Synthesis of S-nitrosoglutathione-alginate for prolonged delivery of nitric oxide in intestines.


:S-nitrosothiols are a class of NO-donors currently under investigation for the treatment of various diseases. In this study, we developed a novel NO-donor (S-nitrosoglutathione-alginate, SNA) by cross-linking alginate with S-nitrosothiols, which can deliver NO in a sustained manner. This compound can be further evaluated for oral delivery to treat Crohn's disease. This new compound was prepared using a two-step procedure involving (I) linkage of reduced glutathione to alginate and (II) post-nitrosation with sodium nitrite (NaNO2). The amount of linked thiol moieties for the possible nitrosation was calculated using Ellman's method, and the amount of NO abducted on the polymer was calculated using the Griess-Saville method. An ex vivo model (i.e. Ussing chamber) was used to investigate the permeation of this new NO-donor across the rat intestinal barrier. We obtained polymers with different numbers of abducted NOs (174 ± 21 μmol/g for SNA F1 and 468 ± 23 μmol/g for SNA F2) depending on the procedure used for nitrosation. In the ex vivo studies in the Ussing chamber, SNA F2 exhibited a sustained release for at least 10 h. The effect of pH on the stability of the new compound was also investigated, and the new compound was more stable at a mildly basic pH of 8.4 where 73% remained after 1 week. However, only 50% remained after 1 week at an acidic pH of 1.2. In the cytotoxicity studies (Caco2), this compound was nontoxic at concentrations of less than 200 μM.


Drug Deliv


Drug delivery


Shah SU,Socha M,Fries I,Gibaud S




Has Abstract


2016-10-01 00:00:00












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    abstract::This article describes the development of solid lipid nanoparticles (SLN) as colloidal carriers for cloricromene. Nanoparticles were prepared by the microemulsion or precipitation technique. In vitro drug release profile from SLN was studied under various experimental conditions mimicking some body fluids. The drug re...

    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Bondì ML,Fontana G,Carlisi B,Giammona G

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  • PLA/PEG-PPG-PEG/dexamethasone implant prepared by hot-melt extrusion for controlled release of immunosuppressive drug to implantable medical devices, Part 2: in vivo evaluation.

    abstract::Hot-melt extrusion (HME) plays an important role in preparing implants as local drug delivery systems in pharmaceutical fields. Here, a new PLA/PEG-PPG-PEG/Dexamethasone (PLA/F68/Dex) implant prepared by HME has been developed. Importantly, the implant was successfully achieved to control release of immunosuppressive ...

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    authors: Li D,Guo G,Deng X,Fan R,Guo Q,Fan M,Liang J,Luo F,Qian Z

    更新日期:2013-04-01 00:00:00

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    abstract::Bone-metastasis prostate cancer (BMPCa)-targeting gene therapy is gaining increasing concern in recent years. The peptide T7-modified polypeptide nanoparticles for delivery DNA (CRD-PEG-T7/pPMEPA1) was prepared as our previous study. However, the feasibility of CRD-PEG-T7/pPMEPA1 for BMPCa treatment, the mechanisms un...

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    authors: Gu Y,Chen X,Zhang H,Wang H,Chen H,Huang S,Xu Y,Zhang Y,Wu X,Chen J

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  • In vivo lymphatic targeting of methylene blue with microemulsion and multiple microemulsion.

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    authors: Wang S,Yang R,Yao H,Zhou G,Zhang Y,Yang B,Ng L,Yan M

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  • Formulation and in vivo assessment of terconazole-loaded polymeric mixed micelles enriched with Cremophor EL as dual functioning mediator for augmenting physical stability and skin delivery.

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    authors: Abd-Elsalam WH,El-Zahaby SA,Al-Mahallawi AM

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    authors: Liu T,Li G,Wu X,Chen S,Zhang S,Han H,Zhang H,Luo X,Cai X,Ma D

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    journal_title:Drug delivery

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    authors: Wenande E,Olesen UH,Boesen MR,Persson DP,Lerche CM,Stürup S,Gammelgaard B,Husted S,Anderson RR,Haedersdal M

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    authors: Rajinikanth PS,Sankar C,Mishra B

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    authors: Qiao H,Fang D,Chen J,Sun Y,Kang C,Di L,Li J,Chen Z,Chen J,Gao Y

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    authors: Zhang Y,He L,Yue S,Huang Q,Zhang Y,Yang J

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    authors: Sezer AD,Akbuğa J,Baş AL

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    authors: Raposo S,Tavares R,Gonçalves L,Simões S,Urbano M,Ribeiro HM

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    authors: Yang S,Wang D,Sun Y,Zheng B

    更新日期:2019-12-01 00:00:00

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    abstract::Electro-phonophoresis (EP) has been used in various clinical fields. The objective of present study is to evaluate the skin permeability of isoniazid (INH) and rifampicin (RIF) in patients with tuberculous lymphadenitis with the aid of EP to validate the clinical applications of this transdermal delivery system for th...

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    authors: Chen S,Qin M,Han Y,Zhao L,Fu Y,Shang Y,Liu Z,Huang H

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    authors: Abou el Ela Ael S,Allam AA,Ibrahim EH

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    authors: Hamidi M,Tajerzadeh H,Dehpour AR,Rouini MR,Ejtemaee-Mehr S

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    abstract::Hydrogels are water swollen networks of polymers and especially hydrogels consisting of poly vinylpyrrolidone/poly ethyleneglycol-dimethacrylate (PVP/PEG-DMA) blends show promising wound care properties. Enhanced functionality of the hydrogels can be achieved by incorporating drugs and other substances that may assist...

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    authors: Wang Y,Zhang H,Hao J,Li B,Li M,Xiuwen W

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    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Myoung Y,Choi HK

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    journal_title:Drug delivery

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    authors: Fan S,Zheng Y,Liu X,Fang W,Chen X,Liao W,Jing X,Lei M,Tao E,Ma Q,Zhang X,Guo R,Liu J

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    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Cao F,Zhang X,Ping Q

    更新日期:2010-09-01 00:00:00

  • The efficiency of a novel delivery system (PEI600-Tat) in development of potent DNA vaccine using HPV16 E7 as a model antigen.

    abstract::DNA vaccination is a promising approach for inducing both humoral and cellular immune responses. The mode of plasmid DNA delivery is critical to make progress in DNA vaccination. Using human papillomavirus type 16 E7 as a model antigen, this study evaluated the effect of peptide-polymer hybrid including PEI600-Tat con...

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    authors: Bolhassani A,Ghasemi N,Servis C,Taghikhani M,Rafati S

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  • Carboplatin-Loaded PLGA Microspheres for Intracerebral Implantation: In Vivo Characterization.

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    pub_type: 杂志文章


    authors: Chen W,He J,Olson JJ,Lu DR

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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Li X,Vinothini K,Ramesh T,Rajan M,Ramu A

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    journal_title:Drug delivery

    pub_type: 杂志文章


    authors: Sinha VR,Trehan A

    更新日期:2008-08-01 00:00:00