Abstract:
:Some cancers such as human breast cancer, prostate cancer, and lung cancer easily metastasize to bone, leading to osteolysis and bone destruction accompanied by a complicated microenvironment. Systemic administration of bisphosphonates (BP) or denosumab is the routine therapy for osteolysis but with non-negligible side effects such as mandibular osteonecrosis and hypocalcemia. Thus, it is imperative to exploit optimized drug delivery systems, and some novel nanotechnology and nanomaterials have opened new horizons for scientists. Targeted and local drug delivery systems can optimize biodistribution depending on nanoparticles (NPs) or microspheres (MS) and implantable biomaterials with the controllable property. Drug delivery kinetics can be optimized by smart and sustained/local drug delivery systems for responsive delivery and sustained delivery. These delicately fabricated drug delivery systems with special matrix, structure, morphology, and modification can minimize unexpected toxicity caused by systemic delivery and achieve desired effects through integrating multiple drugs or multiple functions. This review summarized recent studies about optimized drug delivery systems for the treatment of cancer metastatic osteolysis, aimed at giving some inspiration in designing efficient multifunctional drug delivery systems.
journal_name
Drug Delivjournal_title
Drug deliveryauthors
Cheng X,Wei J,Ge Q,Xing D,Zhou X,Qian Y,Jiang Gdoi
10.1080/10717544.2020.1856225subject
Has Abstractpub_date
2021-12-01 00:00:00pages
37-53issue
1eissn
1071-7544issn
1521-0464journal_volume
28pub_type
杂志文章相关文献
DRUG DELIVERY文献大全abstract::The main aim of this work was to develop rectal suppositories for better delivery of metoprolol tartrate (MT). The various bases used were fatty, water soluble and emulsion bases. The physical properties of the prepared suppositories were characterized such as weight variation, hardness, disintegration time, melting r...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2014.904021
更新日期:2016-01-01 00:00:00
abstract::Surface modification of liposomes with polymer to optimize drug delivery was well developed recently. The objective of the present work was to evaluate the feasibility of chitosan-coated liposomes (CSLP) as vehicles for anti-sense oligodeoxynucleotides (ASON). CSLP was obtained by adding chitosan dropwise to liposomes...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2010.549526
更新日期:2011-04-01 00:00:00
abstract::Melatonin, a pineal gland hormone, exerts oncostatic activity in several types of human cancer, including prostate, the most common neoplasia and the third most frequent cause of male cancer death in the developed world. The growth of androgen-sensitive LNCaP prostate cancer cells in mice is inhibited by 3 mg/kg/week ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2017.1338793
更新日期:2017-11-01 00:00:00
abstract::A micelle system modified with α-Conotoxin ImI (ImI), a potently antagonist for alpha7 nicotinic acetylcholine receptor (α7-nAChR) previously utilized for targeting breast cancer, was constructed. Its targeting efficiency and cytotoxicity against non-small cell lung cancer (NSCLC) highly expressing α7-nAChR was invest...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1436097
更新日期:2018-11-01 00:00:00
abstract::Various ocular diseases like glaucoma, conjunctivitis, and dry eye syndrome require frequent drug administration. Poor ocular bioavailability of drugs (< 1%) from conventional eye drops is due mainly to the precorneal loss factors that include rapid tear turnover, nonproductive absorption, transient residence time in ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540701606426
更新日期:2007-11-01 00:00:00
abstract::Bioadhesive sodium alginate microspheres of Metoprolol tartrate (MT) for intranasal systemic delivery were prepared to avoid the first-pass effect, as an alternative therapy to injection, and to obtain improved therapeutic efficacy in the treatment of hypertension and angina pectoris. The microspheres (Ms) were prepar...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/713840323
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Vorinostat (VRS), a histone deacetylases inhibitor, has significant cytotoxic potential in a large number of human cancer cell lines. OBJECTIVE:To clarify its promising anticancer potential and to improve its drawback related to physical properties and in vivo performance of VRS. METHODS:VRS was successful...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2014.991432
更新日期:2016-05-01 00:00:00
abstract::Novel itraconazole (ITZ)-loaded liposomes (ITZ-LPs) were prepared and their pharmacokinetics and biodistribution were assessed in comparison with commercial formulations (ITZ-CD). The ITZ-LPs were prepared by thin-film hydration method and the physicochemical characterizations of the ITZ-LPs were evaluated. The pharma...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717541003667822
更新日期:2010-05-01 00:00:00
abstract::Etoposide (VP16) is the traditional antitumor agent which has been widely used in a variety of cancers. However, intravenous administration of VP16 was limited in clinical application because of its low aqueous solubility, poor bioavailability and dose-limiting adverse effects. Local chemotherapy with VP16-loaded drug...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2020.1787558
更新日期:2020-12-01 00:00:00
abstract::Enrofloxacin, a third-generation fluoroquinolone, is a broad-spectrum antimicrobial drug against a lot of veterinary bacterial diseases. However, bactericidal activity of enrofloxacin is concentration-dependent and its poor aqueous solubility and bitter taste limit its development and application. Meanwhile, 2-hydroxy...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2020.1724210
更新日期:2020-12-01 00:00:00
abstract::The present work aimed to apply the liquid antisolvent precipitation (LAP) method for preparing the apigenin nanoparticles and thereby improving the solubility and bioavailability of apigenin. The different experimental parameters on particle size were optimized through central composite design (CCD) using the Design-...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2017.1399302
更新日期:2017-11-01 00:00:00
abstract::To improve drug retention in carriers for amphiphilic asulacrine (ASL), a novel active loading method using micelle gradient was developed to fabricate the ASL-loaded multiseed liposomes (ASL-ML). The empty ML were prepared by hydrating a thin film with empty micelles. Then the micelles in liposomal compartment acting...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1440669
更新日期:2018-11-01 00:00:00
abstract::The aim of our study was to investigate the enhancing effect of several essential oils in the percutaneous absorption of trazodone hydrochloride (TZN). For this purpose, fennel oil, eucalyptus oil, citronella oil, and mentha oil were applied on the skin membrane in three different ways: included in the transdermal dev...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540500395064
更新日期:2006-11-01 00:00:00
abstract::Colon is an ideal absorptive site for oral protein and peptide drug (insulin), and yet it poses multiple barriers against the drug absorption, such as the barriers against the drug diffusion from colon lumen toward the absorptive mucosa and permeation across colon epithelium. In this study, modified nanoparticles (Tat...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2015.1048489
更新日期:2016-07-01 00:00:00
abstract::ALA-loaded nanostructured lipid carrier (ALA-NLC) was designed to improve physicochemical stability and water solubility, and promote sustained release of ALA as well as determine the biocompatibility of ALA-NLC. The ALA-NLC manufactured using hot high-pressure homogenization technique was investigated in terms of siz...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2013.846435
更新日期:2014-08-01 00:00:00
abstract::The combined chemotherapy and photodynamic therapy have significant advantages for cancer treatments, which have higher therapeutic effects compared with other medicines. Herein, we focused on the synthesis of carbon quantum dot (CQD) based nanocarrier system. CQD and 5-aminolevulinic acid (5-ALA) were conjugated with...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2020.1765431
更新日期:2020-12-01 00:00:00
abstract::The oral application of pharmaceuticals is unarguably the most convenient method of application. Especially for protein- or peptide-based drugs, however, the effectiveness is significantly reduced due to enzymatic digestion in the stomach as well as a poor bioavailability in the small intestine. For these difficult fo...
journal_title:Drug delivery
pub_type: 杂志文章,评审
doi:10.1080/10717544.2018.1501119
更新日期:2018-11-01 00:00:00
abstract::Efficient and stable delivery system of antisense oligonucleotide (ASO) is important and urgently needed. Here, an ASO delivery system, Lp-PPRP, which contains a cationic polymer based on PEI (branched, 25 kDa), named PEI-PC and a palmitic acid modified R8 (R8-PA) was prepared to deliver a kind of ASO, LOR-2501. The c...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2019.1667453
更新日期:2019-12-01 00:00:00
abstract::The conjugation of tunable peptides or materials with nanocarriers represents a promising approach for drug delivery to tumor cells. In this study, we report the development of a novel liposomal carrier system that exploits the cell surface binding synergism between photo-sensitive peptides (PSPs) and targeting ligand...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2015.1008707
更新日期:2016-09-01 00:00:00
abstract::The aim of this research was to develop pH-sensitive insulin-loaded NOCC (N,O-carboxymethyl chitosan) nanoparticles for the controlled release of insulin via the oral route. Thus, in this study, insulin-loaded NOCC nanoparticles were prepared by ionic gelation of NOCC with TPP (tripolyphosphate). NOCC nanoparticles we...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717540903353090
更新日期:2009-11-01 00:00:00
abstract::Hydrogels based on poly(ethylene glycol)-diacrylate (PEG-DA) and 2-hydroxyethyl methacrylate (HEMA) were polymerized with cross-linking agent ethylene glycol diacrylate (EGDMA) under mild photoinitiating conditions. PEG-DA and HEMA concentrations of disks with 1 +/- 0.3 mm thickness were 30% and 50% w/w and 40% and 60...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540701202911
更新日期:2007-10-01 00:00:00
abstract::The aim of this work was to encapsulate superoxide dismutase (SOD) into biodegradable microparticles by spray-drying technique. The nature of the organic solvent to dissolve the polymer, the method of incorporation of the drug in the organic phase (with or without a surfactant, namely sucrose ester of HLB = 6), the su...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540490280363
更新日期:2004-05-01 00:00:00
abstract::This work evaluates solid lipid nanoparticles of thiopental sodium against obesity-induced cardiac dysfunction and hypertrophy and explores the possible mechanism of action. TS loaded SLNs were formulated by hot-homogenization and solvent diffusion method. TS-SLNs were scrutinized for entrapment efficiency, drug loadi...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2020.1803449
更新日期:2020-12-01 00:00:00
abstract::The purpose of this study was to characterize and evaluate tectorigenin-loaded self-microemulsifying drug delivery system (TG-SMEDDS), a previously studied preparation, and further confirm the improvement of TG in solubility and bioavailability. The appearance of TG-SMEDDS was clear and transparent, with good mobility...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2017.1284946
更新日期:2017-11-01 00:00:00
abstract::Three formulations including methylene blue solution (MB-S), MB water-in-oil microemulsion (MB-ME), and MB multiple microemulsion (MB-MME) were prepared with the aim to evaluate whether the three formulations can carry MB target to regional lymph nodes and show lymphatic tropism after subcutaneous administration. The ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540903075644
更新日期:2009-10-01 00:00:00
abstract::Magnetic nanocomposite particles were synthesized by encapsulating nanosized magnetite with an acrylate-based cationic co-polymer made of MMA, BA, and QMA and modifying with MeOPEGMA using the water replacement method. The composition of the co-polymer formulation was optimized based on zeta-potential measurements and...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540801952597
更新日期:2008-03-01 00:00:00
abstract::The aim of present study was to investigate a pH-responsive and mucoadhesive nanoparticle system for oral bioavailability enhancement of low-molecular weight heparin (LMWH). The thioglycolic acid (TGA) was first covalently attached to chitosan (CS) with 396.97 ± 54.54 μmol thiol groups per gram of polymer and then the...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2014.909908
更新日期:2016-01-01 00:00:00
abstract::In this study, transdermal etodolac-loaded cubosomes were developed in order to relieve patient pain and joints stiffness by providing stable etodolac concentration at the targeting sites through controlled drug delivery via the noninvasive skin route with more sustaining and less frequent dosing. Different ratios and...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2017.1326539
更新日期:2017-11-01 00:00:00
abstract::Carboplatin is a potent anticancer agent that has shown efficacy in clinical trials against malignant glioma, one of the most deadly cancers in humans. However, a high systemic dose is required to achieve an effective concentration in the brain because of the presence of the blood-brain barrier (BBB). Such a high dose...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717549709052017
更新日期:1997-01-01 00:00:00
abstract::This study aimed to examine the effects of bile salts on pharmacokinetics of lovastatin, which has low bioavailability. Lovastatin solid dispersions were prepared using sodium deoxycholate (NaDC) and sodium glycholate (NaGC) at ratios of 1:19, 1:49, and 1:69. The formulated solid dispersions and control (commercial ta...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2010.512024
更新日期:2011-01-01 00:00:00