Novel strategies to improve co-fermentation of pentoses with D-glucose by recombinant yeast strains in lignocellulosic hydrolysates.

Abstract:

:Economically feasible production of second-generation biofuels requires efficient co-fermentation of pentose and hexose sugars in lignocellulosic hydrolysates under very harsh conditions. Baker's yeast is an excellent, traditionally used ethanol producer but is naturally not able to utilize pentoses. This is due to the lack of pentose-specific transporter proteins and enzymatic reactions. Thus, natural yeast strains must be modified by genetic engineering. Although the construction of various recombinant yeast strains able to ferment pentose sugars has been described during the last two decades, their rates of pentose utilization is still significantly lower than D-glucose fermentation. Moreover, pentoses are only fermented after D-glucose is exhausted, resulting in an uneconomical increase in the fermentation time. In this addendum, we discuss novel approaches to improve utilization of pentoses by development of specific transporters and substrate channeling in enzyme cascades.

journal_name

Bioengineered

journal_title

Bioengineered

authors

Oreb M,Dietz H,Farwick A,Boles E

doi

10.4161/bioe.21444

subject

Has Abstract

pub_date

2012-11-01 00:00:00

pages

347-51

issue

6

eissn

2165-5979

issn

2165-5987

pii

21444

journal_volume

3

pub_type

杂志文章
  • CHO-gmt5, a novel CHO glycosylation mutant for producing afucosylated and asialylated recombinant antibodies.

    abstract::Engineered zinc-finger nucleases (ZFNs) are powerful tools for creating double-stranded-breaks (DSBs) in genomic DNA in a site-specific manner. These DSBs generated by ZFNs can be repaired by homology-directed repair or nonhomologous end joining, in which the latter can be exploited to generate insertion or deletion m...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.4161/bioe.22262

    authors: Haryadi R,Zhang P,Chan KF,Song Z

    更新日期:2013-03-01 00:00:00

  • From stale bread and brewers spent grain to a new food source using edible filamentous fungi.

    abstract::By-products from the food sector with a high load of organic matter present both a waste-handling problem related to expenses and to the environment, yet also an opportunity. This study aims to increase the value of stale bread and brewers spent grain (BSG) by re-introducing these residues to the food production chain...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2020.1768694

    authors: Gmoser R,Fristedt R,Larsson K,Undeland I,Taherzadeh MJ,Lennartsson PR

    更新日期:2020-12-01 00:00:00

  • Synthetic biology of modular proteins.

    abstract::The evolution of natural modular proteins and domain swapping by protein engineers have shown the disruptive potential of non-homologous recombination to create proteins with novel functions or traits. Bacteriophage endolysins, cellulosomes and polyketide synthases are 3 examples of natural modular proteins with each ...

    journal_title:Bioengineered

    pub_type: 杂志文章,评审

    doi:10.1080/21655979.2016.1222993

    authors: Maervoet VET,Briers Y

    更新日期:2017-05-04 00:00:00

  • Combining MPDL3280A with adoptive cell immunotherapy exerts better antitumor effects against cervical cancer.

    abstract::As the second most common gynecologic malignant tumors with a high mortality rate, cervical cancer jeopardizes women's life worldwide. The low cure rate in cervical cancer patients is mainly attributed to the lack of effective therapies. One feasible novel strategy is to develop immune-based approaches such as adoptiv...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2016.1230573

    authors: Zheng Y,Yang Y,Wu S,Zhu Y,Tang X,Liu X

    更新日期:2017-07-04 00:00:00

  • Progress toward the development of polyvalent vaccination strategies against multiple viral infections in chickens using herpesvirus of turkeys as vector.

    abstract::Vaccination is the most cost effective strategy for the control and prevention of the plethora of viral diseases affecting poultry production. The major challenge for poultry vaccination is the design of vaccines that will protect against multiple pathogens via a single protective dose, delivered by mass vaccination. ...

    journal_title:Bioengineered

    pub_type: 评论,杂志文章

    doi:10.4161/bioe.20476

    authors: Iqbal M

    更新日期:2012-07-01 00:00:00

  • Polyphosphate, cyclic AMP, guanosine tetraphosphate, and c-di-GMP reduce in vitro Lon activity.

    abstract::Lon protease is conserved from bacteria to humans and regulates cellular processes by degrading different classes of proteins including antitoxins, transcriptional activators, unfolded proteins, and free ribosomal proteins. Since we found that Lon has several putative cyclic diguanylate (c-di-GMP) binding sites and si...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.4161/bioe.29261

    authors: Osbourne DO,Soo VW,Konieczny I,Wood TK

    更新日期:2014-07-01 00:00:00

  • Rhizobium etli asparaginase II: an alternative for acute lymphoblastic leukemia (ALL) treatment.

    abstract::Bacterial L-asparaginase has been a universal component of therapies for childhood acute lymphoblastic leukemia since the 1970s. Two principal enzymes derived from Escherichia coli and Erwinia chrysanthemi are the only options clinically approved to date. We recently reported a study of recombinant L-asparaginase (Ans...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.4161/bioe.21710

    authors: Huerta-Saquero A,Evangelista-Martínez Z,Moreno-Enriquez A,Perez-Rueda E

    更新日期:2013-01-01 00:00:00

  • Different construction strategies affected on the physiology of Pichia pastoris strains highly expressed lipase by transcriptional analysis of key genes.

    abstract::We demonstrated previously that expression of Rhizomucor miehei lipase (RML) in Pichia pastoris could be significantly increased by addition of gene propeptide, optimized signal peptide codons and manipulation of gene dosage. In this study, effects of various strategies on the protein synthesis and secretion pathways ...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2019.1614422

    authors: Huang J,Wang Q,Bu W,Chen L,Yang Z,Zheng W,Li Y,Li J

    更新日期:2019-12-01 00:00:00

  • Tools for metabolic engineering in Streptomyces.

    abstract::During the last few decades, Streptomycetes have shown to be a very important and adaptable group of bacteria for the production of various beneficial secondary metabolites. These secondary metabolites have been of great interest in academia and the pharmaceutical industries. To date, a vast variety of techniques and ...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.4161/bioe.29935

    authors: Bekker V,Dodd A,Brady D,Rumbold K

    更新日期:2014-09-01 00:00:00

  • miR-25 mediates metastasis and epithelial-mesenchymal-transition in human esophageal squamous cell carcinoma via regulation of E-cadherin signaling.

    abstract::MiR-25 is a well-documented oncogenic miRNA implicated in esophageal squamous cell carcinoma (ESCC) development, progression and metastasis. However, whether and how miR-25 is involved in the development and metastasis of ESCC remain un-addressed. By using qRT-PCR analysis to compare levels of miR-25 in ESCC tissues w...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2019.1687391

    authors: Liu B,Li X,Li C,Xu R,Sun X

    更新日期:2019-12-01 00:00:00

  • Engineering low-temperature expression systems for heterologous production of cold-adapted enzymes.

    abstract::Production of psychrophilic enzymes in the commonly used mesophilic expression systems is hampered by low intrinsic stability of the recombinant enzymes at the optimal host growth temperatures. Unless strategies for low-temperature expression are advanced, research on psychrophilic enzymes may end up being biased towa...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2015.1128589

    authors: Bjerga GE,Lale R,Williamson AK

    更新日期:2016-01-01 00:00:00

  • Cell suspension concentration monitoring by using a miniaturized serial high frequency SAWR sensor.

    abstract::In this paper, a miniaturized cell suspension concentration monitoring method was investigated. The sensing unit was a carbon screen-printed electrode (CSPE) in serial with a 433MHz vacuum-packaged surface acoustic wave resonator (SAWR). SAWR provided a stable and high operating frequency, which helps to keep the stab...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2015.1119342

    authors: Li J,Feng H,Fang Y

    更新日期:2015-01-01 00:00:00

  • Knock-down of a RING finger gene confers cold tolerance.

    abstract::The plant-specific RING-domain finger proteins play important roles in plant development and stress responses. We recently identified and functionally characterized a stress-induced gene OsSRFP1 (Oryza sativa Stress-related RING Finger Protein 1) from rice. We showed evidences of the biotechnological potential of the ...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2015.1131368

    authors: Fang H,Meng Q,Zhang H,Huang J

    更新日期:2016-01-01 00:00:00

  • Development and validation of a platform reduced intact mass method for process monitoring of monoclonal antibody glycosylation during routine manufacturing.

    abstract::N-linked glycosylation is a primary source of heterogeneity associated with recombinant monoclonal antibodies and plays a key role in a myriad of drug properties associated with biological function. The glycosylation profile of recombinant monoclonal antibodies is influenced by an array of cell culture inputs which mu...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2020.1842651

    authors: Schilling M,Feng P,Sosic Z,Traviglia SL

    更新日期:2020-12-01 00:00:00

  • Penaeus orientolis prawn freshness rapid determination method based on electronic nose and non-linear stochastic resonance technique.

    abstract::In this paper, Penaeus orientolis prawn freshness rapid determination method using electronic nose (e-nose) and non-linear data processing technique is studied. E-nose responses to prawns stored at 4 °C are measured. Meanwhile, physical/chemical indexes (firmness, pH, total volatile basic nitrogen (TVB-N), total viabl...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.4161/21655979.2014.993294

    authors: Wei L,Yuanyuan H,Yanping C,Jiaojiao J,Guohua H

    更新日期:2015-01-01 00:00:00

  • Rhizoremediation of Cu(II) ions from contaminated soil using plant growth promoting bacteria: an outlook on pyrolysis conditions on plant residues for methylene orange dye biosorption.

    abstract::Rhizoremediation is one of the most accepted, cost-effective bioremediation techniques focusing on the application of rhizospheric microorganisms in combination with plants for the remediation of organic and inorganic pollutants from the contaminated sites. This work focuses on isolation and identification of metal re...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2020.1728034

    authors: Yaashikaa PR,Senthil Kumar P,Varjani S,Saravanan A

    更新日期:2020-12-01 00:00:00

  • Implications of endophytic microbiota in Camellia sinensis: a review on current understanding and future insights.

    abstract::Endophytic fungi and bacteria are the most ubiquitous and representative commensal members that have been studied so far in various higher plants. Within colonization and interaction with their host plants, endophytic microbiota are reportedly to modulate not only the host's growth but also holobiont resilience to abi...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2020.1816788

    authors: Xie H,Feng X,Wang M,Wang Y,Kumar Awasthi M,Xu P

    更新日期:2020-12-01 00:00:00

  • A combination of experimental and numerical methods to investigate the role of strain rate on the mechanical properties and collagen fiber orientations of the healthy and atherosclerotic human coronary arteries.

    abstract::Atherosclerosis enables to alter not only the microstructural but also the physical properties of the arterial walls by plaque forming. Few studies so far have been conducted to calculate the isotropic or anisotropic mechanical properties of the healthy and atherosclerotic human coronary arteries. To date there is a p...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2016.1212134

    authors: Karimi A,Rahmati SM,Sera T,Kudo S,Navidbakhsh M

    更新日期:2017-03-04 00:00:00

  • Anti-microbial and anti-oxidant activities of Illicium verum, Crataegus oxyacantha ssp monogyna and Allium cepa red and white varieties.

    abstract::Illicium verum (badiane or star anise), Crataegus oxyacantha ssp monogyna (hawthorn) and Allium cepa (onion), have traditionnally been used as medicinal plants in Algeria. This study showed that the outer layer of onion is rich in flavonols with contents of 103 ± 7.90 µg/g DW (red variety) and 17.3 ± 0.69 µg/gDW (whit...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.4161/bioe.24435

    authors: Benmalek Y,Yahia OA,Belkebir A,Fardeau ML

    更新日期:2013-07-01 00:00:00

  • Current challenges for the targeted delivery and molecular imaging of stem cells in animal models.

    abstract::In contrast to conventional, molecular medicine that focuses on targeting specific pathways, stem cell therapy aims to perturb many related mechanisms in order to derive therapeutic benefit. This emerging modality is inherently complex due to the variety of cell types that can be used, delivery approaches that need to...

    journal_title:Bioengineered

    pub_type: 杂志文章,评审

    doi:10.1080/21655979.2016.1233090

    authors: Momeni A,Neelamegham S,Parashurama N

    更新日期:2017-07-04 00:00:00

  • The synthetic biology future.

    abstract::Herein, I track the evolution of synthetic biology from its earliest incarnations more than 50 years ago, through the DIYbio revolution, to the next 50 years. ...

    journal_title:Bioengineered

    pub_type: 社论

    doi:10.4161/bioe.28317

    authors: Sleator RD

    更新日期:2014-03-01 00:00:00

  • Effect of testosterone on the proliferation and collagen synthesis of cardiac fibroblasts induced by angiotensin II in neonatal rat.

    abstract::The objective is to explore the effect of testosterone on the proliferation and collagen synthesis of neonatal rat cardiac fibroblasts (CF) induced by Angiotensin II (Ang II) and the underlying mechanisms. Derived from neonatal rats, the CFs were divided into 4 groups: the control group, Ang II group, testosterone gro...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2016.1227141

    authors: Yang X,Wang Y,Yan S,Sun L,Yang G,Li Y,Yu C

    更新日期:2017-01-02 00:00:00

  • The isolation and functional identification on producing cellulase of Pseudomonas mendocina.

    abstract::The straw can be degraded efficiently into humus by powerful enzymes from microorganisms, resulting in the accelerated circulation of N,P,K and other effective elements in ecological system. We isolated a strain through screening the straw degradation strains from natural humic straw in the low temperature area in nor...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2016.1227143

    authors: Zhang J,Hou H,Chen G,Wang S,Zhang J

    更新日期:2016-09-02 00:00:00

  • Bioengineered collagens: emerging directions for biomedical materials.

    abstract::Mammalian collagen has been widely used as a biomedical material. Nevertheless, there are still concerns about the variability between preparations, particularly with the possibility that the products may transmit animal-based diseases. Many groups have examined the possible application of bioengineered mammalian coll...

    journal_title:Bioengineered

    pub_type: 杂志文章,评审

    doi:10.4161/bioe.28791

    authors: Ramshaw JA,Werkmeister JA,Dumsday GJ

    更新日期:2014-07-01 00:00:00

  • Kinetic analysis of IgM monoclonal antibodies for determination of dengue sample concentration using SPR technique.

    abstract::Surface plasmon resonance (SPR) sensing is recently emerging as a valuable technique for measuring the binding constants, association and dissociation rate constants, and stoichimetry for a binding interaction kinetics in a number of emerging biological areas. This technique can be applied to the study of immune syste...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2016.1223413

    authors: Jahanshahi P,Wei Q,Jie Z,Ghomeishi M,Sekaran SD,Mahamd Adikan FR

    更新日期:2017-05-04 00:00:00

  • Improving health from the inside: Use of engineered intestinal microorganisms as in situ cytokine delivery system.

    abstract::The anti-inflammatory cytokine interleukin-10 and its viral homologs were chosen as model proteins for the development of drug delivery systems based on probiotic carriers like E. coli Nissle 1917, E. coli G3/10, and Saccharomyces boulardii. Exterior cytokine secretion was achieved by a modified E. coli hemolysin tran...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.4161/bioe.22646

    authors: Pöhlmann C,Thomas M,Förster S,Brandt M,Hartmann M,Bleich A,Gunzer F

    更新日期:2013-05-01 00:00:00

  • Recombinant Lactococcus lactis fails to secrete bovine chymosine.

    abstract::Bovine chymosin is an important milk-clotting agent used in the manufacturing of cheeses. Currently, the production of recombinant proteins by genetically modified organisms is widespread, leading to greatly reduced costs. Lactococcus (L.) lactis, the model lactic acid bacterium, was considered a good candidate for he...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.4161/bioe.36327

    authors: Luerce TD,Azevedo MS,LeBlanc JG,Azevedo V,Miyoshi A,Pontes DS

    更新日期:2014-01-01 00:00:00

  • Chaperones in maturation of molybdoenzymes: Why specific is better than general?

    abstract::Molybdoenzymes play essential functions in living organisms and, as a result, in various geochemical cycles. It is thus crucial to understand how these complex proteins become highly efficient enzymes able to perform a wide range of catalytic activities. It has been established that specific chaperones are involved du...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2016.1218579

    authors: Lemaire ON,Bouillet S,Méjean V,Iobbi-Nivol C,Genest O

    更新日期:2017-03-04 00:00:00

  • Epstein-Barr virus circRNAome as host miRNA sponge regulates virus infection, cell cycle, and oncogenesis.

    abstract::Epstein-Barr virus (EBV) is an oncogenic virus that infects more than 90% of the world's population. The proteins and miRNAs encoded by EBV are involved in multiple human malignancies. Recently R-resistance RNA-seq demonstrated that EBV-encoded circular RNAs. The current research aims to explore their functions in EBV...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2019.1679698

    authors: Qiao Y,Zhao X,Liu J,Yang W

    更新日期:2019-12-01 00:00:00

  • Characteristics of immune cell infiltration and associated diagnostic biomarkers in ulcerative colitis: results from bioinformatics analysis.

    abstract::Ulcerative colitis (UC) is a type of refractory and recurrent inflammatory disorder that occurs in colon and rectum. Immune cell infiltration plays a critical role in UC progression; therefore, this study aims to explore potential biomarkers for UC and to analyze characteristics of immune cell infiltration based on th...

    journal_title:Bioengineered

    pub_type: 杂志文章

    doi:10.1080/21655979.2020.1863016

    authors: Xue G,Hua L,Zhou N,Li J

    更新日期:2021-12-01 00:00:00