Abstract:
:The effects of pressure-sensitive adhesives and vehicles on the in vitro permeation of ketorolac and in vivo pharmacokinetics were studied. Duro-Tak 87-2196 showed the highest in vitro permeation profiles, and propylene glycol monolaurate-diethylene glycol monoethyl ether (DGME) (60:40, v/v) and propylene glycol monocaprylate-DGME (60:40, v/v) revealed the most favorable in vitro and in vivo results. The decreased Cmax and prolonged Tmax and half-life were obtained with the ketorolac transdermal systems compared with oral administration, indicating that the ketorolac transdermal systems may have a prolonged effect with reduced toxic event. There was an excellent relationship found between in vitro permeation flux and in vivo AUC0-infinity.
journal_name
Drug Delivjournal_title
Drug deliveryauthors
Choi JS,Cho YA,Chun IK,Jung SY,Gwak HSdoi
10.1080/10717540600640336subject
Has Abstractpub_date
2007-02-01 00:00:00pages
69-74issue
2eissn
1071-7544issn
1521-0464pii
770392447journal_volume
14pub_type
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