Abstract:
:Pulmonary bed can retain microparticles (MP) larger than their capillaries' diameter, hence we offer a promising way for lung passive targeting following intravenous (IV) administration. In this study, enoxaparin (Enox)-albumin microspheres (Enox-Alb MS) were, optimally, developed as lung targeted sustained release MP for IV use. Lung tolerability and targeting efficiency of Enox-Alb MS were tested, and the pharmacokinetic profile following IV administration to albino rats was constructed. In vivo studies confirmed high lung targeting efficiency of Enox-Alb MS with lack of potential tissue toxicity. The anticoagulant activity of the selected Alb MS was significantly sustained for up to 38 h compared to 5 h for the market product. Alb MS are promising delivery carriers for controlled and targeted delivery of Enox to the lungs for prophylaxis and treatment of pulmonary embolism.
journal_name
Drug Delivjournal_title
Drug deliveryauthors
Ibrahim SS,Osman R,Mortada ND,Geneidy AS,Awad GAdoi
10.1080/10717544.2016.1245368subject
Has Abstractpub_date
2017-11-01 00:00:00pages
243-251issue
1eissn
1071-7544issn
1521-0464journal_volume
24pub_type
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