Expression of long non-coding RNA H19 predicts distant metastasis in minimally invasive follicular thyroid carcinoma.

Abstract:

:Downregulation of lncRNA H19 (H19) expression is associated with an unfavorable prognosis in some cancers. However, little was known as to whether there was an association between H19 and minimally invasive follicular thyroid carcinoma (MI-FTC). In our study, we used quantitative real-time polymerase chain reaction (qRT-PCR) to determine H19 expression in 186 patients with MI-FTC who underwent initial surgery. Of the 186 patients with MI-FTC, 21 patients show distant metastasis (M+)at the initial operation established the diagnosis of MI-FTC. Of the 165 patients who did not show distant metastasis at diagnosis during the follow-up period (≥10 years), 28 patients undergone M+ and 137 patients has no distant metastasis(M-)after the initial operation. Low H19 expression was associated with large tumor size, vascular invasion, and distant metastasis. Univariate analysis showed that gender (male), age (45 years or older), primary tumor size (4 cm or more), vascular invasion and H19 level (<1.12) were significant prognostic factors related to postoperative distant metastases. Multivariate analysis showed that age, primary tumor size (4 cm or more) and vascular invasion was a significant prognostic factor for survival. Patients with low H19 expression showed a poorer outcome in MI-FTC patients. Receiver-operating characteristic (ROC) curve analysis demonstrated H19 could distinguish M+ from M- patientswith a value of area under the curve (AUC). Our findings suggest that H19 is a potential prognostic factor for evaluating prognosis and the metastatic potential of MI-FTC at an initial operation stage.

journal_name

Bioengineered

journal_title

Bioengineered

authors

Dai Y,Miao Y,Zhu Q,Gao M,Hao F

doi

10.1080/21655979.2019.1658489

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

383-389

issue

1

eissn

2165-5979

issn

2165-5987

journal_volume

10

pub_type

杂志文章
  • Friction properties of biological functional materials: PVDF membranes.

    abstract::Touch is produced by sensations that include approaching, sliding, pressing, and temperature. This concept has become a target of research in biotechnology, especially in the field of bionic biology. This study measured sliding and pressing with traditional tactile sensors in order to improve a machine operator's judg...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2016.1227612

    authors: Chen L,Di C,Chen X,Li Z,Luo J

    更新日期:2017-01-02 00:00:00

  • Cloning, soluble expression, and purification of the RNA polymerase II subunit RPB5 from Saccharomyces cerevisiae.

    abstract::We report the molecular cloning, expression, and single-step homogeneous purification of RNA polymerase II subunit RPB5 from Saccharomyces cerevisiae. RPB5 is a 210 amino acid nuclear protein that functions as the fifth largest subunit of polymerase II and plays a central role in transcription. The gene that codes for...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2014.1002301

    authors: Chhetri G,Ghosh A,Chinta R,Akhtar S,Tripathi T

    更新日期:2015-01-01 00:00:00

  • Clinical significance of serum MicroRNA-203 in patients with acute myeloid leukemia.

    abstract::This study aimed to detect serum miR-203 expression levels in AML and explore its potential clinical significance. Quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) was performed to measure the serum miR-203 levels in 134 patients with AML and 70 healthy controls. The results demonstrated that ser...

    journal_title:Bioengineered

    pub_type: 杂志文章,收录出版

    doi:10.1080/21655979.2019.1652490

    authors: Guo Y

    更新日期:2019-12-01 00:00:00

  • Novel strategies to improve co-fermentation of pentoses with D-glucose by recombinant yeast strains in lignocellulosic hydrolysates.

    abstract::Economically feasible production of second-generation biofuels requires efficient co-fermentation of pentose and hexose sugars in lignocellulosic hydrolysates under very harsh conditions. Baker's yeast is an excellent, traditionally used ethanol producer but is naturally not able to utilize pentoses. This is due to th...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.4161/bioe.21444

    authors: Oreb M,Dietz H,Farwick A,Boles E

    更新日期:2012-11-01 00:00:00

  • Production of L-carnitine-enriched edible filamentous fungal biomass through submerged cultivation.

    abstract::The edible filamentous fungi are hot candidate for future supply of functional food and feed with e.g. protein, essential amino acids, and compounds with immunostimulant activity. L-carnitine that plays a crucial role in energy metabolism represents a functional compound normally produced by Zygomycetes filamentous fu...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2020.1863618

    authors: Rousta N,Ferreira JA,Taherzadeh MJ

    更新日期:2021-12-01 00:00:00

  • Optimization of genome editing through CRISPR-Cas9 engineering.

    abstract::CRISPR (Clustered Regularly-Interspaced Short Palindromic Repeats)-Cas9 (CRISPR associated protein 9) has rapidly become the most promising genome editing tool with great potential to revolutionize medicine. Through guidance of a 20 nucleotide RNA (gRNA), CRISPR-Cas9 finds and cuts target protospacer DNA precisely 3 b...

    journal_title:Bioengineered

    pub_type: 杂志文章,评审

    doi:10.1080/21655979.2016.1189039

    authors: Zhang JH,Adikaram P,Pandey M,Genis A,Simonds WF

    更新日期:2016-04-01 00:00:00

  • miR-25 mediates metastasis and epithelial-mesenchymal-transition in human esophageal squamous cell carcinoma via regulation of E-cadherin signaling.

    abstract::MiR-25 is a well-documented oncogenic miRNA implicated in esophageal squamous cell carcinoma (ESCC) development, progression and metastasis. However, whether and how miR-25 is involved in the development and metastasis of ESCC remain un-addressed. By using qRT-PCR analysis to compare levels of miR-25 in ESCC tissues w...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2019.1687391

    authors: Liu B,Li X,Li C,Xu R,Sun X

    更新日期:2019-12-01 00:00:00

  • Driving biomass breakdown through engineered cellulosomes.

    abstract::Extraction of sugar is the rate-limiting step in converting unpretreated biomass into value-added products through microbial fermentation. Both anaerobic fungi and anaerobic bacteria have evolved to produce large multi-cellulase complexes referred to as cellulosomes, which are powerful machines for biomass deconstruct...

    journal_title:Bioengineered

    pub_type: 杂志文章,评审

    doi:10.1080/21655979.2015.1060379

    authors: Gilmore SP,Henske JK,O'Malley MA

    更新日期:2015-01-01 00:00:00

  • Development and validation of a platform reduced intact mass method for process monitoring of monoclonal antibody glycosylation during routine manufacturing.

    abstract::N-linked glycosylation is a primary source of heterogeneity associated with recombinant monoclonal antibodies and plays a key role in a myriad of drug properties associated with biological function. The glycosylation profile of recombinant monoclonal antibodies is influenced by an array of cell culture inputs which mu...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2020.1842651

    authors: Schilling M,Feng P,Sosic Z,Traviglia SL

    更新日期:2020-12-01 00:00:00

  • Potential of Ophiostoma piceae sterol esterase for biotechnologically relevant hydrolysis reactions.

    abstract::The ascomycete Ophiostoma piceae produces a sterol esterase (OPE) with high affinity toward p-nitrophenol, glycerol, and sterol esters. Recently, this enzyme has been heterologously expressed in the methylotrophic yeast Pichia pastoris under the AOX1 methanol-inducible promoter (PAOX1) using sorbitol as co-susbtrate, ...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.4161/bioe.22818

    authors: Barba Cedillo V,Prieto A,Martínez MJ

    更新日期:2013-07-01 00:00:00

  • The synthetic biology future.

    abstract::Herein, I track the evolution of synthetic biology from its earliest incarnations more than 50 years ago, through the DIYbio revolution, to the next 50 years. ...

    journal_title:Bioengineered

    pub_type: 社论

    doi:10.4161/bioe.28317

    authors: Sleator RD

    更新日期:2014-03-01 00:00:00

  • Effect of testosterone on the proliferation and collagen synthesis of cardiac fibroblasts induced by angiotensin II in neonatal rat.

    abstract::The objective is to explore the effect of testosterone on the proliferation and collagen synthesis of neonatal rat cardiac fibroblasts (CF) induced by Angiotensin II (Ang II) and the underlying mechanisms. Derived from neonatal rats, the CFs were divided into 4 groups: the control group, Ang II group, testosterone gro...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2016.1227141

    authors: Yang X,Wang Y,Yan S,Sun L,Yang G,Li Y,Yu C

    更新日期:2017-01-02 00:00:00

  • The isolation and functional identification on producing cellulase of Pseudomonas mendocina.

    abstract::The straw can be degraded efficiently into humus by powerful enzymes from microorganisms, resulting in the accelerated circulation of N,P,K and other effective elements in ecological system. We isolated a strain through screening the straw degradation strains from natural humic straw in the low temperature area in nor...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2016.1227143

    authors: Zhang J,Hou H,Chen G,Wang S,Zhang J

    更新日期:2016-09-02 00:00:00

  • Transformation of a Malaysian species of Nannochloropsis: gateway to construction of transgenic microalgae as vaccine delivery system to aquatic organisms.

    abstract:NANNOCHLOROPSIS:sp. is a green alga that is widely used in the aquaculture industry as a feed in Malaysia, but genetic engineering studies of this alga are still underexplored even though there is a growing interest in microalgae genetic engineering for various industrial purposes. This study aims to investigate the ef...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2020.1822106

    authors: Zainal Abidin AA,Suntarajh M,Balia Yusof ZN

    更新日期:2020-12-01 00:00:00

  • From stale bread and brewers spent grain to a new food source using edible filamentous fungi.

    abstract::By-products from the food sector with a high load of organic matter present both a waste-handling problem related to expenses and to the environment, yet also an opportunity. This study aims to increase the value of stale bread and brewers spent grain (BSG) by re-introducing these residues to the food production chain...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2020.1768694

    authors: Gmoser R,Fristedt R,Larsson K,Undeland I,Taherzadeh MJ,Lennartsson PR

    更新日期:2020-12-01 00:00:00

  • Epstein-Barr virus circRNAome as host miRNA sponge regulates virus infection, cell cycle, and oncogenesis.

    abstract::Epstein-Barr virus (EBV) is an oncogenic virus that infects more than 90% of the world's population. The proteins and miRNAs encoded by EBV are involved in multiple human malignancies. Recently R-resistance RNA-seq demonstrated that EBV-encoded circular RNAs. The current research aims to explore their functions in EBV...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2019.1679698

    authors: Qiao Y,Zhao X,Liu J,Yang W

    更新日期:2019-12-01 00:00:00

  • Bioengineering advancements, innovations and challenges on green synthesis of 2, 5-furan dicarboxylic acid.

    abstract::The major drawback of chemical transformations for the production of 2, 5-furan dicarboxylic acid (FDCA) implies the usage of hazardous chemicals, high temperature and high pressure from nonrenewable resources. Alternate to chemical methods, biological methods are promising. Microbial FDCA production is improved throu...

    journal_title:Bioengineered

    pub_type: 杂志文章,评审

    doi:10.1080/21655979.2019.1700093

    authors: Rajesh RO,Godan TK,Sindhu R,Pandey A,Binod P

    更新日期:2020-12-01 00:00:00

  • Circular RNA circ-LRP6 facilitates Myc-driven tumorigenesis in esophageal squamous cell cancer.

    abstract::Circular RNA (circRNA) circ-LRP6 was recently proven to be a pivotal player in various human diseases. Nevertheless, its role in esophageal squamous cell cancer (ESCC) remains unknown. In the current study, we investigated the expression level, biological function and mechanism of circ-LRP6 in ESCC. Circ-LRP6 was sign...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2020.1809922

    authors: Wang J,Zhu W,Tao G,Wang W

    更新日期:2020-12-01 00:00:00

  • Characterization of D-xylonate dehydratase YjhG from Escherichia coli.

    abstract::D-xylonate dehydratase YjhG from Escherichia coli can convert D-xylonate into 2-keto-3-deoxy- D-xylonate (KDX), and is a key enzyme in the biosynthesis of 1,2,4-butanetriol and other chemicals. However, the biochemical properties of YjhG still remain unknown. In this study, the activity assay method for YjhG was estab...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2015.1040208

    authors: Jiang Y,Liu W,Cheng T,Cao Y,Zhang R,Xian M

    更新日期:2015-01-01 00:00:00

  • Knockdown of STIM1 expression inhibits non-small-cell lung cancer cell proliferation in vitro and in nude mouse xenografts.

    abstract::Stromal interaction molecule 1 (STIM1) is a calcium-sensing protein localized in the membrane of the endoplasmic reticulum. The expression of STIM1 has been shown to be closely associated with cell proliferation. The aim of the present study was to investigate the role of STIM1 in the regulation of cancer progression ...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2019.1669518

    authors: Ge C,Zeng B,Li R,Li Z,Fu Q,Wang W,Wang Z,Dong S,Lai Z,Wang Y,Xue Y,Guo J,Di T,Song X

    更新日期:2019-12-01 00:00:00

  • Bioengineered collagens: emerging directions for biomedical materials.

    abstract::Mammalian collagen has been widely used as a biomedical material. Nevertheless, there are still concerns about the variability between preparations, particularly with the possibility that the products may transmit animal-based diseases. Many groups have examined the possible application of bioengineered mammalian coll...

    journal_title:Bioengineered

    pub_type: 杂志文章,评审

    doi:10.4161/bioe.28791

    authors: Ramshaw JA,Werkmeister JA,Dumsday GJ

    更新日期:2014-07-01 00:00:00

  • Progress toward the development of polyvalent vaccination strategies against multiple viral infections in chickens using herpesvirus of turkeys as vector.

    abstract::Vaccination is the most cost effective strategy for the control and prevention of the plethora of viral diseases affecting poultry production. The major challenge for poultry vaccination is the design of vaccines that will protect against multiple pathogens via a single protective dose, delivered by mass vaccination. ...

    journal_title:Bioengineered

    pub_type: 评论,杂志文章

    doi:10.4161/bioe.20476

    authors: Iqbal M

    更新日期:2012-07-01 00:00:00

  • Recombinant Lactococcus lactis fails to secrete bovine chymosine.

    abstract::Bovine chymosin is an important milk-clotting agent used in the manufacturing of cheeses. Currently, the production of recombinant proteins by genetically modified organisms is widespread, leading to greatly reduced costs. Lactococcus (L.) lactis, the model lactic acid bacterium, was considered a good candidate for he...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.4161/bioe.36327

    authors: Luerce TD,Azevedo MS,LeBlanc JG,Azevedo V,Miyoshi A,Pontes DS

    更新日期:2014-01-01 00:00:00

  • Fatty acid methyl ester analysis of Aspergillus fumigatus isolated from fruit pulps for biodiesel production using GC-MS spectrometry.

    abstract::In this study, a total of six fungal samples were isolated from apple, strawberry and orange pulp. DNA sequence analysis was used as molecular identification method. ITS region was aligned in DNA sequence analysis, and an algorithm sequence similarity was done using BLAST (Basic Local Alignment Search Tool) program to...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2020.1739379

    authors: Asci F,Aydin B,Akkus GU,Unal A,Erdogmus SF,Korcan SE,Jahan I

    更新日期:2020-12-01 00:00:00

  • Recent advances in synthetic biology of cyanobacteria for improved chemicals production.

    abstract::Cyanobacteria are Gram-negative photoautotrophic prokaryotes and have shown great importance to the Earth's ecology. Based on their capability in oxygenic photosynthesis and genetic merits, they can be engineered as microbial chassis for direct conversion of carbon dioxide to value-added biofuels and chemicals. In the...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2020.1837458

    authors: Wang F,Gao Y,Yang G

    更新日期:2020-12-01 00:00:00

  • Activating transcription factor 3 (ATF3) regulates cell growth, apoptosis, invasion and collagen synthesis in keloid fibroblast through transforming growth factor beta (TGF-beta)/SMAD signaling pathway.

    abstract::The successful treatment of keloids is a great challenge in the plastic surgery field. Activating transcription factor 3 (ATF3) is discovered as an adaptive responsive gene, which plays a critical role in fibroblast activation. This study aimed to investigate the expression and biological role of ATF3 in the pathogene...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2020.1860491

    authors: Wang XM,Liu XM,Wang Y,Chen ZY

    更新日期:2021-12-01 00:00:00

  • Isolation of a novel deep-sea Bacillus circulus strain and uniform design for optimization of its anti-aflatoxigenic bioactive metabolites production.

    abstract::The deep-sea bacterium strain FA13 was isolated from the sediment of the South Atlantic Ocean and identified as Bacillus circulans based on 16S ribosomal DNA sequence. Through liquid fermentation with five media, the cell-free supernatant fermented with ISP2 showed the highest inhibition activities against mycelial gr...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2019.1586055

    authors: Zhou Y,Wang J,Gao X,Wang K,Wang W,Wang Q,Yan P

    更新日期:2019-12-01 00:00:00

  • Production optimization of a heat-tolerant alkaline pectinase from Bacillus subtilis ZGL14 and its purification and characterization.

    abstract::Alkaline pectinase has important applications in the pretreatment of waste water from food processing and in both the fabric and paper industries. In this study, a 2-level factorial design was used to screen significant factors that affect the activity of alkaline pectinase, and the response surface methodology (RSM) ...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2017.1292188

    authors: Yu P,Zhang Y,Gu D

    更新日期:2017-09-03 00:00:00

  • From biocontrol to cancer, probiotics and beyond.

    abstract::This invited commentary covers the period 1997-2012 and has seen changes in terminology that progressed from "basic" and "applied" to "translational" research. In the context of Bioengineered, these changes map readily onto the processes of identifying microbial characteristics appropriate for specific applications, i...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.4161/bioe.23251

    authors: Dunne C

    更新日期:2013-07-01 00:00:00

  • Non-Fourier based thermal-mechanical tissue damage prediction for thermal ablation.

    abstract::Prediction of tissue damage under thermal loads plays important role for thermal ablation planning. A new methodology is presented in this paper by combing non-Fourier bio-heat transfer, constitutive elastic mechanics as well as non-rigid motion of dynamics to predict and analyze thermal distribution, thermal-induced ...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2016.1227609

    authors: Li X,Zhong Y,Smith J,Gu C

    更新日期:2017-01-02 00:00:00