Drug delivery devices based on mesoporous silicate.

Abstract:

:A mesoporous material based on aluminosilicate mixture was studied to investigate its ability to include drugs and then release them. Nonsteroidal anti-inflammatory agents such as diflunisal, naproxen, ibuprofen and its sodium salt have been used in this study. The preparation of the mesoporous material and its characterization by X-ray, N2 absorption-desorption isotherm, and thermogravimetry analysis have been described. Drug loading was performed by a soaking procedure. Drug-loaded matrices were characterized for entrapped drug amount, water absorption ability, and thermogravimetric behavior. Drug release studies also were performed at pH 1.1 and 6.8 mimicking gastrointestinal fluids. Experimental results showed that this type of matrix is able to trap the bioactive agents by a soaking procedure and, then, to release them in conditions mimicking the biological fluids. Also, the high affinity of these matrices for water makes them potentially biocompatible. Release data suggest that the matrix impregnated with diflunisal offers good potential as a system for the modified drug release.

journal_name

Drug Deliv

journal_title

Drug delivery

authors

Cavallaro G,Pierro P,Palumbo FS,Testa F,Pasqua L,Aiello R

doi

10.1080/10717540490265252

keywords:

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

41-6

issue

1

eissn

1071-7544

issn

1521-0464

pii

YNP55RLB6QDN10CQ

journal_volume

11

pub_type

杂志文章
  • Poly(HEMA-Zidovudine) conjugate: a macromolecular pro-drug for improvement in the biopharmaceutical properties of the drug.

    abstract::A macromolecular pro-drug of a known anti-viral agent Zidovudine (AZT) was synthesized and evaluated as a sustained drug delivery system. The pro-drug was synthesized by coupling the drug to 2-hydroxyethyl methacrylate (HEMA) through a succinic spacer to get a monomeric drug conjugate which was polymerized to obtain t...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.3109/10717544.2010.536272

    authors: Neeraj A,Chandrasekar MJ,Sara UV,Rohini A

    更新日期:2011-05-01 00:00:00

  • N-trimethyl chitosan (TMC)-modified microemulsions for improved oral bioavailability of puerarin: preparation and evaluation.

    abstract::The aim of this research was to increase the oral bioavailability of puerarin by N-trimethyl chitosan-modified microemulsions (TMC-MEs) loaded with puerarin. Different concentrations of TMC-modified microemulsions were prepared in our study, and then evaluated for particle size, zeta potential, morphological observati...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.3109/10717544.2013.879398

    authors: Liao D,Liu X,Dai W,Tang T,Ou G,Zhang K,Han M,Kang R,Yang S,Xiang D

    更新日期:2015-01-01 00:00:00

  • Study on the cellular internalization mechanisms and in vivo anti-bone metastasis prostate cancer efficiency of the peptide T7-modified polypeptide nanoparticles.

    abstract::Bone-metastasis prostate cancer (BMPCa)-targeting gene therapy is gaining increasing concern in recent years. The peptide T7-modified polypeptide nanoparticles for delivery DNA (CRD-PEG-T7/pPMEPA1) was prepared as our previous study. However, the feasibility of CRD-PEG-T7/pPMEPA1 for BMPCa treatment, the mechanisms un...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717544.2019.1709923

    authors: Gu Y,Chen X,Zhang H,Wang H,Chen H,Huang S,Xu Y,Zhang Y,Wu X,Chen J

    更新日期:2020-12-01 00:00:00

  • In vitro assessment of lidocaine release from aqueous and oil solutions and from preformed and in situ formed aqueous and oil suspensions. Parenteral depots for intra-articular administration.

    abstract::In vitro drug release rates from aqueous and oil solutions as well as preformed and in situ formed aqueous and oil suspensions intended for intra-articular delivery have been investigated using the rotating dialysis cell model. Using lidocaine as a model drug substance the release kinetics from aqueous and oil suspens...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717540701828657

    authors: Pedersen BT,Larsen SW,Østergaard J,Larsen C

    更新日期:2008-01-01 00:00:00

  • In vitro/in vivo evaluation of an optimized fast dissolving oral film containing olanzapine co-amorphous dispersion with selected carboxylic acids.

    abstract::Improvement of water solubility, dissolution rate, oral bioavailability, and reduction of first pass metabolism of OL (OL), were the aims of this research. Co-amorphization of OL carboxylic acid dispersions at various molar ratios was carried out using rapid solvent evaporation. Characterization of the dispersions was...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.3109/10717544.2016.1153746

    authors: Maher EM,Ali AM,Salem HF,Abdelrahman AA

    更新日期:2016-10-01 00:00:00

  • Sustained ocular drug delivery from a temperature and pH triggered novel in situ gel system.

    abstract::Various ocular diseases like glaucoma, conjunctivitis, and dry eye syndrome require frequent drug administration. Poor ocular bioavailability of drugs (< 1%) from conventional eye drops is due mainly to the precorneal loss factors that include rapid tear turnover, nonproductive absorption, transient residence time in ...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717540701606426

    authors: Gupta H,Jain S,Mathur R,Mishra P,Mishra AK,Velpandian T

    更新日期:2007-11-01 00:00:00

  • Chitosan-based particles as controlled drug delivery systems.

    abstract::Chitosan, a natural-based polymer obtained by alkaline deacetylation of chitin, is nontoxic, biocompatible, and biodegradable. These properties make chitosan a good candidate for conventional and novel drug delivery systems. This article reviews the approaches aimed to associate bioactive molecules to chitosan in the ...

    journal_title:Drug delivery

    pub_type: 杂志文章,评审

    doi:10.1080/10717540590889781

    authors: Prabaharan M,Mano JF

    更新日期:2005-01-01 00:00:00

  • The optimized drug delivery systems of treating cancer bone metastatic osteolysis with nanomaterials.

    abstract::Some cancers such as human breast cancer, prostate cancer, and lung cancer easily metastasize to bone, leading to osteolysis and bone destruction accompanied by a complicated microenvironment. Systemic administration of bisphosphonates (BP) or denosumab is the routine therapy for osteolysis but with non-negligible sid...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717544.2020.1856225

    authors: Cheng X,Wei J,Ge Q,Xing D,Zhou X,Qian Y,Jiang G

    更新日期:2021-12-01 00:00:00

  • Enhanced oral bioavailability of piperine by self-emulsifying drug delivery systems: in vitro, in vivo and in situ intestinal permeability studies.

    abstract::The main purpose of this work was to develop and evaluate a self-emulsifying drug delivery system (SEDDS) of piperine to enhance its solubility and bioavailability. The formulation was optimized by solubility test and ternary phase diagrams. Then physiochemical properties and in vitro release of SEDDS were characteriz...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.3109/10717544.2014.898109

    authors: Shao B,Cui C,Ji H,Tang J,Wang Z,Liu H,Qin M,Li X,Wu L

    更新日期:2015-01-01 00:00:00

  • Formulation and evaluation of dextromethorphan hydrobromide sustained release tablets.

    abstract::Sustained release (SR) matrix tablets of dextromethorphan hydrobromide were prepared by wet granulation using hydroxypropyl methyl cellulose (HPMC-K-100 CR) as the hydrophilic rate controlling polymer. The effect of the concentration of the polymer and different fillers on the in vitro drug release rate was studied. T...

    journal_title:Drug delivery

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/10717540802035301

    authors: Meyyanathan SN,Rajan S,Muralidaharan S,Siddaiah MK,Krishnaraj K,Suresh B

    更新日期:2008-09-01 00:00:00

  • Combined photodynamic-chemotherapy investigation of cancer cells using carbon quantum dot-based drug carrier system.

    abstract::The combined chemotherapy and photodynamic therapy have significant advantages for cancer treatments, which have higher therapeutic effects compared with other medicines. Herein, we focused on the synthesis of carbon quantum dot (CQD) based nanocarrier system. CQD and 5-aminolevulinic acid (5-ALA) were conjugated with...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717544.2020.1765431

    authors: Li X,Vinothini K,Ramesh T,Rajan M,Ramu A

    更新日期:2020-12-01 00:00:00

  • Sodium alginate microspheres of metoprolol tartrate for intranasal systemic delivery: development and evaluation.

    abstract::Bioadhesive sodium alginate microspheres of Metoprolol tartrate (MT) for intranasal systemic delivery were prepared to avoid the first-pass effect, as an alternative therapy to injection, and to obtain improved therapeutic efficacy in the treatment of hypertension and angina pectoris. The microspheres (Ms) were prepar...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/713840323

    authors: Rajinikanth PS,Sankar C,Mishra B

    更新日期:2003-01-01 00:00:00

  • Passive targeting and lung tolerability of enoxaparin microspheres for a sustained antithrombotic activity in rats.

    abstract::Pulmonary bed can retain microparticles (MP) larger than their capillaries' diameter, hence we offer a promising way for lung passive targeting following intravenous (IV) administration. In this study, enoxaparin (Enox)-albumin microspheres (Enox-Alb MS) were, optimally, developed as lung targeted sustained release MP...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717544.2016.1245368

    authors: Ibrahim SS,Osman R,Mortada ND,Geneidy AS,Awad GA

    更新日期:2017-11-01 00:00:00

  • A photo-responsive peptide- and asparagine-glycine-arginine (NGR) peptide-mediated liposomal delivery system.

    abstract::The conjugation of tunable peptides or materials with nanocarriers represents a promising approach for drug delivery to tumor cells. In this study, we report the development of a novel liposomal carrier system that exploits the cell surface binding synergism between photo-sensitive peptides (PSPs) and targeting ligand...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.3109/10717544.2015.1008707

    authors: Xie X,Yang Y,Yang Y,Zhang H,Li Y,Mei X

    更新日期:2016-09-01 00:00:00

  • Β-Cyclodextrin-graft-poly(amidoamine) dendrons as the nitric oxide deliver system for the chronic rhinosinusitis therapy.

    abstract::Chronic rhinosinusitis (CRS) is a rather prevalent condition with a chronic inflammatory process, which is hard to cure. Herein, a new antibacterial drug, nitric oxide (NO), was used for the attempt on CRS therapy. To achieve this, a star copolymer (β-CD-PAMAM) consisting of the β-cyclodextrin (β-CD) core and seven PA...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717544.2021.1876183

    authors: Liu T,Li G,Wu X,Chen S,Zhang S,Han H,Zhang H,Luo X,Cai X,Ma D

    更新日期:2021-12-01 00:00:00

  • Development of artemether and lumefantrine co-loaded nanostructured lipid carriers: physicochemical characterization and in vivo antimalarial activity.

    abstract:CONTEXT:Artemether and lumefantrine combination therapy is well-accepted for uncomplicated malaria treatment. However, the current available formulation has several pharmacokinetic mismatches such as drug degradation in gastrointestinal tract, erratic absorption, etc. Hence, need of the hour is the injectable formulati...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.3109/10717544.2014.905883

    authors: Parashar D,Aditya NP,Murthy RS

    更新日期:2016-01-01 00:00:00

  • Research progress of self-assembled nanogel and hybrid hydrogel systems based on pullulan derivatives.

    abstract::Polymer nano-sized hydrogels (nanogels) as drug delivery carriers have been investigated over the last few decades. Pullulan, a nontoxic and nonimmunogenic hydrophilic polysaccharide derived from fermentation of black yeast like Aureobasidium pullulans with great biocompatibility and biodegradability, is one of the mo...

    journal_title:Drug delivery

    pub_type: 杂志文章,评审

    doi:10.1080/10717544.2018.1425776

    authors: Zhang T,Yang R,Yang S,Guan J,Zhang D,Ma Y,Liu H

    更新日期:2018-11-01 00:00:00

  • The challenges of oral drug delivery via nanocarriers.

    abstract::The oral application of pharmaceuticals is unarguably the most convenient method of application. Especially for protein- or peptide-based drugs, however, the effectiveness is significantly reduced due to enzymatic digestion in the stomach as well as a poor bioavailability in the small intestine. For these difficult fo...

    journal_title:Drug delivery

    pub_type: 杂志文章,评审

    doi:10.1080/10717544.2018.1501119

    authors: Reinholz J,Landfester K,Mailänder V

    更新日期:2018-11-01 00:00:00

  • Assessment of simvastatin niosomes for pediatric transdermal drug delivery.

    abstract::The prevalence of childhood dyslipidemia increases and is considered as an important risk factor for the incidence of cardiovascular disease in the adulthood. To improve dosing accuracy and facilitate the determination of dosing regimens in function of the body weight, the proposed study aims at preparing transdermal ...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.3109/10717544.2014.980896

    authors: Zidan AS,Hosny KM,Ahmed OA,Fahmy UA

    更新日期:2016-06-01 00:00:00

  • Use of biorelevant media for assessment of a poorly soluble weakly basic drug in the form of liquisolid compacts: in vitro and in vivo study.

    abstract::The purpose of this work is to use biorelevant media to evaluate the robustness of a poorly water soluble weakly basic drug to variations along the gastrointestinal tract (GIT) after incorporation in liquisolid compacts and to assess the success of these models in predicting the in vivo performance. Liquisolid tablets...

    journal_title:Drug delivery

    pub_type: 杂志文章,随机对照试验

    doi:10.3109/10717544.2014.917442

    authors: Badawy MA,Kamel AO,Sammour OA

    更新日期:2016-01-01 00:00:00

  • Effect of nanostructured lipid carriers on transdermal delivery of tenoxicam in irradiated rats.

    abstract::Transdermal delivery of non-steroidal anti-inflammatory drugs (NSAIDs) is an effective route of drug administration, as it directs the drug to the inflamed site with reduced incidence of systemic adverse effects such as gastric hemorrhage and ulcers. Tenoxicam (TNX) is a member of NSAIDs that are marketed only as oral...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717544.2020.1803448

    authors: Bawazeer S,El-Telbany DFA,Al-Sawahli MM,Zayed G,Keed AAA,Abdelaziz AE,Abdel-Naby DH

    更新日期:2020-12-01 00:00:00

  • Liraglutide-loaded multivesicular liposome as a sustained-delivery reduces blood glucose in SD rats with diabetes.

    abstract::Subcutaneous liraglutide-loaded multivesicular liposomes (Lrg-MVLs) were developed as a sustained drug-delivery system for treating diabetes and their properties were characterized. The Lrg-MVLs prepared using a two-step water-in-oil-in-water double emulsification process had a spherical appearance with a mean diamete...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717544.2016.1180723

    authors: Zhang L,Ding L,Tang C,Li Y,Yang L

    更新日期:2016-11-01 00:00:00

  • In vivo behavior of hydrogel beads based on amidated pectins.

    abstract::Radio-labeled hydrogel beads, based on amidated pectin, have been produced by adding droplets of an amidated pectin solution to calcium chloride. Incorporation of model drugs into the beads and measurement of the dissolution rate showed that the properties of the beads were unaffected by the incorporation of the radio...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.3109/10717549809065753

    authors: Munjeri O,Collett JH,Fell JT,Sharma HL,Smith AM

    更新日期:1998-01-01 00:00:00

  • Controlled-release carbamazepine matrix granules and tablets comprising lipophilic and hydrophilic components.

    abstract::The objective of this study was to investigate the effect of lipophilic (Compritol 888 ATO) and hydrophilic components (combination of HPMC and Avicel) on the release of carbamazepine from granules and corresponding tablet. Wet granulation followed by compression was employed for preparation of granules and tablets. T...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717540802518157

    authors: Barakat NS,Elbagory IM,Almurshedi AS

    更新日期:2009-01-01 00:00:00

  • Characteristics and biodistribution of soybean sterylglucoside and polyethylene glycol-modified cationic liposomes and their complexes with antisense oligodeoxynucleotide.

    abstract::A novel cationic liposome modified with soybean sterylglucoside (SG) and polyethylene glycol-distearoylphosphatidylethanolamine (PEG-DSPE) as a carrier of antisense oligodeoxynucleotide (ODN) for hepatitis B virus (HBV) therapy was constructed. Characteristics of the cationic liposomes modified with SG and PEG (SG/PEG...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717540590968215

    authors: Shi J,Yan WW,Qi XR,Maitani Y,Nagai T

    更新日期:2005-11-01 00:00:00

  • Development and characterization of sponge-like acyclovir ocular minitablets.

    abstract::For the treatment of ocular keratitis acyclovir, as a highly specific inhibitor of herpes virus replication, is applied topically into the eye. The objective of this study was to design and evaluate freeze-dried, bioadhesive and biodegredable acyclovir ocular minitablets for prolonged local drug action. The sponge-lik...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.3109/10717544.2010.509364

    authors: Refai H,Tag R

    更新日期:2011-01-01 00:00:00

  • Characterizing monoclonal antibodies to antigenic domains of TCblR/CD320, the receptor for cellular uptake of transcobalamin-bound cobalamin.

    abstract::Monoclonal antibodies (mAbs) were generated to the extracellular domain of transcobalamin receptor (TCblR) and used to identify the regions of the receptor protein involved in antibody binding. Based on the effect of transcobalamin bound cobalamin (TC-Cbl) on antibody binding, this study identified both blocking and b...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.3109/10717544.2010.509745

    authors: Jiang W,Nakayama Y,Sequeira JM,Quadros EV

    更新日期:2011-01-01 00:00:00

  • Effects of vehicles and pressure sensitive adhesives on the penetration of isosorbide dinitrate across the hairless mouse skin.

    abstract::The effects of various vehicles and adhesives on the percutaneous absorption of isosorbide dinitrate (ISDN) were evaluated. Lauroglycol FCC showed the highest flux among vehicles tested. The flux of ISDN from silicone and acrylic adhesive matrices was found to be higher than that from other types of adhesive matrices....

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10426500290095430

    authors: Myoung Y,Choi HK

    更新日期:2002-04-01 00:00:00

  • Influence of potential inhalation carriers on stability of thymopentin in rat bronchoalveolar lavage fluid.

    abstract::In the present study, the stability of thymopentin (TP5) in bronchoalveolar lavage fluid (BALF) in presence of potential excipients in inhalation formulation was investigated. The content of TP5 was determined using HPLC method. Commonly used bulking agent, dispersibility enhancers and absorption enhancers in inhalati...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.3109/10717544.2013.878002

    authors: Cai C,Wang L,Dong W,Tang X

    更新日期:2014-09-01 00:00:00

  • Characterization and evaluation of a self-microemulsifying drug delivery system containing tectorigenin, an isoflavone with low aqueous solubility and poor permeability.

    abstract::The purpose of this study was to characterize and evaluate tectorigenin-loaded self-microemulsifying drug delivery system (TG-SMEDDS), a previously studied preparation, and further confirm the improvement of TG in solubility and bioavailability. The appearance of TG-SMEDDS was clear and transparent, with good mobility...

    journal_title:Drug delivery

    pub_type: 杂志文章

    doi:10.1080/10717544.2017.1284946

    authors: Zhang Y,He L,Yue S,Huang Q,Zhang Y,Yang J

    更新日期:2017-11-01 00:00:00