The optimized drug delivery systems of treating cancer bone metastatic osteolysis with nanomaterials.

abstract：:Over the years, research has focused on strategies to increase benefit/risk ratio of corticoids. However, vehicles intended for topical glucocorticoids delivery with an improved benefit/risk ratio are still on demand. The aim of this work was the in vitro and in vivo characterization of cold processed oil-in-water (o/...

journal_title：Drug delivery

authors： Raposo S,Tavares R,Gonçalves L,Simões S,Urbano M,Ribeiro HM

更新日期：2015-01-01 00:00:00

abstract：:The present work aimed to apply the liquid antisolvent precipitation (LAP) method for preparing the apigenin nanoparticles and thereby improving the solubility and bioavailability of apigenin. The different experimental parameters on particle size were optimized through central composite design (CCD) using the Design-...

journal_title：Drug delivery

authors： Wu W,Zu Y,Wang L,Wang L,Wang H,Li Y,Wu M,Zhao X,Fu Y

更新日期：2017-11-01 00:00:00

abstract：:The study was aimed at evaluating the effectiveness of liposomal, micellar, and water-soluble drug forms of diminazene for its localization in cells and selective accumulation at the sites of aggregation of pathogenic organisms. Pharmacological and dynamic properties of a new injection micellar diminazene preparation ...

journal_title：Drug delivery

authors： Staroverov SA,Pristensky DV,Yermilov DN,Gabalov KP,Zhemerichkin DA,Sidorkin VA,Shcherbakov AA,Shchyogolev SY,Dykman LA

更新日期：2006-09-01 00:00:00

abstract：CONTEXT:Propolis has traditionally been used in curing infections and healing wounds and burns. OBJECTIVE:The aim of this study is to formulate pluronic lecithin organogel of propolis to improve its availability and antimicrobial activity. MATERIALS AND METHODS:Different organogels were prepared by using soybean leci...

journal_title：Drug delivery

authors： Balata G,El Nahas HM,Radwan S

更新日期：2014-02-01 00:00:00

abstract：CONTEXT:MicroRNAs (miRNAs) are important and powerful mediators in a variety of diseases including cardiovascular pathology. Thus, they emerged as interesting new drug targets. However, it is important to develop efficient transfer tools to successfully deliver miRNAs or antisense oligonucleotides (antagomirs) to the t...

journal_title：Drug delivery

authors： Chistiakov DA,Sobenin IA,Orekhov AN

更新日期：2012-11-01 00:00:00

abstract：:Melatonin, a pineal gland hormone, exerts oncostatic activity in several types of human cancer, including prostate, the most common neoplasia and the third most frequent cause of male cancer death in the developed world. The growth of androgen-sensitive LNCaP prostate cancer cells in mice is inhibited by 3 mg/kg/week ...

journal_title：Drug delivery

authors： Terraneo L,Bianciardi P,Virgili E,Finati E,Samaja M,Paroni R

更新日期：2017-11-01 00:00:00

abstract：:Kollicoat SR 30D is a unique 30% aqueous dispersion of polyvinvyl acetate stabilized by polyvinyl-pyrrolidone intended for preparation of sustained release products. Detailed evaluation of this polymer dispersion as a sustained release coating for active pharmaceutical ingredients of two diverse classes of drugs was s...

journal_title：Drug delivery

authors： Bordaweka MS,Zia H,Quadir A

更新日期：2006-03-01 00:00:00

abstract：:Pulmonary bed can retain microparticles (MP) larger than their capillaries' diameter, hence we offer a promising way for lung passive targeting following intravenous (IV) administration. In this study, enoxaparin (Enox)-albumin microspheres (Enox-Alb MS) were, optimally, developed as lung targeted sustained release MP...

journal_title：Drug delivery

authors： Ibrahim SS,Osman R,Mortada ND,Geneidy AS,Awad GA

更新日期：2017-11-01 00:00:00

abstract：:ALA-loaded nanostructured lipid carrier (ALA-NLC) was designed to improve physicochemical stability and water solubility, and promote sustained release of ALA as well as determine the biocompatibility of ALA-NLC. The ALA-NLC manufactured using hot high-pressure homogenization technique was investigated in terms of siz...

journal_title：Drug delivery

authors： Wang J,Xia Q

更新日期：2014-08-01 00:00:00

abstract：:Monoclonal antibodies (mAbs) were generated to the extracellular domain of transcobalamin receptor (TCblR) and used to identify the regions of the receptor protein involved in antibody binding. Based on the effect of transcobalamin bound cobalamin (TC-Cbl) on antibody binding, this study identified both blocking and b...

journal_title：Drug delivery

authors： Jiang W,Nakayama Y,Sequeira JM,Quadros EV

更新日期：2011-01-01 00:00:00

abstract：:Lung cancer is still the most common cancer globally. Early screening remains the key to improve the prognosis of patients. There is currently a lack of specific and sensitive methods for early screening of lung cancer. In recent years, studies have found that microRNA plays an important role in the occurrence and dev...

journal_title：Drug delivery

authors： Zhu HZ,Hou J,Guo Y,Liu X,Jiang FL,Chen GP,Pang XF,Sun JG,Chen ZT

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to formulate and evaluate the Ibuprofen niosomal formulation as a transdermal drug delivery system. MATERIALS AND METHODS:Niosomes were prepared by a modified ethanol injection method, using Span 60, Tween 60 and Tween 65 as well as cholesterol with various cholesterol:surfact...

journal_title：Drug delivery

authors： Ghanbarzadeh S,Khorrami A,Arami S

更新日期：2015-12-01 00:00:00

abstract：:Surface modification of liposomes with polymer to optimize drug delivery was well developed recently. The objective of the present work was to evaluate the feasibility of chitosan-coated liposomes (CSLP) as vehicles for anti-sense oligodeoxynucleotides (ASON). CSLP was obtained by adding chitosan dropwise to liposomes...

journal_title：Drug delivery

authors： Wang WX,Gao JQ,Liang WQ

更新日期：2011-04-01 00:00:00

abstract：:Hydrogels based on poly(ethylene glycol)-diacrylate (PEG-DA) and 2-hydroxyethyl methacrylate (HEMA) were polymerized with cross-linking agent ethylene glycol diacrylate (EGDMA) under mild photoinitiating conditions. PEG-DA and HEMA concentrations of disks with 1 +/- 0.3 mm thickness were 30% and 50% w/w and 40% and 60...

journal_title：Drug delivery

authors： Ayhan F,Ozkan S

更新日期：2007-10-01 00:00:00

abstract：:Electro-phonophoresis (EP) has been used as a drug delivery approach in clinical fields. The objective of the present study is to evaluate the skin permeability of isoniazid and rifampin in guinea pigs by EP to provide reference basis for clinical applications of such transdermal delivery system in the treatment of pa...

journal_title：Drug delivery

authors： Chen S,Han Y,Yu D,Huo F,Wang F,Li Y,Dong L,Liu Z,Huang H

更新日期：2017-11-01 00:00:00

abstract：:Improvement of water solubility, dissolution rate, oral bioavailability, and reduction of first pass metabolism of OL (OL), were the aims of this research. Co-amorphization of OL carboxylic acid dispersions at various molar ratios was carried out using rapid solvent evaporation. Characterization of the dispersions was...

journal_title：Drug delivery

authors： Maher EM,Ali AM,Salem HF,Abdelrahman AA

更新日期：2016-10-01 00:00:00

abstract：:Silk was easily dyed in traditional textile industry because of its strong affinity to many colorants. Herein, the biocompatible silk fibroin was firstly extracted from Bombyx mori silkworm cocoons. And SF nanoparticles (SFNPs) were prepared for dyeing indocyanine green (ICG) and construct a therapeutic nano-platform ...

journal_title：Drug delivery

authors： Xu HL,ZhuGe DL,Chen PP,Tong MQ,Lin MT,Jiang X,Zheng YW,Chen B,Li XK,Zhao YZ

更新日期：2018-11-01 00:00:00

abstract：:The objective of this study was to investigate the effect of lipophilic (Compritol 888 ATO) and hydrophilic components (combination of HPMC and Avicel) on the release of carbamazepine from granules and corresponding tablet. Wet granulation followed by compression was employed for preparation of granules and tablets. T...

journal_title：Drug delivery

authors： Barakat NS,Elbagory IM,Almurshedi AS

更新日期：2009-01-01 00:00:00

abstract：:To prolong the circulation time of drug, PEGylation has been widely used via the enhanced permeability and retention (EPR) effect, thereby providing new hope for better treatment. However, PEGylation also brings the "PEG dilemma", which is difficult for the cellular absorption of drugs and subsequent endosomal escape....

journal_title：Drug delivery

authors： Fang Y,Xue J,Gao S,Lu A,Yang D,Jiang H,He Y,Shi K

更新日期：2017-12-01 00:00:00

abstract：:Radio-labeled hydrogel beads, based on amidated pectin, have been produced by adding droplets of an amidated pectin solution to calcium chloride. Incorporation of model drugs into the beads and measurement of the dissolution rate showed that the properties of the beads were unaffected by the incorporation of the radio...

journal_title：Drug delivery

authors： Munjeri O,Collett JH,Fell JT,Sharma HL,Smith AM

更新日期：1998-01-01 00:00:00

abstract：:Although convection-enhanced delivery (CED) can successfully facilitate a bypass of the blood brain barrier, its treatment efficacy remains highly limited in clinic. This can be partially attributed to the brain anisotropic characteristics that lead to the difficulties in controlling the drug spatial distribution. Her...

journal_title：Drug delivery

authors： Zhan W,Rodriguez Y Baena F,Dini D

更新日期：2019-12-01 00:00:00

abstract：:Mucoadhesive drug delivery systems are those that provide intimate contact of the drug with the mucosa for an extended period of time. In our present work, mucoadhesive chitosan microspheres were prepared by emulsion solvent method. Formulations were characterized for various physicochemical attributes, shape, surface...

journal_title：Drug delivery

authors： Jain SK,Chourasia MK,Jain AK,Jain RK,Shrivastava AK

更新日期：2004-03-01 00:00:00

abstract：:This study evaluated three chitosan-N-acetyl cysteine (CAC) conjugates of increasing molecular mass as a valuable tool to improve the absorption of drugs by assessing its permeation enhancing effect regarding the active P-gp substrate rhodamine-123 in comparison to the trans- and paracellular marker FD 4 both in rat i...

journal_title：Drug delivery

authors： Schmitz T,Hombach J,Bernkop-Schnürch A

更新日期：2008-05-01 00:00:00

abstract：:This study aimed to evaluate transdermal delivery of vancomycin hydrochloride using the combination of ethosomes as an encapsulating vesicle and iontophoresis. Ethosomes were prepared and evaluated in terms of electrochemical stability. Cathodal iontophoresis of negatively charged ethosomes and anodal iontophoresis of...

journal_title：Drug delivery

authors： Mohammed MI,Makky AM,Teaima MH,Abdellatif MM,Hamzawy MA,Khalil MA

更新日期：2016-06-01 00:00:00

abstract：:Administration of influenza vaccines to the lungs could be an attractive alternative to conventional parenteral administration. In this study, we investigated the deposition site of pulmonary delivered liquid and powder influenza vaccine formulations and its relation to their immunogenicity and protective efficacy. In...

journal_title：Drug delivery

authors： Bhide Y,Tomar J,Dong W,de Vries-Idema J,Frijlink HW,Huckriede A,Hinrichs WLJ

更新日期：2018-11-01 00:00:00

abstract：:In the present study, the stability of thymopentin (TP5) in bronchoalveolar lavage fluid (BALF) in presence of potential excipients in inhalation formulation was investigated. The content of TP5 was determined using HPLC method. Commonly used bulking agent, dispersibility enhancers and absorption enhancers in inhalati...

journal_title：Drug delivery

authors： Cai C,Wang L,Dong W,Tang X

更新日期：2014-09-01 00:00:00

abstract：:Carboplatin is a potent anticancer agent that has shown efficacy in clinical trials against malignant glioma, one of the most deadly cancers in humans. However, a high systemic dose is required to achieve an effective concentration in the brain because of the presence of the blood-brain barrier (BBB). Such a high dose...

journal_title：Drug delivery

authors： Chen W,He J,Olson JJ,Lu DR

更新日期：1997-01-01 00:00:00

abstract：:Sustained release (SR) matrix tablets of dextromethorphan hydrobromide were prepared by wet granulation using hydroxypropyl methyl cellulose (HPMC-K-100 CR) as the hydrophilic rate controlling polymer. The effect of the concentration of the polymer and different fillers on the in vitro drug release rate was studied. T...

journal_title：Drug delivery

authors： Meyyanathan SN,Rajan S,Muralidaharan S,Siddaiah MK,Krishnaraj K,Suresh B

更新日期：2008-09-01 00:00:00

abstract：:A macromolecular pro-drug of a known anti-viral agent Zidovudine (AZT) was synthesized and evaluated as a sustained drug delivery system. The pro-drug was synthesized by coupling the drug to 2-hydroxyethyl methacrylate (HEMA) through a succinic spacer to get a monomeric drug conjugate which was polymerized to obtain t...

journal_title：Drug delivery

authors： Neeraj A,Chandrasekar MJ,Sara UV,Rohini A

更新日期：2011-05-01 00:00:00

abstract：:The aim of this work was to encapsulate superoxide dismutase (SOD) into biodegradable microparticles by spray-drying technique. The nature of the organic solvent to dissolve the polymer, the method of incorporation of the drug in the organic phase (with or without a surfactant, namely sucrose ester of HLB = 6), the su...

journal_title：Drug delivery

authors： Youan BB

更新日期：2004-05-01 00:00:00