Synthesis of S-nitrosoglutathione-alginate for prolonged delivery of nitric oxide in intestines.

abstract：CONTEXT:Propolis has traditionally been used in curing infections and healing wounds and burns. OBJECTIVE:The aim of this study is to formulate pluronic lecithin organogel of propolis to improve its availability and antimicrobial activity. MATERIALS AND METHODS:Different organogels were prepared by using soybean leci...

journal_title：Drug delivery

authors： Balata G,El Nahas HM,Radwan S

更新日期：2014-02-01 00:00:00

abstract：:Hydroxy genkwanin (HGK), a flavonoid compound from natural resources, showed good inhibition against the growth of breast tumor cells. However, the poor solubility restricted the further study and the in vivo drug delivery of HGK. We prepared HGK nanosuspensions by antisolvent precipitation method and investigated the...

journal_title：Drug delivery

authors： Ao H,Li Y,Li H,Wang Y,Han M,Guo Y,Shi R,Yue F,Wang X

更新日期：2020-12-01 00:00:00

abstract：:Hydrogels based on poly(ethylene glycol)-diacrylate (PEG-DA) and 2-hydroxyethyl methacrylate (HEMA) were polymerized with cross-linking agent ethylene glycol diacrylate (EGDMA) under mild photoinitiating conditions. PEG-DA and HEMA concentrations of disks with 1 +/- 0.3 mm thickness were 30% and 50% w/w and 40% and 60...

journal_title：Drug delivery

authors： Ayhan F,Ozkan S

更新日期：2007-10-01 00:00:00

abstract：:This article describes the development of solid lipid nanoparticles (SLN) as colloidal carriers for cloricromene. Nanoparticles were prepared by the microemulsion or precipitation technique. In vitro drug release profile from SLN was studied under various experimental conditions mimicking some body fluids. The drug re...

journal_title：Drug delivery

authors： Bondì ML,Fontana G,Carlisi B,Giammona G

更新日期：2003-10-01 00:00:00

abstract：:Polysaccharide nucleic acid fractions of bacillus Calmette-Guérin, termed BCG-PSN, have traditionally been used as immunomodulators in the treatment of dermatitis and allergic diseases. While the sales of injectable BCG-PSN have shown steady growth in recent years, no reports of using BCG-PSN powder or its immunothera...

journal_title：Drug delivery

authors： Yan Q,Liu H,Cheng Z,Xue Y,Cheng Z,Dai X,Shan W,Chen F

更新日期：2017-11-01 00:00:00

abstract：:Pueraria lobata (Willd.) Ohwi is a medicinal and edible homologous plant with a long history in China. Puerarin, the main component isolated from the root of Pueraria lobata, possesses a wide range of pharmacological properties. Daidzein and glucuronides are the main metabolites of puerarin and are excreted in the uri...

journal_title：Drug delivery

authors： Zhang L

更新日期：2019-12-01 00:00:00

abstract：:A conjugate consisting of streptavidin (biotinylated transferrin)-biotinylated polylysine for DNA delivery to cells was modified by partial nicotinylation of the polylysine component of the conjugate and used for transfection studies. A conjugate of biotin10-nicotinyl60-polylysine250 containing 60 weakly basic nicotin...

journal_title：Drug delivery

authors： Quick G,van Zyl J,Hawtrey A,Ariatti M

更新日期：2000-10-01 00:00:00

abstract：:DNA vaccination is a promising approach for inducing both humoral and cellular immune responses. The mode of plasmid DNA delivery is critical to make progress in DNA vaccination. Using human papillomavirus type 16 E7 as a model antigen, this study evaluated the effect of peptide-polymer hybrid including PEI600-Tat con...

journal_title：Drug delivery

authors： Bolhassani A,Ghasemi N,Servis C,Taghikhani M,Rafati S

更新日期：2009-05-01 00:00:00

abstract：CONTEXT:Terbinafine hydrochloride is an antifungal drug for onychomycosis. Poor permeability of its external preparation leads to poor curative effect. Transfersomes, also known as flexible liposome, could improve transmission of drug for local external use. Terbinafine hydrochloride-loaded liposome is expected to beco...

journal_title：Drug delivery

authors： Yang Y,Ou R,Guan S,Ye X,Hu B,Zhang Y,Lu S,Zhou Y,Yuan Z,Zhang J,Li QG

更新日期：2015-12-01 00:00:00

abstract：:Ischemic stroke is one of the major causes of severe disability and death worldwide. It is mainly caused by a sudden reduction in cerebral blood flow due to obstruction of the supplying vessel by thrombi and subsequent initiation of a complex cascade of pathophysiological changes, which ultimately lead to brain ischem...

journal_title：Drug delivery

authors： Ma H,Jiang Z,Xu J,Liu J,Guo ZN

更新日期：2021-12-01 00:00:00

abstract：:Combined administration of different drugs is a widely acknowledged approach for effective cancer therapy. However, the limited targeting, as well as inferior drug loading capacities of current drug delivery systems (DDS), are still the bottleneck for better performance in cancer treatment. Herein, we successfully dev...

journal_title：Drug delivery

authors： Li D,Cui R,Xu S,Liu Y

更新日期：2020-12-01 00:00:00

abstract：:Colon is an ideal absorptive site for oral protein and peptide drug (insulin), and yet it poses multiple barriers against the drug absorption, such as the barriers against the drug diffusion from colon lumen toward the absorptive mucosa and permeation across colon epithelium. In this study, modified nanoparticles (Tat...

journal_title：Drug delivery

authors： Guo F,Zhang M,Gao Y,Zhu S,Chen S,Liu W,Zhong H,Liu J

更新日期：2016-07-01 00:00:00

abstract：:Transdermal delivery of non-steroidal anti-inflammatory drugs (NSAIDs) is an effective route of drug administration, as it directs the drug to the inflamed site with reduced incidence of systemic adverse effects such as gastric hemorrhage and ulcers. Tenoxicam (TNX) is a member of NSAIDs that are marketed only as oral...

journal_title：Drug delivery

authors： Bawazeer S,El-Telbany DFA,Al-Sawahli MM,Zayed G,Keed AAA,Abdelaziz AE,Abdel-Naby DH

更新日期：2020-12-01 00:00:00

abstract：CONTEXT:Designing a sustained release system for Carvedilol to increase its residence time in the stomach. OBJECTIVE:Preparation of floating microsphere by the emulsion solvent diffusion method, studying the effect of various process parameters and optimize the formulation using full factorial design. METHODS:Differe...

journal_title：Drug delivery

authors： Nila MV,Sudhir MR,Cinu TA,Aleykutty NA,Jose S

更新日期：2014-03-01 00:00:00

abstract：:A mesoporous material based on aluminosilicate mixture was studied to investigate its ability to include drugs and then release them. Nonsteroidal anti-inflammatory agents such as diflunisal, naproxen, ibuprofen and its sodium salt have been used in this study. The preparation of the mesoporous material and its charac...

journal_title：Drug delivery

authors： Cavallaro G,Pierro P,Palumbo FS,Testa F,Pasqua L,Aiello R

更新日期：2004-01-01 00:00:00

abstract：:The development of mucoadhesive lipidic nanoemulsion based on hyaluronic acid, co-encapsulating two polyphenols (resveratrol and curcumin) for the transnasal treatment of neurodegenerative diseases was attempted in the current manuscript. Nanoemulsions were prepared by the spontaneous emulsification method, and were c...

journal_title：Drug delivery

authors： Nasr M

更新日期：2016-05-01 00:00:00

abstract：:Alzheimer's disease is a neurodegenerative disorder mainly characterized by β-amyloid deposit and tau hyperphosphorylation with no curative treatments. Curcumin (Cur) has been proved to have potential use in Alzheimer's disease with its anti-amyloid, anti-inflammatory, and anti-oxidant properties, etc. However, its hy...

journal_title：Drug delivery

authors： Fan S,Zheng Y,Liu X,Fang W,Chen X,Liao W,Jing X,Lei M,Tao E,Ma Q,Zhang X,Guo R,Liu J

更新日期：2018-11-01 00:00:00

abstract：:Combinational therapy is usually considered as a preferable approach for effective cancer therapy. Especially, combinational chemo and photothermal therapy is of particular interest due to its high flexibility as well as efficiency. In this article, we the silica nanoparticles (SLN) were surface conjugated with Cetuxi...

journal_title：Drug delivery

authors： Zhang X,Li Y,Wei M,Liu C,Yu T,Yang J

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Vorinostat (VRS), a histone deacetylases inhibitor, has significant cytotoxic potential in a large number of human cancer cell lines. OBJECTIVE:To clarify its promising anticancer potential and to improve its drawback related to physical properties and in vivo performance of VRS. METHODS:VRS was successful...

journal_title：Drug delivery

authors： Tran TH,Chu DT,Truong DH,Tak JW,Jeong JH,Hoang VL,Yong CS,Kim JO

更新日期：2016-05-01 00:00:00

abstract：:In the present study, the stability of thymopentin (TP5) in bronchoalveolar lavage fluid (BALF) in presence of potential excipients in inhalation formulation was investigated. The content of TP5 was determined using HPLC method. Commonly used bulking agent, dispersibility enhancers and absorption enhancers in inhalati...

journal_title：Drug delivery

authors： Cai C,Wang L,Dong W,Tang X

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVES:This study introduces the structural design, working principles, performance testing and treatment effects of a newly developed ultrasonic irradiation delivery and treatment catheter system that integrates interventional catheterization technology. BACKGROUND:Systemic administration method needs a high dose...

journal_title：Drug delivery

authors： Yuan QY,Huang J,Li XJ,Peng JB,Li XS,Chen ZP,Si LY

更新日期：2013-08-01 00:00:00

abstract：:Efficient and stable delivery system of antisense oligonucleotide (ASO) is important and urgently needed. Here, an ASO delivery system, Lp-PPRP, which contains a cationic polymer based on PEI (branched, 25 kDa), named PEI-PC and a palmitic acid modified R8 (R8-PA) was prepared to deliver a kind of ASO, LOR-2501. The c...

journal_title：Drug delivery

authors： Yang S,Wang D,Sun Y,Zheng B

更新日期：2019-12-01 00:00:00

abstract：:Monoclonal antibodies (mAbs) were generated to the extracellular domain of transcobalamin receptor (TCblR) and used to identify the regions of the receptor protein involved in antibody binding. Based on the effect of transcobalamin bound cobalamin (TC-Cbl) on antibody binding, this study identified both blocking and b...

journal_title：Drug delivery

authors： Jiang W,Nakayama Y,Sequeira JM,Quadros EV

更新日期：2011-01-01 00:00:00

abstract：CONTEXT:Artemether and lumefantrine combination therapy is well-accepted for uncomplicated malaria treatment. However, the current available formulation has several pharmacokinetic mismatches such as drug degradation in gastrointestinal tract, erratic absorption, etc. Hence, need of the hour is the injectable formulati...

journal_title：Drug delivery

authors： Parashar D,Aditya NP,Murthy RS

更新日期：2016-01-01 00:00:00

abstract：:The effects of pressure-sensitive adhesives and vehicles on the in vitro permeation of ketorolac and in vivo pharmacokinetics were studied. Duro-Tak 87-2196 showed the highest in vitro permeation profiles, and propylene glycol monolaurate-diethylene glycol monoethyl ether (DGME) (60:40, v/v) and propylene glycol monoc...

journal_title：Drug delivery

authors： Choi JS,Cho YA,Chun IK,Jung SY,Gwak HS

更新日期：2007-02-01 00:00:00

abstract：:The aim of present study was to investigate a pH-responsive and mucoadhesive nanoparticle system for oral bioavailability enhancement of low-molecular weight heparin (LMWH). The thioglycolic acid (TGA) was first covalently attached to chitosan (CS) with 396.97 ± 54.54 μmol thiol groups per gram of polymer and then the...

journal_title：Drug delivery

authors： Fan B,Xing Y,Zheng Y,Sun C,Liang G

更新日期：2016-01-01 00:00:00

abstract：:To prolong the circulation time of drug, PEGylation has been widely used via the enhanced permeability and retention (EPR) effect, thereby providing new hope for better treatment. However, PEGylation also brings the "PEG dilemma", which is difficult for the cellular absorption of drugs and subsequent endosomal escape....

journal_title：Drug delivery

authors： Fang Y,Xue J,Gao S,Lu A,Yang D,Jiang H,He Y,Shi K

更新日期：2017-12-01 00:00:00

abstract：:In order to enhance the interaction between nanocarrier and gastrointestinal epithelial cells, we developed nanoparticles (NPs) modified with targeting ligand FQSIYPpIK (FQS), which specifically interact with integrin αvβ3 receptor expressing on the intestinal epithelium. The targeting NPs were prepared by coating the...

journal_title：Drug delivery

authors： Liu C,Shan W,Liu M,Zhu X,Xu J,Xu Y,Huang Y

更新日期：2016-07-01 00:00:00

abstract：:Glycyrrhizin or glycyrrhizic acid (GA) - triterpene glycoside extracted from licorice root - has been intensively studied over the past decade and is considered to be a potential drug delivery system. Glycyrrhizin was found to enhance the therapeutic effect of various drugs; however the detailed mechanism of these eff...

journal_title：Drug delivery

authors： Selyutina OY,Polyakov NE,Korneev DV,Zaitsev BN

更新日期：2016-01-01 00:00:00

abstract：:The purpose of the present study is to develop a new method to prepare magnetite chitosan microspheres conjugated with methotrexate (MTX) for the controlled release of MTX as a magnetic targeting drug delivery system. MTX was first conjugated to the chitosan chain via a peptide bond and then a suspension cross-linking...

journal_title：Drug delivery

authors： Zhang X,Chen F,Ni J

更新日期：2009-07-01 00:00:00