Abstract:
:The main treatment option for Hemophilia A/B patients involves the administration of recombinant coagulation factors on-demand or in a prophylactic approach. Despite the safety and efficacy of this replacement therapy, the development of antibodies against the coagulation factor infused, which neutralize the procoagulant activity, is a severe complication. The production of recombinant coagulation factors in human cell lines is an efficient approach to avoid such complication. Human cell lines can produce recombinant proteins with post translation modifications more similar to their natural counterpart, reducing potential immunogenic reactions. This review provides a brief overview of the most important characteristics of recombinant FVIII and FIX products available on the market and the improvements that have recently been achieved by the production using human cell lines.
journal_name
Bioengineeredjournal_title
Bioengineeredauthors
Swiech K,Picanço-Castro V,Covas DTdoi
10.1080/21655979.2017.1279767subject
Has Abstractpub_date
2017-09-03 00:00:00pages
462-470issue
5eissn
2165-5979issn
2165-5987journal_volume
8pub_type
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