Formulation and evaluation of ketorolac transdermal systems.

Abstract:

:The effects of pressure-sensitive adhesives and vehicles on the in vitro permeation of ketorolac and in vivo pharmacokinetics were studied. Duro-Tak 87-2196 showed the highest in vitro permeation profiles, and propylene glycol monolaurate-diethylene glycol monoethyl ether (DGME) (60:40, v/v) and propylene glycol monocaprylate-DGME (60:40, v/v) revealed the most favorable in vitro and in vivo results. The decreased Cmax and prolonged Tmax and half-life were obtained with the ketorolac transdermal systems compared with oral administration, indicating that the ketorolac transdermal systems may have a prolonged effect with reduced toxic event. There was an excellent relationship found between in vitro permeation flux and in vivo AUC0-infinity.

journal_name

Drug Deliv

journal_title

Drug delivery

authors

Choi JS,Cho YA,Chun IK,Jung SY,Gwak HS

doi

10.1080/10717540600640336

subject

Has Abstract

pub_date

2007-02-01 00:00:00

pages

69-74

issue

2

eissn

1071-7544

issn

1521-0464

pii

770392447

journal_volume

14

pub_type

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