Abstract:
CONTEXT:Designing a sustained release system for Carvedilol to increase its residence time in the stomach. OBJECTIVE:Preparation of floating microsphere by the emulsion solvent diffusion method, studying the effect of various process parameters and optimize the formulation using full factorial design. METHODS:Different microsphere formulations were prepared by varying the ratio ethanol:dichloromethane (1:0 to 1:1.5), ethyl cellulose:hydroxypropyl methyl cellulose and stirring speed (800-1600 rpm). The effect of these variables on particle size, encapsulation parameters, surface topography, in vitro floatability and drug release were evaluated. RESULTS:3(2) full factorial design was used for the optimization of the formulation. Drug entrapment efficiency, particle size and in vitro drug release were dependent on concentration of ethyl cellulose and stirring speed. Microspheres remained buoyant for more than 10 h and showed sustained release of the drug. CONCLUSION:Floating microspheres of Carvedilol with good floating ability and sustained release were developed.
journal_name
Drug Delivjournal_title
Drug deliveryauthors
Nila MV,Sudhir MR,Cinu TA,Aleykutty NA,Jose Sdoi
10.3109/10717544.2013.834414subject
Has Abstractpub_date
2014-03-01 00:00:00pages
110-7issue
2eissn
1071-7544issn
1521-0464journal_volume
21pub_type
杂志文章相关文献
DRUG DELIVERY文献大全abstract::Pulmonary bed can retain microparticles (MP) larger than their capillaries' diameter, hence we offer a promising way for lung passive targeting following intravenous (IV) administration. In this study, enoxaparin (Enox)-albumin microspheres (Enox-Alb MS) were, optimally, developed as lung targeted sustained release MP...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2016.1245368
更新日期:2017-11-01 00:00:00
abstract::Although meloxicam (MX) is relatively safer than other NSAIDs, adverse effects relating to the gastro-intestinal tract are still a problem when administrated MX at high doses and on the long-term treatment. Drug delivery via skin provides an attractive alternative to oral administration, but is limited by the first la...
journal_title:Drug delivery
pub_type: 杂志文章,评审
doi:10.3109/10717544.2016.1157839
更新日期:2016-10-01 00:00:00
abstract::The aim of present study was to investigate a pH-responsive and mucoadhesive nanoparticle system for oral bioavailability enhancement of low-molecular weight heparin (LMWH). The thioglycolic acid (TGA) was first covalently attached to chitosan (CS) with 396.97 ± 54.54 μmol thiol groups per gram of polymer and then the...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2014.909908
更新日期:2016-01-01 00:00:00
abstract::The aim of this work was to prepare salts of 6-methoxy-2-naphthylacetic acid (6-MNA) to improve its physicochemical properties for percutaneous application. 6-MNA, an active metabolite of non-steroidal anti-inflammatory drug nabumetone has long half life and has the tendency to penetrate well into synovial fluid. The ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2014.894595
更新日期:2015-05-01 00:00:00
abstract::Combinational therapy is usually considered as a preferable approach for effective cancer therapy. Especially, combinational chemo and photothermal therapy is of particular interest due to its high flexibility as well as efficiency. In this article, we the silica nanoparticles (SLN) were surface conjugated with Cetuxi...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1564403
更新日期:2019-12-01 00:00:00
abstract::The aim of our study was to investigate the enhancing effect of several essential oils in the percutaneous absorption of trazodone hydrochloride (TZN). For this purpose, fennel oil, eucalyptus oil, citronella oil, and mentha oil were applied on the skin membrane in three different ways: included in the transdermal dev...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540500395064
更新日期:2006-11-01 00:00:00
abstract:CONTEXT:Artemether and lumefantrine combination therapy is well-accepted for uncomplicated malaria treatment. However, the current available formulation has several pharmacokinetic mismatches such as drug degradation in gastrointestinal tract, erratic absorption, etc. Hence, need of the hour is the injectable formulati...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2014.905883
更新日期:2016-01-01 00:00:00
abstract::Tuberculosis (TB) has gained attention over the past few decades by becoming one of the top ten leading causes of death worldwide. This infectious disease of the lungs is orally treated with a medicinal armamentarium. However, this route of administration passes through the body's first-pass metabolism which reduces t...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2019.1676841
更新日期:2019-12-01 00:00:00
abstract::This study aimed to evaluate transdermal delivery of vancomycin hydrochloride using the combination of ethosomes as an encapsulating vesicle and iontophoresis. Ethosomes were prepared and evaluated in terms of electrochemical stability. Cathodal iontophoresis of negatively charged ethosomes and anodal iontophoresis of...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2015.1013200
更新日期:2016-06-01 00:00:00
abstract::In present study, two types of micelles based on sodium cholate (NaC) were prepared through non-covalent bonding interaction and the potential of micelles as oral drug delivery systems for paclitaxel (PTX) was evaluated. Pluronic-chitosan (F127-CS) and Pluronic-poly (acrylic acid) (F127-PAA) copolymers were synthesize...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2015.1028604
更新日期:2016-09-01 00:00:00
abstract::The present work aimed to apply the liquid antisolvent precipitation (LAP) method for preparing the apigenin nanoparticles and thereby improving the solubility and bioavailability of apigenin. The different experimental parameters on particle size were optimized through central composite design (CCD) using the Design-...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2017.1399302
更新日期:2017-11-01 00:00:00
abstract::The aim of this work was to encapsulate superoxide dismutase (SOD) into biodegradable microparticles by spray-drying technique. The nature of the organic solvent to dissolve the polymer, the method of incorporation of the drug in the organic phase (with or without a surfactant, namely sucrose ester of HLB = 6), the su...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540490280363
更新日期:2004-05-01 00:00:00
abstract::Chitosan, a natural-based polymer obtained by alkaline deacetylation of chitin, is nontoxic, biocompatible, and biodegradable. These properties make chitosan a good candidate for conventional and novel drug delivery systems. This article reviews the approaches aimed to associate bioactive molecules to chitosan in the ...
journal_title:Drug delivery
pub_type: 杂志文章,评审
doi:10.1080/10717540590889781
更新日期:2005-01-01 00:00:00
abstract::Among the transcription factors critical for cell cycle regulation is the proto-oncogene c-myc. The expression of c-myc upon vascular injury and its inhibition by antisense oligodeoxynucleotides have demonstrated the importance of this protein in the control of proliferation for many cell types, including vascular smo...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717549609029444
更新日期:1996-01-01 00:00:00
abstract::The development of mucoadhesive lipidic nanoemulsion based on hyaluronic acid, co-encapsulating two polyphenols (resveratrol and curcumin) for the transnasal treatment of neurodegenerative diseases was attempted in the current manuscript. Nanoemulsions were prepared by the spontaneous emulsification method, and were c...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2015.1092619
更新日期:2016-05-01 00:00:00
abstract::DNA vaccination is a promising approach for inducing both humoral and cellular immune responses. The mode of plasmid DNA delivery is critical to make progress in DNA vaccination. Using human papillomavirus type 16 E7 as a model antigen, this study evaluated the effect of peptide-polymer hybrid including PEI600-Tat con...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540902757721
更新日期:2009-05-01 00:00:00
abstract::Administration of influenza vaccines to the lungs could be an attractive alternative to conventional parenteral administration. In this study, we investigated the deposition site of pulmonary delivered liquid and powder influenza vaccine formulations and its relation to their immunogenicity and protective efficacy. In...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1435748
更新日期:2018-11-01 00:00:00
abstract::At present, the chemotherapy of advanced inoperable liver cancer is limited with serious side effects. Curcumin possesses multiple cancer preventive activities and low safety concerns. However, its poor solubility and instability in water pose significant pharmacological barriers to its clinical application. In this s...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1526227
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVE:Insulin is a hormone used in the treatment of diabetes mellitus. Multiple injections of insulin every day may causes pain, allergic reactions at injection site, which lead to low patient compliance. The aim of this work was to develop and evaluate an efficient solid lipid nanoparticle (SLN) carrier for oral d...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2015.1039666
更新日期:2016-07-01 00:00:00
abstract::In the present study, six different molecular weight diblock copolymer of methoxy poly (ethylene glycol)-b-poly (ε-caprolactone) (MPEG-PCL) were synthesized and characterized and was used for fabrication of etoposide-loaded micelles by nanoprecipitation technique. The particle size and percentage drug entrapment of pr...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2012.657721
更新日期:2012-04-01 00:00:00
abstract::The effects of various vehicles and adhesives on the percutaneous absorption of isosorbide dinitrate (ISDN) were evaluated. Lauroglycol FCC showed the highest flux among vehicles tested. The flux of ISDN from silicone and acrylic adhesive matrices was found to be higher than that from other types of adhesive matrices....
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10426500290095430
更新日期:2002-04-01 00:00:00
abstract::Ocular drug delivery remains challenging because of the complex nature and structure of the eye. Conventional systems, such as eye drops and ointments, are inefficient, whereas systemic administration requires high doses resulting in significant toxicity. There is a need to develop novel drug delivery carriers capable...
journal_title:Drug delivery
pub_type: 杂志文章,评审
doi:10.3109/10717544.2010.483257
更新日期:2010-09-01 00:00:00
abstract::The prevalence of childhood dyslipidemia increases and is considered as an important risk factor for the incidence of cardiovascular disease in the adulthood. To improve dosing accuracy and facilitate the determination of dosing regimens in function of the body weight, the proposed study aims at preparing transdermal ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2014.980896
更新日期:2016-06-01 00:00:00
abstract::Electro-phonophoresis (EP) has been used in various clinical fields. The objective of present study is to evaluate the skin permeability of isoniazid (INH) and rifampicin (RIF) in patients with tuberculous lymphadenitis with the aid of EP to validate the clinical applications of this transdermal delivery system for th...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2015.1124474
更新日期:2016-06-01 00:00:00
abstract::The aim of the current study was to formulate terconazole (TCZ) loaded polymeric mixed micelles (PMMs) incorporating Cremophor EL as a stabilizer and a penetration enhancer. A 23 full factorial design was performed using Design-Expert® software for the optimization of the PMMs which were formulated using Pluronic P123...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1436098
更新日期:2018-11-01 00:00:00
abstract:CONTEXT:Intraoral drug delivery as mucosal delivery pathway provides a huge platform in the pharmaceutical field. OBJECTIVE:Combining mucoadhesiveness and controlled release of thio-poly acrylic acid as advanced excipient for buccal drug delivery. MATERIALS AND METHODS:Mediated by carbodiimide, cysteine was covalentl...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2015.1122673
更新日期:2016-07-01 00:00:00
abstract::This work evaluates solid lipid nanoparticles of thiopental sodium against obesity-induced cardiac dysfunction and hypertrophy and explores the possible mechanism of action. TS loaded SLNs were formulated by hot-homogenization and solvent diffusion method. TS-SLNs were scrutinized for entrapment efficiency, drug loadi...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2020.1803449
更新日期:2020-12-01 00:00:00
abstract::This work focused on the developmental aspects, pharmacokinetic evaluation, and pharmacological assessment of a drug inclusion complex for a novel camptothecin analog (CA) and 2-hydroxypropyl-β-cyclodextrin (HP-β-CD). Camptothecins analog belong to topoisomerase-I inhibitor class of compounds with proven anti-tumor ac...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2010.544689
更新日期:2011-05-01 00:00:00
abstract::Biodegradable implantable matrices containing bovine serum albumin were prepared from oligoesters by melting, and subsequently tested on in vitro albumin release. The linear poly (DL-lactic acid) and the branched terpolymer of DL-lactic acid, glycolic acid, and mannitol were synthesized. Products were of similar molec...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717540500313125
更新日期:2006-01-01 00:00:00
abstract::Hypoxic microenvironment commonly occurred in the solid tumors considerably decreases the chemosensitivity of cancer cells. Salidroside (Sal), the main active ingredient of Rhodiola rosea, was shown to be able of regulating the tumor hypoxia micro-environment and enhancing the chemotherapeutic efficacy of drug-resista...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2020.1754528
更新日期:2020-12-01 00:00:00