LINC00528 regulates myocardial infarction by targeting the miR-143-3p/COX-2 axis.

abstract：:Increasing evidence has shown that the tumor microenvironment (TME) plays an important role in tumor occurrence and development and can also affect patient prognosis. In this study, we screened key prognostic genes in the breast cancer (BC) TME by analyzing the immune and stromal scores of tumor samples to detect diff...

journal_title：Bioengineered

authors： Ye Q,Han X,Wu Z

更新日期：2020-12-01 00:00:00

abstract：:For somatic gene therapy of hemophilia B, hepatocytes as the main cellular host for expression of hFIX are attractive targets. In gene therapy protocols, an efficient expression vector equipped with cis-regulatory elements such as introns is required. With this in mind, hFIX-expressing plasmids equipped with different...

journal_title：Bioengineered

authors： Azadbakhsh AS,Sam MR,Farokhi F

更新日期：2016-11-01 00:00:00

abstract：:We previously presented the cloning, heterologous expression, and characterization of a novel multidomain endoxylanase from Arthrobacter sp. GN16 isolated from the feces of Grus nigricollis. Molecular and biochemical characterization studies indicate that the glycoside hydrolase (GH) family 10 domain at the N-terminus...

journal_title：Bioengineered

authors： Zhou J,Liu Y,Shen J,Zhang R,Tang X,Li J,Wang Y,Huang Z

更新日期：2015-01-01 00:00:00

abstract：:This paper investigates the application of anodic porous alumina as an advancement on chip laboratory for gene expressions. The surface was prepared by a suitable electrolytic process to obtain a regular distribution of deep micrometric holes and printed bypen robot tips under standard conditions. The gene expression ...

journal_title：Bioengineered

authors： Nicolini C,Singh M,Spera R,Felli L

更新日期：2013-09-01 00:00:00

abstract：:As the second most common gynecologic malignant tumors with a high mortality rate, cervical cancer jeopardizes women's life worldwide. The low cure rate in cervical cancer patients is mainly attributed to the lack of effective therapies. One feasible novel strategy is to develop immune-based approaches such as adoptiv...

journal_title：Bioengineered

authors： Zheng Y,Yang Y,Wu S,Zhu Y,Tang X,Liu X

更新日期：2017-07-04 00:00:00

abstract：:Prediction of tissue damage under thermal loads plays important role for thermal ablation planning. A new methodology is presented in this paper by combing non-Fourier bio-heat transfer, constitutive elastic mechanics as well as non-rigid motion of dynamics to predict and analyze thermal distribution, thermal-induced ...

journal_title：Bioengineered

authors： Li X,Zhong Y,Smith J,Gu C

更新日期：2017-01-02 00:00:00

abstract：:A genetic recombinant Saccharomyces cerevisiae starter with high ethanol tolerance capacities was constructed. In this study, the gene of trehalose-6-phosphate synthase (encoded by tps1), which catalyzes the first step in trehalose synthesis, was cloned and overexpressed in S. cerevisiae. Moreover, the gene of neutral...

journal_title：Bioengineered

authors： Divate NR,Chen GH,Wang PM,Ou BR,Chung YC

更新日期：2016-11-01 00:00:00

abstract：:The influenza A virus is a critical public health problem that causes epidemics and pandemics, and occurs widely all over the world. Various vaccines against the virus have not provided a solution to the problem. Different approaches, particularly M2e peptide-based vaccines, are available for developing universal vacc...

journal_title：Bioengineered

authors： Kilinc YB,Akdeste ZM,Koc RC,Bagirova M,Allahverdiyev A

更新日期：2014-01-01 00:00:00

abstract：:The plant-specific RING-domain finger proteins play important roles in plant development and stress responses. We recently identified and functionally characterized a stress-induced gene OsSRFP1 (Oryza sativa Stress-related RING Finger Protein 1) from rice. We showed evidences of the biotechnological potential of the ...

journal_title：Bioengineered

authors： Fang H,Meng Q,Zhang H,Huang J

更新日期：2016-01-01 00:00:00

abstract：:The edible filamentous fungi are hot candidate for future supply of functional food and feed with e.g. protein, essential amino acids, and compounds with immunostimulant activity. L-carnitine that plays a crucial role in energy metabolism represents a functional compound normally produced by Zygomycetes filamentous fu...

journal_title：Bioengineered

authors： Rousta N,Ferreira JA,Taherzadeh MJ

更新日期：2021-12-01 00:00:00

abstract：:We propose a mechanism of action for the betL* mutation which is based on DNA topology. Removing a single thymine residue from the betL σ(A) promoter's -10 and -35 spacer results in a 'twist'-mediated activation of transcription which accounts for the osmotolerance phenotype observed for strains expressing betL*. ...

journal_title：Bioengineered

authors： Keane SM,Culligan EP,Hoffmann RF,Gahan CG,Hill C,Snelling WJ,Sleator RD

更新日期：2016-04-02 00:00:00

abstract：:This experiment aimed to investigate the role of 24-epibrassinolide (EBL) against NaCl-induced salinity stress in Acacia gerrardii Benth. NaCl (200 mM) imparted deleterious effects on the growth and chlorophyll contents of A. gerrardii, but foliar application of EBL (1.0 mg/l; each plant received 2.5 ml) mitigated the...

journal_title：Bioengineered

authors： Abd Allah EF,Alqarawi AA,Hashem A,Wirth S,Egamberdieva D

更新日期：2018-01-01 00:00:00

abstract：:Efficient assembly of multiple DNA fragments is a pivotal technology for synthetic biology. A scarless and sequence-independent DNA assembly method (DATEL) using thermal exonucleases has been developed recently. Here, we present a simplified DATEL (sDATEL) for efficient assembly of unphosphorylated DNA fragments with ...

journal_title：Bioengineered

authors： Ding W,Weng H,Jin P,Du G,Chen J,Kang Z

更新日期：2017-05-04 00:00:00

abstract：:Stromal interaction molecule 1 (STIM1) is a calcium-sensing protein localized in the membrane of the endoplasmic reticulum. The expression of STIM1 has been shown to be closely associated with cell proliferation. The aim of the present study was to investigate the role of STIM1 in the regulation of cancer progression ...

journal_title：Bioengineered

authors： Ge C,Zeng B,Li R,Li Z,Fu Q,Wang W,Wang Z,Dong S,Lai Z,Wang Y,Xue Y,Guo J,Di T,Song X

更新日期：2019-12-01 00:00:00

abstract：:Surface plasmon resonance (SPR) sensing is recently emerging as a valuable technique for measuring the binding constants, association and dissociation rate constants, and stoichimetry for a binding interaction kinetics in a number of emerging biological areas. This technique can be applied to the study of immune syste...

journal_title：Bioengineered

authors： Jahanshahi P,Wei Q,Jie Z,Ghomeishi M,Sekaran SD,Mahamd Adikan FR

更新日期：2017-05-04 00:00:00

abstract：:In contrast to conventional, molecular medicine that focuses on targeting specific pathways, stem cell therapy aims to perturb many related mechanisms in order to derive therapeutic benefit. This emerging modality is inherently complex due to the variety of cell types that can be used, delivery approaches that need to...

journal_title：Bioengineered

authors： Momeni A,Neelamegham S,Parashurama N

更新日期：2017-07-04 00:00:00

abstract：:Bacterial CotA-laccases exhibit higher activity in alkaline pH and salt concentration conditions compared to laccases from white-rot fungi. They are considered as green catalysts in decolorizing of industrial dyes. However, CotA-laccases are limited due to the low yield and catalytic efficiency as the spore-bound natu...

journal_title：Bioengineered

authors： Ouyang F,Zhao M

更新日期：2019-12-01 00:00:00

abstract：:In this study, a total of six fungal samples were isolated from apple, strawberry and orange pulp. DNA sequence analysis was used as molecular identification method. ITS region was aligned in DNA sequence analysis, and an algorithm sequence similarity was done using BLAST (Basic Local Alignment Search Tool) program to...

journal_title：Bioengineered

authors： Asci F,Aydin B,Akkus GU,Unal A,Erdogmus SF,Korcan SE,Jahan I

更新日期：2020-12-01 00:00:00

abstract：:The main treatment option for Hemophilia A/B patients involves the administration of recombinant coagulation factors on-demand or in a prophylactic approach. Despite the safety and efficacy of this replacement therapy, the development of antibodies against the coagulation factor infused, which neutralize the procoagul...

journal_title：Bioengineered

authors： Swiech K,Picanço-Castro V,Covas DT

更新日期：2017-09-03 00:00:00

abstract：:Mammalian collagen has been widely used as a biomedical material. Nevertheless, there are still concerns about the variability between preparations, particularly with the possibility that the products may transmit animal-based diseases. Many groups have examined the possible application of bioengineered mammalian coll...

journal_title：Bioengineered

authors： Ramshaw JA,Werkmeister JA,Dumsday GJ

更新日期：2014-07-01 00:00:00

abstract：:Vaccination is the most cost effective strategy for the control and prevention of the plethora of viral diseases affecting poultry production. The major challenge for poultry vaccination is the design of vaccines that will protect against multiple pathogens via a single protective dose, delivered by mass vaccination. ...

journal_title：Bioengineered

authors： Iqbal M

更新日期：2012-07-01 00:00:00

abstract：:The objective is to explore the effect of testosterone on the proliferation and collagen synthesis of neonatal rat cardiac fibroblasts (CF) induced by Angiotensin II (Ang II) and the underlying mechanisms. Derived from neonatal rats, the CFs were divided into 4 groups: the control group, Ang II group, testosterone gro...

journal_title：Bioengineered

authors： Yang X,Wang Y,Yan S,Sun L,Yang G,Li Y,Yu C

更新日期：2017-01-02 00:00:00

abstract：:Protein production through dedicated secretion systems might offer an potential alternative to the conventional cytoplasmical expression. The application of Type 1 secretion systems of Gram-negative bacteria, however, where often not successful in the past for a wide range of proteins. Recently, two studies using the ...

journal_title：Bioengineered

authors： Schwarz CK,Lenders MH,Smits SH,Schmitt L

更新日期：2012-09-01 00:00:00

abstract：:In recent years there has been great progress with the implementation and utilization of Clustered Regularly Interspaced Palindromic Repeats (CRISPR) and CRISPR-associated protein (Cas) systems in the world of genetic engineering. Many forms of CRISPR-Cas9 have been developed as genome editing tools and techniques and...

journal_title：Bioengineered

authors： Perez Rojo F,Nyman RKM,Johnson AAT,Navarro MP,Ryan MH,Erskine W,Kaur P

更新日期：2018-01-01 00:00:00

abstract：:N-linked glycosylation is a primary source of heterogeneity associated with recombinant monoclonal antibodies and plays a key role in a myriad of drug properties associated with biological function. The glycosylation profile of recombinant monoclonal antibodies is influenced by an array of cell culture inputs which mu...

journal_title：Bioengineered

authors： Schilling M,Feng P,Sosic Z,Traviglia SL

更新日期：2020-12-01 00:00:00

abstract：:Ulcerative colitis (UC) is a type of refractory and recurrent inflammatory disorder that occurs in colon and rectum. Immune cell infiltration plays a critical role in UC progression; therefore, this study aims to explore potential biomarkers for UC and to analyze characteristics of immune cell infiltration based on th...

journal_title：Bioengineered

authors： Xue G,Hua L,Zhou N,Li J

更新日期：2021-12-01 00:00:00

abstract：:Rhizoremediation is one of the most accepted, cost-effective bioremediation techniques focusing on the application of rhizospheric microorganisms in combination with plants for the remediation of organic and inorganic pollutants from the contaminated sites. This work focuses on isolation and identification of metal re...

journal_title：Bioengineered

authors： Yaashikaa PR,Senthil Kumar P,Varjani S,Saravanan A

更新日期：2020-12-01 00:00:00

abstract：:This study aimed to detect serum miR-203 expression levels in AML and explore its potential clinical significance. Quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) was performed to measure the serum miR-203 levels in 134 patients with AML and 70 healthy controls. The results demonstrated that ser...

journal_title：Bioengineered

authors： Guo Y

更新日期：2019-12-01 00:00:00

abstract：:The successful treatment of keloids is a great challenge in the plastic surgery field. Activating transcription factor 3 (ATF3) is discovered as an adaptive responsive gene, which plays a critical role in fibroblast activation. This study aimed to investigate the expression and biological role of ATF3 in the pathogene...

journal_title：Bioengineered

authors： Wang XM,Liu XM,Wang Y,Chen ZY

更新日期：2021-12-01 00:00:00

abstract：:Pancreatic adenocarcinoma (PAAD) ranks among the most lethal cancers worldwide with high mortality. A marked increase in the level of long non-coding RNA LINC00460 was reported in PAAD patients, in comparison with the healthy controls. However, the underlying mechanisms of the above phenomenon are not yet well underst...

journal_title：Bioengineered

authors： Cheng J,Lou Y,Jiang K

更新日期：2021-12-01 00:00:00