
Bioengineeredauthors
Liu K,Zhao D,Wang Ddoi
10.1080/21655979.2019.1704535subject
Has Abstractpub_date
2020-12-01 00:00:00pages
11-18issue
1eissn
2165-5979issn
2165-5987journal_volume
11pub_type
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