In vitro assessment of lidocaine release from aqueous and oil solutions and from preformed and in situ formed aqueous and oil suspensions. Parenteral depots for intra-articular administration.

abstract：:The objective of this study was to establish a drug transport study using human nasal epithelial (HNE) cell monolayers cultured by the air-liquid interface (ALI) method using serum-free medium (BEGM:DME/F12, 50:50). The cells were developed and characterized in comparison to those that have been previously cultured by...

journal_title：Drug delivery

authors： Lee MK,Yoo JW,Lin H,Kim YS,Kim DD,Choi YM,Park SK,Lee CH,Roh HJ

更新日期：2005-09-01 00:00:00

abstract：:Biodegradable implantable matrices containing bovine serum albumin were prepared from oligoesters by melting, and subsequently tested on in vitro albumin release. The linear poly (DL-lactic acid) and the branched terpolymer of DL-lactic acid, glycolic acid, and mannitol were synthesized. Products were of similar molec...

journal_title：Drug delivery

authors： Kladnícková I,Dittrich M,Klein T,Pokorová D

更新日期：2006-01-01 00:00:00

abstract：:The aim of the current study was to formulate terconazole (TCZ) loaded polymeric mixed micelles (PMMs) incorporating Cremophor EL as a stabilizer and a penetration enhancer. A 23 full factorial design was performed using Design-Expert® software for the optimization of the PMMs which were formulated using Pluronic P123...

journal_title：Drug delivery

authors： Abd-Elsalam WH,El-Zahaby SA,Al-Mahallawi AM

更新日期：2018-11-01 00:00:00

abstract：:At present, the chemotherapy of advanced inoperable liver cancer is limited with serious side effects. Curcumin possesses multiple cancer preventive activities and low safety concerns. However, its poor solubility and instability in water pose significant pharmacological barriers to its clinical application. In this s...

journal_title：Drug delivery

authors： Chang M,Wu M,Li H

更新日期：2018-11-01 00:00:00

abstract：:Ischemic stroke is one of the major causes of severe disability and death worldwide. It is mainly caused by a sudden reduction in cerebral blood flow due to obstruction of the supplying vessel by thrombi and subsequent initiation of a complex cascade of pathophysiological changes, which ultimately lead to brain ischem...

journal_title：Drug delivery

authors： Ma H,Jiang Z,Xu J,Liu J,Guo ZN

更新日期：2021-12-01 00:00:00

abstract：:IDEC-CE9.1/SB-210396 is a macaque/human chimeric IgG1 monoclonal antibody (mAb) directed against the human T-cell surface marker, CD4. This antibody has been evaluated as a potential treatment for rheumatoid arthritis and asthma, in which T cell activation is believed to play an important role in orchestrating inflamm...

journal_title：Drug delivery

authors： Davis CB,Bugelski PJ

更新日期：1998-01-01 00:00:00

abstract：:Administration of influenza vaccines to the lungs could be an attractive alternative to conventional parenteral administration. In this study, we investigated the deposition site of pulmonary delivered liquid and powder influenza vaccine formulations and its relation to their immunogenicity and protective efficacy. In...

journal_title：Drug delivery

authors： Bhide Y,Tomar J,Dong W,de Vries-Idema J,Frijlink HW,Huckriede A,Hinrichs WLJ

更新日期：2018-11-01 00:00:00

abstract：:Recently, genkwanin (GKA) has been shown to display in vitro antitumor activity against some cancer cells, but its poor solubility restricted the in vivo study and further investigation of its antitumor therapeutic efficacy. In this paper, genkwanin nanosuspensions (GKA-NSps) were successfully prepared using D-alpha t...

journal_title：Drug delivery

authors： Li Y,Hong J,Li H,Qi X,Guo Y,Han M,Wang X

更新日期：2017-11-01 00:00:00

abstract：CONTEXT:Designing a sustained release system for Carvedilol to increase its residence time in the stomach. OBJECTIVE:Preparation of floating microsphere by the emulsion solvent diffusion method, studying the effect of various process parameters and optimize the formulation using full factorial design. METHODS:Differe...

journal_title：Drug delivery

authors： Nila MV,Sudhir MR,Cinu TA,Aleykutty NA,Jose S

更新日期：2014-03-01 00:00:00

abstract：:In the present study, six different molecular weight diblock copolymer of methoxy poly (ethylene glycol)-b-poly (ε-caprolactone) (MPEG-PCL) were synthesized and characterized and was used for fabrication of etoposide-loaded micelles by nanoprecipitation technique. The particle size and percentage drug entrapment of pr...

journal_title：Drug delivery

authors： Ukawala M,Rajyaguru T,Chaudhari K,Manjappa AS,Pimple S,Babbar AK,Mathur R,Mishra AK,Murthy RS

更新日期：2012-04-01 00:00:00

abstract：:Subcutaneous liraglutide-loaded multivesicular liposomes (Lrg-MVLs) were developed as a sustained drug-delivery system for treating diabetes and their properties were characterized. The Lrg-MVLs prepared using a two-step water-in-oil-in-water double emulsification process had a spherical appearance with a mean diamete...

journal_title：Drug delivery

authors： Zhang L,Ding L,Tang C,Li Y,Yang L

更新日期：2016-11-01 00:00:00

abstract：:Systemic chemotherapy with the anticancer agent cisplatin is approved for advanced non-melanoma skin cancer (NMSC), but topical treatment is limited by insufficient cutaneous penetration. We studied the impact of ablative fractional laser (AFL) exposure on topical cisplatin's pharmacokinetics and biodistribution in sk...

journal_title：Drug delivery

authors： Wenande E,Olesen UH,Boesen MR,Persson DP,Lerche CM,Stürup S,Gammelgaard B,Husted S,Anderson RR,Haedersdal M

更新日期：2018-11-01 00:00:00

abstract：:Piroxicam (PX), a main member of non-steroidal anti-inflammatory drugs (NSAIDs), is mainly used orally, which causes side effects of the gastrointestinal tract. It also has systemic effects when administered intramuscularly. Intra-articular (IA) delivery and encapsulation of PX in biodegradable poly-ε-caprolactone (PC...

journal_title：Drug delivery

authors： Rahmani Del Bakhshayesh A,Akbarzadeh A,Alihemmati A,Tayefi Nasrabadi H,Montaseri A,Davaran S,Abedelahi A

更新日期：2020-12-01 00:00:00

abstract：:The combined chemotherapy and photodynamic therapy have significant advantages for cancer treatments, which have higher therapeutic effects compared with other medicines. Herein, we focused on the synthesis of carbon quantum dot (CQD) based nanocarrier system. CQD and 5-aminolevulinic acid (5-ALA) were conjugated with...

journal_title：Drug delivery

authors： Li X,Vinothini K,Ramesh T,Rajan M,Ramu A

更新日期：2020-12-01 00:00:00

abstract：:Three formulations including methylene blue solution (MB-S), MB water-in-oil microemulsion (MB-ME), and MB multiple microemulsion (MB-MME) were prepared with the aim to evaluate whether the three formulations can carry MB target to regional lymph nodes and show lymphatic tropism after subcutaneous administration. The ...

journal_title：Drug delivery

authors： Wang S,Yang R,Yao H,Zhou G,Zhang Y,Yang B,Ng L,Yan M

更新日期：2009-10-01 00:00:00

abstract：:The main aim of this work was to develop rectal suppositories for better delivery of metoprolol tartrate (MT). The various bases used were fatty, water soluble and emulsion bases. The physical properties of the prepared suppositories were characterized such as weight variation, hardness, disintegration time, melting r...

journal_title：Drug delivery

authors： Abou el Ela Ael S,Allam AA,Ibrahim EH

更新日期：2016-01-01 00:00:00

abstract：:HER2-positive breast cancer correlates with more aggressive tumor growth, a poorer prognosis and reduced overall survival. Currently, trastuzumab (Herceptin), which is an anti-HER2 antibody, is one of the key drugs. There is evidence indicating that conjugation of trastuzumab with chemotherapy drugs, such as doxorubic...

journal_title：Drug delivery

authors： You Y,Xu Z,Chen Y

更新日期：2018-11-01 00:00:00

abstract：:The aim of our study was to investigate the enhancing effect of several essential oils in the percutaneous absorption of trazodone hydrochloride (TZN). For this purpose, fennel oil, eucalyptus oil, citronella oil, and mentha oil were applied on the skin membrane in three different ways: included in the transdermal dev...

journal_title：Drug delivery

authors： Das MK,Bhattacharya A,Ghosal SK

更新日期：2006-11-01 00:00:00

abstract：:Raloxifene (RLX) is a second-generation selective estrogen receptor modulator used to treat osteoporosis in postmenopausal women. RLX fails to be developed into injectable dosage forms due to poor solubility. Although oral formulations are clinically available, the lower bioavailability (<2%) embarrasses the pharmaceu...

journal_title：Drug delivery

authors： Du X,Gao N,Song X

更新日期：2021-12-01 00:00:00

abstract：:Nasal colonization of Staphylococcus aureus (S.aureus) is known as a significant risk factor for nosocomial infections, and clearance of its nasal colonization greatly reduces the risk. In the present study the preparation and characterizations of the chitosan-o/w cream incorporated with lysostaphin (CCL) were describ...

journal_title：Drug delivery

authors： Cui F,Li G,Huang J,Zhang J,Lu M,Lu W,Huang Q

更新日期：2010-11-01 00:00:00

abstract：:In this study, transdermal etodolac-loaded cubosomes were developed in order to relieve patient pain and joints stiffness by providing stable etodolac concentration at the targeting sites through controlled drug delivery via the noninvasive skin route with more sustaining and less frequent dosing. Different ratios and...

journal_title：Drug delivery

authors： Salah S,Mahmoud AA,Kamel AO

更新日期：2017-11-01 00:00:00

abstract：:ALA-loaded nanostructured lipid carrier (ALA-NLC) was designed to improve physicochemical stability and water solubility, and promote sustained release of ALA as well as determine the biocompatibility of ALA-NLC. The ALA-NLC manufactured using hot high-pressure homogenization technique was investigated in terms of siz...

journal_title：Drug delivery

authors： Wang J,Xia Q

更新日期：2014-08-01 00:00:00

abstract：:A new strategy based on gastric retention is proposed for the treatment of Helicobacter pylori. (H. pylori). A synergism between a floating and a bioadhesive system has been explored. Floating microspheres containing the antiurease drug acetohydroxamic acid (AHA) were prepared by a novel quasi-emulsion solvent diffusi...

journal_title：Drug delivery

authors： Umamaheswari RB,Jain S,Tripathi PK,Agrawal GP,Jain NK

更新日期：2002-10-01 00:00:00

abstract：:Atorvastatin (AT) is a widely used lipid-regulating drug to reduce cholesterol and triglycerides. Its poor aqueous solubility and hepatic metabolism require development of drug delivery systems able to improve its solubility and bypass hepatic effect. For this purpose, atorvastatin nanostructured lipid carriers (AT-NL...

journal_title：Drug delivery

authors： Elmowafy M,Ibrahim HM,Ahmed MA,Shalaby K,Salama A,Hefesha H

更新日期：2017-11-01 00:00:00

abstract：:The aim of this study was to evaluate the effects of therapeutic pulsed ultrasound with gold nanoparticles on oxidative stress parameters after traumatic muscle injury in Wistar rats. The animals were randomly divided into nine groups (n = 6 each): sham (uninjured muscle); muscle injury without treatment; muscle injur...

journal_title：Drug delivery

authors： Silveira PC,Victor EG,Notoya Fde S,Scheffer Dda L,Silva Ld,Cantú RB,Martínez VH,de Pinho RA,Paula MM

更新日期：2016-01-01 00:00:00

abstract：:Currently, traumatic brain injury (TBI) is the leading cause of death or disabilities in young individuals worldwide. The multi-complexity of its pathogenesis as well as impermeability of the blood-brain barrier (BBB) makes the drug choice and delivery very challenging. The brain-derived neurotrophic factor (BDNF) reg...

journal_title：Drug delivery

authors： Khalin I,Alyautdin R,Wong TW,Gnanou J,Kocherga G,Kreuter J

更新日期：2016-11-01 00:00:00

abstract：:Silk was easily dyed in traditional textile industry because of its strong affinity to many colorants. Herein, the biocompatible silk fibroin was firstly extracted from Bombyx mori silkworm cocoons. And SF nanoparticles (SFNPs) were prepared for dyeing indocyanine green (ICG) and construct a therapeutic nano-platform ...

journal_title：Drug delivery

authors： Xu HL,ZhuGe DL,Chen PP,Tong MQ,Lin MT,Jiang X,Zheng YW,Chen B,Li XK,Zhao YZ

更新日期：2018-11-01 00:00:00

abstract：:Carboplatin is a potent anticancer agent that has shown efficacy in clinical trials against malignant glioma, one of the most deadly cancers in humans. However, a high systemic dose is required to achieve an effective concentration in the brain because of the presence of the blood-brain barrier (BBB). Such a high dose...

journal_title：Drug delivery

authors： Chen W,He J,Olson JJ,Lu DR

更新日期：1997-01-01 00:00:00

abstract：:Bioadhesive sodium alginate microspheres of Metoprolol tartrate (MT) for intranasal systemic delivery were prepared to avoid the first-pass effect, as an alternative therapy to injection, and to obtain improved therapeutic efficacy in the treatment of hypertension and angina pectoris. The microspheres (Ms) were prepar...

journal_title：Drug delivery

authors： Rajinikanth PS,Sankar C,Mishra B

更新日期：2003-01-01 00:00:00

abstract：:Although convection-enhanced delivery (CED) can successfully facilitate a bypass of the blood brain barrier, its treatment efficacy remains highly limited in clinic. This can be partially attributed to the brain anisotropic characteristics that lead to the difficulties in controlling the drug spatial distribution. Her...

journal_title：Drug delivery

authors： Zhan W,Rodriguez Y Baena F,Dini D

更新日期：2019-12-01 00:00:00